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The ubiquity of references to happiness and wellbeing indicates widespread anxiety that all may not be well, reflecting the erosion of the social in late capitalist modernity. The paper finds that, rather than helping to solve this problem, individualist formulations of wellbeing in policy mimic or deepen the underlying pathology. Drawing on empirical research in Zambia and India, it advocates an alternative approach, relational wellbeing, which is grounded in a relational ontology that can challenge dominant ideologies of the self, places central the generative quality of relationality which is critical to societal change and engenders a socially inclusive political vision.

The executive dysfunction theory attempts to explain not only the repetitive behaviours but also the socio-communicative difficulties in autism. While it is clear that some individuals with autism perform poorly on certain executive function tasks, it remains unclear what underlies these impairments. The most consistent and striking difficulties are seen on tasks that are open-ended in structure, lack explicit instructions and involve arbitrary rules. I propose that impairment on such tasks is not due to executive dysfunction; instead, poor performance results from difficulties forming an implicit understanding of the experimenter’s expectations for the task, resulting in egocentric and idiosyncratic behaviour. These difficulties in taking another’s perspective may be explained parsimoniously by the mentalising difficulties robustly demonstrated to exist in autism.

This article presents a framework for analysing wellbeing in development practice, drawing on the work of the Wellbeing in Developing Countries Research Group (WeD). Wellbeing is viewed as a social process with material, relational, and subjective dimensions. Wellbeing may be assessed at individual and collective levels, but at base is something that happens in relationship - between individual and collective; between local and global; between people and state. The article considers potential hazards in taking wellbeing as focus, and concludes by considering what real difference such a focus could make.

Coronaviruses have caused three major epidemics since 2003, including the ongoing SARS-CoV-2 pandemic. In each case, the emergence of coronavirus in our species has been associated with zoonotic transmissions from animal reservoirs 1 , 2 , underscoring how prone such pathogens are to spill over and adapt to new species. Among the four recognized genera of the family Coronaviridae , human infections reported so far have been limited to alphacoronaviruses and betacoronaviruses 3 – 5 . Here we identify porcine deltacoronavirus strains in plasma samples of three Haitian children with acute undifferentiated febrile illness. Genomic and evolutionary analyses reveal that human infections were the result of at least two independent zoonoses of distinct viral lineages that acquired the same mutational signature in the genes encoding Nsp15 and the spike glycoprotein. In particular, structural analysis predicts that one of the changes in the spike S1 subunit, which contains the receptor-binding domain, may affect the flexibility of the protein and its binding to the host cell receptor. Our findings highlight the potential for evolutionary change and adaptation leading to human infections by coronaviruses outside of the previously recognized human-associated coronavirus groups, particularly in settings where there may be close human–animal contact. The presence of porcine deltacoronavirus has been detected in three children from Haiti that could have originated from zoonotic spillover.

Assisting smokers to quit before surgery reduces surgical site infection (SSI) risk. The short-term economic benefits of reducing SSIs by embedding tobacco dependence treatment in Australian hospitals are unknown. Estimated annual number of SSIs prevented, and hospital bed-days (HBD) and costs saved from reducing smoking before surgery are calculated. The most recent number of surgical procedures and SSI rates for Australia were sourced. The number of smokers and non-smokers having a SSI were calculated using the UK Royal College of Physicians reported adjusted odds ratio (1.79), and the proportion of SSIs attributable to smoking calculated. The potential impact fraction was used to estimate reductions in SSIs and associated HBDs and costs from reducing the smoking rates among surgical patients from 23.9% to 10% or 5% targets. Uncertainty around the final estimates was calculated using probabilistic sensitivity analysis. In 2016-17, approximately 40,593 (95% UI 32,543, 50,239) people having a surgical procedure in Australia experienced a SSI leading to 101,888 extra days (95% UI 49,988, 200,822) in hospital. If the smoking rate among surgical patients was reduced to 10%, 3,580 (95% UI 2,312, 5,178) SSIs would be prevented, and 8,985 (95% UI 4,094, 19,153) HBDs and $19.1M (95% UI $7.7M, $42.5M) saved in one year. If the smoking rate was reduced to 5%, 4,867 (95% UI 3,268, 6,867) SSIs would be prevented, and 12,217 (95% UI 5,614, 25,642) HBDs and $26.0M (95% UI $10.8M, $57.0M) would be saved. The findings suggest achieving smoking rate targets of 10% or 5% would provide substantial short-term health and economic benefits through reductions in SSIs. Embedding tobacco dependence treatment in Australian hospitals would provide value for money by reducing costs and improving clinical quality and safety. A more comprehensive, modelled economic evaluation synthesising the best available evidence is needed to confirm findings.

Super-ionic solids, which exhibit ion mobilities as high as those in liquids or molten salts, have been employed as solid-state electrolytes in batteries, improved thermoelectrics and fast-ion conductors in super-capacitors and fuel cells. Fast-ion transport in many of these solids is supported by a disordered, ‘liquid-like’ sub-lattice of cations mobile within a rigid anionic sub-lattice, often achieved at high temperatures or pressures via a phase transition. Here we show that ultrasmall clusters of copper selenide exhibit a disordered cationic sub-lattice under ambient conditions unlike larger nanocrystals, where Cu + ions and vacancies form an ordered super-structure similar to the bulk solid. The clusters exhibit an unusual cationic sub-lattice arrangement wherein octahedral sites, which serve as bridges for cation migration, are stabilized by compressive strain. The room-temperature liquid-like nature of the Cu + sub-lattice combined with the actively tunable plasmonic properties of the Cu 2 Se clusters make them suitable as fast electro-optic switches. Copper selenide is super-ionic only at high temperatures. Here, the authors discover room temperature super-ionic behaviour in ultrasmall clusters of Cu 2 Se—but not in its larger or bulk forms—owing to an unusual liquid-like cationic sub-lattice, in which octahedral sites are stabilized by size-dependent compressive strain.

