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"Weems, Scott"
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Ha! : the science of when we laugh and why
\"Humor, like pornography, is famously difficult to define. We know it when we see it, but is there any way to figure out what we really find funny? In this fascinating investigation into the science of humor and laughter, neuroscientist Scott Weems uncovers what's happening in our heads when we giggle, guffaw, or double over with laughter.\" -- Provided by publisher.
Book
Ha!
An entertaining tour of the science of humor and laughter Humor, like pornography, is famously difficult to define. We know it when we see it, but is there any way to figure out what we really find funny? In this fascinating investigation into the science of humor and laughter, neuroscientist Scott Weems uncovers what's happening in our heads when we giggle, guffaw, or double over with laughter. Beginning with the premise that humor arises from inner conflict in the brain, Weems explores such issues as why surprise is so important for humor, why computers are terrible at recognizing what's funny, and why cringe-worthy stereotypes make us laugh the hardest. From the role of insult jokes to the benefit of laughing for our immune system responses, Ha! reveals why humor is so idiosyncratic, and why how-to books alone will never help us become funnier people. Packed with the latest research, amusing anecdotes (and even a few jokes), Ha! is a delightful tour of why humor is so important to our daily lives.
eBook
Fabricating Heterogeneous Alginate Microbead Arrays With Spatially Prescribed Distributions Using Laser Direct-Write Bioprinting
Manufacturing 3D tumor systems with control over the spatial placement of disparate cell types (e.g., tumor, stromal) has posed a significant challenge. Compared to other fabrication methods, bioprinting approaches are particularly well suited to the task because they offer the fabrication of high-resolution constructs with high spatial control. Inkjet bioprinting represents the benchmark bioprinting approach because it can print multiple live cells and rapidly generate intricate patterns with high-throughput fabrication. However, inkjet bioprinting has limited resolution, increased potential for clogging cell-loaded bioinks, and could potentially introduce high shear stresses to cells. Alternatively, LDW bioprinting enables nozzle-free, noncontact fabrication of cells and cell-loaded microbeads with high resolution and spatial control. Further, LDW can create and pattern size-controlled 3D cell microenvironments (i.e., microbeads, microcapsules) in a single step. Herein, this work addresses the fabrication of spatially heterogeneous microbead arrays across multiple bioinks via LDW bioprinting. Two methods for bioprinting multiple bioinks onto the same substrate were explored, utilizing untagged and fluorescent-tagged alginates, demonstrating potential approaches to fabricate spatially heterogeneous constructs. LDW showed accurate and precise microbead placement for creating constructs with prescribed spatial composition. Further, spatially heterogeneous constructs were fabricated with individual microbead placement and guided by either user-defined idealized geometries or histologic image templates. This platform provides critical foundations for fabricating heterogeneous 3D tumor models that better reflect patient heterogeneities.
Dissertation