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"Webb, Heather"
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Dante, artist of gesture
A new approach to reading Dante's 'La Comedia Divinia' through the lens of art history. 'Dante, Artist of Gesture' brings Dante's canonical text into conversation with the visual art of his time to suggest the importance of visual cues to the reading and interpretation of the text itself.
Book
The role of age in the physiological adaptations and psychological responses in bikini-physique competitor contest preparation: a case series
The increased popularity of the bikini-physique competitions has not translated to greater research identifying the influence of age on adaptations during contest preparation. The purpose of this case series was to observe how age may influence the adaptations normally seen during preparation and the exploration of newer protocols to address adaptations more relative to the judging standards. Over a 16-week pre-contest preparation, a 32-y bikini competitor (BC) and 44-y master’s bikini competitor (MBC) visited the laboratory bi-weekly to observe changes in body fat mass (BF), lean body mass (LBM), bone mineral density (BMD), total body water (TBW); exploratory measures of deltoid cross-sectional area (Delt
CSA
), gluteus maximus muscle thickness (GM
MT
), and subcutaneous adipose tissue thickness (SAT); reproductive hormones estradiol (E2), luteinizing hormone (LH), and energy balance hormones triiodothyronine (T
3
), leptin and ghrelin; hydration status during contest preparation and the week of competition; resting metabolic rate (RMR); psychometric data related to perceived anxiety, stress, and body image were assessed. No differences between BC and MBC were observed in BF, LBM, BMD, and TBW. Both competitors showed a small loss in LBM. Both BC and MBC showed a contrasting increase in Delt
CSA
and a loss in GM
MT
. MBC showed to be slightly more dehydrated (1.025 vs 1.021 g·mL
− 1
) than BC. Both competitors maintained a euhydration status the day of the competition. No time differences were found between BC and MBC during RMR. BC showed a higher mean difference RMR compared to MBC (2.66 ± 0.75 kcal·kgLBM
− 1
·d
− 1
). MBC showed a higher mean difference in LH concentration (84.6 ± 6.01 IU·L
− 1
), which may be explained by perimenopausal status. MBC had a higher mean difference concentration of leptin (2.51 ± 0.24 ng·mL
− 1
·kgFM
− 1
), which was unperturbed by fat loss may be interrelated LH. BC self-reported a higher mean energy intake (15.07 ± 3.43 kcal·kgLBM
− 1
·d
− 1
) and higher aerobic training volume (93.26 ± 40.68 min·d). BC and MBC showed similar composition changes, slightly differing metabolic rates, and differing hormonal LH and leptin responses. This finding is in contrast to previous work showing both LH inhibition and leptin diurnal disturbance in younger, female athletes with low energy availability. The exploratory measures may have some benefit for bikini-physique competitors related to the judging criteria. Age did not seem to play a role in contest preparation adaptations.
Journal Article
Ribbons of scarlet : a novel of the French Revolution's women
\"Six best-selling and award-winning authors bring to life a breathtaking epic novel illuminating the hopes, desires, and destinies of princesses and peasants, harlots and wives, fanatics and philosophers - six unforgettable women whose paths cross during one of the most tumultuous and transformative events in history: the French Revolution. Ribbons of Scarlet is a timely story of the power of women to start a revolution - and change the world. In late 18th-century France, women do not have a place in politics. But as the tide of revolution rises, women from gilded salons to the streets of Paris decide otherwise - upending a world order that has long oppressed them. Blue-blooded Sophie de Grouchy believes in democracy, education, and equal rights for women and marries the only man in Paris who agrees. Emboldened to fight the injustices of King Louis XVI, Sophie aims to prove that an educated populace can govern itself - but one of her students, fruit-seller Louise Audu, is hungrier for bread and vengeance than learning. When the Bastille falls and Louise leads a women's march to Versailles, the monarchy is forced to bend, but not without a fight. The king's pious sister, Princess Elisabeth, takes a stand to defend her brother, spirit her family to safety, and restore the old order, even at the risk of her head. But when fanatics use the newspapers to twist the revolution's ideals into a new tyranny, even the women who toppled the monarchy are threatened by the guillotine. Putting her faith in the pen, brilliant political wife Manon Roland tries to write a way out of France's blood-soaked Reign of Terror while pike-bearing Pauline Leon and steely Charlotte Corday embrace violence as the only way to save the nation. With justice corrupted by revenge, all the women must make impossible choices to survive - unless unlikely heroine and courtesan's daughter Emilie de Sainte-Amaranthe can sway the man who controls France's fate: the fearsome Robespierre.\"--provided by publisher.
