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"Wu, Qi"
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Re-examining the \Chinese learner\
Although a great deal of literature contrasts the Chinese learner with Western learning conceptions and practice, a closer look at these studies reveals that many are explored through the lens of cultural knowledge and assumptions. The results of these studies generate a distorted understanding of Chinese students. Moreover, students' learning is best explained in the context of local environments. This study therefore examines the \"Chinese learner\" through a case study of mainland Chinese postgraduate students' intercultural learning experiences at British universities. The results show that learning beliefs and behaviors evolve as individuals participate in authentic situations. It is essential to break the stereotypes of Chinese students and constantly document the progress of their learning so as to generate effective intercultural pedagogy and practices in culturally diverse classrooms. Further, how Chinese students approach their learning is a complex phenomenon with multiple facets interacting including external factors, namely sociohistorical, cultural, and academic contexts, and internal factors, such as each student's intellectual development. Academic staff in multicultural classrooms should recognize not just similarities but also diversity of students from the same culture and amend their teaching practices in response to students' developing needs and interests (HRK / Abstract übernommen).
Journal Article
World-class universities : towards a global common good and seeking national and institutional contributions
In the era marked by globalization and its profound impacts on individuals, societies, states and markets, world-class universities need to position themselves in the forefront of seeking conceptual and practical solutions to daunting challenges by paying greater attention to their roles in serving local society and contributing to global common goods. Based on the findings of the Seventh International Conference on World-Class Universities, World-Class Universities: Towards a Global Common Good and Seeking National and Institutional Contributions provides updated insights and debates on how world-class universities will contribute to the global common good and balance their global, national and local roles in doing so.
Book
Asymmetric dearomatization catalysed by chiral Brønsted acids via activation of ynamides
Chiral Brønsted acid-catalysed asymmetric synthesis has received tremendous interest over the past decades, and numerous efficient synthetic methods have been developed based on this approach. However, the use of chiral Brønsted acids in these reactions is mostly limited to the activation of imine and carbonyl moieties, and the direct activation of carbon–carbon triple bonds has so far not been invoked. Here we show that chiral Brønsted acids enable the catalytic asymmetric dearomatization reactions of naphthol-, phenol- and pyrrole-ynamides by the direct activation of alkynes. This method leads to the practical and atom-economic construction of various valuable spirocyclic enones and 2H-pyrroles that bear a chiral quaternary carbon stereocentre in generally good-to-excellent yields with excellent chemo-, regio- and enantioselectivities. The activation mode of chiral Brønsted acid catalysis revealed in this study is expected to be of broad utility in catalytic asymmetric reactions that involve ynamides and the related heteroatom-substituted alkynes.Chiral Brønsted acid catalysis is mostly limited to the activation of imine and carbonyl moieties. Now, by direct activation of alkynes, chiral Brønsted acids have been used to enable the catalytic asymmetric dearomatization of naphthol-, phenol- and pyrrole-ynamides for the construction of various spirocyclic enones and 2H-pyrroles bearing a chiral quaternary carbon stereocentre.
Journal Article
الحياة
صدرت حديثا عن مؤسسة بيت الحكمة، سلسلة \"قصص الرموز الصينية\"، وهي أول سلسلة تثقيفية وتعليمية مترجمة تتناول البحث في قصص الرموز الصينية، والكشف عن أصل الرموز والحكايات التاريخية التي خلفها، حيث تعتمد على مقولات مبسطة تقود القارئ لمعرفة منابع الرموز الصينية وتاريخ تطورها. وتتشكل السلسلة من خمسة كتب، وهي \"الإنسان، والحيوان، والنبات، والطبيعة، والحياة\"، ويتناول كل منها عددا من الرموز التي يحكي أصلها وطرق كتابتها على مر العصور وصولا لشكلها الحالي، بالإضافة إلى التعريف بأشكال النقوش وأنواع الخطوط الصينية ونماذج لكل منها، والطرق الأساسية لابتكار الرموز الصينية إما المعبرة عن الأشياء، أو المشتقة من معنى أجزائها، كما تتناول السلسلة، الكلمات والعبارات التي تدخل الرموز في تكوينها، والأمثال والحكم والقصص التراثية التي تستخدم الرمز أو مدلولاته في إطار أدبي شيق.
Book
Designable ultra-smooth ultra-thin solid-electrolyte interphases of three alkali metal anodes
Dendrite growth of alkali metal anodes limited their lifetime for charge/discharge cycling. Here, we report near-perfect anodes of lithium, sodium, and potassium metals achieved by electrochemical polishing, which removes microscopic defects and creates ultra-smooth ultra-thin solid-electrolyte interphase layers at metal surfaces for providing a homogeneous environment. Precise characterizations by AFM force probing with corroborative in-depth XPS profile analysis reveal that the ultra-smooth ultra-thin solid-electrolyte interphase can be designed to have alternating inorganic-rich and organic-rich/mixed multi-layered structure, which offers mechanical property of coupled rigidity and elasticity. The polished metal anodes exhibit significantly enhanced cycling stability, specifically the lithium anodes can cycle for over 200 times at a real current density of 2 mA cm
–2
with 100% depth of discharge. Our work illustrates that an ultra-smooth ultra-thin solid-electrolyte interphase may be robust enough to suppress dendrite growth and thus serve as an initial layer for further improved protection of alkali metal anodes.
