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The MENC Handbook of Research on Music Learning, Volume 2: Applications brings together the best and most current research on best practice for music learning, focusing squarely on the profession's empirical and conceptual knowledge of how students gain competence in music at various ages and in different contexts. The collection of chapters, written by the foremost figures active in the field, addresses a range of best practices for approaching current andimportant areas in the field, including cognition and perception, music listening, vocal/choral learning, and the needs of special learners. The book's companion volume, Strategies, provides the solid theoretical framework and extensive research upon which these practices stand.Throughout both volumes in this essential set, focus is placed on the musical knowledge and musical skills needed to perform, create, understand, reflect on, enjoy, value, and respond to music. A key point of emphasis rests on the relationship between music learning and finding meaning in music, and as music technology plays an increasingly important role in learning today, chapters move beyond exclusively formal classroom instruction into other forms of systematic learning and informalinstruction. Either individually or paired with its companion Volume 1: Strategies, this indispensable overview of this growing area of inquiry will appeal to students and scholars in Music Education, as well as front-line music educators in the classroom.

This book brings together the best and most current research on best practice for music learning, focusing squarely on the profession’s empirical and conceptual knowledge of how students gain competence in music at various ages and in different contexts. The collection of chapters, written by the foremost figures active in the field, addresses a range of best practices for approaching current and important areas in the field, including cognition and perception, music listening, vocal/choral learning, and the needs of special learners. The book’s companion volume, Strategies, provides the solid theoretical framework and extensive research upon which these practices stand. Focus is placed on the musical knowledge and musical skills needed to perform, create, understand, reflect on, enjoy, value, and respond to music. A key point of emphasis rests on the relationship between music learning and finding meaning in music, and as music technology plays an increasingly important role in learning today, chapters move beyond exclusively formal classroom instruction into other forms of systematic learning and informal instruction.

Peter Webster believes that a study of the history of music teaching and learning in North America will likely reveal very few examples of extended and well-argued professional discourse. By \"discourse\" he means a continuous expression or exchange of ideas designed to present contrasting views on important issues in the music teaching profession. Webster says that often annual teaching conventions are filled with presentations that address a single perspective in research, pedagogy, or theory. \"Special theme\" issues of magazines are rarely devoted to contrasting points of view about music teaching and learning. Conferences are organized to promote single views on a subject, often speaking to a partisan audience that expects to be neither challenged to think in a contrary way nor encouraged to develop alternative perspectives. Webster believes that, in his paper, Paul Woodford, makes this point forcefully and effectively as he challenges educators to consider just how few examples there are of real discourse in the profession. Webster, says that he enjoyed enormously the case made in Woodford's paper for liberal education as not defined by the teaching of a canon of great books or art works as an end, but as a thoughtful discussion of ideas in light of contemporary circumstance. Webster responds to that idea by saying that the paper reminds educators that the idea of criticism in the field of education need not be a negative concept in this current age of post-modern thought, but rather, a positive mark of a maturing profession. (Contains 4 footnotes.)

The central purpose of this research was to determine the nature of children's verbal responses to repeated hearings of a brief music excerpt when asked systematically-designed questions that encouraged interpretative responses. Three specific research questions served as the basis for the investigation: (a) Is there consistent agreement about the basic form and content of the responses as the result of independent analyses by expert judges? (b) If so, is the subsequent assignment of categories to responses systematically related to age? (c) If so, is this relationship similar to research findings in other developmental literature? Thirty-three kindergarten through fifth-grade children from a Midwestern public elementary school were interviewed individually. Their responses were recorded, transcribed to written text, and submitted to three judges who were directed to (a) devise a categorization system that they felt encompassed the range and character of responses; (b) assign the devised categories to the individual responses. The data were analyzed for patterns that suggested a developmental sequence, either unique to music listening or related to other developmental studies. Results indicate: (a) judge consensus over the form and content of the responses; (b) age tendencies in responses to three of the four questions asked; (c) similarities between the development of verbal responses to music and visual art; (d) general agreement with descriptions of the artistic growth of elementary school-aged children.

Mammalian biology adapts to physical activity but the molecular mechanisms sensing the activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses mechanical force to enable vascular development. Here, we address Piezo1 in adult endothelium, the major control site in physical activity. Mice without endothelial Piezo1 lack obvious phenotype but close inspection reveals a specific effect on endothelium-dependent relaxation in mesenteric resistance artery. Strikingly, the Piezo1 is required for elevated blood pressure during whole body physical activity but not blood pressure during inactivity. Piezo1 is responsible for flow-sensitive non-inactivating non-selective cationic channels which depolarize the membrane potential. As fluid flow increases, depolarization increases to activate voltage-gated Ca 2+ channels in the adjacent vascular smooth muscle cells, causing vasoconstriction. Physical performance is compromised in mice which lack endothelial Piezo1 and there is weight loss after sustained activity. The data suggest that Piezo1 channels sense physical activity to advantageously reset vascular control. The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial communication to mesenteric vessel muscle cells, leading to vasoconstriction.

