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Head into the unknown with explorer Steve Backshall as he journeys to the world's last unexplored places and faces challenges around the globe, encountering extraordinary wildlife and meeting remarkable people along the way. Steve and the team head to the Tien Shan mountains of Kyrgyzstan to find one of the world's most endangered big cats - the snow leopard. If they can find evidence of a breeding population in the remote and almost inaccessible Djangart valley, they hope to persuade the government of Kyrgyzstan to turn the Djangart valley into a protected nature reserve.

Head into the unknown with explorer Steve Backshall as he journeys to the world's last unexplored places and faces challenges around the globe, encountering extraordinary wildlife and meeting remarkable people along the way. Regarded as the Eden of Africa, Gabon is one of the most biodiverse countries on the planet--home to gorillas, chimpanzees, crocodiles and forest elephants. Steve heads to the Moukalaba Doudou National Park, where alongside primatologists and jungle experts, he wants to discover whether this unexplored rainforest could be home to a mythical, undiscovered population of chimpanzees.

White House hawks seeking to widen the war on terrorism to Iraq had their case strengthened Thursday when an Iraqi defector claimed Saddam Hussein had accelerated work on biological, chemical and nuclear weapons. Britain remains deeply uneasy about the possibility of any \"reckless\" escalation of the war against terrorism. One senior British minister told the Times: \"There appear to be elements in the U.S. administration -- or people on the fringes like Richard Perle (a defence adviser to President George W. Bush) -- who want to take this on to Iraq. We think that is not a good idea.\" The UN Security Council is reviewing British proposals to change the sanctions and inspections regime in Iraq to focus more tightly on weapons and give Iraq an incentive to allow UN inspectors back into the country.

Bush administration hawks, seeking to widen the war on terrorism to Iraq, had their case strengthened yesterday when an Iraqi defector claimed that Saddam Hussein had accelerated work on biological, chemical and nuclear weapons. Adnan Ihsan Saeed al-Haideri, a civil engineer who defected in August, said that he had been to at least 20 sites that he believed were connected to biological or chemical programs, and he had carried out repairs on nuclear weapons facilities. He said that production and storage facilities were hidden at government companies and villas in residential areas.

Targeting subunits of BAF/PBAF chromatin remodeling complexes has been proposed as an approach to exploit cancer vulnerabilities. Here, we develop proteolysis targeting chimera (PROTAC) degraders of the BAF ATPase subunits SMARCA2 and SMARCA4 using a bromodomain ligand and recruitment of the E3 ubiquitin ligase VHL. High-resolution ternary complex crystal structures and biophysical investigation guided rational and efficient optimization toward ACBI1, a potent and cooperative degrader of SMARCA2, SMARCA4 and PBRM1. ACBI1 induced anti-proliferative effects and cell death caused by SMARCA2 depletion in SMARCA4 mutant cancer cells, and in acute myeloid leukemia cells dependent on SMARCA4 ATPase activity. These findings exemplify a successful biophysics- and structure-based PROTAC design approach to degrade high profile drug targets, and pave the way toward new therapeutics for the treatment of tumors sensitive to the loss of BAF complex ATPases. A structure-based design allows the development of a potent PROTAC to degrade BAF ATPase subunits SMARCA2 and SMARCA4 via recruitment of E3 ubiquitin ligase VHL and induce cancer cell death.

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is largely caused by inactivating germline mutations in the tumour suppressor gene CDH1, although pathogenic variants in CTNNA1 occur in a minority of families with HDGC. In this Policy Review, we present updated clinical practice guidelines for HDGC from the International Gastric Cancer Linkage Consortium (IGCLC), which recognise the emerging evidence of variability in gastric cancer risk between families with HDGC, the growing capability of endoscopic and histological surveillance in HDGC, and increased experience of managing long-term sequelae of total gastrectomy in young patients. To redress the balance between the accessibility, cost, and acceptance of genetic testing and the increased identification of pathogenic variant carriers, the HDGC genetic testing criteria have been relaxed, mainly through less restrictive age limits. Prophylactic total gastrectomy remains the recommended option for gastric cancer risk management in pathogenic CDH1 variant carriers. However, there is increasing confidence from the IGCLC that endoscopic surveillance in expert centres can be safely offered to patients who wish to postpone surgery, or to those whose risk of developing gastric cancer is not well defined.

Undifferentiated febrile illness (UFI) is one of the most common reasons for people seeking healthcare in low-income countries. While illness and death due to specific infections such as malaria are often well-quantified, others are frequently uncounted and their impact underappreciated. A number of high consequence infectious diseases, including Ebola virus, are endemic or epidemic in the Federal Republic of Sudan which has experienced at least 12 UFI outbreaks, frequently associated with haemorrhage and high case fatality rates (CFR), since 2012. One of these occurred in Darfur in 2015/2016 with 594 cases and 108 deaths (CFR 18.2%). The aetiology of these outbreaks remains unknown. We report a retrospective cohort study of the 2015/2016 Darfur outbreak, using a subset of 65 of 263 outbreak samples received by the National Public Health Laboratory which met selection criteria of sufficient sample volume and epidemiological data. Clinical features included fever (95.8%), bleeding (95.7%), headache (51.6%) and arthralgia (42.2%). No epidemiological patterns indicative of person-to-person transmission or health-worker cases were reported. Samples were tested at the Public Health England Rare and Imported Pathogens Laboratory using a bespoke panel of likely pathogens including haemorrhagic fever viruses, arboviruses and Rickettsia, Leptospira and Borrelia spp. Seven (11%) were positive for Crimean-Congo haemorrhagic fever virus (CCHFV) by real-time reverse transcription PCR. The remaining samples tested negative on all assays. CCHFV is an important cause of fever and haemorrhage in Darfur, but not the sole major source of UFI outbreaks in Sudan. Prospective studies are needed to explore other aetiologies, including novel pathogens. The presence of CCHFV has critical infection, prevention and control as well as clinical implications for future response. Our study reinforces the need to boost surveillance, lab and investigative capacity to underpin effective response, and for local and international health security.

[David Nicholson]'s plea was part of a deal in which he will be sentenced next month to five years' probation. It will be served in Britain, where he will be required to attend alcohol and sexual abuse programmes. Under the deal, Nicholson can be sent back to America and possibly jailed if he violates his probation. She met Nicholson in a cafe and later transcribed the conversation herself. In the transcript - now part of the court papers - asked if they had sex, he said: \"No, well not properly... I'm 99 per cent sure we didn't have sex. We played around with one another, yes.\"

A pair of For All Mankind Jeans currently costing $210 ( pounds 106.50) would fall to $194 ( pounds 98), while a pair of Jimmy Choo satin T-strap sandals would drop from $1,042 ( pounds 528.50) to $960 ( pounds 487). A Prada canvas bag would drop from $1,910 ( pounds 969) to $1,750 ( pounds 878). And, if you really must, the price tag on an Armani Collezioni deerskin jacket would fall from $3,840 ( pounds 1,950) to $3,535 ( pounds 1,790).