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"Wu, Shengnan"
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Application of multimedia technology to innovative vocational education on learning satisfaction in China
Multimedia technology holds paramount importance in driving innovation within vocational education, significantly influencing learning satisfaction. Its integration facilitates dynamic and interactive learning environments, catering to diverse learning styles and preferences. Moreover, multimedia technology enables educators to simulate real-world scenarios, providing practical and hands-on training opportunities. This aspect is particularly valuable in vocational education, where practical skills and application are required. The paper investigates the impact of multimedia technology in enhancing learning satisfaction within innovative vocational education. It delves into the utilization of multimedia tools and their correlation with learner satisfaction, exploring how these technologies augment engagement and comprehension in vocational training. The primary data from 515 students of vocational colleges of China has been collected and regression analysis is applied for empirical analysis. The findings of the study highlight that multimedia technology has positive relationship with innovative vocational education and learning outcome. The findings contribute valuable insights for policymakers regarding significant role multimedia plays in fostering enhanced learning experiences and overall satisfaction among vocational learners.
Journal Article
FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes are involved in angiogenesis and neoangiogenesis
FUN14 domain-containing protein 1 (FUNDC1) is an integral mitochondrial outer-membrane protein, and mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs). This study aims to determine the contributions of FUNDC1-mediated MAMs to angiogenesis in vitro and in vivo. In cultured endothelial cells, VEGF significantly increases the formation of MAMs and MAM-related proteins, including FUNDC1. Endothelial cell-specific deletion of FUNDC1, which disrupts MAM formation in endothelial cells, lowers VEGFR2 expression and reduces tube formation, spheroid-sprouting, and functional blood vessel formation in vitro and in vivo. Conversely, increased MAM formation using MAM linkers mimics the effects of VEGF and promotes endothelial angiogenesis. Mechanistically, increased MAMs formation led to increased levels of Ca
2+
in cytosol, promoted the phosphorylation of serum response factor (SRF) and enhanced the binding of SRF to VEGFR2 promoter, resulting in increased VEGFR2 production, with consequent angiogenesis. Moreover, blocking FUNDC1-related MAM formation with a cell-penetrating inhibitory peptide significantly suppresses the expressions of downstream angiogenic genes and inhibits tumor angiogenesis. We conclude that decreased MAMs formation by silencing FUNDC1 can inhibit angiogenesis by decreasing VEGFR2 expression, and targeting FUNDC1-dependent MAMs might be a promising approach for treating human disorders characterized by defective angiogenesis.
Mitochondria-associated ER membranes (MAMs) are involved in the regulation of many cellular functions. Here, the authors report that FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes play an essential role in the process of angiogenesis and neoangiogenesis.
Journal Article
Core microbes regulate plant-soil resilience by maintaining network resilience during long-term restoration of alpine grasslands
The alpine grasslands of the Qinghai-Tibetan Plateau (QTP), the world’s highest plateau, have been severely degraded. To address this degradation, human-involved restoration efforts, including grassland cultivation, have been implemented. However, the impact of these practices on soil microbial community stability and its relationship with plant-soil system resilience has not been explored. In this study, we evaluate the effects of grassland restoration on microbial communities. We show that bacteria demonstrate higher composition resistance and resilience during the restoration process, when compared to fungi. The changes we observe in microbial community interactions support the stress gradient hypothesis. Our results emphasize the synergistic role of network resilience and the restoration of the plant-soil system. Importantly, we find that core microbial species significantly influence the resilience of the plant-soil system by sustaining the co-occurrence networks. These insights underscore the critical roles of microbial communities in grassland restoration and suggest new strategies for boosting grassland resilience by safeguarding core microbes.
The impacts of alpine grassland restoration on microbial community stability and its relationship with the plant-soil system are unclear. Here, using co-occurrence network analysis, the authors find that core microbes contribute to plant-soil resilience.
