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\"In A Teacher's Guide to Excellence in Every Classroom: Creating Support Systems for Student Success, author John R. Wink acknowledges the unique and significant role that educators play in the lives of their students both as role models and guides. Teachers in the 21st century are far more than simple educators in the lives of their students. As such, this book acts as a guide for educators who wish to maximize their impact in their students' lives and unlock their students' full potential. Readers will not only learn how to increase their effectiveness as educators, but how to push all their students toward academic excellence\"-- Provided by publisher.

A bstract The measurements of coherent elastic neutrino-nucleus scattering (CE ν NS) experiments have opened up the possibility to constrain neutrino physics beyond the standard model of elementary particle physics. Furthermore, by considering neutrino-electron scattering in the keV-energy region, it is possible to set additional limits on new physics processes. Here, we present constraints that are derived from Conus germanium data on beyond the standard model (BSM) processes like tensor and vector non-standard interactions (NSIs) in the neutrino-quark sector, as well as light vector and scalar mediators. Thanks to the realized low background levels in the C onus experiment at ionization energies below 1 keV, we are able to set the world’s best limits on tensor NSIs from CE ν NS and constrain the scale of corresponding new physics to lie above 360 GeV. For vector NSIs, the derived limits strongly depend on the assumed ionization quenching factor within the detector material, since small quenching factors largely suppress potential signals for both, the expected standard model CE ν NS process and the vector NSIs. Furthermore, competitive limits on scalar and vector mediators are obtained from the CE ν NS channel at reactor-site which allow to probe coupling constants as low as 5 ∙ 10 − 5 of low mediator masses, assuming the currently favored quenching factor regime. The consideration of neutrino-electron scatterings allows to set even stronger constraints for mediator masses below ∼ 1 MeV and ∼ 10 MeV for scalar and vector mediators, respectively.

We report first constraints on electromagnetic properties of neutrinos from neutrino-electron scattering using data obtained from the CONUS germanium detectors, i.e. an upper limit on the effective neutrino magnetic moment and an upper limit on the effective neutrino millicharge. The electron antineutrinos are emitted from the 3.9 GWth reactor core of the Brokdorf Nuclear Power Plant in Germany. The CONUS low-background detectors are positioned at a distance of 17.1 m from the reactor core center. The analyzed data set includes 689.1 kg d collected during reactor ON periods and 131.0 kg d collected during reactor OFF periods in the energy range of . With the current statistics, we are able to determine an upper limit on the effective neutrino magnetic moment of μν<7.5·10-11μB at 90% confidence level. No neutrino signal in this channel or in the CEνNS channel has been observed at a nuclear power plant so far. From this first magnetic moment limit we can derive an upper bound on the neutrino millicharge of |qν|<3.3·10-12e0.

CONUS is a novel experiment aiming at detecting elastic neutrino–nucleus scattering in the almost fully coherent regime using high-purity germanium (Ge) detectors and a reactor as antineutrino source. The detector setup is installed at the commercial nuclear power plant in Brokdorf, Germany, at a short distance to the reactor core to guarantee a high antineutrino flux. A good understanding of neutron-induced backgrounds is required, as the neutron recoil signals can mimic the predicted neutrino interactions. Especially events correlated with the reactor thermal power are troublesome. On-site measurements revealed such a correlated, highly thermalized neutron field with a maximum fluence rate of \\[(745\\pm 30)\\,\\hbox {cm}^{-2}\\,\\hbox {day}^{-1}\\]. These neutrons, produced inside the reactor core, are reduced by a factor of \\[\\sim 10^{20}\\] on their way to the CONUS shield. With a high-purity Ge detector without shield the \\[\\gamma \\]-ray background was examined including thermal power correlated \\[^{16}\\hbox {N}\\] decay products and neutron capture \\[\\gamma \\]-lines. Using the measured neutron spectrum as input, Monte Carlo simulations demonstrated that the thermal power correlated field is successfully mitigated by the CONUS shield. The reactor-induced background contribution in the region of interest is exceeded by the expected signal by at least one order of magnitude assuming a realistic ionization quenching factor.

