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"Weisel, Gary J"
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The Plasma Archipelago: Plasma Physics in the 1960s
With the foundation of the Division of Plasma Physics of the American Physical Society in April 1959, plasma physics was presented as the general study of ionized gases. This paper investigates the degree to which plasma physics, during its first decade, established a community of interrelated specialties, one that brought together work in gaseous electronics, astrophysics, controlled thermonuclear fusion, space science, and aerospace engineering. It finds that, in some regards, the plasma community was indeed greater than the sum of its parts and that its larger identity was sometimes glimpsed in inter-specialty work and studies of fundamental plasma behaviors. Nevertheless, the plasma specialties usually worked separately for two inter-related reasons: prejudices about what constituted “basic physics,” both in the general physics community and within the plasma community itself; and a compartmentalized funding structure, in which each funding agency served different missions.
Journal Article
Properties and Phenomena: Basic Plasma Physics and Fusion Research in Postwar America
I review the changing conceptions of basic physics that the U.S. plasma-physics community put forward in postwar America. I give special attention to the tense relationship between fusion research and the more general study of plasmas in astrophysics, space science, and industry.Although fusion research often led to results that were regarded as basic plasma physics, its dominating influence tended to weaken other plasma work, as becomes evident when I compare the public statements and professional fortunes of plasma scientists during the 1960s, when fusion research experienced a downturn, with those of the 1970s, when fusion research flourished. I also show that the plasmaphysics community’s conceptions of basic physics were not highly regarded or easily understood by science administrators and the general physics community. To make this point, I contrast two general ideas of basic physics: the Big Questions conception and the Properties and Phenomena conception.
Journal Article
Einstein: The Passions of a Scientist
Weisel reviews Einstein: The Passions of a Scientist by Barry Parker.
Book Review
The Genesis of General Relativity
Weisel reviews The Genesis of General Relativity. Volume 1: Einstein's Zurich Notebook: Introduction and Source. Volume 2: Einstein's Zurich Notebook: Commentary and Essays. Volume 3: Gravitation in the Twilight of Classical Physics: Between Mechanics, Field Theory, and Astronomy. Volume 4: Gravitation in the Twilight of Classical Physics: The Promise of Mathematics edited by Jurgen Renn.
Book Review
Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration
Parkinson's disease (PD) targets some dopamine (DA) neurons more than others. Sex differences offer insights, with females more protected from DA neurodegeneration. The mammalian vesicular glutamate transporter VGLUT2 and
ortholog dVGLUT have been implicated as modulators of DA neuron resilience. However, the mechanisms by which VGLUT2/dVGLUT protects DA neurons remain unknown. We discovered DA neuron dVGLUT knockdown increased mitochondrial reactive oxygen species in a sexually dimorphic manner in response to depolarization or paraquat-induced stress, males being especially affected. DA neuron dVGLUT also reduced ATP biosynthetic burden during depolarization. RNA sequencing of VGLUT
DA neurons in mice and flies identified candidate genes that we functionally screened to further dissect VGLUT-mediated DA neuron resilience across PD models. We discovered transcription factors modulating dVGLUT-dependent DA neuroprotection and identified dj-1β as a regulator of sex-specific DA neuron dVGLUT expression. Overall, VGLUT protects DA neurons from PD-associated degeneration by maintaining mitochondrial health.
Journal Article