Nutrient enrichment of surface waters degrades water quality. Municipalities need effective and economical solutions to remove nutrients from surface waters. From July 2016 to May 2020, full-scale (900 m2, 5% cover) floating treatment wetlands (FTWs) were deployed in Wickham Park pond, a eutrophic water body (0.13 mg/L total phosphorus (P), 0.96 mg/L total nitrogen (N)). The plants in FTWs in close proximity to a SB10000 mixer fixed N and P more efficiently. The rate of N (g/m2/year) fixed within tissues was highest for Juncus effusus (13.5), Agrostis alba (13.2), and Sagittaria lancifolia (12.1). The rate of P (g/m2/year) fixed within plant tissues was similar for all species (3.77, Agrostis alba, Canna spp., Iris hexagona, Juncus effusus, and Sagittaria lancifolia) save Pontederia cordata (2.52) volunteer species (1.41). The N and P removed with plant harvest were similar for non-mixed and mixed FTWs. Notably, the N:P ratio in plant tissues in 2017 (pre-mixer installation) was 11:1; after mixer installation (2018–2020), N:P ratios averaged 2.7:1, indicating increased P fixation within plant tissues. In 2017, 12,828 kg of plant tissues was harvested, removing 334 kg of N and 29.5 kg of P. In 2019, 32,958 kg of plant biomass was harvested from the pond, removing 425 kg of N and 138 kg of P. In 2020, 27,945 kg of biomass was harvested from FTWs, removing 267 kg of N and 95 kg of P. From 2016 to 2020, 73,000 kg of biomass was harvested, removing 1026 kg of N and 262 kg of P from Wickham Park pond. Knowing the total fresh biomass of tissues removed from FTWs at harvest is critical for accuracy in reporting nutrient removal aided by FTWs.

Background Peer support is being introduced into mental health services internationally, often in response to workforce policy. Earlier systematic reviews incorporate different modalities of peer support (i.e. group and one-to-one), offer inconsistent evidence of effectiveness, and also indicate substantial heterogeneity and issues of quality in the evidence base at that time. An updated review, focussed on one-to-one peer support, is timely given current policy interest. This study aims to systematically review evidence for the effectiveness of one-to-one peer support interventions for adults using mental health services, and to explore heterogeneity in peer support interventions. Method We searched MEDLINE, PsycINFO, Embase, CINAHL and Cochrane databases from inception until 13 June 2019. Included studies were assessed for risk of bias, and meta-analyses conducted where multiple trials provided usable data. Results Twenty-three studies reporting nineteen trials were eligible, providing data from 3329 participants. While seven trials were of low to moderate risk of bias, incomplete reporting of data in many studies suggested bias in the evidence base. Peer support interventions included peer workers in paraclinical roles (e.g. case manager), providing structured behavioural interventions, or more flexible support for recovery. Meta-analyses were conducted for eleven outcomes, with evidence that one-to-one peer support may have a modest positive impact on self-reported recovery and empowerment. There was no impact on clinical symptoms or service use. Analyses of heterogeneity suggest that peer support might improve social network support. Conclusions One-to-one peer support in mental health services might impact positively on psychosocial outcomes, but is unlikely to improve clinical outcomes. In order to better inform the introduction of peer support into mental health services, improvement of the evidence base requires complete reporting of outcome data, selection of outcomes that relate to intervention mechanisms, exploration of heterogeneity in the implementation of peer support and focused reviews of specific types of one-to-one peer support. Trial registration Prospero identifier: CRD42015025621 .

There is a significant emerging burden of chronic and end-stage kidney disease in low- and middle-income countries, driven by population ageing and the global epidemic of type 2 diabetes. Sufferers of end-stage kidney disease require ongoing dialysis or kidney transplantation to survive; however, in many low- and middle-income countries, treatment options are strictly limited or unaffordable. Low numbers of maintenance dialysis patients and transplant recipients reflect profound economic and service provision challenges for health-care systems in low- and middle-income countries in sustaining renal replacement therapy programmes. Underdeveloped organ donor and transplant programmes, health system and financing issues, ethical regulation of transplantation and the cost of pharmaceuticals commonly pose additional barriers to the delivery of efficient and cost-effective renal replacement therapy. Development of locally appropriate transplant programmes, effective use of nongovernmental sources of funding, service planning and cost containment, use of generic drugs and local manufacture of dialysis consumables have the potential to make life-saving renal replacement therapy available to many more in need. Select low- and middle-income countries demonstrate more equitable provision of renal replacement therapy is possible outside high-income countries. For other low- and middle-income countries, education, the development of good public policy and a supportive international environment are critical. Prevention of end-stage kidney disease, ideally as part of an integrated approach to chronic vascular diseases, must also be a key objective.

In English testamentary history, there is a clear divide between Anglo-Saxon and Anglo-Norman testamentary practice, with the primary difference being that in the latter case, heritable land could not be bequeathed. Once the transfer of land required the livery of seisin, a practice introduced during the reign of Henry II (1154–89), it was not possible for a gift of land to take effect upon the death of the owner, and the royal courts did not consider the intention to dispose of a tenement, as expressed in a will, sufficient in itself to complete the transfer. Nonetheless, an examination of extant wills from the period 1180–1300 demonstrates that some testators (or indeed beneficiaries) may have thought that bequests of land were possible or even enforceable. How do these wills fit into the legal framework of the time? If a bequest could not be enforced in the royal courts, what reasons might someone have for attempting to make one, and how might they try to ensure that the bequest held?