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The Freedom Writers diary : how a teacher and 150 teens used writing to change themselves and the world around them
Told through anonymous entries to protect their identities and allow for complete candor, The Freedom Writers Diary is filled with vignettes from 150 students who, like civil rights activist Rosa Parks and the Freedom Riders, heard society tell them where to go - and refused to listen.
Book
Dosage adjustment in obese children, even for common drugs, is largely unclear and a treat-to-effect approach may work best
Obesity in children, often accompanied by comorbidities, is increasingly common. For many frequently used paediatric drugs, information on dosage adjustment in obese children is lacking or absent. Scalars, such as total body weight, are not always helpful as obese children may weigh more than adults, but differ with regard to aspects of their anatomy and physiology, especially hepatic function. Further pharmacokinetic studies in obese children are urgently needed and, in the interim, close monitoring for therapeutic effect and toxicity is recommended.
Journal Article
Manage cardiovascular risk in patients with type 2 diabetes by using agents with proven cardiovascular benefits
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D). Not only is T2D a risk factor for ASCVD, common comorbid conditions, such as dyslipidaemia and hypertension, are also risk factors for ASCVD. Controlling these risk factors with agents with proven cardiovascular benefits (e.g. metformin, glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter-2 receptor inhibitors, statins, ACE inhibitors and angiotensin receptor blockers) provides considerable clinical benefits.
Journal Article
Modify treatment for atopic dermatitis when patient response to dupilumab is partial or non-durable
Patients with moderate-to-severe atopic dermatitis may have partial or non-durable responses to subcutaneous dupilumab, the first targeted systemic agent approved for this indication. Subsequent management approaches in such patients include optimising topical therapy, considering alternative diagnoses, adjusting the dosage of dupilumab dosage and/or using dupilumab in combination with traditional systemic immunosuppressive agents.
Journal Article
Monitor recipients of phosphodiesterase type 5 inhibitors for glaucoma, pending more clinical evidence of risk
Glaucoma is a leading cause of bilateral blindness. Phosphodiesterase type 5 inhibitors (PDE5Is; e.g. avanafil, sildenafil, tadalafil and vardenafil) may increase blood flow to the ciliary body, thereby elevating intraocular pressure and increasing the risk of glaucoma. PDE5Is are commonly used to treat erectile dysfunction, as well as benign prostatic hyperplasia (tadalafil) and pulmonary hypertension (sildenafil). Patients receiving PDE5Is require glaucoma education and ongoing screening, especially if they are taking a high dosage of a daily PDE5I or have risk factors for glaucoma (e.g. increased age, African-American or Hispanic race, hypertension, intraocular pressure > 21 mm Hg, diabetes, suspicious eye changes or a family history of glaucoma).
Journal Article
Manage perioperative pain in morbidly obese patients by taking an all-round multimodal approach
Morbidly obese individuals often require surgery, including bariatric (weight management) surgery. Acute pain management in the morbidly obese must consider the risk of chronic post-surgical pain, opioid dependence, and comorbidities (e.g. sleep-disordered breathing). A stepped, multimodal, opioid-sparing approach titrated to the type and severity of pain type should be taken, with co-administration of systemic and local anaesthetic agents when appropriate.
Journal Article