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This isMark Twain's first novel about Tom Sawyer and Huckleberry Finn, and it has become one of the world's best-loved books. It is a fond reminiscence of life in Hannibal, Missouri, an evocation of Mark Twain's own boyhood along the banks of the Mississippi during the 1840s. \"Most of the adventures recorded in this book really occurred, \" he tells us. The Mark Twain Library edition contains the only text since the first edition (1876) to be based directly on the author's manuscript and to include all of the \"200 rattling pictures' Mark Twain commissioned from one of his favorite illustrators, True W. Williams. This landmark anniversary edition contains a selection of original documents by Mark Twain, including several letters in his inimitable voice about writing Tom Sawyer and about its original publication.

Mark Twain's humorous account of his six years in Nevada, San Francisco, and the Sandwich Islands is a patchwork of personal anecdotes and tall tales, many of them told in the \"vigorous new vernacular\" of the West. Selling seventy five thousand copies within a year of its publication in 1872, Roughing It was greeted as a work of \"wild, preposterous invention and sublime exaggeration\" whose satiric humor made \"pretension and false dignity ridiculous.\" Meticulously restored from a variety of original sources, the text is the first to adhere to the author's wishes in thousands of details of wording, spelling, and punctuation, and includes all of the 304 first-edition illustrations. With its comprehensive and illuminating notes and supplementary materials, which include detailed maps tracing Mark Twain's western travels, this Mark Twain Library Roughing It must be considered the standard edition for readers and students of Mark Twain.

The inner circumgalactic medium (CGM) of galaxies, where disk and halo processes intersect, remains poorly characterized despite its critical role in regulating galaxy evolution. We present results from Project AMIGA Insider, mapping Andromeda’s (M31) inner CGM within 0.25 Rvir (∼75 kpc) using 11 QSO sightlines, bringing our total sample to 54 sightlines from the disk to 2Rvir. We detect a clear transition between M31’s thick disk and CGM at R ≲ 30 kpc, where low/intermediate ions show thick-disk corotating components with higher column densities than the CGM ones, while high ions exhibit similar column densities in both the CGM and thick disk. Beyond this region, all ion column densities decrease with impact parameter, with steeper gradients for low ions than high ions. The inner CGM (R ≲ 100 kpc) shows more complex gas phases and multicomponent absorption compared to the predominantly single-component outer CGM. We find no significant azimuthal dependence for any observed ions, suggesting M31’s CGM is shaped by radial processes (e.g., cooling flows, precipitation) rather than disk-aligned outflows. We estimate the total metal mass in M31’s cool (Si ii, Si iii, Si iv) CGM within Rvir to be (1.9 ± 0. 3stat ± 0. 7sys) × 107 M⊙, leading to a cool gas mass of ≈6×109(Z/0.3Z⊙)−1 M⊙. The warmer O vi gas may contain at least 10 times more metal and gas mass. Compared to the COS-Halos L*galaxies, M31’s cool CGM shows lower Si column densities at R ≲ 0.4 R200 and overall lower cool CGM masses, likely reflecting differences in galaxy mass and environment.

The late stages of progression of prostate carcinoma are typically characterized by an androgen-insensitive, rapidly proliferative state. Some late-stage tumors are composed predominantly of neuroendocrine cells. Virtually no animal models of a neuroendocrine/small cell variant of prostate carcinoma are available for experimental studies. We report a human neuroendocrine/small cell prostate carcinoma xenograft that was developed from a nodal metastasis of a human prostate carcinoma and that has been propagated as serial subcutaneous implants in severe combined immunodeficient mice for >4 years. Designated LuCaP 49, all tumor passages exhibit a neuroendocrine/small cell carcinoma phenotype—insensitivity to androgen deprivation, expression of neuroendocrine proteins, lack of expression of prostate-specific antigen or androgen receptor, and an unusually rapid growth (a doubling time of 6.5 days) for prostate cancer xenografts. Genetically this tumor exhibits loss of heterozygosity for the short arm of chromosome 8 and has a complex karyotype. This xenograft should prove to be useful in the investigation of mechanisms underlying the androgen-insensitive state of progressive prostate carcinoma.

Oil and gas companies increasingly are adopting comprehensive programs of social responsibility in their operations worldwide. Such programs are now seen as essential both to good relations in the areas in which industry operates and also to business success. This trend has evolved to the extent that there is accelerating momentum within the industry to standardize social responsibility programs through the adoption of industry best-practices standards. This theme and the role deepwater basins will play in filling growing oil demand emerged as a major trend in sessions at the World Energy Council's 18th World Energy Congress in Buenos Aires last week.

Royalty issues were a key topic of discussion at the Offshore Technology Conference in Houston last week. Of concern was the threat of changes to the US Outer Continental Shelf Deepwater Royalty Relief Act (DRRA), and their possible dampening of drilling activity in the deepwater Gulf of Mexico. Recent increases in deepwater work, shallow water also assumed a prominent position in the conference presentations. Conspicuous by its absence from the discussion was the recent decline in oil prices. A number of key topics were discussed in Canada addresses, individual presentations and panel discussions, including: The US Interior Department is considering raising the deepwater royalty rates set following the passage of the DRRA.