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Mackenzie Clark has been best friends with Nolan Walker for as long as she can remember. She's shared everything with him. The only thing she hasn't shared is the fact that she is in love with him.
Book
Relational wellbeing: re-centring the politics of happiness, policy and the self
The ubiquity of references to happiness and wellbeing indicates widespread anxiety that all may not be well, reflecting the erosion of the social in late capitalist modernity. The paper finds that, rather than helping to solve this problem, individualist formulations of wellbeing in policy mimic or deepen the underlying pathology. Drawing on empirical research in Zambia and India, it advocates an alternative approach, relational wellbeing, which is grounded in a relational ontology that can challenge dominant ideologies of the self, places central the generative quality of relationality which is critical to societal change and engenders a socially inclusive political vision.
Journal Article
The Triple I Hypothesis: Taking Another(’s) Perspective on Executive Dysfunction in Autism
The executive dysfunction theory attempts to explain not only the repetitive behaviours but also the socio-communicative difficulties in autism. While it is clear that some individuals with autism perform poorly on certain executive function tasks, it remains unclear what underlies these impairments. The most consistent and striking difficulties are seen on tasks that are open-ended in structure, lack explicit instructions and involve arbitrary rules. I propose that impairment on such tasks is not due to executive dysfunction; instead, poor performance results from difficulties forming an implicit understanding of the experimenter’s expectations for the task, resulting in egocentric and idiosyncratic behaviour. These difficulties in taking another’s perspective may be explained parsimoniously by the mentalising difficulties robustly demonstrated to exist in autism.
Journal Article
Analysing wellbeing: a framework for development practice
This article presents a framework for analysing wellbeing in development practice, drawing on the work of the Wellbeing in Developing Countries Research Group (WeD). Wellbeing is viewed as a social process with material, relational, and subjective dimensions. Wellbeing may be assessed at individual and collective levels, but at base is something that happens in relationship - between individual and collective; between local and global; between people and state. The article considers potential hazards in taking wellbeing as focus, and concludes by considering what real difference such a focus could make.
Journal Article
Independent infections of porcine deltacoronavirus among Haitian children
Coronaviruses have caused three major epidemics since 2003, including the ongoing SARS-CoV-2 pandemic. In each case, the emergence of coronavirus in our species has been associated with zoonotic transmissions from animal reservoirs
1
,
2
, underscoring how prone such pathogens are to spill over and adapt to new species. Among the four recognized genera of the family
Coronaviridae
, human infections reported so far have been limited to alphacoronaviruses and betacoronaviruses
3
–
5
. Here we identify porcine deltacoronavirus strains in plasma samples of three Haitian children with acute undifferentiated febrile illness. Genomic and evolutionary analyses reveal that human infections were the result of at least two independent zoonoses of distinct viral lineages that acquired the same mutational signature in the genes encoding Nsp15 and the spike glycoprotein. In particular, structural analysis predicts that one of the changes in the spike S1 subunit, which contains the receptor-binding domain, may affect the flexibility of the protein and its binding to the host cell receptor. Our findings highlight the potential for evolutionary change and adaptation leading to human infections by coronaviruses outside of the previously recognized human-associated coronavirus groups, particularly in settings where there may be close human–animal contact.
The presence of porcine deltacoronavirus has been detected in three children from Haiti that could have originated from zoonotic spillover.
Journal Article
Cy Twombly, Treatise on the Veil, 1970
A breathtaking exploration of one of Twombly's largest paintings, the second version of his Treatise on the Veil. One of the most important American postwar artists, Cy Twombly (1928-2011) engaged with mythological and poetic source material, setting him apart from other artists of his generation. In 1970, Twombly revisited his 1968 painting Treatise on the Veil and, in a short period of focused creativity, produced a painting-Treatise on the Veil (Second Version)-on a single, 33-foot canvas along with more than a dozen related drawings. This handsomely produced oversize book features three essays that examine these works in relation to Twombly's oeuvre, contemporaneous explorations of time, the Orpheus myth, and a musical composition that Twombly cited as an influence. Large images and details bring us in close to Twombly's magnificent meditation on time and space.
Book
What is the likely impact on surgical site infections in Australian hospitals if smoking rates are reduced? A cost analysis
Assisting smokers to quit before surgery reduces surgical site infection (SSI) risk. The short-term economic benefits of reducing SSIs by embedding tobacco dependence treatment in Australian hospitals are unknown. Estimated annual number of SSIs prevented, and hospital bed-days (HBD) and costs saved from reducing smoking before surgery are calculated.
The most recent number of surgical procedures and SSI rates for Australia were sourced. The number of smokers and non-smokers having a SSI were calculated using the UK Royal College of Physicians reported adjusted odds ratio (1.79), and the proportion of SSIs attributable to smoking calculated. The potential impact fraction was used to estimate reductions in SSIs and associated HBDs and costs from reducing the smoking rates among surgical patients from 23.9% to 10% or 5% targets. Uncertainty around the final estimates was calculated using probabilistic sensitivity analysis.
In 2016-17, approximately 40,593 (95% UI 32,543, 50,239) people having a surgical procedure in Australia experienced a SSI leading to 101,888 extra days (95% UI 49,988, 200,822) in hospital. If the smoking rate among surgical patients was reduced to 10%, 3,580 (95% UI 2,312, 5,178) SSIs would be prevented, and 8,985 (95% UI 4,094, 19,153) HBDs and $19.1M (95% UI $7.7M, $42.5M) saved in one year. If the smoking rate was reduced to 5%, 4,867 (95% UI 3,268, 6,867) SSIs would be prevented, and 12,217 (95% UI 5,614, 25,642) HBDs and $26.0M (95% UI $10.8M, $57.0M) would be saved.
The findings suggest achieving smoking rate targets of 10% or 5% would provide substantial short-term health and economic benefits through reductions in SSIs. Embedding tobacco dependence treatment in Australian hospitals would provide value for money by reducing costs and improving clinical quality and safety. A more comprehensive, modelled economic evaluation synthesising the best available evidence is needed to confirm findings.
Journal Article