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A cell delivery strategy was investigated that was hypothesized to enable magnetic targeting of endothelial cells to the steel surfaces of intraarterial stents because of the following mechanisms: (i) preloading cells with biodegradable polymeric superparamagnetic nanoparticles (MNPs), thereby rendering the cells magnetically responsive; and (ii) the induction of both magnetic field gradients around the wires of a steel stent and magnetic moments within MNPs because of a uniform external magnetic field, thereby targeting MNP-laden cells to the stent wires. In vitro studies demonstrated that MNP-loaded bovine aortic endothelial cells (BAECs) could be magnetically targeted to steel stent wires. In vivo MNP-loaded BAECs transduced with adenoviruses expressing luciferase (Luc) were targeted to stents deployed in rat carotid arteries in the presence of a uniform magnetic field with significantly greater Luc expression, detected by in vivo optical imaging, than nonmagnetic controls.

Magnetite nanoparticles were synthesized and functionalized by coating the particle surfaces with gum arabic (GA) to improve particle stability in aqueous suspensions (i.e. biological media). Particle characterization was performed using transmission electron microscopy (TEM) and dynamic light scattering (DLS) to analyze the morphology and quantify the size distribution of the nanoparticles, respectively. The results from DLS indicated that the GA-treated nanoparticles formed smaller agglomerates as compared to the untreated samples over a 30-h time frame. Thermogravimetric analyses indicated an average weight loss of 23%, showing that GA has a strong affinity toward the iron oxide surface. GA most likely contributes tocolloid stability via steric stabilization. It was determined that the adsorption of GA onto magnetite exhibits Langmuir behavior.[PUBLICATION ABSTRACT]

Recently, the Navajo Nation has shown much interest in promoting engineering education within the community. Capitalizing on the Diné's history and strength in making, one initiative toward this goal has been the development of makerspaces. While these makerspaces show promise and are a great resource to the Navajo Nation, they resemble Western understandings of makerspaces and have not incorporated the unique cultural identity of the Diné into the design of the space, limiting their potential. To better support this initiative, this study looks to answer the following research question: How can the Navajo experience of making be integrated to design a culturally contextualized makerspace? The results include four design considerations to help guide the design of a makerspace for the Diné: inclusivity, individualism, community building, and cultural conflicts and connections. This article also presents one interpretation of a culturally contextualized Diné makerspace.

Death qualification-a process through which capital prosecutors may strike potential jurors based on their hesitancy to imposing a death sentence-lies at the heart of this problem. Because death-qualified juries tend to be less diverse and more prosecution-friendly, then vote to sentence defendants to death at a higher rate than would a jury that represented a true cross-section of society. In that case, the Court faced a state statute that gave prosecutors the authority to strike a juror for cause if they showed even the slightest hesitation toward imposing a death sentence.!® Using that authority, the prosecutor in Witherspoon struck nearly half of the jury pool based on hesitation about the death penalty.' The Supreme Court agreed. [...]the Court concluded general objections to the death penalty, standing alone, could not support a potential juror's removal. The Court, therefore, held that, although a juror's aversions to the death penalty may be relevant, exclusion based on \"any broader basis\" than a juror's unambiguously expressed inability to follow instructions and abide by their oath would violate the defendant's constitutional guarantees.?· Put differently, \"[t]he most that can be demanded from a [potential juror] in this regard is that [they] be willing to consider all penalties provided by state law.\"· In holding as it did, the Court necessarily believed the risk to a defendant's Sixth Amendment rights outweighed the risk to the government's interest.

Encouraging persistence, success, and interest in science, technology, engineering, and mathematics (STEM) fields of study continues to be a point of emphasis across the United States. While there does exist a body of research exploring STEM education and STEM learning, less is understood about the informal factors that may encourage STEM pursuit. In particular, parents can play a critical role in influencing their children to pursue STEM. High school is a key period in the development and promotion of science capital. Therefore, we explore how parent employment in STEM occupations relates to student decisions to participate in both applied and academic STEM coursework in high school. We find that parent STEM occupation does matter, and that the impact is linked to the number of parents in a STEM occupation as well as income level of the family. Our findings provide evidence for the growing theory focusing on the growth of science capital among individuals and how this form of capital may be passed from parent to child. Policy and practice implications are discussed.

This project seeks to equip the members of Anna Heights Baptist Church in the assimilation of visitors to the discipleship process of the church. The equipping will accomplish the church’s mission of “making followers of Christ.” Chapter 1 describes the context of AHBC, the weaknesses and strengths of the church, and the goals of the project. Chapter 2 details the exegesis of five passages of Scripture (Matt 28:16-20; 2 Tim 2:1-2; Col 4:2-6; 1 Cor 10:31-11:1; Phil 3:13-21), which demonstrate the use of relational discipleship in the early church. Chapter 3 provides a historical example of how the Puritans discipled one another to Christian maturity. Further, it contains examples of relational discipleship used in the modern church. Chapter 4 details the project itself, with the curriculum used in the equipping of members. Chapter 5 is an evaluation of the project’s success, including the completion of the stated goals. This project seeks to demonstrate that discipleship is effective in the local church when members, outside of the pastorate, are themselves discipled, equipped, and active in engaging visitors that come to church services.

Modern Electricity Systems Awarded \"The Best Book for Energy Engineers\" by The American Energy Society 2023 A welcome textbook instructing on many current aspects of energy generation, transmission, distribution, and consumption The importance of a well-informed group of individuals in charge of energy production and use is essential to create a sustainable and greener tomorrow. Technologies and costs are rapidly changing, and environmental goals widely debated in this book. The future of energy is at a crossroads. In addition, energy and technology poverty affects as much as 25% of the world's population. Having the correct set of \"tools\"—a basic understanding of modern electrical systems—is essential, not just for engineers but for our leaders and decision-makers. With decades of experience in industry and academia behind them, the team of authors in Modern Electricity Systems offers a \"toolbox\" from which the reader will learn what is essential to make informed decisions. As such, this textbook provides an introduction to the fundamentals of how electricity is generated, financed, regulated, rationed, and stored – with consideration not just of the current status of these issues but a glance at what the next decade may hold. Without this basic level of comprehension, the growing global impact and social issues can be discussed and advocated for, but real change in this sector can only be achieved through understanding the systems. Modern Electricity Systems readers will also find: * Support to create a course on energy transition and energy policy for sustainable development * International modern day case studies, that represent the most current and essential topics, to illustrate key concepts, as well as ones focused on the United States * Sample problem sets that bring together essential ideas learned from each chapter * A textbook written by a team of working professionals with international experience in real-world applications of policy, engineering, and operations Modern Electricity Systems is a helpful reference for graduate and advanced undergraduate students and researchers, policymakers, environmentalists, humanitarians, business leaders, and decision-makers in all three sectors of electricity operations, engineering, and policy matters.

Clinics and hospitals all along the US-Mexico border are hiring promotoras de salud (health promoters). To many immigrants who live along the US-Mexico border, effective, aggressive promotoras are the sole link to the health care system. Beyond the humanitarian reasons to engage promotoras in improving health care for border residents, national interests argue for doing so.