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مفاهيم جديدة للدبلوماسية الصينية
ناقش الكاتب خلاله مفهوم التدخل الإبداعي في الدبلوماسية الصينية الجديدة وقدم عددا من القضايا والشخصيات التي تجسده-وفقا له-في تاريخ الممارسات الدبلوماسية الصينية منذ انتهاء الحرب الباردة واستخلص من خلالها عددا من المبادئ والمفاهيم المرتبطة بالتدخل الإبداعي وكيفية تطبيقه وقدم أخيرا عددا من الافتراضات التصورية للتدخل الإبداعي ليمتد تأثيره إلى ممارسات المرحلة القادمة للدبلوماسية الصينية. ثم طرح المؤلف عددا من القضايا التي تحمل في ثناياها مفهوم التدخل الإبداعي ومعناه وتجسد رؤية الدبلوماسيين الصينيين وسعة خيالهم في التعامل مع الأزمات وأبرزها قضية الوساطة في ميانمار والتدخل في أزمة دارفور.
BOOK
Adaptive Huber Regression
Big data can easily be contaminated by outliers or contain variables with heavy-tailed distributions, which makes many conventional methods inadequate. To address this challenge, we propose the adaptive Huber regression for robust estimation and inference. The key observation is that the robustification parameter should adapt to the sample size, dimension and moments for optimal tradeoff between bias and robustness. Our theoretical framework deals with heavy-tailed distributions with bounded
th moment for any
. We establish a sharp phase transition for robust estimation of regression parameters in both low and high dimensions: when
, the estimator admits a sub-Gaussian-type deviation bound without sub-Gaussian assumptions on the data, while only a slower rate is available in the regime
and the transition is smooth and optimal. In addition, we extend the methodology to allow both heavy-tailed predictors and observation noise. Simulation studies lend further support to the theory. In a genetic study of cancer cell lines that exhibit heavy-tailedness, the proposed methods are shown to be more robust and predictive.
Supplementary materials
for this article are available online.
Journal Article
Zhu Guangqian and Benedetto Croce on aesthetic thought : with a translation of the Wenyi xinlixue (The psychology of art and literature)
\"In Zhu Guangqian and Benedetto Croce on Aesthetic Thought, Mario Sabattini analyses Croce's influence on the aesthetic thought of Zhu Guangqian. Zhu Guangqian is one of the most representative figures of contemporary Chinese aesthetics. Since the '30s, he had an active role in China both on the literary and philosophical scenes, and, through his writings, he exerted an important influence in the moulding of numerous generations of intellectuals. Some of his works have been widely read, and they still provoke considerable interest in China, on the mainland as well as in Taiwan and Hong Kong. The volume also presents a revised translation of Zhu Guangqian's Wenyi xinlixue (Psychology of Art and Literature)\"-- Provided by publisher.
Book
The clinical value of neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage
Inflammatory mechanisms play important roles in intracerebral hemorrhage (ICH) and have been linked to the development of stroke-associated pneumonia (SAP). The neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) are inflammatory indexes that influence systemic inflammatory responses after stroke. In this study, we aimed to compare the predictive value of the NLR, SII, SIRI and PLR for SAP in patients with ICH to determine their application potential in the early identification of the severity of pneumonia.
Patients with ICH in four hospitals were prospectively enrolled. SAP was defined according to the modified Centers for Disease Control and Prevention criteria. Data on the NLR, SII, SIRI and PLR were collected at admission, and the correlation between these factors and the clinical pulmonary infection score (CPIS) was assessed through Spearman's analysis.
A total of 320 patients were enrolled in this study, among whom 126 (39.4%) developed SAP. The results of the receiver operating characteristic (ROC) analysis revealed that the NLR had the best predictive value for SAP (AUC: 0.748, 95% CI: 0.695-0.801), and this outcome remained significant after adjusting for other confounders in multivariable analysis (RR=1.090, 95% CI: 1.029-1.155). Among the four indexes, Spearman's analysis showed that the NLR was the most highly correlated with the CPIS (r=0.537, 95% CI: 0.395-0.654). The NLR could effectively predict ICU admission (AUC: 0.732, 95% CI: 0.671-0.786), and this finding remained significant in the multivariable analysis (RR=1.049, 95% CI: 1.009-1.089, P=0.036). Nomograms were created to predict the probability of SAP occurrence and ICU admission. Furthermore, the NLR could predict a good outcome at discharge (AUC: 0.761, 95% CI: 0.707-0.8147).
