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"Wilson, Scott"
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When and where does dispersal limitation matter in primary succession?
1. Primary succession encompasses the earliest and most fundamental stages of community assembly. The relative contributions of plant dispersal and ecosystem development, the main drivers that control the rate of primary succession, remain largely unknown, in spite of their central roles in community organization in general. Understanding the contribution of dispersal is especially critical because it casts light on our ability to manage succession resulting from climate change or anthropogenic disturbance. 2. Here, we review the literature in order to understand when and where dispersal limits primary succession. Studies from many systems (tropical, temperate, boreal, arctic, alpine, floodplain forest, desert, mines, volcanic eruption and glacier forelands) show that dispersal limitation occurs consistently in the early stages of primary succession, suggesting that this is a general pattern. On the other hand, we found strong biases in study sites towards the Northern Hemisphere, temperate regions, volcanic eruptions and glacier forelands, which suggests that there are risks in drawing general conclusions about the importance of dispersal for primary succession for other biomes. 3. Little is known about the contribution of dispersal to the later stages of primary succession. We present a recently developed method, multiscale chronosequence comparison that compares rates of succession in similar systems at relatively small and large spatial scales. Rapid succession at small scales compared to large scales suggests that seed dispersal influences succession over time periods of centuries and also limits the development of ecosystem functions such as vegetation cover and soil carbon accumulation. 4. Synthesis. Dispersal limitation likely matters not only in the early stages but also in the late stages of primary succession by controlling the rate at which new species arrive. Both the accumulation of comparable case studies and novel approaches, such as multiscale chronosequence comparisons and factorial experiments, in contrasting biomes, are necessary to clarify the generality or context dependency of the role of dispersal in future primary successions undergoing changing climate.
Journal Article
DNA Methylation in Autoimmune Thyroid Disease
Abstract
Graves disease and Hashimoto disease form part of the spectrum of autoimmune thyroid disease (AITD), to which genetic and environmental factors are recognized contributors. Epigenetics provides a potential link between environmental influences, gene expression, and thyroid autoimmunity. DNA methylation (DNAm) is the best studied epigenetic process, and global hypomethylation of leukocyte DNA is reported in several autoimmune disorders. This review summarizes the current understanding of DNAm in AITD. Targeted DNAm studies of blood samples from AITD patients have reported differential DNAm in the promoter regions of several genes implicated in AITD, including TNF, IFNG, IL2RA, IL6, ICAM1, and PTPN22. In many cases, however, the findings await replication and are unsupported by functional studies to support causal roles in AITD pathogenesis. Furthermore, thyroid hormones affect DNAm, and in many studies confounding by reverse causation has not been considered. Recent studies have shown that DNAm patterns in candidate genes including ITGA6, PRKAA2, and DAPK1 differ between AITD patients from regions with different iodine status, providing a potential mechanism for associations between iodine and AITD. Research focus in the field is moving from candidate gene studies to an epigenome-wide approach. Genome-wide methylation studies of AITD patients have demonstrated multiple differentially methylated positions, including some in immunoregulatory genes such as NOTCH1, HLA-DRB1, TNF, and ICAM1. Large, epigenome-wide studies are required to elucidate the pathophysiological role of DNAm in AITD, with the potential to provide novel diagnostic and prognostic biomarkers as well as therapeutic targets.
Journal Article
Climate change reduces extent of temperate drylands and intensifies drought in deep soils
Drylands cover 40% of the global terrestrial surface and provide important ecosystem services. While drylands as a whole are expected to increase in extent and aridity in coming decades, temperature and precipitation forecasts vary by latitude and geographic region suggesting different trajectories for tropical, subtropical, and temperate drylands. Uncertainty in the future of tropical and subtropical drylands is well constrained, whereas soil moisture and ecological droughts, which drive vegetation productivity and composition, remain poorly understood in temperate drylands. Here we show that, over the twenty first century, temperate drylands may contract by a third, primarily converting to subtropical drylands, and that deep soil layers could be increasingly dry during the growing season. These changes imply major shifts in vegetation and ecosystem service delivery. Our results illustrate the importance of appropriate drought measures and, as a global study that focuses on temperate drylands, highlight a distinct fate for these highly populated areas.
