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"Weller, John"
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Themes in the Christian History of Central Africa
This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1975.
eBook
The last ocean : Antarctica's Ross Sea project : saving the most pristine ecosystem on earth
\"A stunning collection of oceanic photography documenting the world's last pristine ocean. Due to its remoteness and harsh weather, Antarctica's Ross Sea remained free from human interference until 1996, when commercial fishing discovered it. Now that fishery removes 3,000 tons of fish annually, threatening to destroy the world's last intact ecosystem. The Last Ocean organization started in 2004, joining scientists and environmental groups in a campaign to have the entire Ross Sea designated as an international marine protected area. One of the founding members of The Last Ocean is John Weller, whose photographs from the Ross Sea were collected during four trips to the Antarctic, including a four-month stay at McMurdo and Cape Royds, home of the southernmost penguin colony in the world. Offering a rare glimpse into life at the edge of the world--from Emperor and Adâelie penguins to silverfish, seals, and minke whales--Weller takes the reader on an unprecedented journey above and below the ocean surface. The Last Ocean is more than stunningly beautiful photography. It is a story central to our own: our struggle to sustain a population in a changing climate and with exponentially increasing pressures on world resources\"--Amazon.com, viewed October 10, 2013.
Book
The G Protein-Coupled Receptor Repertoires of Human and Mouse
Diverse members of the G protein-coupled receptor (GPCR) superfamily participate in a variety of physiological functions and are major targets of pharmaceutical drugs. Here we report that the repertoire of GPCRs for endogenous ligands consists of 367 receptors in humans and 392 in mice. Included here are 26 human and 83 mouse GPCRs not previously identified. A direct comparison of GPCRs in the two species reveals an unexpected level of orthology. The evolutionary preservation of these molecules argues against functional redundancy among highly related receptors. Phylogenetic analyses cluster 60% of GPCRs according to ligand preference, allowing prediction of ligand types for dozens of orphan receptors. Expression profiling of 100 GPCRs demonstrates that most are expressed in multiple tissues and that individual tissues express multiple GPCRs. Over 90% of GPCRs are expressed in the brain. Strikingly, however, the profiles of most GPCRs are unique, yielding thousands of tissue- and cell-specific receptor combinations for the modulation of physiological processes.
Journal Article
علم الجلد السريري
جاءت الطبعة الإنجليزية الرابعة من هذا الكتاب، وهو الأكثر مبيعا، بعد مراجعة وتجديد شاملين، يحتوي هذا الكتاب على أكثر من 500 من الصور والمخططات فائقة الجودة والمرفقة بعبارات متعددة الألوان، فتوضح الأفكار وتجعل من تدريسه متعة. لقد اشتهر هذا الكتاب بكونه \"وسيلة للتعلم\"، فهو يرشد القارئ عبر المتاهة التي تمتد بين الشكوى الجلدية المستعلنة وتشخيصها النهائي ومعالجتها، وهي كثيرة المصادفة في أمراض الجلد. لقد أعد المؤلفون كتابا سهل القراءة مع تفاصيل كافية لإيضاح الموضوع.
BOOK
Building a coordinated framework for research and monitoring in large‐scale international marine protected areas: The Ross Sea region as a model system
To fulfill their conservation potential and provide safeguards for biodiversity, marine protected areas (MPAs) need coordinated research and monitoring for informed management through effective evaluation of ecosystem dynamics. However, coordination is challenging, often due to knowledge gaps caused by inadequate access to data and resources, compounded by insufficient communication between scientists and managers. We propose to use the world's largest MPA in the Ross Sea, Antarctica as a model system to create a comprehensive framework for an interdisciplinary network supporting research and monitoring that could be implemented in other remote large‐scale international MPAs. Our proposed framework has three key components: (i) policy engagement, including delineation of policy needs and ecosystem metrics to assess MPA effectiveness; (ii) community partner engagement to elevate diverse voices, build trust, and share resources; and (iii) integrated science comprising three themes. These themes are: advancement of data science and cyberinfrastructure to facilitate data synthesis and sharing; biophysical modeling towards understanding ecosystem changes and uncertainties; and execution of observational and process studies to address uncertainties and evaluate ecosystem metrics. This proposed framework can improve MPA implementation by generating policy‐relevant science through this coordinated network, which can in turn improve MPA effectiveness in the Ross Sea and beyond.
