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Large-eddy simulation (LES), coupled with a wind-turbine model, is used to investigate the characteristics of a wind-turbine wake in a neutral turbulent boundary-layer flow. The tuning-free Lagrangian scale-dependent dynamic subgrid-scale (SGS) model is used for the parametrisation of the SGS stresses. The turbine-induced forces (e.g., thrust, lift and drag) are parametrised using two models: (a) the ‘standard' actuator-disk model (ADM-NR), which calculates only the thrust force and distributes it uniformly over the rotor area; and (b) the actuator-disk model with rotation (ADM-R), which uses the blade-element theory to calculate the lift and drag forces (that produce both thrust and rotation), and distribute them over the rotor disk based on the local blade and flow characteristics. Simulation results are compared to high-resolution measurements collected with hot-wire anemometry in the wake of a miniature wind turbine at the St. Anthony Falls Laboratory atmospheric boundary-layer wind tunnel. In general, the characteristics of the wakes simulated with the proposed LES framework are in good agreement with the measurements in the far-wake region. The ADM-R yields improved predictions compared with the ADM-NR in the near-wake region, where including turbine-induced flow rotation and accounting for the non-uniformity of the turbine-induced forces appear to be important. Our results also show that the Lagrangian scale-dependent dynamic SGS model is able to account, without any tuning, for the effects of local shear and flow anisotropy on the distribution of the SGS model coefficient.

A numerical study of atmospheric turbulence effects on wind-turbine wakes is presented. Large-eddy simulations of neutrally-stratified atmospheric boundary layer flows through stand-alone wind turbines were performed over homogeneous flat surfaces with four different aerodynamic roughness lengths. Emphasis is placed on the structure and characteristics of turbine wakes in the cases where the incident flows to the turbine have the same mean velocity at the hub height but different mean wind shears and turbulence intensity levels. The simulation results show that the different turbulence intensity levels of the incoming flow lead to considerable influence on the spatial distribution of the mean velocity deficit, turbulence intensity, and turbulent shear stress in the wake region. In particular, when the turbulence intensity level of the incoming flow is higher, the turbine-induced wake (velocity deficit) recovers faster, and the locations of the maximum turbulence intensity and turbulent stress are closer to the turbine. A detailed analysis of the turbulence kinetic energy budget in the wakes reveals also an important effect of the incoming flow turbulence level on the magnitude and spatial distribution of the shear production and transport terms.

Studies on the association between adiponectin and leptin and anxiety and depression among postmenopausal women are limited. Therefore, the present study specifically evaluates the mutual relationships between adiponectin and leptin and anxiety and depression in postmenopausal women. In this cross-sectional study, a total of 190 women aged 40-65 years were enrolled. Depression symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D), and anxiety symptoms were evaluated using the Hamilton Anxiety Rating Scale (HAM-A). Fasting specimens were collected to measure sex hormone, glucose, insulin, and adipokine levels. Multiple linear regression analysis was performed to evaluate the associations between depression and anxiety and adipocyte-derived hormones. The study was performed in a hospital medical center. Among 190 enrolled postmenopausal women, Spearman's rank correlation analysis revealed significant correlations between CES-D and HAM-A (r = 0.715, P < 0.0001), between CES-D and adiponectin (p = 0.009) and leptin (p = 0.015), and between HAM-A and adiponectin (p = 0.01) and leptin (p = 0.001). The subjects with CES-D ≥ 16 and with HAM-A ≥ 18 had higher adiponectin levels than those with CES-D < 16 and HAM-A < 18, respectively. After adjusting for age, body mass index, exercise, alanine amino transferase and parameters of lipid profiles, Log adiponectin levels were found to be significantly associated with both CES-D and HAM-A, and Log leptin levels were only significantly associated with HAM-A. The data show that adiponectin and leptin levels are significantly associated with depression and anxiety symptoms. These results suggest that higher adiponectin and lower leptin levels may serve as potential markers related to anxiety and mood in postmenopausal women. More future research that is designed to deal with the important confounders (e.g., population heterogeneity) is needed to investigate comprehensively on these associations.

Mechanical products are becoming more diversified with the continuous development of precision processing and materials technologies. The friction force generated by the O-ring seal in a hydraulic cylinder was once considered redundant. However, its utilization has recently been proposed. The hardness of the O-ring and the inner diameter of its groove directly affect the normal pressure between the O-ring and the inner wall of the cylinder, thereby affecting the friction behavior. In order to explore this friction behavior, a strain-based friction force measurement system is developed in this study, and the steady-state and dynamic friction values under different working conditions are studied and discussed in depth. This research on the friction behavior in the cylinder provides a theoretical basis for more convenient design and utilization of the friction force generated between the O-ring and the inner wall of the cylinder.

