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"Wolfson, Evelyn"
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Play offers Catholics a chance to question
I went to see \"Sister Mary Ignatius Explains It All to You\" out of curiosity: What could Christopher Durang say about religious education that hasn't been said before? Especially parochial school education. Plenty!
Newspaper Article
Mythology of the inuit
Touches on the landscape, climate, and history of the Inuit people and how oral traditions have kept these myths alive for generations.
Book
'Capers' from your flower garden
The emblem of the medieval Knights of Malta was a thick cross with arms shaped like arrows facing inward. For caper lovers, the Maltese cross marks one of the Mediterranean's hot spots for gathering these delectable wild goodies. (They also grow...
Newspaper Article
They call it 'Oyster Sunday'
Cape Codders who have stalked the blue-eyed scallop and combed the sand for clams, switch to rubber waders in October, grab special metal rakes and go after the blue ribbon of shellfish: the oyster.
Newspaper Article
What hauled firewood in Kenya is a handbag in the United States
WITH one uninterrupted motion my daughter emptied her wallet, cosmetics, and books onto the table. I was reminded of the Kenya housewife who had dumped her load of firewood from the same basket when she learned I was interested in buying it.
Newspaper Article
A comprehensive review of the clinical presentation, diagnosis, and treatment of calcineurin inhibitor-induced pain syndrome
Calcineurin inhibitor-induced pain syndrome (CIPS), a rare but recognized complication of calcineurin inhibitor (CNI) therapy in transplant recipients, presents as severe bilateral lower extremity pain. This syndrome, first described in 1989, primarily affects patients receiving tacrolimus or cyclosporine. Proposed mechanisms include intraosseous vasoconstriction, bone marrow edema, and altered bone metabolism, possibly involving TRSK channels and NFAT signaling. The diagnosis relies on clinical history, characteristic pain patterns, and imaging findings such as bone marrow edema on MRI. The management of CIPS revolves around reducing or discontinuing the offending CNI while maintaining immunosuppression. Alternative immunosuppressants like mammalian target rapamycin (mTOR) inhibitors or mycophenolate mofetil are considered to mitigate symptoms. Symptomatic relief includes calcium channel blockers, bisphosphonates, and analgesics like NSAIDs or opioids. Physical therapy and close monitoring are also integral to improving outcomes and managing chronic pain effectively in affected transplant recipients. This review synthesizes current knowledge on CIPS, highlighting diagnostic challenges, treatment options, and areas for future research to optimize clinical management and enhance patient outcomes.
Journal Article
Coproduction of Research Questions and Research Evidence in Public Health: The Study to Prevent Teen Drinking Parties
Community-based participatory research (CBPR) provides a set of principles and practices intended to foster coproduction of knowledge. However, CBPR often has shortcomings when applied to population-level policy and practice interventions, including a focus on single communities and a lack of focus on policy change. At the same time, community trials focused on policy have shortcomings, including lack of stakeholder involvement in framing research questions and modest engagement in study implementation and interpretation and dissemination of results. We describe an attempt to hybridize CBPR and community trials by creating a partnership that included a national membership organization, a coalition advisory board, intervention and delayed intervention communities, and an academic study team, which collaborated on a study of community strategies to prevent underage drinking parties. We use qualitative and quantitative data to critically assess the partnership. Areas where the partnership was effective included (1) identifying a research question with high public health significance, (2) enhancing the intervention, and (3) improving research methods. Challenges included community coalition representatives’ greater focus on their own communities rather than the production of broader scientific knowledge. This model can be applied in future attempts to narrow the gap between research, policy, and practice.
Journal Article
Modeling human phenotypes in the nematode C. elegans during an undergraduate developmental biology course
Caenorhabditis elegans is a widely used model organism in biomedical research due to its genetic tractability, short life cycle, and conservation of many developmental processes with humans. In this study, undergraduate students conducted nine independent experiments during a Developmental Biology course to model human phenotypes using C. elegans. Each group selected a human phenotype of interest, identified a gene associated with the phenotype, and then determined the orthologous or homologous gene in C. elegans. By obtaining mutants and designing phenotypic assays, students investigated the extent to which the worm models could recapitulate aspects of the human condition. This collective work highlights both the potential and limitations of C. elegans as a model for human phenotypic variation and disease and demonstrates the value of undergraduate inquiry as a catalyst for scientific engagement and research-based learning.
Paper