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AimThe impact of pelvis on the development of anastomotic leak (AL) in rectal cancer (RC) patients who underwent anterior resection (AR) remains unclear. The aim of this study was to evaluate the impact of pelvic dimensions on the risk of AL.MethodsA total of 1058 RC patients undergoing AR from January 2013 to January 2016 were enrolled. Pelvimetric parameters were obtained using abdominopelvic computed tomography scans.ResultsUnivariate analyses showed that pelvic inlet, pelvic outlet, interspinous distance, and intertuberous distance were significantly associated with the risk for AL (P < 0.05). Multivariate analysis confirmed that pelvic inlet and intertuberous distance were independent risk factors for AL (P < 0.05). Significant factors from multivariate analysis were assembled into the nomogram A (without pelvic dimensions) and nomogram B (with pelvic dimensions). The area under curve (AUC) of nomogram B was 0.72 (95% CI 0.67–0.77), which was better than the AUC of nomogram A (0.69, [95% CI 0.65–0.74]), but didn’t reach a statistical significance (P = 0.199). Decision curve supported that nomogram B was better than nomogram A.ConclusionPelvic dimensions, specifically pelvic inlet and intertuberous distance, seemed to be independent predictors for postoperative AL in RC patients. Pelvic inlet and intertuberous distance incorporated with preoperative radiotherapy, preoperative albumin, conversion, and tumor diameter in the nomogram might provide a clinical tool for predicting AL.

The influences of coiling temperature and cooling condition on structural transformation of the hot-rolled tertiary oxide scale formed under continuous cooling conditions were studied by thermal gravimetric analyzer. The fourth oxide scale formed under different conditions were classified and plotted. Because the oxide scale structure transformation is diffusion-controlled and the transformation law is similar to ＂C＂ curve, the eutectoid transformation nose temperature is 450 ℃. Under condition of low temperature and high cooling rate, ion diffusion behavior is restricted so that the eutectoid reaction is suppressed, resulting in that the fourth oxide scale is mainly made up of pre-eutectoid Fe304 and FeO without eu- tectoid products. From scale structure transition diagram, the eutectoid reaction process was affected by coiling temperature and cooling rate, leading to various scale structures.

Hot-rolled Fe-（0.75-2.20）Si （mass%） alloys were oxidized in dry air at 600-1200 ℃. The oxidation process was carried out by thermal gravimetric analysis （TGA）. At 600- 1 150 ℃, oxidation gain curves were approximately parabolic. Electron probe mieroanalysis （EPMA） was applied to investigate cross-section morphology of oxide layer and element distribution across the layer. At lower temperature of 700 ℃, the oxide layer consisted of internal oxidation zone （IOZ）, inner Si-rich layer （conglomerate of fayalite and magnetite） and outer hematite layer, while at higher temperature of 1200 ℃, fayalite and wustite were observed in external oxide scale. Liquidus temperature of fayalite was detected by differential scanning calorimetry （DSC）. Through comparing the oxidation mass gain and parabolic rate constant of the alloys, it was found that oxidation resistance of Fe-Si alloy was enhanced by increasing Si content below 1 150 ℃ while increasing Si content of the alloy resulted in higher oxidation rate above 1150 ℃ owing to the liquid fayalite formation.

In this work, SnO2 porous nanosolids were obtained from SnO2 nanopowders by using a solvo-thermal hot-press method. Then, by using the conventional thick-film sensors preparation technology, SnO2 porous thick-film gas sensor was prepared from it. Meanwhile, polyaniline (PANI) was synthesized by chemical oxidation polymerization. After that, by mechanical method, the SnO2/PANI composite gas sensors were fabricated. The intrinsic resistances and gas sensing properties of sensors to NO2, NH3, H2 and ethanol vapor were tested. Compared with the SnO2 porous gas sensors, the optimum operation temperature of SnO2/PANI hybrid gas sensors decreased dramatically. And SnO2/PANI hybrid gas sensors showed satisfying selectivity and high sensitivity for NO2.

