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"Williams, Louis"
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Charleston syllabus : readings on race, racism, and racial violence
\"A collection of new essays and columns published in the wake of the 2015 Charleston, SC, massacre, along with excerpts from key scholarly books. It draws from a variety of disciplines--history, sociology, urban studies, law, critical race theory--and includes discussion questions and a selected and annotated bibliography for further reading\"--Amazon.com.
Book
Viewing of abstract art follows a gist to survey gaze pattern over time regardless of broad categorical titles
Artworks are often shown alongside informative contextual text. This can be as simple as its title and date, or it can be a more descriptive or elaborative explanation of the piece, such as describing its content or explaining the symbolism of the work. Contextual information has been shown to have no impact on early viewing behaviour. A consistent impact on observer eye movement scan paths and fixations is only found in the later periods of looking. One explanation for this is that early eye movement responses to artworks support automatic low-level visual processing that quickly extracts a broad, holistic gist or sense of the works, allowing rapid categorization. The influence of contextual information may only be felt in later periods as it concentrates fixations on descriptive or elaborative elements more quickly and for longer periods. To examine this explanation, we recorded eye movement responses to abstract paintings that were preceded by basic-level categorical labels. In Experiment 1, abstract works were preceded by the labels Landscape, Portrait or Abstract, while in Experiment 2 the labels Action, Still Life or Abstract were given. We found that saccadic eye movements were more common in the first 2 seconds of viewing and were spread over a large portion of the artworks. They became less frequent and were spatially clustered over time. This changing pattern of saccades and their fixation periods was not affected by the contextual information provided by the category labels suggesting a minimal role for top-down control of eye movements when viewers are faced with abstract artworks.
Journal Article
Torchbearers of Democracy
On April 2, 1917, Woodrow Wilson thrust the United States into World War I by declaring, \"The world must be made safe for democracy.\" For the 380,000 African American soldiers who fought and labored in the global conflict, these words carried life or death meaning. Relating stories bridging the war and postwar years, spanning the streets of Chicago and the streets of Harlem, from the battlefields of the American South to the battlefields of the Western Front, Chad L. Williams reveals the central role of African American soldiers in World War I and how they, along with race activists and ordinary citizens alike, committed to fighting for democracy at home and beyond.Using a diverse range of sources, Williams connects the history of African American soldiers and veterans to issues such as the obligations of citizenship, combat and labor, diaspora and internationalism, homecoming and racial violence, \"New Negro\" militancy, and African American historical memories of the war. Democracy may have been distant from the everyday lives of African Americans at the dawn of the war, but it nevertheless remained a powerful ideal that sparked the hopes of black people throughout the country for societal change.Torchbearers of Democracyreclaims the legacy of black soldiers and establishes the World War I era as a defining moment in the history of African Americans and peoples of African descent more broadly.
eBook
Post-transplantation Cyclophosphamide: From HLA-Haploidentical to Matched-Related and Matched-Unrelated Donor Blood and Marrow Transplantation
Following allogeneic blood and marrow transplantation (BMT), graft-versus-host disease (GvHD) continues to represent a significant cause of treatment failure, despite the routine use of conventional, mainly calcineurin inhibitor-based prophylaxis. Recently, post-transplant cyclophosphamide (PTCy) has emerged as a safe and efficacious alternative. First, omitting the need for
T-cell depletion in the setting of haploidentical transplantation, growing evidence supports PTCy role in GvHD prevention in matched-related and matched-unrelated transplants. Through improved understanding of GvHD pathophysiology and advancements in drug development, PTCy emerges as a unique opportunity to design calcineurin inhibitor-free strategies by integrating agents that target different stages of GvHD development.
Journal Article
The Concurrent Programming of Saccades
Sequences of saccades have been shown to be prepared concurrently however it remains unclear exactly what aspects of those saccades are programmed in parallel. To examine this participants were asked to make one or two target-driven saccades: a reflexive saccade; a voluntary saccade; a reflexive then a voluntary saccade; or vice versa. During the first response the position of a second target was manipulated. The new location of the second saccade target was found to impact on second saccade latencies and second saccade accuracy showing that some aspects of the second saccade program are prepared in parallel with the first. However, differences were found in the specific pattern of effects for each sequence type. These differences fit well within a general framework for saccade control in which a common priority map for saccade control is computed and the influence of saccade programs on one another depends not so much on the types of saccade being produced but rather on the rate at which their programs develop.
Journal Article
Impact of Extraosseous Extramedullary Disease on Outcomes of Patients with Relapsed-Refractory Multiple Myeloma receiving Standard-of-Care Chimeric Antigen Receptor T-Cell Therapy
The presence of extramedullary disease (EMD) has been associated with poor outcomes in patients with relapsed-refractory multiple myeloma (RRMM). Herein, we report the outcomes of RRMM patients who were treated with standard-of-care (SOC) chimeric antigen receptor (CAR) T-cell therapy and had active extraosseous EMD before the infusion. Data were retrospectively collected from patients at three US institutions with the intent to receive SOC CAR T. Responses were assessed per the International Myeloma Working Group criteria. A total of 152 patients proceeded with infusion, of whom 47 (31%) had EMD (EMD group) and 105 (69%) did not (non-EMD group). Baseline patient characteristics were comparable between the two groups. The EMD group had a higher incidence of high-grade CRS, steroid and anakinra use, and thrombocytopenia on day +30 compared to the non-EMD group. In addition, the EMD group had an inferior overall response rate (58% vs 96%,
p
< 0.00001), median progression-free survival (PFS) (5.1 vs 12.4 months;
p
< 0.0001), and overall survival (OS) (12.2 vs 27.5 months;
p
= 0.00058) compared to the non-EMD group. We further subdivided the non-EMD patients into those with paramedullary disease (PMD-only group,
n
= 26 [17%]) and those with neither EMD nor PMD (bone marrow-contained group or BM-only group,
n
= 79 [52%]). Patients with PMD-only had similar median PFS (11.2 vs 13.6 months,
p
= 0.3798) and OS (not reached [NR] vs 27.5 months,
p
= 0.6446) compared to patients with BM-only disease. However, patients with EMD exhibited inferior median PFS (5.1 vs 13.6 months,
p
< 0.0001) and OS (12.2 vs 27.5,
p
= 0.0008) compared to patients in the BM-only group. Treatment with SOC CAR T yielded meaningful clinical outcomes in real-world RRMM patients with extraosseous EMD, though responses and survival outcomes were suboptimal compared to patients without EMD. The presence of only EMD but not PMD was associated with significantly worse survival outcomes following the CAR T infusion.
