Explore the vast range of titles available.

Shifts in global climate patterns can alter animal behavior, including movement and space use. The southwestern United States of America is currently undergoing a period of megadrought, which can have profound consequences on small ectothermic organisms like box turtles. We radiotracked eight adult ornate box turtles (Terrapene ornata) in eastern New Mexico from September 2019 to July 2022, when the environmental conditions transitioned from a dry season with low cumulative precipitation in 2020 to high cumulative precipitation in 2021, followed by a regression to exceptional drought conditions that culminated with a high-intensity wildfire in early 2022. Turtles exhibited greater mean daily movement and were more active in 2021 in comparison to 2020 and 2022. Turtles were least active in 2022, while mean daily movement was comparative to 2020. All turtles in our study exhibited homing behavior after the wildfire, but individual responses varied. While some turtles initially moved out of the burned area and returned within a month, others remained inactive within a small portion of the burned area. The greatest movement was documented in one female turtle following the wildfire, whose home range expanded to seven times the average maximum annual home range size observed among other turtles. Overall, this is the first documentation of T. ornata response to highly altered habitat after high-severity wildfire.

ObjectivesVenous thromboembolism (VTE) is a major cause of morbidity and mortality globally, with hospital-associated thrombosis (HAT) accounting for at least half of VTE. We set out to understand more about deaths from HAT in England, to focus improvement efforts where they are needed most.DesignA retrospective cohort combining death certification and hospital activity data to identify people with an inpatient or day case hospitalisation where no VTE diagnosis was recorded, and who died from VTE in a hospital or within 90 days of discharge, between April 2017 and March 2020.SettingAll deaths occurring in England and all National Health Service-funded hospital care in England.ParticipantsAfter 0.1% of cases were excluded due to duplicate but conflicting records, a cohort of 13 995 deaths remained; 54% were women, and 26% were aged under 70 years.Outcome measuresAnalysis of age, gender, primary diagnosis, type of admission, specialties and (for day cases) procedure types were preplanned.ResultsOnly 5% of these deaths followed planned inpatient admissions. Day case admissions preceded 7% of VTE deaths. Emergency inpatient admissions, medical specialties and infection-related primary diagnoses predominated in people who died from VTE after hospitalisation where no VTE diagnosis was recorded. Most deaths occurred in a hospital or within 30 days of discharge.ConclusionsInternational efforts to reduce HAT historically focused on planned inpatient admissions. Further initiatives and research to prevent deaths from VTE after hospitalisation should focus on the emergency care pathway where most deaths occurred, with people undergoing day case procedures an important additional focus.

Automation will be central to the next phase of business technology transformation, driving new levels of customer value such as faster delivery of products, higher quality and dependability, deeper personalization, and greater convenience. This business transformation phase will require workers with new skills at all levels. There are significant shortages of women in leadership job roles in information technology and automation. There are also significant disparities with pay and opportunities for women in those fields. As a result, it is critical to understand the organizational cultural change strategies that information technology (IT) and automation companies can make to employ more females in information technology and automation positions and address gender pay issues and gender exclusivity issues currently existing in today's workplace. This article intends to influence the world of practice through the execution of a literature review content analysis.

Bioactive surfaces and materials have displayed great potential in a variety of tissue engineering applications but often struggle to completely emulate complex bodily systems. The extracellular matrix (ECM) is a crucial, bioactive component in all tissues and has recently been identified as a potential solution to be utilized in combination with biomaterials. In tissue engineering, the ECM can be utilized in a variety of applications by employing the biochemical and biomechanical cues that are crucial to regenerative processes. However, viable solutions for maintaining the dimensionality, spatial orientation, and protein composition of a naturally cell-secreted ECM remain challenging in tissue engineering. Therefore, this work used soft lithography to create micropatterned polydimethylsiloxane (PDMS) substrates of a three-dimensional nature to control cell adhesion and alignment. Cells aligned on the micropatterned PDMS, secreted and assembled an ECM, and were decellularized to produce an aligned matrix biomaterial. The cells seeded onto the decellularized, patterned ECM showed a high degree of alignment and migration along the patterns compared to controls. This work begins to lay the groundwork for elucidating the immense potential of a natural, cell-secreted ECM for directing cell function and offers further guidance for the incorporation of natural, bioactive components for emerging tissue engineering technologies.

