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With autonomous driving developing in a booming stage, accurate object detection in complex scenarios attract wide attention to ensure the safety of autonomous driving. Millimeter wave (mmWave) radar and vision fusion is a mainstream solution for accurate obstacle detection. This article presents a detailed survey on mmWave radar and vision fusion based obstacle detection methods. First, we introduce the tasks, evaluation criteria, and datasets of object detection for autonomous driving. The process of mmWave radar and vision fusion is then divided into three parts: sensor deployment, sensor calibration, and sensor fusion, which are reviewed comprehensively. Specifically, we classify the fusion methods into data level, decision level, and feature level fusion methods. In addition, we introduce three-dimensional(3D) object detection, the fusion of lidar and vision in autonomous driving and multimodal information fusion, which are promising for the future. Finally, we summarize this article.

For autonomous driving, it is important to detect obstacles in all scales accurately for safety consideration. In this paper, we propose a new spatial attention fusion (SAF) method for obstacle detection using mmWave radar and vision sensor, where the sparsity of radar points are considered in the proposed SAF. The proposed fusion method can be embedded in the feature-extraction stage, which leverages the features of mmWave radar and vision sensor effectively. Based on the SAF, an attention weight matrix is generated to fuse the vision features, which is different from the concatenation fusion and element-wise add fusion. Moreover, the proposed SAF can be trained by an end-to-end manner incorporated with the recent deep learning object detection framework. In addition, we build a generation model, which converts radar points to radar images for neural network training. Numerical results suggest that the newly developed fusion method achieves superior performance in public benchmarking. In addition, the source code will be released in the GitHub.

Unmanned Aerial Vehicles (UAVs) can cooperate through formations to perform tasks. Wireless communication allows UAVs to exchange information, but for the situations requiring high security, electromagnetic silence is needed to avoid potential threats. The passive UAV formation maintenance strategies can fulfill the requirement of electromagnetic silence at the cost of heavy real-time computing and precise locations of UAVs. To pursue high real-time performance without the localization of UAVs, this paper proposes a scalable distributed control algorithm for bearing-only passive UAV formation maintenance. By minimizing necessary communication, pure angle information is applied to maintain UAV formations through distributed control, without the knowledge of the UAVs’ precise locations. The convergency of the proposed algorithm is proven strictly and the converging radius is derived. Through simulation, the proposed algorithm is proven to be suitable for a general case and demonstrates fast convergence speed, strong anti-interference capability, and high scalability.

In order to achieve the vision of seamless wireless communication coverage, a space–air–ground integrated network is proposed as a key component of the sixth-generation (6G) mobile communication system. However, the spectrum used by aerial networks has become gradually crowded with the increase in wireless devices. Space networks are also in dire need of developing new bands to address spectrum shortages. As an effective way to solve the spectrum shortage problem, spectrum sharing between aerial/space networks and ground networks has been extensively studied. This article summarizes state-of-the-art studies on spectrum sharing between aerial/space networks and ground networks. First, this article provides an overview of aerial networks and space networks and introduces the main application scenarios of aerial networks and space networks. Then, this article summarizes the spectrum sharing techniques between aerial/space networks and ground networks, including existing spectrum utilization rules, spectrum sharing modes and key technologies. Finally, we summarize the challenges of spectrum sharing between aerial/space networks and ground networks. This article provides guidance for spectrum allocation and spectrum sharing of space–air–ground integrated networks.

A novel breast ultrasound tomography system based on a circular array of capacitive micromechanical ultrasound transducers (CMUT) has broad application prospects. However, the images produced by this system are not suitable as input for the training phase of the super-resolution (SR) reconstruction algorithm. To solve the problem, this paper proposes an improved medical image super-resolution (MeSR) method based on the sparse domain. First, we use the simultaneous algebraic reconstruction technique (SART) with high imaging accuracy to reconstruct the image into a training image in a sparse domain model. Secondly, we denoise and enhance the contrast of the SART images to obtain improved detail images before training the dictionary. Then, we use the original detail image as the guide image to further process the improved detail image. Therefore, a high-precision dictionary was obtained during the testing phase and applied to filtered back projection SR reconstruction. We compared the proposed algorithm with previously reported algorithms in the Shepp Logan model and the model based on the CMUT background. The results showed significant improvements in peak signal-to-noise ratio, entropy, and average gradient compared to previously reported algorithms. The experimental results demonstrated that the proposed MeSR method can use noisy reconstructed images as input for the training phase of the SR algorithm and produce excellent visual effects.

