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Objective. The present study aimed to investigate the effectiveness and safety of platelet-rich plasma (PRP) application in arthroscopic repair of complete vertical tear of meniscus located in the red-white zone. Methods. This single center, prospective, randomized, double-blind, placebo-controlled, parallel-arm study included 37 patients with complete vertical meniscus tears. Patients received an intrarepair site injection of either PRP or sterile 0.9% saline during an index arthroscopy. The primary endpoint was the rate of meniscus healing in the two groups. The secondary endpoints were changes in the International Knee Documentation Committee (IKDC) score, Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and analog scale (VAS) in the two groups at 42 months. Results. After 18 weeks, the meniscus healing rate was significantly higher in the PRP-treated group than in the control group (85% versus 47%, P=0.048). Functional outcomes were significantly better 42 months after treatment than at baseline in both groups. The IKDC score, WOMAC, and KOOS were significantly better in the PRP-treated group than in the control group. No adverse events were reported during the study period. Conclusions. The findings of this study indicate that PRP augmentation in meniscus repair results in improvements in both meniscus healing and functional outcome.

Diagnosis of complete XY gonadal dysgenesis exposes the patient to the prospect of infertility and many years of medical treatment in order to avoid the development of diseases associated with this condition. However, sufficiently early diagnosis followed by the implementation of proper therapy improves the prognosis for enabling future pregnancies after IVF through the development of reproductive organs and prevention of health complications of hypoestrogenism such as cardiovascular problems and osteoporosis. This syndrome is very rare and affects 1 in 80,000 women. Due to the high risk of developing a gonadal tumour, prophylactic bilateral gonadectomy is one of the main procedures performed in a relatively brief time after diagnosis. Unfortunately, despite characteristic symptoms like primary amenorrhoea and underdeveloped breasts, the diagnosis is often made quite late. We report the case of a 45-year-old woman who had been diagnosed with Swyer syndrome at the age of 16 years. The patient underwent bilateral gonadectomy one year after the diagnosis due to the associated risk of developing malignancy and was treated since with hormone replacement therapy. At the age of 32 and 34 years, 2 successful IVF procedures were performed with oocyte donations. The pregnancies proceeded without any complications and both were resolved by caesarean section. The healthy sons’ weights were 3600 γ and 3700 g, respectively.

The flaring events observed in the Sagittarius A* supermassive black hole system can be attributed to the non-homogeneous nature of the near-horizon accretion flow. Bright regions in this flow may be associated with density or temperature anisotropies, so-called \"bright spot\" or \"hot spots\". Such orbiting features may explain observations at infrared wavelengths as well as recent findings at millimeter wavelengths. In this work, we study the emission from an orbiting equatorial bright spot, imposed on a radiatively inefficient accretion flow background, to find polarimetric features indicative of the underlying magnetic field structure and other system variables including inclination angle, spot size, black hole spin, and more. Specifically, we investigate the impact of these parameters on the Stokes Q-U signatures that commonly exhibit a typical double loop (pretzel-like) structure. Our semi-analytical model, describing the underlying plasma conditions and the orbiting spot, is built within the framework of the numerical radiative transfer code ipole, which calculates synchroton emission at 230 GHz. We showcase the wide variety of Q-U loop signatures and the relation between inner and outer loops. For the vertical magnetic field topology, the inner Q-U loop is explained by the suppression of the synchrotron emission as seen by the distant observer. For the radial and toroidal magnetic field topologies, the inner corresponds to the part of the orbit where the spot it is receding with respect to the observer. Based on our models we conclude that it is possible to constrain the underlying magnetic field topology with an analysis of the Q-U loop geometry, particularly in combination with a circular polarization measurements.

