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Twinmaker
When her best friend, Libby, misuses instant transportation technology to alter her appearance, seventeeen-year-old Clair is drawn into a shadowy world of conspiracies and cover-ups as she attempts to save Libby from the hidden consequences of her actions.
Book
‘Ring the Bells’: Sound and Silence in Garth Nix’s Old Kingdom
Australian author Garth Nix has set six critically acclaimed and internationally bestselling novels and several shorter works in and around the fictional world of the Old Kingdom, beginning with Sabriel (1995) and continuing most recently with Terciel & Elinor (2021). This loose series of texts, with its bellringing protagonists, is the prime contributor to his reputation as an author of high fantasy fiction, although he is also marketed as and known for writing science fiction and other related subgenres. Most notably, his work prominently features elements of the Gothic. This aspect of his work and the ways in which it creates tension within the “high” fantasy genre becomes increasingly apparent when examined through the lens of sound—a critical method that has potential for charting the entanglements of this genre with other popular genres of fiction.
Journal Article
Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study
The ability to investigate therapeutic interventions in animal models of neurodegenerative diseases depends on extensive characterization of the model(s) being used. There are numerous models that have been generated to study Alzheimer’s disease (AD) and the underlying pathogenesis of the disease. While transgenic models have been instrumental in understanding AD mechanisms and risk factors, they are limited in the degree of characteristics displayed in comparison with AD in humans, and the full spectrum of AD effects has yet to be recapitulated in a single mouse model. The Model Organism Development and Evaluation for Late-Onset Alzheimer’s Disease (MODEL-AD) consortium was assembled by the National Institute on Aging (NIA) to develop more robust animal models of AD with increased relevance to human disease, standardize the characterization of AD mouse models, improve preclinical testing in animals, and establish clinically relevant AD biomarkers, among other aims toward enhancing the translational value of AD models in clinical drug design and treatment development. Here we have conducted a detailed characterization of the 5XFAD mouse, including transcriptomics, electroencephalogram, in vivo imaging, biochemical characterization, and behavioral assessments. The data from this study is publicly available through the AD Knowledge Portal.
Journal Article
Crashland : a Twinmaker novel
\"In this sequel to Twinmaker, the world's teleportation network has crashed, armies of dupes are attacking--and Clair must determine her allegiances, figure out how to find her mysterious online friend called Q, and stay alive\"-- Provided by publisher.
Book
A Meta-Analysis of Injuries in Senior Men’s Professional Rugby Union
Background
Rugby Union has one of the highest reported incidences of match injuries amongst all professional team sports. The majority of research within this field has focused on elite male cohorts; in this study we present the first meta-analytic review of these data.
Objective
The aim of this study was to summarise the incidence and severity of injuries in senior men’s professional Rugby Union, and determine the overall effects of level of play, new versus recurrent injuries, playing position, type of injuries, location of injuries, severity of injuries, period of match, and injury incident.
Methods
Electronic databases were searched using keywords ‘Rugby Union’ and ‘inj*’. Fifteen papers addressing injuries in senior men’s professional Rugby Union (from 1995 through September 2012) were included in the review. A maximum of ten of these papers provided incidence data that could be modelled via a Poisson mixed-effects generalised linear model, while up to nine studies provided severity data that could be modelled via a general linear mixed model. Magnitude based inferences were used to assess differences between factors. A descriptive analysis was provided for studies that could not be included in the pooled analysis due to incongruent injury definitions.
Results
The overall incidence of injuries in senior men’s professional Rugby Union matches was 81 per 1,000 player hours (95 % CI 63–105), and 3 per 1,000 player hours (95 % CI 2–4) during training. Estimated mean severity for match injuries was 20 days (95 % CI 14–27), and 22 days (95 % CI 19–24) for training injuries. A higher level of play was associated with a greater incidence of injuries in matches, with no clear difference in severity. New injuries occurred substantially more often than recurrent injuries, while the severity of recurrent injuries was, on average, 10 days (95 % CI 4–17) greater than new injuries. Trivial differences were found in injury incidence and severity between forwards and backs. Muscle/tendon and joint (non-bone)/ligament injuries were the two most prevalent injury groups, whereas fractures and bone stress injuries had the highest average severity. The lower limb was the body region with the highest injury incidence, while upper limb injuries were most severe. The third quarter (40–60 min) of matches had the highest injury rate, and injuries most commonly occurred as a result of being tackled.
Conclusions
This meta-analysis confirms match injury incidence rates in professional Rugby Union can be considered high in comparison with other team sports, but similar to other collision sports. In order to markedly reduce overall injury burden, efforts should target lower-limb injury prevention strategies and technique during contact, as these may render the largest effect.
Journal Article
Hollowgirl : a Twinmaker novel
\"In the final book in the Twinmaker series, Clair, Q, and Kari Sargent must enter The Yard, a digital landscape created by their enemy, in order to save the world\"-- Provided by publisher.
Book
Injuries in Elite Men’s Rugby Union: An Updated (2012–2020) Meta-Analysis of 11,620 Match and Training Injuries
Background
The most recent meta-analytic review of injuries in elite senior men’s Rugby Union was published in 2013. The demands of the game at the elite level are continually changing alongside law amendments and developments in player preparation. As such, an updated meta-analysis of injury data in this setting is necessary.
Objective
To meta-analyse time-loss injury data in elite senior men’s Rugby Union between 2012 and 2020.
Methods
Electronic databases were searched using the keywords ‘rugby’ and ‘inj*’. Nineteen studies met the inclusion criteria. Injury incidence rate data were modelled using a mixed-effects Poisson regression model. Days missed data were modelled using a general linear mixed model.
Results
The included data encompassed a total of 8819 match injuries and 2801 training injuries. The overall incidence rate of injuries in matches was 91 per 1000 h (95% confidence interval (CI) 77–106). The estimated mean days missed per match injury was 27 days (95% CI 23–32). The overall incidence rate of match concussions was 12 per 1000 h (95% CI 9–15). The overall incidence rate of training injuries was 2.8 per 1000 h (95% CI 1.9–4.0). Playing level was not a significant effect modifier for any outcome.
Conclusions
The injury incidence rate and mean days missed per injury in the present meta-analysis were higher, but statistically equivalent to, the 2013 meta-analysis (81 per 1000 h and 20 days, respectively). The injury incidence rate for match injuries in elite senior men’s Rugby Union is high in comparison to most team sports, though the training injury incidence rate compares favourably. The tackle event and concussion injuries should continue to be the focus of future preventative efforts.
Journal Article