Background Aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) is the most common subtype of non-Hodgkin lymphoma in children and adolescents. However, little progress has been made in determining the prognostic factors of children and adolescents with B-NHL. Based on the effect of cytokines in other cancer types, this study explored the effect of cytokines on the prognosis of children and adolescents with B-NHL. Methods The levels of serum cytokines including interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were detected at diagnosis. Correlations between cytokines, clinical characteristics, and treatment outcomes were retrospectively analyzed. Results In total, 139 patients aged < 18 years with newly diagnosed mature B-NHL were enrolled. Patients with elevated IL-6 levels at diagnosis ( n  = 35) had worse 5-year event-free survival (85.3% vs. 97.1%, p  = 0.01) and overall survival (OS) rates (91.2% vs. 99.0%, p  = 0.02) than those with normal IL-6 levels. Patients with elevated IL-10 ( n  = 35) had worse 5-year OS rates (91.4% vs. 99.0%, p  = 0.02) than those with normal IL-10 levels. Cox multivariate analysis identified elevated IL-6 levels at diagnosis as an independent adverse prognostic factor in pediatric B-NHL. Elevated IL-6 levels correlated positively with IL-10 levels, and patients with simultaneously elevated IL-6 and IL-10 levels had the worst prognosis in the entire cohort. Conclusions Our study suggests that elevated serum IL-6 and IL-10 levels at diagnosis are associated with poor prognosis in pediatric mature B-NHL and may have the potential to inform risk stratification. Future prospective, multi-center studies are required to validate these findings.

In mammals, female fecundity is determined by the size of the primordial follicle (PF) pool, which is established during the perinatal period. As a non-renewable resource, the preservation of dormant PFs is crucial for sustaining female reproduction throughout life. Although studies have revealed that several oocyte-derived functional genes and pathways, such as newborn ovary homeobox (NOBOX) and 3-phosphoinositide-dependent protein kinase-1, participate in maintaining the PF pool, our understanding of the underlying molecular mechanisms is still incomplete. Here, we demonstrate that E-cadherin (E-cad) plays a crucial role in the maintenance of PFs in mice. E-cad is specifically localized to the cytomembrane of oocytes in PFs. Knockdown of E-cad in neonatal ovaries resulted in significant PF loss owing to oocyte apoptosis. In addition, the expression pattern of NOBOX is similar to that of E-cad. Knockdown of E-cad resulted in a decreased NOBOX level, whereas overexpression of Nobox partially rescued the follicle loss induced by silencing E-cad . Furthermore, E-cad governed NOBOX expression by regulating the shuttle protein, β-catenin, which acts as a transcriptional co-activator. Notably, E-cad, which is a transmembrane protein expressed in the oocytes, was also responsible for maintaining the PF structure by facilitating cell–cell adhesive contacts with surrounding pregranulosa cells. In conclusion, E-cad in oocytes of PFs plays an indispensable role in the maintenance of the PF pool by facilitating follicular structural stability and regulating NOBOX expression. These findings shed light on the physiology of sustaining female reproduction.