The CONUS experiment is searching for coherent elastic neutrino nucleus scattering of reactor anti-neutrinos with four low-energy threshold point-contact high-purity germanium spectrometers. Excellent background suppression within the region of interest below 1 keV (ionization energy) is absolutely necessary to enable signal detection. The collected data also make it possible to set limits on various models regarding beyond the standard model physics. These analyses benefit as well from the low background level of ∼ 10 d - 1  kg - 1 below 1 keV and at higher energies. The low background level is achieved by employing a compact shell-like shield that was adapted to the most relevant background sources at the shallow depth location of the experiment: environmental gamma radiation and muon-induced secondaries. Overall, the compact CONUS shield including the active anticoincidence muon-veto reduces the background by more than four orders of magnitude. The remaining background is described with validated Monte Carlo simulations which include the detector response. It is the first time that a full background decomposition in germanium operated at a reactor site has been achieved. Next to the remaining muon-induced background, 210 Pb within the shield and cryostat end caps, cosmogenic activation and airborne radon are the most relevant background sources. The reactor-correlated background is negligible within the shield. The validated background model, together with the parameterization of the noise, is used as input to the likelihood analyses of the various physics cases.

For over a year, the coronavirus disease 2019 has been affecting the world population by causing severe tissue injuries and death in infected people. Adenosine triphosphate (ATP) and the nicotinamide adenine dinucleotide (NAD +) are two molecules that are released into the extracellular microenvironment after direct virus infection or cell death caused by hyper inflammation and coagulopathy. Also, these molecules are well known to participate in multiple pathways and have a pivotal role in the purinergic signaling pathway. Thus, using public datasets available on the Gene Expression Omnibus (GEO), we analyzed raw proteomics data acquired using mass spectrometry (the gold standard method) and raw genomics data from COVID-19 patient samples obtained by microarray. The data was analyzed using bioinformatics and statistical methods according to our objectives. Here, we compared the purinergic profile of the total leukocyte population and evaluated the levels of these soluble biomolecules in the blood, and their correlation with coagulation components in COVID-19 patients, in comparison to healthy people or non-COVID-19 patients. The blood metabolite analysis showed a stage-dependent inosine increase in COVID-19 patients, while the nucleotides ATP and ADP had positive correlations with fibrinogen and other coagulation proteins. Also, ATP, ADP, inosine, and hypoxanthine had positive and negative correlations with clinical features. Regarding leukocyte gene expression, COVID-19 patients showed an upregulation of the P2RX1, P2RX4, P2RX5, P2RX7, P2RY1, P2RY12, PANX1, ADORA2B, NLPR3, and F3 genes. Yet, the ectoenzymes of the canonical and non-canonical adenosinergic pathway (ENTPD1 and CD38) are upregulated, suggesting that adenosine is produced by both active adenosinergic pathways. Hence, approaches targeting these biomolecules or their specific purinoreceptors and ectoenzymes may attenuate the high inflammatory state and the coagulopathy seen in COVID-19 patients.Key messagesAdenosinergic pathways are modulated on leukocytes from COVID-19 patients.Plasmatic inosine levels are increased in COVID-19 patients.ATP, ADP, AMP, hypoxanthine, and inosine are correlated with coagulation players.The nucleotides and nucleosides are correlated with patients’ clinical features.The P2 receptors and ectoenzymes are correlated with Tissue factor in COVID-19.

Point-contact p-type high-purity germanium detectors (PPC HPGe) are particularly suited for detection of sub-keV nuclear recoils from coherent elastic scattering of neutrinos or light dark matter particles. While these particles are expected to interact homogeneously in the entire detector volume, specific classes of external background radiation preferably deposit their energy close to the semi-active detector surface, in which diffusion processes dominate that subsequently lead to slower rising pulses compared to the ones from the fully active bulk volume. Dedicated studies of their shape are therefore highly beneficial for the understanding and the rejection of these unwanted events. This article reports about the development of a data-driven pulse shape discrimination (PSD) method for the four 1 kg size PPC HPGe detectors of the Conus experiment in the keV and sub-keV regime down to 210 eV ee . The impact of the electronic noise at such low energies is carefully examined. It is shown that for an acceptance of 90% of the faster signal-like pulses from the bulk volume, approx. 50% of the surface events can be rejected at the energy threshold and that their contribution is fully suppressed above 800 eV ee . Applied to the Conus background data, such a PSD rejection cut allows to achieve an overall ( 15 - 25 ) % reduction of the total background budget. The new method allows to improve the sensitivity of future Conus analyses and to refine the corresponding background model in the sub-keV energy region.

