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Determining the brain perfusion is an important task for diagnosis of vascular diseases such as occlusions and intracerebral haemorrhage. Even after successful diagnosis, there is a high risk of restenosis or rebleeding such that patients need intense attention in the days after treatment. Within this work, we present a diagnostic tomographic imager that allows access to brain perfusion quantitatively in short intervals. The device is based on the magnetic particle imaging technology and is designed for human scale. It is highly sensitive and allows the detection of an iron concentration of 263 pmol Fe  ml −1 , which is one of the lowest iron concentrations imaged by MPI so far. The imager is self-shielded and can be used in unshielded environments such as intensive care units. In combination with the low technical requirements this opens up a variety of medical applications and would allow monitoring of stroke on intensive care units. Magnetic particle imaging (MPI) has been applied to various pre-clinical settings, including detection of ischemic stroke in mice. Translation of MPI to a clinical setting has been obstacled by the lack of a device with sufficient bore size and, at the same time, reasonable technical requirements. Here the authors present a human-sized MPI device with low technical requirements designed for detection of brain ischemia.

In these proceedings, an overview on recent results of a novel imaging modality based on magnetic nanoparticles is given. This imaging concept, called magnetic particle imaging (MPI), falls into the category of functional imaging and, hence, the magnetic nanoparticles may serve as tracers of metabolic processes. Today, there are interesting challenges within the practical set-up of a scanning device and also in the design of new MPI nanoparticles. During this workshop at the University of Lübeck in 2010, scientists from chemical engineering, biology, electrical engineering, physics, computer sciences and medicine discussed the promises and challenges of MPI.

Determining the brain perfusion is an important task for the diagnosis and treatment of vascular diseases such as occlusions and intracerebral haemorrhage. Even after successful diagnosis and treatment, there is a high risk of restenosis or rebleeding such that patients need intense and frequent attention in the days after treatment. Within this work, we will present a diagnostic tomographic imager that allows access to brain perfusion information quantitatively in short intervals. The imager is the first functional magnetic particle imaging device for brain imaging on a human-scale. It is highly sensitive and allows the detection of an iron concentration of 14.7 ng /ml (263 pmol), which is the lowest iron concentration imaged by MPI so far. The imager is self-shielded and can be used in unshielded environments such as intensive care units. In combination with the low technical requirements this opens up a whole variety of possible medical applications and would allow monitoring possibilities on the stroke and intensive care units.