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EMC for Product Designers (4th Edition)
Widely regarded as the standard text on EMC, this book provides all the key information needed to meet the requirements of the latest EMC Directive. Most importantly, it shows how to incorporate EMC principles into the product design process, avoiding cost and performance penalties, meeting the needs of specific standards and resulting in a better overall product. As well as covering the very latest legal requirements, the Fourth Edition has been thoroughly updated in line with the latest best practice in EMC compliance and product design. Coverage has been considerably expanded to include the R&TTE and Automotive EMC Directives, as well the military aerospace standards of DEF STAN 59-41 and DO160E. A new chapter on systems EMC is included, while short case studies demonstrate how EMC product design is put into practice. Electronic design engineers, compliance engineers, regulatory engineers, test engineers, EMC consultants, and managers responsible for product compliance and product design will benefit from this book.
eBook
Neural correlates of the LSD experience revealed by multimodal neuroimaging
Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimaging techniques: arterial spin labeling (ASL), blood oxygen level-dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in brain activity after LSD that correlated strongly with its characteristic psychological effects. Increased visual cortex cerebral blood flow (CBF), decreased visual cortex alpha power, and a greatly expanded primary visual cortex (V1) functional connectivity profile correlated strongly with ratings of visual hallucinations, implying that intrinsic brain activity exerts greater influence on visual processing in the psychedelic state, thereby defining its hallucinatory quality. LSD’s marked effects on the visual cortex did not significantly correlate with the drug’s other characteristic effects on consciousness, however. Rather, decreased connectivity between the parahippocampus and retrosplenial cortex (RSC) correlated strongly with ratings of “ego-dissolution” and “altered meaning,” implying the importance of this particular circuit for the maintenance of “self” or “ego” and its processing of “meaning.” Strong relationships were also found between the different imaging metrics, enabling firmer inferences to be made about their functional significance. This uniquely comprehensive examination of the LSD state represents an important advance in scientific research with psychedelic drugs at a time of growing interest in their scientific and therapeutic value. The present results contribute important new insights into the characteristic hallucinatory and consciousness-altering properties of psychedelics that inform on how they can model certain pathological states and potentially treat others.
Journal Article
Symptoms and risk factors for long COVID in non-hospitalized adults
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with a range of persistent symptoms impacting everyday functioning, known as post-COVID-19 condition or long COVID. We undertook a retrospective matched cohort study using a UK-based primary care database, Clinical Practice Research Datalink Aurum, to determine symptoms that are associated with confirmed SARS-CoV-2 infection beyond 12 weeks in non-hospitalized adults and the risk factors associated with developing persistent symptoms. We selected 486,149 adults with confirmed SARS-CoV-2 infection and 1,944,580 propensity score-matched adults with no recorded evidence of SARS-CoV-2 infection. Outcomes included 115 individual symptoms, as well as long COVID, defined as a composite outcome of 33 symptoms by the World Health Organization clinical case definition. Cox proportional hazards models were used to estimate adjusted hazard ratios (aHRs) for the outcomes. A total of 62 symptoms were significantly associated with SARS-CoV-2 infection after 12 weeks. The largest aHRs were for anosmia (aHR 6.49, 95% CI 5.02–8.39), hair loss (3.99, 3.63–4.39), sneezing (2.77, 1.40–5.50), ejaculation difficulty (2.63, 1.61–4.28) and reduced libido (2.36, 1.61–3.47). Among the cohort of patients infected with SARS-CoV-2, risk factors for long COVID included female sex, belonging to an ethnic minority, socioeconomic deprivation, smoking, obesity and a wide range of comorbidities. The risk of developing long COVID was also found to be increased along a gradient of decreasing age. SARS-CoV-2 infection is associated with a plethora of symptoms that are associated with a range of sociodemographic and clinical risk factors.
A retrospective analysis of primary care records in the United Kingdom reveals individual symptoms associated with SARS-CoV-2 infections, which persisted for 12 weeks or more after infection, as well as risk factors associated with developing long COVID.