In this work, SnO sub(2) porous nanosolids were obtained from SnO sub(2) nanopowders by using a solvo-thermal hot-press method. Then, by using the conventional thick-film sensors preparation technology, SnO sub(2) porous thick-film gas sensor was prepared from it. Meanwhile, polyaniline (PANI) was synthesized by chemical oxidation polymerization. After that, by mechanical method, the SnO sub(2)/PANI composite gas sensors were fabricated. The intrinsic resistances and gas sensing properties of sensors to NO sub(2), NH sub(3), H sub(2) and ethanol vapor were tested. Compared with the SnO sub(2) porous gas sensors, the optimum operation temperature of SnO sub(2)/PANI hybrid gas sensors decreased dramatically. And SnO sub(2)/PANI hybrid gas sensors showed satisfying selectivity and high sensitivity for NO sub(2).

Approximately 10-20% of the world population experiences tinnitus, which is increased with age and comorbid with frustration, annoyance, anxiety, depression, cognitive dysfunction, insomnia and stress. The underlying mechanisms of tinnitus remain largely unknown and there are no quantifiable biomarkers, making this prevalent disorder a global burden. There are no FDA-approved therapeutics and the current assessment mainly relies on self-reports (e.g., questionnaires), which underscore the need for diagnostic tools for tinnitus. Memristors, nanoscale electronic components mimicking synaptic plasticity, can monitor and control neuronal activity, hold transformative potential for detecting and characterizing tinnitus objectively. Here, we harvested the blood from human and mice with tinnitus, and engineered memristors via magnetron sputtering and made the functional layer with serum. Its core mechanism lies in regulating the reversible formation and rupture of conductive filaments which is formed by utilizing abnormally elevated glutamate concentrations in serum assisted Ag+ ions. This serum-based memristor achieves unprecedented discrimination between tinnitus and non-tinnitus individuals. Furthermore, this platform provides mechanistic insights into tinnitus pathogenesis, with potential implications in other neurological disorders.

Aim： In the penumbra after focal cerebral ischemia, an increase of protease Omi is linked to a decrease of Hsl-associated protein X-1 （Hax-1）, a protein belonging to the Bcl-2 family. In this study we investigated the mechanisms underlying the regulation of Hax-1 by protease Omi in cerebral ischemia/reperfusion （I/R） injury. Methods： Mouse neuroblastoma N2a cells were subjected to oxygen-glucose deprivation and reoxygenation （OGD/R）; cell viability was assessed with MTT assay. Mice underwent 2-h middle cerebral artery occlusion （MCAO） and reperfusion, and the infarct volume was determined with TTC staining. The expression of Omi and Hax-1 was detected using immunoblot and immunofluorescence assays. The mitochondrial membrane potential was measured using TMRM staining. Results： In the brains of MCAO mice, the protein level of Omi was significantly increased, while the protein level of Hax-1 was decreased. Similar changes were observed in OGD/R-treated N2a cells, but the mRNA level of Hax-1 was not changed. Furthermore, in OGD/R-treated N2a cells, knockdown of Omi significantly increased Hax-1 protein level. Immunofluorescence assay showed that Omi and Hax-1 were co-localized in mitochondria of N2a cells. OGD/R caused marked mitochondrial damage and apoptosis in N2a cells, while inhibition of Omi protease activity with UCF-101 （10 pmol/L） or overexpression of Hax-1 could restore the mitochondrial membrane potential and attenuate cell apoptosis. Moreover, pretreatment of MCAO mice with UCF-101 （7.15 mg/kg, ip） could restore Hax-1 expression, inhibit caspase activation, and significantly reduce the infarct volume. Conclusion： Protease Omi impairs mitochondrial function by cleaving Hax-1, which induces apoptosis in OGD/R-treated N2a cells and causes I/R injury in MCAO mice.