This study uses numerical methods (ANSYS-Fluent) to investigate the viscous fingering of the displaced phase as a shear-thinning fluid in the classic three-dimensional Hele-Shaw cell. Comparing the behavior of fingerings with different properties on the upper and lower surfaces of a three-dimensional model, it was found that when the upper and lower surfaces are walls, under the combined action of moving contact lines and Saffman-Taylor instability, fingering splitting occurs at the tip, resulting in the appearance of two fingers at the interface. In addition, we have found that interfacial tension has a suppressive effect on short waves. As the interfacial tension increases, the velocity at the advancing tip decreases. Therefore, when the interface tension is 0, viscous fingering displacement reaches the farthest distance. We have also conducted research on the viscous fingering at different temperatures. The results indicate that increasing the temperature leads to a decrease in the viscosity of the displaced phase, making the flow more stable. As the temperature rises, the pressure gradient inside the flow path increases, pushing the viscous fingering further.

Background Adolescent depressive patients generally have clinical manifestations such as emotional depression and cognitive decline, and family caregivers play an irreplaceable and important role in the disease management and rehabilitation process. Despite the heavy burden of caring for adolescent depressed patients, it is possible that family caregivers are also experiencing anxiety, which may increase their burden, and previous research has reported that psychological resilience plays an important role in reducing the physical and mental burden on caregivers. Objective This study aims to assess the current status of caregiver burden, psychological resilience, and anxiety among family caregivers of adolescents with depression and to explore whether psychological resilience mediates the relationship between caregiver burden and anxiety. Methods A cross-sectional study design was employed to recruit 256 family caregivers of adolescents with depression. The caregivers completed questionnaires, including general demographic information, the Zarit Caregiver Burden Scale, the Self-Rating Anxiety Scale, and the Psychological Resilience Scale. Data analysis was performed via SPSS 26.0. Results There was a significant positive correlation between care burden and anxiety ( r  = 0.561, P  < 0.01), psychological resilience and care burden and anxiety showed a significant negative correlation ( r = -0.895, -0.556, P  < 0.01), and psychological resilience played a partial mediating role between care burden and anxiety (β = 0.198, P  < 0.01), and the indirect effect accounted for 42.95%. Conclusion Perceived resilience plays a mediating role in the association between caregiving burden and anxiety among family caregivers of adolescent patients with depression, and it can be considered as a longitudinal follow-up or intervention study in the future. Implications for clinical practice This study emphasizes that caregiver burden is associated with higher anxiety levels, and psychological resilience may play a moderating role in this association, suggesting that clinicians need to include resilience assessment in routine screening and implement hierarchical interventions based on the “burden-resilience” combined risk: priority is given to providing structured psychological support to high-burden-low resilience groups. The final realization: (1) reduce the burden on caregivers (2) improve the quality of care.

Renewable energy provides an effective solution to the problem existing between energy and environmental protection. Tidal energy has great potential as a form of renewable energy. Tidal current generation (TCG) technology is the earliest renewable energy power generation technology. The advancement of science and technology has led to TCG rapidly developing since its emergence in the last century. This paper investigates the development of TCG in recent years based on the key components of TCG systems, both in terms of tidal energy harvesting research and power generation unit research. A summary of tidal energy harvesting is presented, investigating the main tidal energy harvesting units currently available. In addition, research on generators and generator control is summarized. Lastly, a comparison between horizontal and vertical axis turbines is carried out, and predictions are made about the future trends in TCG development. The purpose of this review is to summarize the research status and research methods of key components in tidal energy power generation technology and to provide insight into the research of tidal energy-related technologies.