Journal Article
Comprehensive assessment of adverse event profiles associated with bispecific antibodies in multiple myeloma
Bispecific antibodies (BsAbs) have shown promise in the management of relapsed/refractory multiple myeloma (MM). Despite its efficacy, this class of drugs is associated with significant toxicities. In this study, we conducted a pooled analysis of the available clinical trials on BsAbs for the treatment of MM, including full publications and abstracts until April 2025. BsAbs were classified into two groups: B-cell maturation antigen (BCMA), and GPRC5D/FcRH5 BsAbs. Welch’s t-test was performed to compare the safety profiles of each agent. For clustering, we used principal component analysis (PCA). Our study analyzed 22 trials involving 2374 patients with MM from early 2023 to April 2025. Among these, 1276 patients received BCMA BsAbs, 841 treated with GPRC5D/FcRH5 BsAbs, 157 received teclistamab + talquetamab, and 65 patients received a talquetamab + daratumumab, and 35 patients received talquetamab + pomalidomide. The median follow-up for all groups was 11.83 months. Among all-grade hematologic adverse events (AEs), neutropenia occurred in 40.4%, anemia in 39.2%, thrombocytopenia in 21.4%, lymphopenia in 19.2%, infections in 45.8%, and cytokine release syndrome (CRS) in 65%. For grade 3/4 AEs, infections occurred in 20.3%, CRS in 1.5%, neutropenia in 35.2%, anemia in 24.5%%, thrombocytopenia in 13.5%, and lymphopenia in 17.7%. CRS and the need for tocilizumab were significantly less frequent with BCMA BsAbs vs GPRC5D/FcRH5 BsAbs, (P < 0.002). Skillings Mack (Generalized Friedman’s) findings emphasized substantial distinctions between BCMA and GPRC5D/FcRH5×CD3 in both overall and severe grade 3/4 AEs (p ≤ 0.0002). PCA revealed agents with all grades and grade 3/4 showed similar clustering patterns except for three agents. Overall, our findings demonstrated the excellent efficacy on the use of BsAbs in MM; however, these agents have been linked to a unique AE profile. GPRC5D/FcRH5 are associated with less grade 3/4 hematologic toxicity whereas BCMA BsAbs were associated with lower grade 3/4 CRS rates, compared to GPRC5D/FcRH5. These insights are crucial for guiding treatment decisions and developing strategies to improve patient outcomes.
Journal Article
Enhanced Associations With Actions of the Artist Influence Gaze Behaviour
The aesthetic experience of the perceiver of art has been suggested to relate to the art-making process of the artist. The artist’s gestures during the creation process have been stated to influence the perceiver’s art-viewing experience. However, limited studies explore the art-viewing experience in relation to the creative process of the artist. We introduced eye-tracking measures to further establish how congruent actions with the artist influence perceiver’s gaze behaviour. Experiments 1 and 2 showed that simultaneous congruent and incongruent actions do not influence gaze behaviour. However, brushstroke paintings were found to be more pleasing than pointillism paintings. In Experiment 3, participants were trained to associate painting actions with hand primes to enhance visuomotor and visuovisual associations with the artist’s actions. A greater amount of time was spent fixating brushstroke paintings when presented with a congruent prime compared with an incongruent prime, and fewer fixations were made to these styles of paintings when presented with an incongruent prime. The results suggest that explicit links that allow perceivers to resonate with the artist’s actions lead to greater exploration of preferred artwork styles.
Journal Article
Insights from Clinical Trials: Evidence-Based Recommendations for Induction Treatment of Newly Diagnosed Transplant-Eligible Multiple Myeloma
Multiple myeloma (MM) is a hematological malignancy and poses significant therapeutic challenges. This review synthesizes evidence from pivotal clinical trials to guide induction treatment for transplant-eligible (TE), newly diagnosed MM (NDMM) patients. Emphasizing the evolution from three-drug to four-drug induction therapies, we highlight the integration of monoclonal antibodies, particularly CD38 recombinant monoclonal antibody agents, into treatment regimens. This analysis includes a comprehensive literature review of research from major databases and conferences conducted between 2010 and 2023, culminating in the detailed evaluation of 47 studies. The findings underscore the superiority of quadruple regimens in TE NDMM, notably those incorporating daratumumab, in achieving superior responses including progression-free survival (PFS), minimal residual disease (MRD) negativity, objective response rate (ORR), and overall survival (OS) when compared to triple-drug regimens. As treatment regimens evolve with additional agents, the improved outcomes with treatment-related adverse events should be carefully balanced. This review advocates for a paradigm shift towards quadruple induction therapies for TE NDMM, offers a detailed insight into the current landscape of MM treatment, and reinforces a new standard of care.
Journal Article