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result(s) for
"Woods, John E. (John Edwin)"
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A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants
by
Sorgho, Hermann
,
Abdulla, Salim
,
Maingi, Charity
in
Africa
,
Appropriate technology
,
Biological and medical sciences
2012
In this ongoing phase 3 study of over 6000 infants (6 to 12 weeks of age) at 11 centers in Africa, the RTS,S/AS01 vaccine had 30% efficacy in preventing the first episode of clinical malaria and 26% efficacy in preventing severe malaria over a period of 14 months.
Considerable gains have been achieved in malaria control during the past decade.
1
,
2
Nonetheless, malaria remains a major public health concern. In 2010, an estimated 216 million cases of malaria and 655,000 malaria-related deaths occurred, with the vast majority of deaths occurring in African children.
1
The RTS,S/AS01 candidate malaria vaccine targets the pre-erythrocytic stage of the
Plasmodium falciparum
parasite. It was developed to reduce clinical and severe malaria in African children. Ideally, it would be administered through the well-established Expanded Program on Immunization (EPI).
In 2011, we reported the results for the first coprimary end point from an ongoing phase . . .
Journal Article
Genomics in medicine: a novel elective rotation for internal medicine residents
by
Ahuja, Neera
,
Hom, Jason
,
Witteles, Ronald
in
Attitude of Health Personnel
,
California
,
Core curriculum
2019
It is well recognised that medical training globally and at all levels lacks sufficient incorporation of genetics and genomics education to keep up with the rapid advances and growing application of genomics to clinical care. However, the best strategy to implement these desired changes into postgraduate medical training and engage learners is still unclear. We developed a novel elective rotation in ‘Genomic Medicine and Undiagnosed Diseases’ for categorical Internal Medicine Residents to address this educational gap and serve as an adaptable model for training that can be applied broadly across different specialties and at other institutions. Key curriculum goals achieved include increased understanding about genetic testing modalities and tools available for diagnosis and risk analysis, the role of genetics-trained allied health professionals, and indications and limitations of genetic and genomic testing in both rare and common conditions.
Journal Article