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Cocoa is a concentrated source of dietary flavanols—putative bioactive compounds associated with health benefits. It is known that fermentation and roasting reduce levels of native flavonoids in cocoa, and it is generally thought that this loss translates to reduced bioactivity. However, the mechanisms of these losses are poorly understood, and little data exist to support this paradigm that flavonoid loss results in reduced health benefits. To further facilitate large-scale studies of the impact of fermentation on cocoa flavanols, a controlled laboratory fermentation model system was increased in scale to a large (pilot) scale system. Raw cocoa beans (15 kg) were fermented in 16 L of a simulated pulp media in duplicate for 168 h. The temperature of the fermentation was increased from 25–55 °C at a rate of 5 °C/24 h. As expected, total polyphenols and flavanol levels decreased as fermentation progressed (a loss of 18.3% total polyphenols and 14.4% loss of total flavanols during fermentation) but some increases were observed in the final timepoints (120–168 h). Fermentation substrates, metabolites and putative cocoa bioactive compounds were monitored and found to follow typical trends for on-farm cocoa heap fermentations. For example, sucrose levels in pulp declined from >40 mg/mL to undetectable at 96 h. This model system provides a controlled environment for further investigation into the potential for optimizing fermentation parameters to enhance the flavanol composition and the potential health benefits of the resultant cocoa beans.

Raw cocoa beans were processed to produce cocoa powders with different combinations of fermentation (unfermented, cool, or hot) and roasting (not roasted, cool, or hot). Cocoa powder extracts were characterized and assessed for α-glucosidase inhibitory activity in vitro. Cocoa processing (fermentation/roasting) contributed to significant losses of native flavanols. All of the treatments dose-dependently inhibited α-glucosidase activity, with cool fermented/cool roasted powder exhibiting the greatest potency (IC50: 68.09 µg/mL), when compared to acarbose (IC50: 133.22 µg/mL). A strong negative correlation was observed between flavanol mDP and IC50, suggesting flavanol polymerization as a marker of enhanced α-glucosidase inhibition in cocoa. Our data demonstrate that cocoa powders are potent inhibitors of α-glucosidase. Significant reductions in the total polyphenol and flavanol concentrations induced by processing do not necessarily dictate a reduced capacity for α-glucosidase inhibition, but rather these steps can enhance cocoa bioactivity. Non-traditional compositional markers may be better predictors of enzyme inhibitory activity than cocoa native flavanols.

Objectives. To examine levels and temporal changes in the frequency of defensive gun use by US crime victims. Methods. We computed national-level counts of criminal incidents involving firearm defense during 3 periods: 1993 to 2005, 2007 to 2015, and 2016 to 2021. We also considered earlier national estimates for 1987 to 1990. The data came from the US Bureau of Justice Statistics National Crime Victimization Survey (NCVS). We counted firearm defenses as incidents in which victims used a gun to threaten or attack an offender. Results. Over the 4 periods, for all crimes, victims reported gun defenses in an average range of between 61 000 and 65 000 incidents per year. This included between 38 000 and 53 000 personal (violent) incidents and between 12 000 and 23 000 household (property) incidents. Conclusions. Firearm defenses occurred at a relatively low and nearly constant level over the 35-year period. Although some victims use guns for defense, these uses are infrequent compared with the incidence of crime. Public Health Implications. The continuing relative rarity of NCVS armed defenses suggests that claims about the protective benefits of widespread firearm ownership may be overstated. ( Am J Public Health. 2024;114(12):1384–1387. https://doi.org/10.2105/AJPH.2024.307838 )

BY any measure, firearms — especially handguns — are a leading instrument of violent injury. In 1987, firearms accounted for 32,919 fatalities in the United States: 18,144 suicides, 12,665 homicides, and 2110 unintentional fatalities, legal interventions (killings by law-enforcement officials), or deaths of undetermined type. 1 Sixty percent of all homicides and suicides during this year were committed with guns, 1 and handguns accounted for three fourths of the homicides by firearms. 2 A central question in research on the prevention of gunrelated mortality is whether restricting access to handguns would reduce deaths by firearms. 3 One approach to the issue is to examine . . .

Objectives. This study assessed the consistency of estimates of the number of justifiable homicides committed by US police officers and identified sources of underreporting. Methods. The number of justifiable homicides committed by police officers between 1976 and 1998 was estimated from supplementary homicide report (SHR) and National Vital Statistics System (NVSS) mortality data. Results. Nationally, the SHR estimate was 29% larger than the NVSS estimate. However, in most states this pattern was reversed, with more deaths reported in the NVSS. Conclusions. Both systems underreport, but for different reasons. The NVSS misclassifies cases as homicides, rather than justifiable homicides committed by police officers, because certifiers fail to mention police involvement. The SHR misses cases because some jurisdictions fail to file reports or omit justifiable homicides committed by police officers. (Am J Public Health. 2003;93:1117–1121)

It is well known that many crimes in the United States are committed with firearms. Less adequately documented is the frequency with which victims use guns in self-defense. We used National Crime Victimization Survey data to examine incidents where victims employed guns against offenders. Between 1987 and 1990 there were an estimated 258,460 incidents of firearm defense, an annual mean of 64,615. Victims used firearms in 0.18% of all crimes recorded by the survey and in 0.83% of violent offenses. Firearm self-defense is rare compared with gun crimes.

McDowall et al examine the frequency of homicides in the large urban areas of Florida, Mississippi and Oregon, before and after their shall issue laws began. The analysis finds evidence of an increase in firearm murders.

The strength of research designs is relative. Compared with true experiments, quasi-experimental designs are weak. Compared with cross-sectional designs, they are strong. One can further strengthen inferences from quasi-experiments by examining a broader pattern of data. We agree with Britt, Kleck, and Bordua when they recommend that researchers expand the range of inquiry. We disagree with them when they recommend that researchers restrict it. The District of Columbia study is largely consistent with the available evidence, but it does not prove that restrictive handgun licensing will always reduce firearm deaths.

Nothing reshuffles the business deck faster than change in supply and demand.Take commercial real estate in San Diego County, which is still a bargain compared to other markets such as San Francisco and Orange County.

Mandatory sentence enhancement laws promise to reduce the use of firearms by criminals by providing stiff and certain penalties when a gun is involved in an offense. The preventive effects of mandatory sentencing on firearm offenses are investigated.