Acetylation modification has become one of the most popular topics in protein post-translational modification (PTM) research and plays an important role in bacterial virulence. A previous study indicated that the virulence-associated caseinolytic protease proteolytic subunit (ClpP) is acetylated at the K165 site in Vibrio alginolyticus strain HY9901, but its regulation regarding the virulence of V. alginolyticus is still unknown. We further confirmed that ClpP undergoes lysine acetylation (Kace) modification by immunoprecipitation and Western blot analysis and constructed the complementation strain (C-clpP) and site-directed mutagenesis strains including K165Q and K165R. The K165R strain significantly increased biofilm formation at 36 h of incubation, and K165Q significantly decreased biofilm formation at 24 h of incubation. However, the acetylation modification of ClpP did not affect the extracellular protease (ECPase) activity. In addition, we found that the virulence of K165Q was significantly reduced in zebrafish by in vivo injection. To further study the effect of lysine acetylation on the pathogenicity of V. alginolyticus, GS cells were infected with four strains, namely HY9901, C-clpP, K165Q and K165R. This indicated that the effect of the K165Q strain on cytotoxicity was significantly reduced compared with the wild-type strain, while K165R showed similar levels to the wild-type strain. In summary, the results of this study indicate that the Kace of ClpP is involved in the regulation of the virulence of V. alginolyticus.

Background The prognosis of high‐risk neuroblastomas (NB) that are resistant to first‐line induction chemotherapy is relatively poor. This study explored the mechanism of resistance to first‐line chemotherapeutics mediated by TXNDC17 and its potential solutions in NB. Methods The genetic and clinical data of patients with NB were obtained from the Therapeutically Applicable Research to Generate Effective Treatments dataset. TXNDC17 and BECN1 expressions in NB cells were up‐ and downregulated by transfection with plasmids and shRNA, respectively. Autophagy‐related proteins were detected by western blot. Cell viability was determined using cell proliferation and toxicity experiments. Apoptotic cells were detected using flow cytometry. Results Overall, 1076 pediatric and adolescent patients with NB were enrolled in this study. The 10‐year overall survival (OS) rates and event‐free survival (EFS) rates for the patients with a mutation of BECN1 were 37.4 ± 9.1% and 34.5 ± 8.8%, respectively. For patients with a mutation of TXNDC17, the 10‐year OS and EFS were 41.4 ± 5.9% and 24.3 ± 5.1%, respectively, which were significantly lower than those in the unaltered group. The overexpression of BECN1 and TXNDC17 reduced NB sensitivity to cisplatin (DDP), etoposide (VP16), and cyclophosphamide (CTX). Autophagy mediated by BECN1 was regulated by TXNDC17, and this process was involved in the resistance to DDP, VP16, and CTX in NB. Suberoylanilide hydroxamic acid (SAHA) can enhance the sensitivity and apoptosis of NB cells to chemotherapeutics by inhibiting TXNDC17, ultimately decreasing autophagy‐mediated chemoresistance. Conclusions Acquired resistance to first‐line chemotherapeutics was associated with autophagy mediated by BECN1 and regulated by TXNDC17, which can be reversed by SAHA.

Lysine acetylation modification is a dynamic and reversible post-translational modification, which plays an important role in the metabolism and pathogenicity of pathogenic bacteria. Vibrio alginolyticus is a common pathogenic bacterium in aquaculture, and bile salt can trigger the expression of bacterial virulence. However, little is known about the function of lysine acetylation in V. alginolyticus under bile salt stress. In this study, 1,315 acetylated peptides on 689 proteins were identified in V. alginolyticus under bile salt stress by acetyl-lysine antibody enrichment and high-resolution mass spectrometry. Bioinformatics analysis found that the peptides motif *** A * Kac *** and *** Kac *** A * were highly conserved, and protein lysine acetylation was involved in regulating various cellular biological processes and maintaining the normal life activities of bacteria, such as ribosome, aminoacyl-tRNA biosynthesis, fatty acid metabolism, two-component system, and bacterial secretion system. Further, 22 acetylated proteins were also found to be related to the virulence of V. alginolyticus under bile salt stress through secretion system, chemotaxis and motility, and adherence. Finally, comparing un-treated and treated with bile salt stress lysine acetylated proteins, it was found that there were 240 overlapping proteins, and found amino sugar and nucleotide sugar metabolism, beta-Lactam resistance, fatty acid degradation, carbon metabolism, and microbial metabolism in diverse environments pathways were significantly enriched in bile salt stress alone. In conclusion, this study is a holistic analysis of lysine acetylation in V. alginolyticus under bile salt stress, especially many virulence factors have also acetylated.