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"Wu, Cheng"
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BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation
Bone morphogenetic protein 2 (BMP2) is highly overexpressed in human non-small cell lung cancer (NSCLC) and correlates with tumor stage and metastatic burden. Although several lines of evidence suggest that BMP2 promotes cell migration and invasiveness in vitro, the in vivo role of BMP2 in the metastasis of lung adenocarcinoma cells remains less well understood. Here, we revealed that BMP2 is highly overexpressed in lung adenocarcinoma patients with lymph node metastasis compared with patients without lymph node metastasis. Using an in vivo orthotopic mouse model, we clearly demonstrated that BMP2 promotes lung adenocarcinoma metastasis. The depletion of BMP2 or its receptor BMPR2 significantly reduced cell migration and invasiveness. We further identified that BMP2/BMPR2-mediated cell migration involves the activation of the SMAD1/5/8 signaling pathway, independent of the KRAS signaling pathway. Significantly, the depletion of SMAD1/5/8 or the inhibition of SMAD1/5/8 by LDN193189 inhibitor significantly reduced cell migration. These findings show that BMP2 promotes NSCLC metastasis, indicating that targeting the BMP2 signaling pathway may represent a potential therapeutic strategy for treating patients with metastatic NSCLC.
Journal Article
الاقتصاد الصيني
طوال 30 عاما من التطور المستمر السريع منذ تطبيق سياسة الإصلاح والانفتاح، حقق الاقتصاد الصيني إنجازات جذبت أنظار العالم وأصبحت ثالث كيان اقتصادي في العالم وما زالت المكانة الدولية للصين ترتقي من يوم إلى يوم عندما اندلعت الأزمة المالية الآسيوية في عام 1997، ظهرت على الصين \"صورة الدولة الكبرى المسئولة\" فلم يتمالك العالم أن يلفت أنظاره إلى الصين وينتظر الصين إذا، لماذا ينتظر العالم الصين ؟ هل سيواصل الاقتصاد الصيني نموه أم سيتوقف دون تقدم ؟ ما أسرار نجاح الاقتصاد الصيني ؟ هل تستطيع الصين أن تصبح دولة غنية، منسجمة وديمقراطية ؟ ما الإسهامات التي تستطيع الصين تقديمها لاقتصاد العالم ؟ كل هذه الأسئلة سيجيب عليها المؤلف في هذا الكتاب بشكل مبسط.
BOOK
Analgesic effect of dance movement therapy: An fNIRS study
•This study showed DMT significantly activated the VLPFC and DLPFC in healthy adults.•Provide new insights into the neurophysiological mechanisms of EIH from the perspective of changes in cerebral hemodynamics.•In order to deepen the understanding of pain models, DMT was used as the intervention method in this study.•DMT can produce a diffuse EIH effect on improving PPTs, emotion and cognitive function.•Provided a highly accepted and mentally enjoyable pain management plan for individuals with chronic pain.
This study aims to explores the physiological and psychological mechanisms of exercise-induced hypoalgesia (EIH) by combining the behavioral results with neuroimaging data on changes oxy-hemoglobin (HbO) in prefrontal cortex (PFC).
A total of 97 healthy participants were recruited and randomly divided into three groups: a single dance movement therapy (DMT) group, a double DMT group, and control group. Evaluation indicators included the pressure pain threshold (PPT) test, the color-word stroop task (CWST) for wearing functional near-infrared spectroscopy (fNIRS), and the self-assessment manikin (SAM). The testing time is before intervention, after intervention, and one hour of sit rest after intervention.
1) Repeated measures ANOVA revealed that, there is a time * group effect on the PPT values of the three groups of participants at three time points. After 30 min of acute dance intervention, an increase in the PPT values of 10 test points occurred in the entire body of the participants in the experimental group with a significant difference than the control group. 2) In terms of fNIRS signals, bilateral DLPFC and left VLPFC channels were significantly activated in the experimental group. 3) DMT significantly awakened participants and brought about pleasant emotions, but cognitive improvement was insignificant. 4) Mediation effect analysis found that the change in HbO concentration in DLPFC may be a mediator in predicting the degree of improvement in pressure pain threshold through dance intervention (total effect β = 0.7140).
In healthy adults, DMT can produce a diffuse EIH effect on improving pressure pain threshold, emotional experience but only showing an improvement trend in cognitive performance. Dance intervention significantly activates the left ventrolateral and bilateral dorsolateral prefrontal cortex. This study explores the central nervous system mechanism of EIH from a physiological and psychological perspective.
