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According to the researchers, hazard ratios for the incidence of RA were 0.93 (95% CI, 0.9-0.96) for the EAT-Lancet diet index and 0.8 (95% CI, 0.7-0.93) for corresponding metabolomic signatures, with a mediation percentage of 34.07% (95% CI, 21.44%-47%). [...]metabolites including the degree of unsaturation, omega-3 fatty acids, docosahexaenoic acid and albumin were negatively associated with RA risk\" After an analysis of gene-environment interactions, Feng and colleagues found that genes B2M, SLC30A4, SHF, SORD, CASC4, SPG11, CRIP2, BTBD6 and TEX22 interacted with the EAT-Lancet diet index. Red meat, added sugars and saturated fats are restricted due to their association with cardiovascular disease, obesity, cancer and environmental degradation.