Journal Article
Solid-state microcellular polycarbonate foams. I. The steady-state process space using subcritical carbon dioxide
The process parameters for production of solid‐state microcellular polycarbonate using subcritical CO2 were explored. Sufficiently long foaming times were used to produce foams, where cell growth had completed, resulting in steady‐state structures. A wide range of foaming temperatures and saturation pressures below the critical pressure of CO2 were investigated, establishing the steady state process space for this polymer–gas system. Processing conditions are presented that produce polycarbonate foams where both the foam density and the average cell size can be controlled. The process space showed that we could produce foams at a constant density, while varying the cell size by and order of magnitude. At a relative density of 0.5, the average cell size could be varied from 4 to 40 μm. The ability to produce such a family of foams opens the possibility to explore the effect of microstructure, like cell size on the properties of cellular materials. It was found that the minimum foaming temperature for a given concentration of CO2, determined from the process space, agrees well with the predicted glass transition temperature of the gas–polymer solution. A characterization of the average cell size, cell size distribution, and cell nucleation density for this system is also reported. POLYM. ENG. SCI., 2010. © 2010 Society of Plastics Engineers
Journal Article
Solid-state microcellular polycarbonate foams. II. The effect of cell size on tensile properties
The effect of cell size on the tensile behavior of high‐relative‐density microcellular polycarbonate foams is investigated. Microcellular PC foams were produced in a way that allowed the average cell size to be varied, while the foam density was held constant. The polycarbonate‐CO2 system offers an order of magnitude variation in the average cell size at a given density, allowing the tensile properties of microcellular polycarbonate to be investigated as a function of cell size. It was found that the tensile modulus, tensile strength, elongation to break, and toughness are not significantly affected when the average cell size is varied from 2.8 to 37.1 μm, and the nominal relative density is held constant at 0.5. This result is significant for solid‐state processing of microcellular polycarbonate foams of the type produced here, for it shows that regardless of the processing conditions and regardless of the average cell size, if two foams have the same density then they will also have the same tensile properties. POLYM. ENG. SCI., 2010. © 2010 Society of Plastics Engineers
Journal Article
Circadian desynchronization of core body temperature and sleep stages in the rat
Proper functioning of the human circadian timing system is crucial to physical and mental health. Much of what we know about this system is based on experimental protocols that induce the desynchronization of behavioral and physiological rhythms within individual subjects, but the neural (or extraneural) substrates for such desynchronization are unknown. We have developed an animal model of human internal desynchrony in which rats are exposed to artificially short (22-h) light-dark cycles. Under these conditions, locomotor activity, sleep-wake, and slow-wave sleep (SWS) exhibit two rhythms within individual animals, one entrained to the 22-h light-dark cycle and the other free-running with a period >24 h (τ>₂₄ h). Whereas core body temperature showed two rhythms as well, further analysis indicates this variable oscillates more according to the τ>₂₄ h rhythm than to the 22-h rhythm, and that this oscillation is due to an activity-independent circadian regulation. Paradoxical sleep (PS), on the other hand, shows only one free-running rhythm. Our results show that, similarly to humans, (i) circadian rhythms can be internally dissociated in a controlled and predictable manner in the rat and (ii) the circadian rhythms of sleep-wake and SWS can be desynchronized from the rhythms of PS and core body temperature within individual animals. This model now allows for a deeper understanding of the human timekeeping mechanism, for testing potential therapies for circadian dysrhythmias, and for studying the biology of PS and SWS states in a neurologically intact model.
Journal Article
Divergent and nonuniform gene expression patterns in mouse brain
Considerable progress has been made in understanding variations in gene sequence and expression level associated with phenotype, yet how genetic diversity translates into complex phenotypic differences remains poorly understood. Here, we examine the relationship between genetic background and spatial patterns of gene expression across seven strains of mice, providing the most extensive cellular-resolution comparative analysis of gene expression in the mammalian brain to date. Using comprehensive brain-wide anatomic coverage (more than 200 brain regions), we applied in situ hybridization to analyze the spatial expression patterns of 49 genes encoding well-known pharmaceutical drug targets. Remarkably, over 50% of the genes examined showed interstrain expression variation. In addition, the variability was nonuniformly distributed across strain and neuroanatomic region, suggesting certain organizing principles. First, the degree of expression variance among strains mirrors genealogic relationships. Second, expression pattern differences were concentrated in higher-order brain regions such as the cortex and hippocampus. Divergence in gene expression patterns across the brain could contribute significantly to variations in behavior and responses to neuroactive drugs in laboratory mouse strains and may help to explain individual differences in human responsiveness to neuroactive drugs.
Journal Article