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135 result(s) for "Wood, Janine"
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Phase II Open Label Study of Valproic Acid in Spinal Muscular Atrophy
Preliminary in vitro and in vivo studies with valproic acid (VPA) in cell lines and patients with spinal muscular atrophy (SMA) demonstrate increased expression of SMN, supporting the possibility of therapeutic benefit. We performed an open label trial of VPA in 42 subjects with SMA to assess safety and explore potential outcome measures to help guide design of future controlled clinical trials. Subjects included 2 SMA type I ages 2-3 years, 29 SMA type II ages 2-14 years and 11 type III ages 2-31 years, recruited from a natural history study. VPA was well-tolerated and without evident hepatotoxicity. Carnitine depletion was frequent and temporally associated with increased weakness in two subjects. Exploratory outcome measures included assessment of gross motor function via the modified Hammersmith Functional Motor Scale (MHFMS), electrophysiologic measures of innervation including maximum ulnar compound muscle action potential (CMAP) amplitudes and motor unit number estimation (MUNE), body composition and bone density via dual-energy X-ray absorptiometry (DEXA), and quantitative blood SMN mRNA levels. Clear decline in motor function occurred in several subjects in association with weight gain; mean fat mass increased without a corresponding increase in lean mass. We observed an increased mean score on the MHFMS scale in 27 subjects with SMA type II (p
Passive range of motion exercise to enhance growth in infants following the Norwood procedure: a safety and feasibility trial
The aim of this study was to evaluate the safety and feasibility of a passive range of motion exercise programme for infants with CHD. Study design This non-randomised pilot study enrolled 20 neonates following Stage I palliation for single-ventricle physiology. Trained physical therapists administered standardised 15-20-minute passive range of motion protocol, for up to 21 days or until hospital discharge. Safety assessments included vital signs measured before, during, and after the exercise as well as adverse events recorded through the pre-Stage II follow-up. Feasibility was determined by the percent of days that >75% of the passive range of motion protocol was completed. A total of 20 infants were enrolled (70% males) for the present study. The median age at enrolment was 8 days (with a range from 5 to 23), with a median start of intervention at postoperative day 4 (with a range from 2 to 12). The median hospital length of stay following surgery was 15 days (with a range from 9 to 131), with an average of 13.4 (with a range from 3 to 21) in-hospital days per patient. Completion of >75% of the protocol was achieved on 88% of eligible days. Of 11 adverse events reported in six patients, 10 were expected with one determined to be possibly related to the study intervention. There were no clinically significant changes in vital signs. At pre-Stage II follow-up, weight-for-age z-score (-0.84±1.20) and length-for-age z-score (-0.83±1.31) were higher compared with historical controls from two earlier trials. A passive range of motion exercise programme is safe and feasible in infants with single-ventricle physiology. Larger studies are needed to determine the optimal duration of passive range of motion and its effect on somatic growth.
Parents should talk less, take charge more, thank you
One Saturday morning, sitting among the double-buggy crowd at Starbucks, a father begins a conversation with his 3-year-old son: \"Jake, do you know what the word `analogy' means?\" Jake fumbles with his fat-free muffin and dribbles his hot chocolate, while dad launches into a lecture on analogy. \"Well, Jake, an analogy is like when Pooh Bear compares his life in the Hundred Acre Woods to a pot of honey.\" That's fine, but do all Starbucks patrons need to revisit Lit. 101?
Only geniuses need apply
\"Mom, don't worry. I have six months to work on this,\" my 17-year-old son said last June as he left for his summer job.
What does Play-Doh have to do with Plato? A mother's battle with the college essay
Teaching someone how to write is a torturous business. [...] I felt more and more compelled to take the advice of a close friend:
What does Play-Doh have to do with Plato? A mother's battle with the college essay
\"Mom, don't worry, I have six months to work on this,\" my 17-year-old son said last June as he left for his summer job.
Where have all the people gone?
[...] I would talk to a real person. Why don't you hold a flash mob as a protest,\" suggested my daughter when she heard that her favorite librarian was relegated to the back office and was not at the checkout desk talking to a young patron about \"Little House on the Prairie.
Where have all the people gone?
I was standing in the 15-item express line at the grocery store... with 16 items in my cart. When the man behind me saw that I was over the limit, he threw me a look of disgust, and moved on to a shorter line. \"No respect for the rules,\" he muttered as he left.
Google Offers vs. Groupon? Nah! Real rival to online coupons is bulletin board
Despite all the hoopla about online ads and coupons, most of America still advertises in amazingly archaic ways: a sign in a shop window, a business card on a bulletin board, a flier under the windshield wiper. \"The sites offer great deals to the consumers at the expense of the small businesses,\" says Utpal Dholakia, a marketing professor at Rice University's business school in Houston, and author of a recent study on Groupon.