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Lost in the storm
\"Ella's kitten, Fluff loves to play outside especially when it's snowing. Suddenly, a blizzard sets in, and Fluff can't find her way home. Will Ella ever be reunited with her kitten?\"--Page [4] of cover.
Book
Relaxation Mechanism of the Hydrated Electron
The relaxation dynamics of the photoexcited hydrated electron have been subject to conflicting interpretations. Here, we report time-resolved photoelectron spectra of hydrated electrons in a liquid microjet with the aim of clarifying ambiguities from previous experiments. A sequence of three ultrashort laser pulses (~100 femtosecond duration) successively created hydrated electrons by charge-transfer-to-solvent excitation of dissolved anions, electronically excited these electrons via the s→p transition, and then ejected them into vacuum. Two distinct transient signals were observed. One was assigned to the initially excited p-state with a lifetime of ~75 femtoseconds, and the other, with a lifetime of ~400 femtoseconds, was attributed to s-state electrons just after internal conversion in a nonequilibrated solvent environment. These assignments support the nonadiabatic relaxation model.
Journal Article
The scruffy puppy
\"Bella has always dreamed of getting her very own dog, and her wish finally comes true when she and her family visit the rescue shelter to choose a pet. One of the puppies, Jack, has wild, frizzy ears and a huge, fluffy tail, and he has always dreamed of the perfect home. Both are thrilled when Bella chooses Jack. The puppy loves living with Bella, and she adores playing with him. But then Bella's friends start saying mean things about Jack. Can Bella prove to everyone that there's more to her scruffy puppy than meets the eye?\"--Page [4] of cover.
Book
A Qualitative Analysis of How Online Access to Mental Health Notes Is Changing Clinician Perceptions of Power and the Therapeutic Relationship
As part of the national OpenNotes initiative, the Veterans Health Administration (VHA) provides veterans online access to their clinical progress notes, raising concern in mental health settings.
The aim of this study was to examine the perspectives and experiences of mental health clinicians with OpenNotes to better understand how OpenNotes may be affecting mental health care.
We conducted individual semi-structured interviews with 28 VHA mental health clinicians and nurses. Transcripts were analyzed using a thematic analysis approach, which allows for both inductive and deductive themes to be explored using an iterative, constant comparative coding process.
OpenNotes is changing VHA mental health care in ways that mental health clinicians perceive as both challenging and beneficial. At the heart of these changes is a shifting power distribution within the patient-clinician relationship. Some clinicians view OpenNotes as an opportunity to better partner with patients, whereas others feel that it has the potential to undo the therapeutic relationship. Many clinicians are uncomfortable with OpenNotes, but acknowledge that this discomfort could both improve and diminish care and documentation practices. Specifically, we found that (1) OpenNotes is empowering patients, (2) OpenNotes is affecting how clinicians build and maintain the therapeutic relationship, and (3) mental health clinicians are adjusting their practices to protect patients and themselves from adverse consequences of OpenNotes.
Our findings suggest that future research should monitor whether OpenNotes notes facilitates stronger patient-clinician relationships, enhancing patient-centered mental health care, or diminishes the quality of mental health care through disruptions in the therapeutic relationship and reduced documentation.
Journal Article
The secret kitten
Lucy can't help but feel lonely when she and her brother move in with their gran, leaving behind their old school and friends. Lucy wishes she could have a pet, but Gran isn't keen on animals. A black and white stray kitten catches Lucy's attention, and she instantly falls in love with it. But Lucy is upset when she reads in a magazine that the kitten's colour will make it difficult to rehome. Too young to look after herself, where will the kitten go if she can't find anyone to take her in?
Book
Responding to the Syrian crisis: the needs of women and girls
If adequate psychosocial services are not in place, then women face long-term consequences related to anxiety and post-traumatic stress disorder.11 Additionally, prolonged emergencies can weaken health systems, with long-lasting effects on maternal and infant mortality, as seen in countries previously affected by conflict.10,12 As in most conflicts, Syrian women and children comprise the largest proportion of displaced people, at present about 78%.3 Similar to the Iraqi crisis, a recent assessment from Jordan noted that Syrian women view reproductive health to be a crucial issue, but that barriers prevent them from accessing services.13,14 An assessment in Egypt reported that primary health care is expensive and not easily accessible for Syrian refugees.5 In Lebanon, Syrian refugee women have reported that they attend few antenatal care visits and delay pregnancy because of high out-of-pocket costs associated with these services.15 Additionally, the effect of the refugee influx has been felt in the host community and health sector.