Among the four indexes, the NLR was the best predictor for SAP occurrence and a poor outcome at discharge in ICH patients. It can therefore be used for the early identification of severe SAP and to predict ICU admission.
Journal Article
وثائق مكافحة كوفيد-19
بين يدي القارئ كتاب يجمع بين دفتيه الترجمة العربية لوثائق مكافحة كوفيد 19- التي أصدرتها لجنة الصحة الوطنية الصينية، ومـن بـين هذه الوثائق النسخ الست مـن آليات الوقاية مـن الالتهاب الرئوي الناجم عـن فيروس كـورونا المستجد ومكافحته، والنسخة التجريبية السابعة لآليات تـشخيص الالتـِهاب الـرئوي الناجِم عـن فـيروس كـورونا المستجد وعلاجه وغـيرها مـن الـمرفقات. وعـمل على ترجمة النـسخة الـعربية لوثائق مكافحة كـوفيد 19- الصينية فريـق ترجمة به أكـثر من عشريـن أستاذا وطالبا مـن قسم اللغة العربية بكلية اللغات الأجنبية بجامعة بكين بـالتعاون مع كلية الآداب في جامعة القاهرة والمعهد العالي للغات بتونس في جامعة قرطاج، في الفترة مـن مارس وحتى مايو 2020، قام خلالها فـريق الترجمة بترجمة قرابة 100 ألـف رمز صيني.
BOOK
Simulation-Based Hypothesis Testing of High Dimensional Means Under Covariance Heterogeneity
In this article, we study the problem of testing the mean vectors of high dimensional data in both one-sample and two-sample cases. The proposed testing procedures employ maximum-type statistics and the parametric bootstrap techniques to compute the critical values. Different from the existing tests that heavily rely on the structural conditions on the unknown covariance matrices, the proposed tests allow general covariance structures of the data and therefore enjoy wide scope of applicability in practice. To enhance powers of the tests against sparse alternatives, we further propose two-step procedures with a preliminary feature screening step. Theoretical properties of the proposed tests are investigated. Through extensive numerical experiments on synthetic data sets and an human acute lymphoblastic leukemia gene expression data set, we illustrate the performance of the new tests and how they may provide assistance on detecting disease-associated gene-sets. The proposed methods have been implemented in an R-package HD test and are available on CRAN.
Journal Article
Integrability and multisoliton solutions of the reverse space and/or time nonlocal Fokas–Lenells equation
This paper studies reverse space and/or time nonlocal Fokas–Lenells (FL) equation, which describes the propagation of nonlinear light pulses in monomode optical fibers when certain higher-order nonlinear effects are considered, by Hirota bilinear method. Firstly, we construct variable transformations from reverse space nonlocal FL equation to reverse time and reverse space-time nonlocal FL equations. Secondly, the multisoliton and quasi-periodic solutions of the reverse space nonlocal FL equation are derived through Hirota bilinear method, and the soliton solutions of reverse time and reverse space-time nonlocal FL equations are given through variable transformations. Also, dynamical behaviors of the multisoliton solutions are discussed in detail by analyzing their wave structures. Thirdly, asymptotic analysis of two- and three-soliton solutions of reverse space nonlocal FL equation is used to investigate the elastic interaction and inelastic interaction. Finally, the infinite conservation laws of three types of nonlocal FL equations are found by using their lax pairs. The results obtained in this paper possess new properties that different from the ones for FL equation, which are useful in exploring novel physical phenomena of nonlocal systems in nonlinear media.
Journal Article
Normal foot loading parameters and repeatability of the Footscan® platform system
Background
The Footscan® platform system is one of the most commonly used clinical tools for the measurement of the foot pressure. The present study was designed to assess the repeatability of the system and identify the range of loading parameters observed in the normal foot.
Methods
Measurements were collected from 32 healthy participants, 15 females and 17 males, twice at an interval of 1 week. Peak pressure (PP), contact time (CT), contact area (CA), pressure-time integral (PTI), and maximum force (MaF) were recorded; these parameters were investigated in 10 areas of the foot: medial heel, lateral heel, midfoot, first to fifth metatarsals, hallux, and toes 2–5. The intra-session repeatability was evaluated by calculating the intraclass correlation coefficients (ICCs) and coefficients of variation (CVs) across the three repeated trials within the same session. The inter-session repeatability was assessed using the average of the three trials in each session to determine the ICCs and CVs.
Results
The ICCs showed moderate to good repeatability for every variable of interest, and the CVs were all <28%. The highest zones of PP were found under the second and third metatarsals, followed by the medial heel. The CT was 68.5–82.8% of the total stance time under the metatarsal heads. CA was highest under the midfoot, PTI was highest under the second metatarsal, and MaF was highest under the medial heel.