Journal Article
America's great mountain trails : 100 highcountry hikes of a lifetime
\"A hiker's inspirational bucket list is embodied in this lavishly illustrated celebration of our nation's one hundred best mountain trails. America's mountain trails lure us to exquisite heights, from the Atlantic Coast in Maine, to the Pacific edge in California and the Northwest. These rugged yet seductive pathways call to all who seek both solace and adventure, whether out for a day hike or an extended backpacking expedition. America's Great Mountain Trails introduces readers to one hundred hikes of a lifetime. The book covers some of our nation's most legendary trails and some that are scarcely known, but all can take us on journeys to remarkable places. Between the ancient Appalachians and the Pacific Coast's uplift lie the Rockies, Desert Range, Sierra Nevada, Cascade Mountains, Olympics, and more. Beyond are the resoundingly wild terrain of Alaska and the islands of Hawaii and Puerto Rico, which ascend like dreamy visions from the sea. Readers get practical details about the length and difficulty of each hike, along with concise directions to each trailhead, tips about the best seasons to go, advice on permit requirements, and a selection of alternate routes. An appendix offers information about what must be done to protect these special places so they'll remain alluring and rewarding to all the generations ahead. With fascinating text and beautiful photography by Tim Palmer, America's Great Mountain Trails is sure to become the definitive reference book to the most outstanding mountain trails in America.\"--Publisher's description.
Book
Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers
Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profound anti-inflammatory properties mediated by 5-HT2A receptor signaling, supporting their evaluation as a therapeutic for neuroinflammation associated with neurodegenerative disease.ObjectiveThis study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of orally repeated administration of 5 μg, 10 μg, and 20 μg LSD in older healthy individuals. In the current paper, we present safety, tolerability, pharmacokinetics, and pharmacodynamic measures that relate to safety, tolerability, and dose response.MethodsThis was a phase 1 double-blind, placebo-controlled, randomized study. Volunteers were randomly assigned to 1 of 4 dose groups (5 μg, 10 μg, 20 μg LSD, and placebo), and received their assigned dose on six occasions (i.e., every 4 days).ResultsForty-eight older healthy volunteers (mean age = 62.9 years) received placebo (n = 12), 5 μg (n = 12), 10 μg (n = 12), or 20 μg (n = 12) LSD. LSD plasma levels were undetectable for the 5 μg group and peak blood plasma levels for the 10 μg and 20 μg groups occurred at 30 min. LSD was well tolerated, and the frequency of adverse events was no higher than for placebo. Assessments of cognition, balance, and proprioception revealed no impairment.ConclusionsOur results suggest safety and tolerability of orally administered 5 μg, 10 μg, and 20 μg LSD every fourth day over a 21-day period and support further clinical development of LSD for the treatment and prevention of Alzheimer’s disease (AD).
Journal Article
Silk roads
In the ninth century CE, an Arabian ship sank off the coast of Indonesia. The objects found in the wreckage have provided extraordinary evidence of the nature, scale and diversity of trade between Tang China and the Islamic Abbasid dynasty, revealing the extent of a large-scale operation. This is just one example of the sprawling and extensive networks of contacts and exchanges across Afro-Eurasia, from Japan to Britain, in the period 500 to 1000 CE. This book challenges the concept of the 'Silk Roads' as a simple history of trade between East and West.
BOOK
Nomadic ecology shaped the highland geography of Asia’s Silk Roads
There are many unanswered questions about the evolution of the ancient ‘Silk Roads’ across Asia. This is especially the case in their mountainous stretches, where harsh terrain is seen as an impediment to travel. Considering the ecology and mobility of inner Asian mountain pastoralists, we use ‘flow accumulation’ modelling to calculate the annual routes of nomadic societies (from 750 m to 4,000 m elevation). Aggregating 500 iterations of the model reveals a high-resolution flow network that simulates how centuries of seasonal nomadic herding could shape discrete routes of connectivity across the mountains of Asia. We then compare the locations of known high-elevation Silk Road sites with the geography of these optimized herding flows, and find a significant correspondence in mountainous regions. Thus, we argue that highland Silk Road networks (from 750 m to 4,000 m) emerged slowly in relation to long-established mobility patterns of nomadic herders in the mountains of inner Asia.
The authors use modelling to show that the network of trading routes known as the Silk Road emerged from hundreds of years of interactions between pastoralists as they moved their herds and flocks between higher and lower elevations in generally mountainous regions.
Smoothing out the Silk Road (Frachetti 21696, Biology Article, ed Henry Gee)
The Silk Road refers to a network of ancient trade routes that have crossed central Asia since time immemorial. But how did it get started? Conventional models usually start by inferring the easiest paths between sites already known to be part of the network. This introduces a circular argument as it biases the results towards what is already known. Here Michael Frachetti and colleagues take a different approach to show that the network emerged from hundreds of years of interactions between pastoralists moving their livestock between higher and lower elevations in response to the seasons in this generally mountainous region. They suggest that the Silk Road network therefore materialized slowly from the long-established, local mobility patterns of nomadic herders. This finding may encourage archaeologists to seek more nuanced explanations for the evolution of ancient connectivity.
Journal Article