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May We Be Spared to Meet on Earth is a privileged glimpse into the private correspondence of the officers and sailors who set out in May 1845 on the Erebus and Terror for Sir John Franklin's fateful expedition to the Arctic. The letters of the crew and their correspondents begin with the journey's inception and early planning, going on to recount the ships' departure from the river Thames, their progress up the eastern coast of Great Britain to Stromness in Orkney, and the crew's exploits as far as the Whalefish Islands off the western coast of Greenland, from where the ships forever departed the society that sent them forth. As the realization dawned that something was amiss, heartfelt letters to the missing were sent with search expeditions; those letters, returned unread, tell poignant stories of hope. Assembled completely and conclusively from extensive archival research, including in far-flung family and private collections, the correspondence allows the reader to peer over the shoulders of these men, to experience their excitement and anticipation, their foolhardiness, and their fears. The Franklin expedition continues to excite enthusiasts and scholars worldwide. May We Be Spared to Meet on Earth provides new insights into the personalities of those on board, the significance of the voyage as they saw it, and the dawning awareness of the possibility that they would never return to British shores or their families.

We introduce , a foundation multimodal language model that freely mixes text and speech. Our model is based on a 7B pretrained text language model that we extend to the speech modality by continuously training it on text and speech units. Speech and text sequences are concatenated as a single stream of tokens, and trained with a word-level method using a small automatically curated speech-text parallel corpus. comes in two versions: a version that uses speech phonetic units (HuBERT) and an version that models expressivity using pitch and style units in addition to the phonetic units. For both versions, the text is encoded with subword BPE tokens. The resulting model displays both the semantic abilities of text models and the expressive abilities of speech models. Additionally, we demonstrate that can learn new tasks in a few-shot fashion across modalities (i.e., ASR, TTS, Speech Classification). We make available model weights and inference code.

Correlative gene expression analysis of two putative mouse “immunogenicity” genes, ZG16 and HORMAD1, was used to assay their human homologous expression levels in human pluripotent stem cells and their derivatives. We found that ZG16 expression is heterogeneous across multiple human embryonic stem cell and human induced pluripotent stem cell‐derived cell types. Neither of the previous immunogenicity‐associated genes in the mouse currently appears to be relevant in a human context. Autologous human induced pluripotent stem cells (hiPSCs) should allow cellular therapeutics without an associated immune response. This concept has been controversial since the original report that syngeneic mouse iPSCs elicited an immune response after transplantation. However, an investigative analysis of any potential acute immune responses in hiPSCs and their derivatives has yet to be conducted. In the present study, we used correlative gene expression analysis of two putative mouse “immunogenicity” genes, ZG16 and HORMAD1, to assay their human homologous expression levels in human pluripotent stem cells and their derivatives. We found that ZG16 expression is heterogeneous across multiple human embryonic stem cell and hiPSC‐derived cell types. Additionally, ectopic expression of ZG16 in antigen‐presenting cells is insufficient to trigger a detectable response in a peripheral blood mononuclear cell coculture assay. Neither of the previous immunogenicity‐associated genes in the mouse currently appears to be relevant in a human context.

Improving access to athletic trainers and increasing diversity in the profession have been major goals of the Strategic Alliance, with a particular interest in the secondary school setting. Within many marginalized communities, individuals are often faced with a lack of resources, high rates of poverty, and limited access to health care. This social and economic climate often extends to inequitable athletic training services and patterns of disparate health. Widely used and recognized strategies to cultivate diversity and address health inequities include community-engaged partnerships; however, these approaches are not well implemented across the athletic training discipline. Successful community-engaged partnerships link communities and universities, and they are rooted in intentionality to address intermediate and long-term health equity outcomes. Athletic training professionals and scholars frequently encounter gaps in resources and process-oriented methods to participate in community-engaged efforts that could include a roadmap or pathway to follow. To bridge this gap, our aims were 2-fold: (1) to disseminate a roadmap for building sustainable community-engaged partnerships in athletic training with the intent of promoting diversity, equity, inclusion, and social justice across athletic training education, research, and professional service and (2) to demonstrate how the roadmap can be implemented using a community-based athletic training education camp as an example. Implementation of the athletic training camp using the roadmap took place at secondary schools where community-engaged partnerships have been established throughout a geographic region known as the Alabama Black Belt, a region burdened with poor health outcomes, limited athletic trainer presence, and lower quality of life, exacerbated by racial and socioeconomic inequalities. Implementing this roadmap as a strategy to build sustainable community-engaged partnerships offers an innovative, interactive, and effective approach to addressing community needs by exposing secondary school students to the athletic training profession, advancing equitable athletic training research practices, and upholding and promoting the principles of diversity, equity, inclusion, and social justice in athletic training education.

Background: This study aimed to enhance diversity, equity, and inclusion in pain-related clinimetrics by evaluating the reliability, validity, and suitability of five measurement tools in an underrepresented population: Black and African American adolescent male athletes. The integrity and generalizability of these instruments are essential for advancing pain and injury research across diverse populations and for refining theoretical frameworks guiding scientific inquiry, clinical practice, and health education. Purpose: The primary objective was to assess the clinimetric properties of the Athlete Fear-Avoidance Questionnaire (AFAQ), Multidimensional Health Locus of Control Scale – Form C (MHLC-C), Pain Catastrophizing Scale (PCS), Pain Resilience Scale (PRS), and Pain Self-Efficacy Questionnaire (PSEQ). Methods: Using an integrative mixed methods approach, quantitative analysis assessed item performance, reliability, and validity, while qualitative analysis explored participants' perceptions of the tools' comprehensibility and suitability through semi-structured interviews and cognitive assessments. Results: Quantitatively, the AFAQ demonstrated the best performance with strong item performance, reliability, and validity, followed closely by the PSEQ. The internal and chance MHLC-C also showed good results, but the PCS and PRS had variable outcomes. The PCS exhibited high reliability but had slight structural inconsistencies. The PRS showed good internal consistency but only acceptable item performance and problematic structural validity. A significant issue across all but the PSEQ was the threshold ordering of rating scale categories, with abnormal category ordering and overlap. Qualitatively, participants generally found the tools comprehensible and suitable for adolescents but noted some concerns, especially with the chance MHLC-C and PRS. Item repetition was a common issue, particularly in the internal MHLC-C, chance MHLC-C, PCS, and PRS. Despite these concerns, participants were positive about the tools' use in adolescent populations and provided constructive feedback for improvement. Conclusion: The study found that while the measurement tools demonstrated promising clinimetric properties, refinements are needed, particularly regarding their rating scale structures. Qualitative feedback affirmed the tools' overall suitability but highlighted areas for enhancement to improve applicability and effectiveness in adolescent populations. Future research should continue refining these tools and expanding theoretical frameworks to incorporate psychosocial elements, ensuring a holistic approach to understanding and managing pain in diverse populations.

Identifies and summarizes thousands of books, article, exhibition catalogues, government publications, and theses published in many countries and in several languages from the early nineteenth century to 1981.