We report on 85-101 GHz light curves of the Galactic Center supermassive black hole, Sagittarius A* (Sgr A*), observed in April 2017 with the Atacama Large Millimeter/submillimeter Array (ALMA). This study of high-cadence full-Stokes data provides new measurements of the fractional linear polarization at a 1-2% level resolved in 4 s time segments, and stringent upper limits on the fractional circular polarization at 0.3%. We compare these findings to ALMA light curves of Sgr A* at 212-230 GHz observed three days later, characterizing a steep depolarization of the source at frequencies below about 150 GHz. We obtain time-dependent rotation measure (RM) measurements, with the mean RM at 85-101 GHz being a factor of two lower than that at 212-230 GHz. Together with the rapid temporal variability of the RM and its different statistical characteristics in both frequency bands, these results indicate that the Faraday screen in Sgr A* is largely of internal character, with about half of the Faraday rotation taking place inside the inner 10 gravitational radii, contrary to the common external Faraday screen assumption. We then demonstrate how this observation can be reconciled with theoretical models of radiatively inefficient accretion flows for a reasonable set of physical parameters. Comparisons with numerical general relativistic magnetohydrodynamic simulations suggest that the innermost part of the accretion flow in Sgr A* is much less variable than what these models predict, in particular, the observed magnetic field structure appears to be coherent and persistent.

We report on the polarized light curves of the Galactic Center supermassive black hole Sagittarius A*, obtained at millimeter wavelength with the Atacama Large Millimeter/submillimeter Array (ALMA). The observations took place as a part of the Event Horizon Telescope campaign. We compare the observations taken during the low variability source state on 2017 Apr 6 and 7 with those taken immediately after the X-ray flare on 2017 Apr 11. For the latter case, we observe rotation of the electric vector position angle with a timescale of \\(\\sim 70\\) min. We interpret this rotation as a signature of the equatorial clockwise orbital motion of a hot spot embedded in a magnetic field dominated by a dynamically important vertical component, observed at a low inclination \\(\\sim20^\\circ\\). The hot spot radiates strongly polarized synchrotron emission, briefly dominating the linear polarization measured by ALMA in the unresolved source. Our simple emission model captures the overall features of the polarized light curves remarkably well. Assuming a Keplerian orbit, we find the hot spot orbital radius to be \\(\\sim\\) 5 Schwarzschild radii. We observe hints of a positive black hole spin, that is, a prograde hot spot motion. Accounting for the rapidly varying rotation measure, we estimate the projected on-sky axis of the angular momentum of the hot spot to be \\(\\sim 60^\\circ\\) east of north, with a 180\\(^\\circ\\) ambiguity. These results suggest that the accretion structure in Sgr A* is a magnetically arrested disk rotating clockwise.

We report on the observations of the quasar NRAO 530 with the Event Horizon Telescope (EHT) on 2017 April 5-7, when NRAO 530 was used as a calibrator for the EHT observations of Sagittarius A*. At z=0.902 this is the most distant object imaged by the EHT so far. We reconstruct the first images of the source at 230 GHz, at an unprecedented angular resolution of \\(\\) 20 \\(\\)as, both in total intensity and in linear polarization. We do not detect source variability, allowing us to represent the whole data set with static images. The images reveal a bright feature located on the southern end of the jet, which we associate with the core. The feature is linearly polarized, with a fractional polarization of \\(\\)5-8% and has a sub-structure consisting of two components. Their observed brightness temperature suggests that the energy density of the jet is dominated by the magnetic field. The jet extends over 60 \\(\\)as along a position angle PA\\( -\\)28\\(^\\). It includes two features with orthogonal directions of polarization (electric vector position angle, EVPA), parallel and perpendicular to the jet axis, consistent with a helical structure of the magnetic field in the jet. The outermost feature has a particularly high degree of linear polarization, suggestive of a nearly uniform magnetic field. Future EHT observations will probe the variability of the jet structure on \\(\\)as scales, while simultaneous multi-wavelength monitoring will provide insight into the high energy emission origin.

We present MeqSilhouette v2.0 (MeqSv2), a fully polarimetric, time-and frequency-resolved synthetic data generation software for simulating millimetre (mm) wavelength very long baseline interferometry (VLBI) observations with heterogeneous arrays. Synthetic data are a critical component in understanding real observations, testing calibration and imaging algorithms, and predicting performance metrics of existing or proposed sites. MeqSv2 applies physics-based instrumental and atmospheric signal corruptions constrained by empirically-derived site and station parameters to the data. The new version is capable of applying instrumental polarization effects and various other spectrally-resolved effects using the Radio Interferometry Measurement Equation (RIME) formalism and produces synthetic data compatible with calibration pipelines designed to process real data. We demonstrate the various corruption capabilities of MeqSv2 using different arrays, with a focus on the effect of complex bandpass gains on closure quantities for the EHT at 230 GHz. We validate the frequency-dependent polarization leakage implementation by performing polarization self-calibration of synthetic EHT data using PolSolve. We also note the potential applications for cm-wavelength VLBI array analysis and design and future directions.