Chad, my boyfriend of two years, smashed his foot into a borrowed ice skate as we sat side by side on the cold smooth rocks of the river, the mountains an eerie blue gray rising steep and sharp all around us. The cut of Doug's skate far behind me, the bite of cold against my exposed ear, the heavy footsteps of something upstream along the treeline, Chad's unexpected vulnerability, what I knew I was capable of—I'm not sure what it was, but suddenly I had to go. [...]the quick crack, the ice opening, my shins exploding in pain, the icy water filling my thick work pants, stealing the scream from my chest, the water a cold hand covering my face.

Patients with asthma experience circadian variations in their symptoms. However it remains unclear how specific aspects of this common airway disease relate to clock genes, which are critical to the generation of circadian rhythms in mammals. Here, we used a viral model of acute and chronic airway disease to examine how circadian clock disruption affects asthmatic lung phenotypes. Deletion of the core clock gene bmal1 or environmental disruption of circadian function by jet lag exacerbated acute viral bronchiolitis caused by Sendai virus (SeV) and influenza A virus in mice. Post-natal deletion of bmal1 was sufficient to trigger increased SeV susceptibility and correlated with impaired control of viral replication. Importantly, bmal1−/− mice developed much more extensive asthma-like airway changes post infection, including mucus production and increased airway resistance. In human airway samples from two asthma cohorts, we observed altered expression patterns of multiple clock genes. Our results suggest a role for bmal1 in the development of asthmatic airway disease via the regulation of lung antiviral responses to common viral triggers of asthma.

This dissertation describes the factors influencing teacher efficacy among teachers currently or recently working in a juvenile detention center education program in southeastern Pennsylvania. The single-case study examined the barriers and facilitators to high teacher efficacy in that school setting, since these factors were previously unknown. The research population for the study consisted of all teachers who are working or who have worked within the past five years at the juvenile detention center education program (n = 9). Research was conducted using the Teachers’ Sense of Efficacy Scale (Tschannen-Moran & Hoy, 2001), a questionnaire, and in-person interviews. The following were found to be barriers to high teacher efficacy at the juvenile detention center: student misbehavior, classroom distractions, student groupings of mixed ability levels, limited assessment options, negative student attitudes, and limited background information about students. The following were found to be facilitators of high teacher efficacy at the juvenile detention center: positive learning climate, presence of detention officers, classroom rules and expectations, differentiated instruction, relevant lessons, educational activities, and rapport with students.

In \"Apartment Therapy: Complete + Happy Home\" (Potter Style, $35), Ryan and co-author Janel Laban teach readers how to do just that by sharing their best advice for ideal ways to set up a home, live in a home and maintain a home. Ryan, co-founder of the Apartment Therapy blog network, has spent the last decade sharing his design know-how with the world. In \"Apartment Therapy: Complete + Happy Home\" (Potter Style, $35), Ryan and co-author Janel Laban teach readers how to do just that by sharing their best advice for ideal ways to set up a home, live in a home and maintain a home. Ryan, co-founder of the Apartment Therapy blog network, has spent the last decade sharing his design know-how with the world.

In \"Apartment Therapy: Complete + Happy Home\" (Potter Style, $35), Ryan and co-author Janel Laban teach readers how to do just that by sharing their best advice for ideal ways to set up a home, live in a home and maintain a home. In \"Apartment Therapy: Complete + Happy Home\" (Potter Style, $35), Ryan and co-author Janel Laban teach readers how to do just that by sharing their best advice for ideal ways to set up a home, live in a home and maintain a home.