Book
p66α—MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2—NuRD complex
Nucleosome remodeling complexes comprise several large families of chromatin modifiers that integrate multiple epigenetic control signals to play key roles in cell type-specific transcription regulation. We previously isolated a methyl-binding domain protein 2 (MBD2)-containing nucleosome remodeling and deacetylation (NuRD) complex from primary erythroid cells and showed that MBD2 contributes to DNA methylation-dependent embryonic and fetal β-type globin gene silencing during development in vivo. Here we present structural and biophysical details of the coiledcoil interaction between MBD2 and p66α, a critical component of the MBD2-NuRD complex. We show that enforced expression of the isolated coiled-coil domain relieves MBD2-mediated globin gene silencing and that the expressed peptide interacts only with a subset of components of the MBD2-NuRD complex that does not include native or Mi-2. These results demonstrate the central importance of the coiled-coil interaction and suggest that MBD2-dependent DNA methylation-driven gene silencing can be disrupted by selectively targeting this coiled-coil complex.
Journal Article
Hydration Status and Acute Kidney Injury Biomarkers in NCAA Female Soccer Athletes During Preseason Conditioning
Exercise training in extreme temperatures concurrent with hypohydration status may potentiate the development of acute kidney injury (AKI) in young, healthy persons. Background/Objectives: It is unknown how repeated training bouts in ambient higher temperatures and humidity may influence measures of AKI. The purpose of this study was to investigate hydration status and renal biomarkers related to AKI in NCAA Division I female soccer athletes during preseason conditioning. Methods: A convenience sample of n = 21 athletes were recruited (mean ± SEM; age: 19.3 ± 0.25 y; height: 169.6 ± 1.36 cm; mass: 68.43 ± 2.46 kg; lean body mass: 45.91 ± 1.13 kg; fat mass: 22.51 ± 1.69 kg; body fat %: 32.22 ± 1.32%). The average temperature was 27.43 ± 0.19 °C, and the humidity was 71.69 ± 1.82%. Body composition, anthropometric, workload, and 14 urine samples were collected throughout the preseason training period for urine specific gravity (USG), creatinine (uCr), cystatin C (uCyst-C), and neutrophil gelatinase-associated lipocalin (uNGAL) analyses. Results: Our investigation showed that, when compared to baseline (D0), the athletes maintained a USG-average euhydrated status (1.019 ± 0.001) and were euhydrated prior to each exhibition game (D5-Pre: p = 0.03; 1.011 ± 0.001; D10-Pre: p = 0.0009; 1.009 ± 0.001); uCr was elevated on D8 (p = 0.001; 6.29 ± 0.44 mg·dL−1·LBM−1) and D10-Post (p = 0.02; 6.61 ± 0.44 mg·dL−1·LBM−1); uCyst-C was elevated on D6 through D10 (p = 0.001; ~0.42 ± 0.01 mg·dL−1); no differences were found in uNGAL concentration. The highest distance (m) displaced was found during exhibition games (D5: p = <0.0001; ~8.6 km and D10: p = <0.0001; ~9.6 km). During the preseason conditioning, the athletes maintained a euhydrated status (~1.019) via USG, an increase in uCr that averaged within a normal range (208 mg·dL−1), and an increase in uCyst-C to near AKI threshold levels (0.42 mg·L−1) for several practice sessions, followed by an adaptive decline. No differences were found in uNGAL, which may be explained by athlete variation, chosen time sample collection, and variation in training and hydration status. Conclusions: The athletes maintained a euhydrated status, and this may help explain why urinary markers did not change or meet the reference threshold for AKI.
Journal Article
The Medieval Heart
Drawing from the works of Dante, Catherine of Siena, Boccaccio, Aquinas, and Cavalcanti and other literary, philosophic, and scientific texts, Heather Webb studies medieval notions of the heart to explore the \"lost circulations\" of an era when individual lives and bodies were defined by their extensions into the world rather than as self-perpetuating, self-limited entities.
eBook
Beliefs and Attitudes of Health Care Professionals Toward Mental Health Services Users’ Rights: A Cross-Sectional Study from the United Arab Emirates
Purpose: The beliefs and attitudes of healthcare professionals (HCPs) towards service user's rights in mental healthcare are critical to understanding as it impacts the quality of care and treatment, leading to social discrimination and possible coercive professional practices. This study aimed to investigate the association between the HCPs' beliefs and attitudes towards service users' rights in seeking treatment in the UAE and to identify or may predict the stigmatized attitudes and behaviors among HCPs. Patients and Methods: Data was collected from HCPs participants working at three healthcare entities (n=307) allocated at selected primary and tertiary healthcare settings that specifically treat mental disorders. The Health Professionals Beliefs and Attitudes towards Mental Health Users' Rights Scale (BAMHS) questionnaire was used to assess the beliefs and attitudes. Unconditional associations using regression models included whether HCPs provide care to specific mental health patients, whether treating mental health patients is part of their jobs, whether HCPs receive professional training for mental healthcare, nationality of HCPs, and the number of years of professional experience. Results: Our findings demonstrate that HPCs understand mental disorders and feel that individuals' rights should be equal to those who do not have mental disorders while believing in autonomy and freedom, but there is a level of discrimination and a high level of social distance. HCPs are less tolerant when interacting with those with mental disorders outside their professional lives. Conclusion: Interventions with long-term follow-up activities must be implemented and assessed using assessment systems that measure acquired knowledge and actual behavioral change to ensure anti-stigma impact in practice and policy. Keywords: attitudes, HCPs, mental disorder, BAMHS, the United Arab Emirates, service users' rights
Journal Article
Aerobic fitness impacts sympathoadrenal axis responses to concurrent challenges
The combination of mental and physical challenges can elicit exacerbated cardiorespiratory (CR) and catecholamine responses above that of a single challenge alone.