Journal Article
Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice
Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic target for Alzheimer’s disease (AD). In this study, based on the superficial spatial distribution of mLVs, a near-infrared light is employed to modulate lymphatic drainage, significantly improving cognition of both aged and AD (5xFAD and APP/PS1) mice, and alleviating AD-associated pathology by reducing Aβ deposition, neuroinflammation and neuronal damage. Furthermore, transmission electron microscopy imaging and RNA sequencing data indicate amelioration of mitochondrial metabolism and cellular junction of meningeal lymphatic endothelial cells (mLECs) by light modulation. These studies collectively suggest that near-infrared light treatment can improve cognitive function by strengthening scavenging ability of mLVs through restoring mLEC function. In conclusion, lymphatic drainage potentiation by light promotes pathological remission and cognitive enhancement in aging and AD mouse models, which offers a potential amelioration strategy for neurodegenerative diseases.
Meningeal lymphatic vessels have been associated with amyloid beta clearance, which is considered as a modulation target for Alzheimer’s disease (AD) treatment. Here, the authors show that transcranial light treatment can enhance meningeal lymphatic drainage in aged and AD model mice and improve AD-associated pathology and cognitive function.
Journal Article
The prognostic evaluation of ALBI score in endoscopic treatment of esophagogastric varices hemorrhage in liver cirrhosis
To analyze the independent risk factors for recurrent bleeding and death within 1 year after endoscopic treatment of esophagogastric varices hemorrhage (EGVB) in patients with liver cirrhosis, and to validate the predictive value of ALBI score for recurrent bleeding and death within 1 year after endoscopic treatment of EGVB in patients with liver cirrhosis. A total of 338 patients with EGVB who received endoscopic treatment for the first time in the Department of Gastroenterology, First Affiliated Hospital of Nanchang University from January 1, 2016 to March 1, 2020 were selected. A database was established to analyze the patients’ demographic data, surgical variables and postoperative outcomes. All patients were contacted and followed up to verify the predictive value of ALBI score for recurrent bleeding and mortality. 130 patients had rebleeding within 1 year after surgery (38.5%). 66 patients died within 1 year after surgery (19.5%). Patients with ALBI grade 3 had significantly higher rebleeding and mortality rates than those with grades 1 and 2. The AUC was used to compare the predictive value of the four scores for rebleeding and mortality within one year after endoscopic surgery. Both ALBI scores had the largest AUC. The ALBI score has certain predictive value for rebleeding and mortality within 1 year after endoscopic therapy in patients with cirrhotic EGVB.
Journal Article
Spatiotemporal variation of flash floods in the Hengduan Mountains region affected by rainfall properties and land use
Understanding the spatiotemporal characteristics of flash floods is important for reasonable and accurate identification of high-risk regions and for prediction of future hydrological regimes. Therefore, using time series datasets (1979–2015) of historical flash flood events, rainfall, and land use in the Hengduan Mountains region (HMR) of China, this study analyzed the effects of changes in precipitation and land use on spatiotemporal variation of flash floods. Analysis of the linear trend revealed that flash floods increased by 12 events/10 years and that 82% of events occurred in the flood season (June–August). The increase in flash flood events was found closely correlated with the increased frequency (rainstorm days increased by 3.5 d/10 years) and magnitude (rainstorm amount increased by 10.2 mm/10 years) of heavy rainfall as well as the expansion of the area of artificial surfaces (increase of 999 km2). Morlet wavelet analysis revealed significant periodic variation in the occurrence of flash floods on scales of 3–7, 8–15, and 21–31 years. On the basis of the standard elliptical difference, we identified displacement of the center of gravity of flash flooding from the northwest toward the southeast. Generally, more disasters were recorded in southern parts of the HMR owing to the frequent occurrence of rainstorms and the increase in area of both cultivated land and artificial surfaces with higher runoff potential. These findings improve understanding regarding the spatiotemporal dynamics of flash floods in the HMR and could support policymakers in identifying high-risk areas in mountainous watershed.