The understanding of ectomycorrhizal (ECM) fungi's role in shaping bacterial groups and regulating heavy metals in soils was limited in the past. A mesocosm experiment with inoculation treatments (Pezicula ericae K2 and Pisolithus tinctorius) was applied to Pinus taiwanensis. The study aimed to explore the impact of ECM fungi, specifically, P. ericae K2 and P. tinctorius, on bacterial communities within the rhizosphere and endorhiza (root tips) of P. taiwanensis seedlings. Additionally, it sought to evaluate the interaction between environmental factors, including heavy metals and bacteria associated with ECM fungi. Furthermore, the study aimed to elucidate the influence of ECM fungi on host plant biomass, environmental conditions, and heavy metal concentrations. Next‐generation sequencing analyzed rhizosphere soils and root tip bacterial communities. Results confirmed P. ericae K2 as an ECM fungi; dominant phyla in rhizosphere soils were Acidobacteria and Proteobacteria, while in mycorrhizal root tips were Actinobacteria and Proteobacteria; rhizosphere soils had a more robust influence of environmental factors and heavy metals; the most dominant Actinomycetales and Burkholderiales were associated with rhizosphere soils and root tips, respectively; diversity indices escalated for seedlings with ECM fungi; most negative correlations of bacterial rhizosphere soils signified their resistance to heavy metals; nitrogen fixers displayed intricate positive correlations in the root tips; ECM fungi increased plant biomass, soil cations, pH, and cation exchange capacity while reducing soil nitrogen and heavy metal concentrations. The study highlighted that ECM fungi's ecological contributions were crucial for regulating metal‐laden soils, benefiting plant health and tolerance, and sustaining ecosystems.

Background Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is a rare inherited mitochondrial disease mainly caused by the m.8344A > G mutation in mitochondrial tRNA Lys gene, and usually manifested as complex neurological disorders and muscle weakness. Currently, the pathogenic mechanism of this disease has not yet been resolved, and there is no effective therapy for MERRF syndrome. In this study, MERRF patients-derived iPSCs were used to model patient-specific neurons for investigation of the pathogenic mechanism of neurological disorders in mitochondrial disease. Methods MERRF patient-derived iPSCs were differentiated into excitatory glutamatergic neurons to unravel the effects of the m.8344A > G mutation on mitochondrial bioenergetic function, neural-lineage differentiation and neuronal function. By the well-established differentiation protocol and electrophysiological activity assay platform, we examined the pathophysiological behaviors in cortical neurons of MERRF patients. Results We have successfully established the iPSCs-derived neural progenitor cells and cortical-like neurons of patients with MERRF syndrome that retained the heteroplasmy of the m.8344A > G mutation from the patients’ skin fibroblasts and exhibited the phenotype of the mitochondrial disease. MERRF neural cells harboring the m.8344A > G mutation exhibited impaired mitochondrial bioenergetic function, elevated ROS levels and imbalanced expression of antioxidant enzymes. Our findings indicate that neural immaturity and synaptic protein loss led to the impairment of neuronal activity and plasticity in MERRF neurons harboring the m.8344A > G mutation. By electrophysiological recordings, we monitored the in vivo neuronal behaviors of MERRF neurons and found that neurons harboring a high level of the m.8344A > G mutation exhibited impairment of the spontaneous and evoked potential-stimulated neuronal activities. Conclusions We demonstrated for the first time the link of mitochondrial impairment and synaptic dysfunction to neurological defects through impeding synaptic plasticity in excitatory neurons derived from iPSCs of MERRF patients harboring the m.8344A > G mutation. This study has provided new insight into the pathogenic mechanism of the tRNA Lys gene mutation of mtDNA, which is useful for the development of a patient-specific iPSCs platform for disease modeling and screening of new drugs to treat patients with MERRF syndrome.

Women with unilateral breast cancer are at an increased risk for the development of contralateral breast cancers. We hypothesis that combined breast MRI would detect more contralateral synchronous breast cancer than conventional imaging alone, and resulted in less contralateral metachronous breast cancer during follow-up. We retrospectively collected two groups of breast cancer patients diagnosed from 2009 to 2013 for evaluating the effectiveness and value of adding pre-operative breast MRI to conventional breast images (mammography and sonography) for detection of contralateral synchronous breast cancer. The new metachronous contralateral breast cancer diagnosed during follow-up was prospectively evaluated and compared. Group A (n = 733) comprised patients who underwent conventional preoperative imaging and group B (n = 735) combined with MRI were enrolled and compared. Seventy (9.5%) of the group B patients were found to have contralateral lesions detected by breast MRI, and 65.7% of these lesions only visible with MRI. The positive predictive value of breast MRI detected contralateral lesions was 48.8%. With the addition of breast MRI to conventional imaging studies, more surgical excisions were performed in contralateral breasts (6% (44/735) versus 1.4% (10/733), P< 0.01), more synchronous contralateral breast cancer detected (2.9% (21/735) versus 1.1% (8/733), P = 0.02), and resulted in numerical less (2.2% (16/714) versus 3% (22/725), p = 0.3) metachronous contralateral breast cancer during a mean follow-up of 102 months. Our study provides useful estimates of the pre-operative breast MRI for the increased detection of contralateral synchronous breast cancer and less subsequent contralateral metachronous breast cancer.