The blazar J1924-2914 is a primary Event Horizon Telescope (EHT) calibrator for the Galactic Center's black hole Sagittarius A*. Here we present the first total and linearly polarized intensity images of this source obtained with the unprecedented 20 \\(\\mu\\)as resolution of the EHT. J1924-2914 is a very compact flat-spectrum radio source with strong optical variability and polarization. In April 2017 the source was observed quasi-simultaneously with the EHT (April 5-11), the Global Millimeter VLBI Array (April 3), and the Very Long Baseline Array (April 28), giving a novel view of the source at four observing frequencies, 230, 86, 8.7, and 2.3 GHz. These observations probe jet properties from the subparsec to 100-parsec scales. We combine the multi-frequency images of J1924-2914 to study the source morphology. We find that the jet exhibits a characteristic bending, with a gradual clockwise rotation of the jet projected position angle of about 90 degrees between 2.3 and 230 GHz. Linearly polarized intensity images of J1924-2914 with the extremely fine resolution of the EHT provide evidence for ordered toroidal magnetic fields in the blazar compact core.

The Event Horizon Telescope (EHT) observed the compact radio source, Sagittarius A* (Sgr A*), in the Galactic Center on 2017 April 5-11 in the 1.3 millimeter wavelength band. At the same time, interferometric array data from the Atacama Large Millimeter/submillimeter Array and the Submillimeter Array were collected, providing Sgr A* light curves simultaneous with the EHT observations. These data sets, complementing the EHT very-long-baseline interferometry, are characterized by a cadence and signal-to-noise ratio previously unattainable for Sgr A* at millimeter wavelengths, and they allow for the investigation of source variability on timescales as short as a minute. While most of the light curves correspond to a low variability state of Sgr A*, the April 11 observations follow an X-ray flare, and exhibit strongly enhanced variability. All of the light curves are consistent with a red noise process, with a power spectral density (PSD) slope measured to be between -2 and -3 on timescales between 1 min and several hours. Our results indicate a steepening of the PSD slope for timescales shorter than 0.3 h. The spectral energy distribution is flat at 220 GHz and there are no time-lags between the 213 and 229 GHz frequency bands, suggesting low optical depth for the event horizon scale source. We characterize Sgr A*'s variability, highlighting the different behavior observed just after the X-ray flare, and use Gaussian process modeling to extract a decorrelation timescale and a PSD slope. We also investigate the systematic calibration uncertainties by analyzing data from independent data reduction pipelines.

We report measurements of the gravitationally lensed secondary image -- the first in an infinite series of so-called \"photon rings\" -- around the supermassive black hole M87* via simultaneous modeling and imaging of the 2017 Event Horizon Telescope (EHT) observations. The inferred ring size remains constant across the seven days of the 2017 EHT observing campaign and is consistent with theoretical expectations, providing clear evidence that such measurements probe spacetime and a striking confirmation of the models underlying the first set of EHT results. The residual diffuse emission evolves on timescales comparable to one week. We are able to detect with high significance a southwestern extension consistent with that expected from the base of a jet that is rapidly rotating in the clockwise direction. This result adds further support to the identification of the jet in M87* with a black hole spin-driven outflow, launched via the Blandford-Znajek process. We present three revised estimates for the mass of M87* based on identifying the modeled thin ring component with the bright ringlike features seen in simulated images, one of which is only weakly sensitive to the astrophysics of the emission region. All three estimates agree with each other and previously reported values. Our strongest mass constraint combines information from both the ring and the diffuse emission region, which together imply a mass-to-distance ratio of \\(4.20^{+0.12}_{-0.06}~\\mu{\\rm as}\\) and a corresponding black hole mass of \\((7.13\\pm0.39)\\times10^9M_\\odot\\), where the error on the latter is now dominated by the systematic uncertainty arising from the uncertain distance to M87*.