Purpose
This study examined the effects of a combination of acute mental challenges and physical stress on cardiorespiratory and catecholamine responses.
Method
Eight below-average fitness (LF
V
O
2max
= 36.58 ± 3.36 ml
−1
kg
−1
min
−1
) and eight above-average fitness (HF
V
O
2max
= 51.18 ± 2.09 ml
−1
kg
−1
min
−1
) participants completed an exercise-alone condition (EAC) session consisting of moderate-intensity cycling at 60%
V
O
2max
for 37 min, and a dual-challenge condition (DCC) that included concurrent participation in mental challenges while cycling.
Result
The DCC resulted in increases in perceived workload, CR, epinephrine, and norepinephrine responses overall. HF participants had greater absolute CR and catecholamine responses compared to LF participants and quicker HR recovery after the dual challenge.
Conclusion
These findings demonstrate that cardiorespiratory fitness does impact the effect of concurrent stressors on CR and catecholamine responses.
Journal Article
The Effect of an Acute Farmers Walk Exercise Bout on Muscle Damage and Recovery in Recreationally Trained Adults
Purpose
The Farmer’s Walk (FW) may supplement resistance training through functional tasks like lifting and carrying weight over various distances. Minimal information exists concerning the intramuscular responses resulting from FW performance, possibly impacting its application in exercise prescription. Therefore, the purpose of the study was to investigate Creatine Kinase (CK) and myoglobin (Mb) responses following the Farmers Walk Condition (FWC) compared to a control protocol (NWC).
Methods
Fifteen participants (Mean ± SEM; age: 21.6 ± 0.5 years; height: 172.5 ± 2.4 cm; body weight: 81.8 ± 4.0 kg) completed an initial session to measure body composition, lower body power, and strength. Participants then completed two counter-balanced exercise protocols consisting of a 20-m walk performed within 5 sets of 2 repetitions while either carrying weight (FWC; average wt: 85.15 ± 25.55 kg) or not (NWC) with collection of Visually Perceived Muscle Soreness (VPMS), Ratings of Perceived Exertion (RPE), and blood samples. VPMS, blood samples, and Countermovement Jump (CMJ) height were also collected during recovery from each exercise protocol with significance of
P
< 0.05.
Results
Significant differences were observed between exercise protocols performed including participant RPE (
P
< 0.01), CK (
P
= 0.01), and overall, upper body, and lower body VPMS (
P
< 0.05) post-FWC. No significant differences were noted for Mb or CMJ height.
Conclusion
Training variables implemented during the FWC may have indirectly minimized muscle damage and neuromuscular inhibitions in performance. Although participants reported mild soreness, the negligible physiological damage suggests the FWC is a safe and appropriate functional movement exercise.
Journal Article
Acute L-arginine alpha ketoglutarate supplementation fails to improve muscular performance in resistance trained and untrained men
Background
Dietary supplements containing L-arginine are marketed to improve exercise performance, but the efficacy of such supplements is not clear. Therefore, this study examined the efficacy of acute ingestion of L-arginine alpha-ketoglutarate (AAKG) muscular strength and endurance in resistance trained and untrained men.
Methods
Eight resistance trained and eight untrained healthy males ingested either 3000mg of AAKG or a placebo 45 minutes prior to a resistance exercise protocol in a randomized, double-blind crossover design. One-repetition maximum (1RM) on the standard barbell bench press and leg press were obtained. Upon determination of 1RM, subjects completed repetitions to failure at 60% 1RM on both the standard barbell bench press and leg press. Heart rate was measured pre and post exercise. One week later, subjects ingested the other supplement and performed the identical resistance exercise protocol.
Results
Our data showed statistical significant differences (p<0.05) between resistance trained and untrained males for both 1RM and total load volume (TLV; multiply 60% of 1RM times the number of repetitions to failure) for the upper body. However, 1RM and TLV were not statistically different (p>0.05) between supplementation conditions for either resistance trained or untrained men in the bench press or leg press exercises. Heart rate was similar at the end of the upper and lower body bouts of resistance exercise with AAKG vs. placebo.
Conclusion
The results from our study indicate that acute AAKG supplementation provides no ergogenic benefit on 1RM or TLV as measured by the standard barbell bench press and leg press, regardless of the subjects training status.
Journal Article