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"Wolf, David"
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بوفن بوي والذئب الأحمر
تتناول قصة (بوفن بوي والذئب الأحمر) والتي قام بتأليفها دايفد أورم ؛ رسوم بيتر ريكاردسون في حوالي (30) صفحة من القطع الكبير، وهي من مجموعة قصصية للأطفال، ومجموعة بوفن بوي، تتميز بروح النكتة الغريبة التي تتسم بها وبرسومها الرائعة وتشكل مادة مثالية للمطالعة بالنسبة للقراء المبتدئين. وتتناول هذه القصة عزم الضفدع على إقامة وليمة غداء في الطبيعة ودعا إليها كل أصدقائه. تابع القصة الشائقة حيث يلبي كل صديق الدعوة بصخب. فكل صفحة تحتوي على مفاجأة جديدة. وتضم أسئلة إضافية فتشاركي وطفلك في الإجابة عليها للمزيد من متعة التعلم.
Book
High Frequency Sampling of TTL Pulses on a Raspberry Pi for Diffuse Correlation Spectroscopy Applications
Diffuse Correlation Spectroscopy (DCS) is a well-established optical technique that has been used for non-invasive measurement of blood flow in tissues. Instrumentation for DCS includes a correlation device that computes the temporal intensity autocorrelation of a coherent laser source after it has undergone diffuse scattering through a turbid medium. Typically, the signal acquisition and its autocorrelation are performed by a correlation board. These boards have dedicated hardware to acquire and compute intensity autocorrelations of rapidly varying input signal and usually are quite expensive. Here we show that a Raspberry Pi minicomputer can acquire and store a rapidly varying time-signal with high fidelity. We show that this signal collected by a Raspberry Pi device can be processed numerically to yield intensity autocorrelations well suited for DCS applications. DCS measurements made using the Raspberry Pi device were compared to those acquired using a commercial hardware autocorrelation board to investigate the stability, performance, and accuracy of the data acquired in controlled experiments. This paper represents a first step toward lowering the instrumentation cost of a DCS system and may offer the potential to make DCS become more widely used in biomedical applications.
Journal Article
Social Belonging and College Retention: Results From a Quasi-Experimental Pilot Study
Educators, policymakers, and institutions have worked for decades to increase rates of college graduation, but about half of students who enter college drop out without completing a bachelor's degree. Although the rate of student attrition is higher in the United States than in any other industrialized nation, about 30% of U.S. students will drop out during their first year of college. Persistence and retention point to an array of negative individual-level consequences that can have implications for society in general. This article presents results from a quasi-experimental pilot study testing a social-belonging intervention to improve retention among college students. The project was approved by the institutional review boards at Washington University in St. Louis and at the community college campus. The sample was drawn from students who were enrolled in the first semester of their first year at the campus and registered for a required college-preparation course during Fall 2013 . An administrator contacted every third instructor on the list of those teaching any of the 20 sections of the course and continued contacting them until the number of students in sessions taught by participating instructors was equal to half of the desired student sample. Standardized administrative data was collected by the St. Louis Community College system. The findings of this study suggest that social belonging interventions may serve as an important complement to college preparation and other activities. The findings also suggest the need for further research. If these results are replicated in subsequent research, administrators should consider adding belonging interventions to the menu of academic services available to students.
Journal Article
Victimization and Substance Use Among Native American College Students
According to Tribal Critical Race Theory, Native American students have low retention rates due to the structural barriers and racism inherent in colleges and universities. Similarly, structural barriers and racism could put Native American students at risk for victimization and substance use, thus influencing their academic success. The purposes of this study were to examine rates of victimization and substance use among Native American students in comparison to other students and to assess the perceived impact of these experiences on academics. Results suggest that Native American college students experience disproportionate rates of victimization, which in turn affects their academic functioning. Implications for college retention are discussed.
Journal Article
Ankyrin repeat-containing N-Ank proteins shape cellular membranes
Cells of multicellular organisms need to adopt specific morphologies. However, the molecular mechanisms bringing about membrane topology changes are far from understood—mainly because knowledge of membrane-shaping proteins that can promote local membrane curvatures is still limited. Our analyses unveiled that several members of a large, previously unrecognised protein family, which we termed N-Ank proteins, use a combination of their ankyrin repeat array and an amino (N)-terminal amphipathic helix to bind and shape membranes. Consistently, functional analyses revealed that the N-Ank protein ankycorbin (NORPEG/RAI14), which was exemplarily characterised further, plays an important, ankyrin repeat-based and N-terminal amphipathic helix-dependent role in early morphogenesis of neurons. This function furthermore required coiled coil-mediated self-assembly and manifested as ankycorbin nanodomains marked by protrusive membrane topologies. In summary, here, we unveil a class of powerful membrane shapers and thereby assign mechanistic and cell biological functions to the N-Ank protein superfamily.
Wolf et al. show that N-Ank proteins combine their curvature-sensing ankyrin repeat array and N-terminal amphipathic helix to shape membranes, and ankycorbin shapes membrane protrusions in developing neurons.
Journal Article
Oxytocin induces the formation of distinctive cortical representations and cognitions biased toward familiar mice
Social recognition is essential for the formation of social structures. Many times, recognition comes with lesser exploration of familiar animals. This lesser exploration has led to the assumption that recognition may be a habituation memory. The underlying memory mechanisms and the thereby acquired cortical representations of familiar mice have remained largely unknown, however. Here, we introduce an approach directly examining the recognition process from volatile body odors among male mice. We show that volatile body odors emitted by mice are sufficient to identify individuals and that more salience is assigned to familiar mice. Familiarity is encoded by reinforced population responses in two olfactory cortex hubs and communicated to other brain regions. The underlying oxytocin-induced plasticity promotes the separation of the cortical representations of familiar from other mice. In summary, neuronal encoding of familiar animals is distinct and utilizes the cortical representational space more broadly, promoting storage of complex social relationships.
Recognition memory for other individuals forms quickly. Here the authors show that such memories are enabled by oxytocin and can be retrieved from reinforced and more distinct neural representations even when only limited sensory information is available.
Journal Article