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"Wu, Min"
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Tauopathies: new perspectives and challenges
Background
Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions.
Main body
Clinically, tauopathies can present with a range of phenotypes that include cognitive/behavioral-disorders, movement disorders, language disorders and non-specific amnestic symptoms in advanced age. Pathologically, tauopathies can be classified based on the predominant tau isoforms that are present in the inclusion bodies (i.e., 3R, 4R or equal 3R:4R ratio). Imaging, cerebrospinal fluid (CSF) and blood-based tau biomarkers have the potential to be used as a routine diagnostic strategy and in the evaluation of patients with tauopathies. As tauopathies are strongly linked neuropathologically and genetically to tau protein abnormalities, there is a growing interest in pursuing of tau-directed therapeutics for the disorders. Here we synthesize emerging lessons on tauopathies from clinical, pathological, genetic, and experimental studies toward a unified concept of these disorders that may accelerate the therapeutics.
Conclusions
Since tauopathies are still untreatable diseases, efforts have been made to depict clinical and pathological characteristics, identify biomarkers, elucidate underlying pathogenesis to achieve early diagnosis and develop disease-modifying therapies.
Journal Article
Genuine tripartite nonlocality and entanglement in curved spacetime
We study the genuine tripartite nonlocality (GTN) and the genuine tripartite entanglement (GTE) of Dirac fields in the background of a Schwarzschild black hole. We find that the Hawking radiation degrades both the physically accessible GTN and the physically accessible GTE. The former suffers from “sudden death” at some critical Hawking temperature, and the latter approaches to the nonzero asymptotic value in the limit of infinite Hawking temperature. We also find that the Hawking effect cannot generate the physically inaccessible GTN, but can generate the physically inaccessible GTE for fermion fields in curved spacetime. These results show that on the one hand the GTN cannot pass through the event horizon of black hole, but the GTE do can, and on the other hand the surviving physically accessible GTE and the generated physically inaccessible GTE for fermions in curved spacetime are all not nonlocal. Some monogamy relations between the physically accessible GTE and the physically inaccessible GTE are found.
Journal Article
Bionic gliding underwater robots : design, control, and implementation
\"Underwater robots play a significant role in ocean exploration. This book provides full coverage of the theoretical and practical aspects of bionic gliding underwater robots, including system design, modeling control and motion planning. To overcome the inherent shortcomings of traditional underwater robots that can simultaneously lack maneuverability and endurance, a new type of robot, the bionic gliding underwater robot, has attracted much attention from scientists and engineers. On the one hand, by imitating the appearance and swimming mechanisms of natural creatures, bionic gliding underwater robots achieve high maneuverability, swimming efficiency, and strong concealment. On the other hand, borrowing from the buoyancy adjustment systems of underwater gliders, bionic gliding underwater robots can obtain strong endurance, which is significant in practical applications. Taking gliding robotic dolphin and fish as examples, the designed prototypes and proposed methods are discussed, offering valuable insights into the development of next-generation underwater robots that are well-suited for various oceanic applications. This book will be of great interest to students and professionals alike in the field of robotics or intelligent control. It will also be a great reference for engineers or technicians who deal with the development of underwater robots\"-- Provided by publisher.
BOOK
A Review on the Development of Earthquake Warning System Using Low-Cost Sensors in Taiwan
Seismic instrumentation for earthquake early warnings (EEWs) has improved significantly in the last few years, considering the station coverage, data quality, and the related applications. The official EEW system in Taiwan is operated by the Central Weather Bureau (CWB) and is responsible for issuing the regional warning for moderate-to-large earthquakes occurring in and around Taiwan. The low-cost micro-electro-mechanical system (MEMS)-based P-Alert EEW system is operational in Taiwan for on-site warnings and for producing shakemaps. Since 2010, this P-Alert system, installed by the National Taiwan University (NTU), has shown its importance during various earthquakes that caused damage in Taiwan. Although the system is capable of acting as a regional as well as an on-site warning system, it is particularly useful for on-site warning. Using real-time seismic signals, each P-Alert system can provide a 2–8 s-long warning time for the locations situated in the blind zone of the CWB regional warning system. The shakemaps plotted using this instrumentation help to assess the damage pattern and rupture directivity, a key feature in the risk mitigation process. These shakemaps are delivered to the intended users, including the disaster mitigation authorities, for possible relief purposes. Earlier, the network provided only peak ground acceleration (PGA) shakemaps, but has now been updated to include peak ground velocity (PGV), spectral acceleration (Sa) at different periods, and CWB intensity maps. The PGA and PGV shakemaps plotted using this network have proven helpful in establishing the fact that PGV is a better indicator of damage detection than PGA. This instrumentation is also useful in structural health-monitoring and estimating co-seismic deformations. Encouraged by the performance of the P-Alert network, more instruments are installed in Asia-Pacific countries.
Journal Article
Transient Dynamics of a Food Chain Model with Vigilance in the Biparameter Spaces
This article focuses on the asymptotic and transient behavior of a food chain model with vigilance in the biparameter spaces. Firstly, the local asymptotic stability conditions of the positive equilibrium point are obtained. Then, the transient dynamical behavior of the positive equilibrium point is analyzed based on eight parameters. Using numerical simulation, the stable regions of the model with single and double parameters are plotted, as well as the value changes of resilience, reactivity, and amplification envelope within the stable regions. The results show that the coexistence equilibrium point is always reactive, and the corresponding parameter ranges for system stability are large, but the resilience values are small. The vigilance parameter of the middle- and lower-level organisms has the greatest impact on the system’s resilience and reactivity, and the lowest vigilance corresponds to the maximum resilience and reactivity. Our results provide important references for effective management and protection of wild animal populations by the potential for transient amplification, disturbance growth time, and amplitude.
Journal Article
Balanced Xylan Acetylation is the Key Regulator of Plant Growth and Development, and Cell Wall Structure and for Industrial Utilization
Xylan is the most abundant hemicellulose, constitutes about 25–35% of the dry biomass of woody and lignified tissues, and occurs up to 50% in some cereal grains. The accurate degree and position of xylan acetylation is necessary for xylan function and for plant growth and development. The post synthetic acetylation of cell wall xylan, mainly regulated by Reduced Wall Acetylation (RWA), Trichome Birefringence-Like (TBL), and Altered Xyloglucan 9 (AXY9) genes, is essential for effective bonding of xylan with cellulose. Recent studies have proven that not only xylan acetylation but also its deacetylation is vital for various plant functions. Thus, the present review focuses on the latest advances in understanding xylan acetylation and deacetylation and explores their effects on plant growth and development. Baseline knowledge about precise regulation of xylan acetylation and deacetylation is pivotal to developing plant biomass better suited for second-generation liquid biofuel production.
Journal Article