Disruption in reciprocal connectivity between the right anterior insula and the left dorsolateral prefrontal cortex is associated with depression and may be a target for neuromodulation. In a five-center, parallel, double-blind, randomized controlled trial we personalized resting-state functional magnetic resonance imaging neuronavigated connectivity-guided intermittent theta burst stimulation (cgiTBS) at a site based on effective connectivity from the right anterior insula to the left dorsolateral prefrontal cortex. We tested its efficacy in reducing the primary outcome depression symptoms measured by the GRID Hamilton Depression Rating Scale 17-item over 8, 16 and 26 weeks, compared with structural magnetic resonance imaging (MRI) neuronavigated repetitive transcranial magnetic stimulation (rTMS) delivered at the standard stimulation site (F3) in patients with ‘treatment-resistant depression’. Participants were randomly assigned to 20 sessions over 4–6 weeks of either cgiTBS ( n  = 128) or rTMS ( n  = 127) with resting-state functional MRI at baseline and 16 weeks. Persistent decreases in depressive symptoms were seen over 26 weeks, with no differences between arms on the primary outcome GRID Hamilton Depression Rating Scale 17-item score (intention-to-treat adjusted mean, −0.31, 95% confidence interval (CI) −1.87, 1.24, P  = 0.689). Two serious adverse events were possibly related to TMS (mania and psychosis). MRI-neuronavigated cgiTBS and rTMS were equally effective in patients with treatment-resistant depression over 26 weeks (trial registration no. ISRCTN19674644). A randomized controlled trial found that functional connectivity-guided approaches to intermittent theta burst stimulation and repetitive transcranial magnetic stimulation both reduced depressive symptoms in patients with moderate to severe treatment-resistant depression over 26 weeks.

Some of the largest climatic changes in the Arctic have been observed in Alaska and the surrounding marginal seas. Near-surface air temperature (T2m), precipitation (P), snowfall, and sea ice changes have been previously documented, often in disparate studies. Here, we provide an updated, long-term trend analysis (1957–2021; n = 65 years) of such parameters in ERA5, NOAA U.S. Climate Gridded Dataset (NClimGrid), NOAA National Centers for Environmental Information (NCEI) Alaska climate division, and composite sea ice products preceding the upcoming Fifth National Climate Assessment (NCA5) and other near-future climate reports. In the past half century, annual T2m has broadly increased across Alaska, and during winter, spring, and autumn on the North Slope and North Panhandle (T2m > 0.50°C decade−1). Precipitation has also increased across climate divisions and appears strongly interrelated with temperature–sea ice feedbacks on the North Slope, specifically with increased (decreased) open water (sea ice extent). Snowfall equivalent (SFE) has decreased in autumn and spring, perhaps aligned with a regime transition of snow to rain, while winter SFE has broadly increased across the state. Sea ice decline and melt-season lengthening also have a pronounced signal around Alaska, with the largest trends in these parameters found in the Beaufort Sea. Alaska’s climatic changes are also placed in context against regional and contiguous U.S. air temperature trends and show ~50% greater warming in Alaska relative to the lower-48 states. Alaska T2m increases also exceed those of any contiguous U.S. subregion, positioning Alaska at the forefront of U.S. climate warming.

Cationic polymers have emerged as promising next-generation antimicrobial agents, albeit with inherent limitations such as low potency and limited biocompatibility. Classical cationic polymers kill bacteria via physical membrane disruption. We propose a non-classical mechanism of crossing the bacterial plasma membrane barrier, a step required for subsequent inhibition of intracellular targets, by cationic polymers which are carbon acids. Oligoimidazolium (OIM) carbon acids, instead of lysing bacteria, transiently deprotonate in water to form hydrophobic N-heterocyclic carbenes (NHCs) and exhibit efficient plasma membrane translocation. Only OIMs that are carbon acids have potent antibacterial activities against even colistin- and multidrug-resistant bacteria. OIM amide derivatives exhibit excellent antibacterial efficacy in murine sepsis and thigh infection models, while a polymeric version acts as a prophylactic agent against bovine mastitis, which is a global agricultural problem. This study unveils a promising path for the development of an alternative class of potent antimicrobial agents. Cationic polymers conventionally kill bacteria via physical membrane disruptions. Here, the authors report the development of carbon acid cationic polymers that show potent activity against multidrug-resistant strains in murine infection models and prevent bovine mastitis, and present evidence that these polymers translocate across bacterial membrane aided by N-heterocyclic carbene.