The dendrite growth of alkali metal anodes leads to charge/discharge cycling instability. Here, the authors show that electrochemical polishing can yield near-perfect anodes of three alkali metals by constructing smooth and thin solid-electrolyte interphase layers.
Journal Article
Sectional curvatures distribution of complexity geometry
A
bstract
In the geometric approach to defining complexity, operator complexity is defined as the distance in the operator space. In this paper, based on the analogy with the circuit complexity, the operator size is adopted as the metric of the operator space where the path length is the complexity. The typical sectional curvatures of this complexity geometry are positive. It is further proved that the typical sectional curvatures are always positive if the metric is an arbitrary function of operator size, while complexity geometry is usually expected to be defined on negatively curved manifolds. By analyzing the sectional curvatures distribution for the
N
-qubit system, it is shown that surfaces generated by Hamiltonians of size smaller than the typical size can have negative curvatures. In the large
N
limit, the form of complexity metric is uniquely constrained up to constant corrections if we require sectional curvatures are of order 1
/N
2
. With the knowledge of states, the operator size should be modified due to the redundant action of operators, and thus is generalized to be state-dependent. Then we use this state-dependent operator size as the metric of the Hilbert space to define state complexity. It can also be shown that in the Hilbert space, 2-surfaces generated by operators of size much smaller than the typical size acting on typical states also have negative curvatures.
Journal Article
سرقة فاكهة الجينسنغ
في بداية العالم عم الظلام الكون في الفترة التي سميت بـ «الفوضى الأزلية». وبعد مرور 5400 عام، طارت المواد الخفيفة إلى السماء وتحولت إلى الشمس والقمر والنجوم والأجرام الفلكية، وبعد 5400 عام أخرى تجمدت المواد الثقيلة وكونت المياه والنار والجبال والصخور والتربة، وبمرور 5400 عام أخرى وجدت الحياة على الأرض وانقسم العالم إلى أربع قارات الشرقية والغربية والجنوبية والشمالية، وفي القارة الشرقية كان هناك جبل يسمى جبل الأزهار والثمار على قمته صخرة خالدة، تعرضت الصخرة لضوء الشمس والقمر فاكتسبت قدرات خارقة، إلى أن انفجرت وجلبت الفوضى للعالم. وبعد أكثر من 500 كلف راهب من القارة الجنوبية بإحضار الكتب المقدسة من القارة عام الغربية للقضاء على الكوارث والآلام في العالم، ولم تنجح رحلته إلا بعد أن مر بعقبات بلغ عددها 81 عقبة. وترتبط هذه الأسطورة ارتباطا وثيقا بشخصية «القرد» الذي تجرأ وأعلن تمرده على السماء والأرض.
Book
LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer
Background
Long noncoding RNAs (lncRNAs) play nonnegligible roles in the epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that promotes the colorectal cancer (CRC) progression and could be a potential therapeutic target.
Methods
We screened highly expressed lncRNAs in human CRC samples compared with their matched adjacent normal tissues. The proteins that interact with
LINRIS
(Long Intergenic Noncoding RNA for IGF2BP2 Stability) were confirmed by RNA pull-down and RNA immunoprecipitation (RIP) assays. The proliferation and metabolic alteration of CRC cells with
LINRIS
inhibited were tested in vitro and in vivo
.
Results
LINRIS
was upregulated in CRC tissues from patients with poor overall survival (OS), and
LINRIS
inhibition led to the impaired CRC cell line growth. Moreover, knockdown of
LINRIS
resulted in a decreased level of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), a newly found N
6
-methyladenosine (m
6
A) ‘reader’.
LINRIS
blocked K139 ubiquitination of IGF2BP2, maintaining its stability. This process prevented the degradation of IGF2BP2 through the autophagy-lysosome pathway (ALP). Therefore, knockdown of
LINRIS
attenuated the downstream effects of IGF2BP2, especially MYC-mediated glycolysis in CRC cells. In addition, the transcription of
LINRIS
could be inhibited by GATA3 in CRC cells. In vivo experiments showed that the inhibition of
LINRIS
suppressed the proliferation of tumors in orthotopic models and in patient-derived xenograft (PDX) models.
Conclusion
LINRIS
is an independent prognostic biomarker for CRC. The
LINRIS
-IGF2BP2-MYC axis promotes the progression of CRC and is a promising therapeutic target.
Journal Article