Journal Article
الاقتصاد الصيني
طوال 30 عاما من التطور المستمر السريع منذ تطبيق سياسة الإصلاح والانفتاح حقق الاقتصاد الصيني إنجازات جذبت أنظار العالم وأصبحت ثالث كيان اقتصادي في العالم وما زالت المكانة الدولية للصين ترتقي من يوم إلى يوم عندما اندلعت الأزمة المالية الآسيوية في عام 1997 ظهرت على الصين \"صورة الدولة الكبرى المسئولة\" فلم يتمالك العالم أن يلفت أنظاره إلى الصين وينتظر الصين إذا لماذا ينتظر العالم الصين ؟ هل سيواصل الاقتصاد الصيني نموه أم سيتوقف دون تقدم ؟ ما أسرار نجاح الاقتصاد الصيني ؟ هل تستطيع الصين أن تصبح دولة غنية منسجمة وديمقراطية ؟ ما الإسهامات التي تستطيع الصين تقديمها لاقتصاد العالم ؟ سيجيب هذا الكتاب عن هذه الأسئلة بشكل مبسط.
BOOK
Thermocatalytic hydrogen peroxide generation and environmental disinfection by Bi2Te3 nanoplates
The highly reactive nature of reactive oxygen species (ROS) is the basis for widespread use in environmental and health-related fields. Conventionally, there are only two kinds of catalysts used for ROS generation: photocatalysts and piezocatalysts. However, their usage has been limited due to various environmental and physical factors. To address this problem, herein, we report thermoelectric materials, such as Bi
2
Te
3
, Sb
2
Te
3
, and PbTe, as thermocatalysts which can produce hydrogen peroxide (H
2
O
2
) under a small surrounding temperature difference. Being the most prevalent environmental factors in daily life, temperature and related thermal effects have tremendous potential for practical applications. To increase the practicality in everyday life, bismuth telluride nanoplates (Bi
2
Te
3
NPs), serving as an efficient thermocatalyst, are coated on a carbon fiber fabric (Bi
2
Te
3
@CFF) to develop a thermocatalytic filter with antibacterial function. Temperature difference induced H
2
O
2
generation by thermocatalysts results in the oxidative damage of bacteria, which makes thermocatalysts highly promising for disinfection applications. Antibacterial activity as high as 95% is achieved only by the treatment of low-temperature difference cycles. The current work highlights the horizon-shifting impacts of thermoelectric materials for real-time purification and antibacterial applications.
Temperature difference induced H
2
O
2
generation by thermoelectric materials is an attractive strategy for environmental remediation purposes. Here the authors demonstrate Bi
2
Te
3
nanoplates based antibacterial filter as an effective candidate for indoor disinfection applications.
Journal Article
Improving Pumped Hydro Storage Flexibility in China: Scenarios for Advanced Solutions Adoption and Policy Recommendations
The decarbonisation targets of the People’s Republic of China are ambitious. Their achievement relies on the large-scale deployment of variable renewable energy sources (VRES), such as wind and solar. High penetration of VRES may lead to balancing problems on the grid, which can be compensated by increasing the shifting flexibility capacity of the system by integration with energy storage, e.g., by installing additional electricity storage. Pumped Hydro Storage (PHS) is the most diffused electricity storage technology at the global level and the only fully mature solution for long-term electricity storage. China already has the highest PHS capacity installed worldwide and plans to increase it strongly before 2030. The present study, based on the data from the “Pumped Storage Tracking Tool” of the International Hydropower Association, investigates the potential for technological improvement of the existing and future PHS fleet in China. The aims of adopting advanced PHS solutions allow China to better cope with the task of balancing the VRES production. The potential for adopting advanced PHS solutions is evaluated through five different intervention possibilities (here referred to as scenarios). These scenarios consider revamping part of the operational Pumped Storage Plant (PSP) fleet and redesigning future installations that are already planned. As a result, considering all the major technical and authorisation process constraints, 4.0% (5.2 GW) of the 132 GW fleet expected to be commissioned before 2035 could additionally adopt advanced PHS in a high-potential scenario. Meanwhile in the medium and low potential scenarios, the quota can reach 11.1% (14.6 GW) and 26.2% (34.5 GW), respectively. Furthermore, policy recommendations are elaborated to promote, facilitate, and support the adoption of these advanced PHS solutions.
Journal Article
The role of host–guest interactions in organic emitters employing MR-TADF
Research into organic light emitters employing multiple resonance-induced thermally activated delayed fluorescence (MR-TADF) materials is presently attracting a great deal of attention due to the potential for efficient deep-blue emission. However, the origins and mechanisms of successful TADF are unclear, as many MR-TADF materials do not show TADF behaviour in solution, but only as particular pure solids. Here, an investigation into a well-known MR-TADF material, DABNA-1, together with other new MR materials (9H-quinolino[3,2,1-kl]phenothiazin-9-one (QPO) and 9H-quinolino-[3,2,1-kl]-phenothiazin-9-one 5,5-dioxide (QP3O)), yields new insights regarding the origin of TADF. Although a material system may support the concept of MR, inefficiency in both forward and reverse intersystem crossings forbids TADF unless a suitable host material allows an exciplex-like host–emitter interaction that boosts TADF. This boosted-TADF mechanism can be generalized to any fluorescence dye that lacks TADF in the photoluminescence measurement but has a thermally accessible S1–T1 energy gap, opening the way to high-performance organic light-emitting diodes.This study reveals the importance of host–guest interactions for effective multiple-resonance thermally activated delayed fluorescence in organic light emitters.
Journal Article