Journal Article
Sammy the shy kitten
Emma wants to adopt Sammy, one of the kittens that live in her riding school's stable, but must first convince her parents that this is a good idea.
Book
Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer
Although the addition of the prosthetic group lipoate is essential to the activity of critical mitochondrial catabolic enzymes, its regulation is unknown. Here, we show that lipoylation of the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase (αKDH) complexes is a dynamically regulated process that is inhibited under hypoxia and in cancer cells to restrain mitochondrial respiration. Mechanistically, we found that the polymerase-δ interacting protein 2 (Poldip2), a nuclear-encodedmitochondrial protein of unknown function, controls the lipoylation of the pyruvate and α-KDH dihydrolipoamide acetyltransferase subunits by a mechanism that involves regulation of the caseinolytic peptidase (Clp)-protease complex and degradation of the lipoate-activating enzyme Ac-CoA synthetase medium-chain family member 1 (ACSM1). ACSM1 is required for the utilization of lipoic acid derived from a salvage pathway, an unacknowledged lipoylation mechanism. In Poldip2-deficient cells, reduced lipoylation represses mitochondrial function and induces the stabilization of hypoxia-inducible factor 1α (HIF-1α) by loss of substrate inhibition of prolyl-4-hydroxylases (PHDs). HIF-1α–mediated retrograde signaling results in a metabolic reprogramming that resembles hypoxic and cancer cell adaptation. Indeed, we observe that Poldip2 expression is down-regulated by hypoxia in a variety of cell types and basally repressed in triple-negative cancer cells, leading to inhibition of lipoylation of the pyruvate and α-KDH complexes and mitochondrial dysfunction. Increasing mitochondrial lipoylation by forced expression of Poldip2 increases respiration and reduces the growth rate of cancer cells. Our work unveils a regulatory mechanism of catabolic enzymes required for metabolic plasticity and highlights the role of Poldip2 as key during hypoxia and cancer cell metabolic adaptation.
Journal Article
Alone in the night
\"Jasmine is thrilled when her neighbors ask her to cat-sit while they go away for Christmas. Now she'll be able to spend her entire vacation with their beautiful cat named Star. Star loves playing with Jasmine, and soon the pair are inseparable. But what Jasmine doesn't know is that Star has a secret. Although it is cold and dark outside, the time has come for Star to leave Jasmine and her warm, safe home and find a place to hide. But where should she go?\"--Page [4] of cover.
Book
Perceptions of Health Communication, Water Treatment and Sanitation in Artibonite Department, Haiti, March-April 2012
The international response to Haiti's ongoing cholera outbreak has been multifaceted, including health education efforts by community health workers and the distribution of free water treatment products. Artibonite Department was the first region affected by the outbreak. Numerous organizations have been involved in cholera response efforts in Haiti with many focusing on efforts to improve water, sanitation, and hygiene (WASH). Multiple types of water treatment products have been distributed, creating the potential for confusion over correct dosage and water treatment methods. We utilized qualitative methods in Artibonite to determine the population's response to WASH messages, use and acceptability of water treatment products, and water treatment and sanitation knowledge, attitudes and practices at the household level. We conducted eighteen focus group discussions (FGDs): 17 FGDs were held with community members (nine among females, eight among males); one FGD was held with community health workers. Health messages related to WASH were well-retained, with reported improvements in hand-washing. Community health workers were identified as valued sources of health information. Most participants noted a paucity of water-treatment products. Sanitation, specifically the construction of latrines, was the most commonly identified need. Lack of funds was the primary reason given for not constructing a latrine. The construction and maintenance of potable water and sanitation services is needed to ensure a sustainable change.
Journal Article