Future stress on water resources, and on temperate drylands in particular, remains uncertain. Here, the authors show that climate in the late twenty first century may reduce the extent of temperate drylands, dry deep soils, and create intra-regional and intercontinental differences in ecological drought.
Journal Article
Virgil in the Renaissance
\"The disciplines of classical scholarship were established in their modern form between 1300 and 1600, and Virgil was a test case for many of them. This book is concerned with what became of Virgil in this period, how he was understood, and how his poems were recycled. What did readers assume about Virgil in the long decades between Dante and Sidney, Petrarch and Spenser, Boccaccio and Ariosto? Which commentators had the most influence? What story, if any, was Virgil's Eclogues supposed to tell? What was the status of his Georgics? Which parts of his epic attracted the most imitators? Building on specialized scholarship of the last hundred years, this book provides a panoramic synthesis of what scholars and poets from across Europe believed they could know about Virgil's life and poetry\"--Provided by publisher.
BOOK
Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria
Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have metabolic disturbances including insulin resistance and dysregulation of glucose homeostasis. PCOS is diagnosed with two different sets of diagnostic criteria, resulting in a phenotypic spectrum of PCOS cases. The genetic similarities between cases diagnosed based on the two criteria have been largely unknown. Previous studies in Chinese and European subjects have identified 16 loci associated with risk of PCOS. We report a fixed-effect, inverse-weighted-variance meta-analysis from 10,074 PCOS cases and 103,164 controls of European ancestry and characterisation of PCOS related traits. We identified 3 novel loci (near PLGRKT, ZBTB16 and MAPRE1), and provide replication of 11 previously reported loci. Only one locus differed significantly in its association by diagnostic criteria; otherwise the genetic architecture was similar between PCOS diagnosed by self-report and PCOS diagnosed by NIH or non-NIH Rotterdam criteria across common variants at 13 loci. Identified variants were associated with hyperandrogenism, gonadotropin regulation and testosterone levels in affected women. Linkage disequilibrium score regression analysis revealed genetic correlations with obesity, fasting insulin, type 2 diabetes, lipid levels and coronary artery disease, indicating shared genetic architecture between metabolic traits and PCOS. Mendelian randomization analyses suggested variants associated with body mass index, fasting insulin, menopause timing, depression and male-pattern balding play a causal role in PCOS. The data thus demonstrate 3 novel loci associated with PCOS and similar genetic architecture for all diagnostic criteria. The data also provide the first genetic evidence for a male phenotype for PCOS and a causal link to depression, a previously hypothesized comorbid disease. Thus, the genetics provide a comprehensive view of PCOS that encompasses multiple diagnostic criteria, gender, reproductive potential and mental health.
Journal Article
A beginner's guide to Japanese haiku : major works by Japan's best-loved poets - from Basho and Issa to Ryokan and Santoka, with works by six women poets
This comprehensive introduction to Japan's best-loved haiku poets is the perfect book for anyone wanting to learn about haiku.
BOOK
Species richness of arbuscular mycorrhizal fungi: associations with grassland plant richness and biomass
Although experiments show a positive association between vascular plant and arbuscular mycorrhizal fungal (AMF) species richness, evidence from natural ecosystems is scarce. Furthermore, there is little knowledge about how AMF richness varies with belowground plant richness and biomass. We examined relationships among AMF richness, above‐ and belowground plant richness, and plant root and shoot biomass in a native North American grassland. Root‐colonizing AMF richness and belowground plant richness were detected from the same bulk root samples by 454‐sequencing of the AMF SSU rRNA and plant trnL genes. In total we detected 63 AMF taxa. Plant richness was 1.5 times greater belowground than aboveground. AMF richness was significantly positively correlated with plant species richness, and more strongly with below‐ than aboveground plant richness. Belowground plant richness was positively correlated with belowground plant biomass and total plant biomass, whereas aboveground plant richness was positively correlated only with belowground plant biomass. By contrast, AMF richness was negatively correlated with belowground and total plant biomass. Our results indicate that AMF richness and plant belowground richness are more strongly related with each other and with plant community biomass than with the plant aboveground richness measures that have been almost exclusively considered to date.
Journal Article