Journal Article
Metabolic toxicity and neurological dysfunction in methylmalonic acidemia: from mechanisms to therapeutics
Methylmalonic acidemia (MMAemia) is an inborn error of organic acid metabolism characterized by the accumulation of toxic metabolites—including methylmalonic acid (MMA), 2-methylcitric acid (2-MCA), propionic acid (PA), homocysteine (Hcy), ammonia, and lactate—due to defects in methylmalonyl-CoA mutase or impaired cobalamin metabolism. These metabolites exert profound effects on the central nervous system, contributing to neurological injury through tightly interconnected mechanisms, including mitochondrial dysfunction, neuroinflammation, and excitotoxicity. This review synthesizes current evidence on how these metabolites trigger neurological dysfunction, integrating findings from clinical studies, animal models, and cellular systems. We also highlight the increasingly recognized role of aberrant post-translational modifications (e.g., methylmalonylation, propionylation, lactylation) in disrupting metabolic network architecture and reprogramming cellular metabolism. Despite advances in supportive therapies, intracerebral metabolite accumulation remains a therapeutic challenge. We discuss emerging strategies targeting mitochondrial protection, redox homeostasis, and inflammation—including enzyme replacement, gene therapy, antioxidant regimens, and exosome-based delivery. A deeper mechanistic understanding of metabolite-driven neurotoxicity is critical to the development of targeted interventions that can improve neurological outcomes in MMAemia.
Journal Article
Resilience Assessment of Urban Road Transportation in Rainfall
Transportation resilience, as a component of city sustainability, plays a crucial role in the daily management and emergency response of urban road systems. With coastal cities becoming increasingly vulnerable to typhoons, rainstorms, and other disasters, it is essential to assess the resilience of urban road transportation in a refined and differentiated approach. Existing resilience assessment methods often overlook significant biases, neglecting the dynamic response of road traffic and non-stationary characteristics of traffic systems. To address these limitations, we develop a quantitative resilience assessment method for urban road transportation during rainfall that is based on the improved Resilience Triangle. The method is applied to DiDi urban traffic speed and meteorological data of Shenzhen, China, from April to September 2018, with a focus on Typhoon Mangkhut as an extreme weather case. By analyzing transportation resilience variations across road densities, road hierarchies, and rainfall scenarios, we found that road densities and rainfall intensities explain resilience variations better than road hierarchies. Specifically, as accumulative precipitation exceeds 100 mm, a substantial surge in loss of performance is observed. Typhoon rainfalls result in a greater loss in urban road traffic compared to general rainfalls. The results offer valuable insights for urban road planning, traffic emergency management, and transportation resilience construction in the face of increasingly severe weather challenges.
Journal Article
Spatial Differences and Influencing Factors of Energy Poverty: Evidence From Provinces in China
The complex and severe problem of energy poverty seriously affects the health and quality of life of residents and poses a significant challenge to the country’s macroeconomic development. The purpose of this paper is to analyze the spatial distribution of energy poverty and the characteristics of regional differences in 30 provinces in mainland China from 2008 to 2019 by constructing an energy poverty evaluation index system and explore the main reasons for the gap between energy poverty regions in China from the perspective of “relational data.” The results show that the spatial distribution of energy poverty in China is “high in the west and central area and low in the east,” and the spatial pattern is relatively stable. From the perspective of the time dimension, the problem of energy poverty in China has been alleviated during the sample period, and the overall gap in energy poverty has shown a decreasing trend. The difference in energy poverty between regions is the primary source of the overall gap, but its contribution is gradually decreasing. The empirical results suggest that reducing the imbalance of industrial structure, energy price, and energy investment among regions can effectively narrow the inter-regional energy poverty gap. Moreover, there are differences in the dominant factors that determine the difference in energy poverty within the eastern, central, and western regions. In this regard, it is recommended to further improve the relevant policies in developing new energy sources according to local conditions, reasonably increasing energy construction investment, strengthening technological innovation, establishing financial guarantee mechanisms, and guiding residents to consume modern, clean energy.
Journal Article