Intense fluxes of reactor antineutrinos offer a unique possibility to probe the fully coherent character of elastic neutrino scattering off atomic nuclei. In this regard, detectors face the challenge to register tiny recoil energies of a few keV at the maximum. The Conus experiment was installed in 17.1 m distance from the reactor core of the nuclear power plant in Brokdorf, Germany, and was designed to detect this neutrino interaction channel by using four 1 kg-sized point contact germanium detectors with sub-keV energy thresholds. This report describes the unique specifications addressed to the design, the research and development, and the final production of these detectors. It demonstrates their excellent electronic performance obtained during commissioning under laboratory conditions as well as during the first 2 years of operation at the reactor site which started on April 1, 2018. It highlights the long-term stability of different detector parameters and the achieved background levels of the germanium detectors inside the Conus shield setup.

Mesenchymal stem cells (MSCs) have recently been described to home to brain tumors and to integrate into the tumor-associated stroma. Understanding the communication between cancer cells and MSCs has become fundamental to determine whether MSC-tumor interactions should be exploited as a vehicle for therapeutic agents or considered a target for intervention. Therefore, we investigated whether conditioned medium from adipose-derived stem cells (ADSCs-CM) modulate glioma tumor cells by analyzing several cell biology processes in vitro. C6 rat glioma cells were treated with ADSCs-CM, and cell proliferation, cell cycle, cell viability, cell morphology, adhesion, migration, and expression of epithelial-mesenchymal transition (EMT)-related surface markers were analyzed. ADSCs-CM did not alter cell viability, cell cycle, and growth rate of C6 glioma cells but increased their migratory capacity. Moreover, C6 cells treated with ADSC-CM showed reduced adhesion and underwent changes in cell morphology. Up-regulation of EMT-associated markers (vimentin, MMP2, and NRAS) was also observed following treatment with ADSC-CM. Our findings demonstrate that the paracrine factors released by ADSCs are able to modulate glioma cell biology. Therefore, ADSC-tumor cell interactions in a tumor microenvironment must be considered in the design of clinical application of stem cell therapy. Graphical Abstract Factors released by adipose-derived stem cells (ADSCs) may modulate the biology of C6 glioma cells. When C6 cells are exposed to a conditioned medium from adipose-derived stem cells (ADSCs-CM), some of these cells can undergo an EMT-like process and trans-differentiate into cells with a more mesenchymal phenotype, characterized by enhanced expression of EMT-related surface markers, reduced cell adhesion capacity, increased migratory capacity, as well as changes in cell and nuclei morphology.

To investigate the influence of patient characteristics on the course of spinal radiographic progression in a large prospective longitudinal cohort study of ankylosing spondylitis (AS) patients treated long-term with TNF-α inhibitors. Consecutive patients from the Groningen Leeuwarden AS (GLAS) cohort starting TNF-α inhibitors with spinal radiographs at least available at baseline and 6 years of follow-up were included. Radiographs were scored using mSASSS by two independent readers. Generalized estimating equations (GEE) were used to explore the associations between baseline characteristics and spinal radiographic progression. The course of radiographic progression in patients with and without risk factors for poor radiographic outcome was investigated using different time models (linear and non-linear). Single linear imputation was used in case of missing radiographic data at the intermediate (2 or 4 years) follow-up visits. 80 AS patients were included with mean baseline mSASSS 8.7±13.3. Baseline syndesmophytes, male gender, older age, longer symptom duration, smoking, and higher BMI were significantly associated with more radiographic damage over time. GEE analysis in patients with these risk factors revealed that radiographic progression followed a non-linear course with mean mSASSS progression rates reducing from max. 2.8 units over 0-2 years to min. 0.9 units over 4-6 years. The GEE model revealed a linear course with overall very low progression (≤1 mSASSS units/2yrs) in patients without risk factors. Complete case analysis in 53 patients showed similar results. AS patients at risk of poor radiographic outcome showed the highest but diminishing spinal radiographic progression during long-term treatment with TNF-α inhibitors.