Conclusions
Footscan® platform system was found to be repeatable. Thus, it can be used as a valuable tool in the assessment of plantar pressure distribution, and the normal values of the foot loading parameters identified in this study can be employed to provide a reference range for the gait analysis performed by the Footscan® system.
Journal Article
Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice
Background
Major depressive disorder (MDD) is a common but severe psychiatric illness characterized by depressive mood and diminished interest. Both nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 1 (NLRP1) inflammasome and autophagy have been reported to implicate in the pathological processes of depression. However, the mechanistic interplay between NLRP1 inflammasome, autophagy, and depression is still poorly known.
Methods
Animal model of depression was established by chronic social defeat stress (CSDS). Depressive-like behaviors were determined by social interaction test (SIT), sucrose preference test (SPT), open field test (OFT), forced swim test (FST), and tail-suspension test (TST). The protein expression levels of NLRP1 inflammasome complexes, pro-inflammatory cytokines, phosphorylated-phosphatidylinositol 3-kinase (p-PI3K)/PI3K, phosphorylated-AKT (p-AKT)/AKT, phosphorylated-mechanistic target of rapamycin (p-mTOR)/mTOR, brain-derived neurotrophic factor (BDNF), phosphorylated-tyrosine kinase receptor B (p-TrkB)/TrkB, Bcl-2-associated X protein (Bax)/B-cell lymphoma-2 (Bcl2) and cleaved cysteinyl aspartate-specific proteinase-3 (caspase-3) were examined by western blotting. The mRNA expression levels of pro-inflammatory cytokines were tested by quantitative real-time PCR. The interaction between proteins was detected by immunofluorescence and coimmunoprecipitation. Neuronal injury was assessed by Nissl staining. The autophagosomes were visualized by transmission electron microscopy.
Nlrp1a
knockdown was performed using an adeno-associated virus (AAV) vector containing
Nlrp1a
–shRNA–eGFP infusion.
Results
CSDS exposure caused a bidirectional change in hippocampal autophagy function, which was activated in the initial period but impaired at the later stage. In addition, CSDS exposure increased the expression levels of hippocampal NLRP1 inflammasome complexes, pro-inflammatory cytokines, p-PI3K, p-AKT and p-mTOR in a time-dependent manner. Interestingly, NLRP1 is immunoprecipitated with mTOR but not PI3K/AKT and CSDS exposure facilitated the immunoprecipitation between them. Hippocampal
Nlrp1a
knockdown inhibited the activity of PI3K/AKT/mTOR signaling, rescued the impaired autophagy and ameliorated depressive-like behavior induced by CSDS. In addition, rapamycin, an autophagy inducer, abolished NLRP1 inflammasome-driven inflammatory reactions, alleviated depressive-like behavior and exerted a neuroprotective effect.
Conclusions
Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behavior in mice and the regulation of autophagy could be a valuable therapeutic strategy for the management of depression.
Journal Article
A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer
Background
Hypoxia is a hallmark of solid tumors and leads to the metabolic reprogramming of cancer cells. The role of epigenetic regulation between hypoxia and aberrant cholesterol metabolism in colorectal cancer (CRC) remains elusive.
Methods
Hypoxia-responsive circular RNAs (circRNAs) were identified by high throughput RNA sequencing between CRC cells cultured under normoxia or hypoxia. The protein-coding potential of circINSIG1 was identified by polysome profiling and LC–MS. The function of circINSIG1 was validated in vitro and in vivo by gain or loss of function assays. Mechanistic results were concluded by immunoprecipitation analyses.
Results
A novel hypoxia-responsive circRNA named circINSIG1 was identified, which was upregulated in CRC tissues and correlated with advanced clinical stages and poor survival. Mechanistically, circINSIG1 encoded a 121 amino acid protein circINSIG1-121 to promote K48-linked ubiquitination of the critical cholesterol metabolism regulator INSIG1 at lysine 156 and 158 by recruiting CUL5-ASB6 complex, a ubiquitin E3 ligase complex, thereby inducing cholesterol biosynthesis to promote CRC proliferation and metastasis. The orthotopic xenograft tumor models and patient-derived xenograft models further identified the role of circINSIG1 in CRC progression and potential therapeutic target of CRC.
Conclusions
circINSIG1 presents an epigenetic mechanism which provides insights into the crosstalk between hypoxia and cholesterol metabolism, and provides a promising therapeutic target for the treatment of CRC.
Journal Article