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This paper examines the role of leadership as it is a key ingredient to mission readiness within the military structure. Mission readiness can be evaluated by a myriad of factors; however, leadership is truly a factor that can be linked to several factors due to the management and impacts daily contributions and functions. The involvement of the leadership can determine the outcome of everything, but a toxic environment can deter any future goals. Toxic leadership inflicts serious and enduring harm on individuals, groups, organizations, and communities who align with unpredictable patterns.The purpose of the research is to investigate if the leadership’s toxic ways affect mission readiness. The primary research question was, \"Does toxic leadership negatively affect mission readiness? The sub-questions for research included: (1) What is the relationship between toxic leadership and job satisfaction? (2) How does the quality of leadership influence career retention? (3) How does good leadership positively affect the mental health of the team members?The methodology utilized in this research was circled around technology and human interactions by utilizing surveys and in-person interviews. These methods generated a multitude of data capturing the personal needs of people and how leadership is key in their personal development. Conclusions from the methodology showed that theinteraction and communication from the leadership weigh heavily on the type of environment you foster in your workplace. Recommendations are to positively communicate and implicate techniques to effectively communicate with everyone and utilize tools for continuous improvement involving communication, a key recipe that affects mission readiness.

Many species regenerate lost body parts following amputation. Most limb regeneration research has focused on the immediate injury site. Meanwhile, body-wide injury responses remain largely unexplored but may be critical for regeneration. Here, we discovered a role for the sympathetic nervous system in stimulating a body-wide stem cell activation response to amputation that drives enhanced limb regeneration in axolotls. This response is mediated by adrenergic signaling, which coordinates distant cellular activation responses via the α -adrenergic receptor, and local regeneration responses via β-adrenergic receptors. Both α - and β-adrenergic signaling act upstream of mTOR signaling. Notably, systemically-activated axolotls regenerate limbs faster than naïve animals, suggesting a potential selective advantage in environments where injury from cannibalism or predation is common. This work challenges the predominant view that cellular responses underlying regeneration are confined to the injury site and argues instead for body-wide cellular priming as a foundational step that enables localized tissue regrowth.

The 2002 bottom line was boosted by one-time gains of 71 million euros, primarily from the sale of assets. Last year, Euronext sold shares in clearinghouse Clearnet and Dutch settlement activities to Euroclear, the world's largest settlement system for cross-border trades. It also sold a 25% stake in index provider Stoxx. In 2002, revenue growth and tight price controls pushed Euronext's Ebit to 237.8 million euros, compared with a pro forma 111.16 million euros a year earlier, Euronext said.

French reinsurer Scor SA said Friday that it has dismissed its senior vice president, Francois Reach, the first high-level departure from the company since Chief Executive Jacques Blondeau was ousted in November. Mr. Blondeau was replaced by Denis Kessler, then No. 2 at the French employers' federation, Medef, after Scor had racked up losses of more than 500 million euros in 2001 and 2002 as a result of a sharp downturn in world-equity prices.

Like similar companies, Euro Disney in recent months has been fighting a downturn in tourism from a combination of terrorist threats, the economic downturn and scares like severe acute respiratory syndrome. Attendance at Euro Disney's theme parks slipped 5.3% to 12.4 million visitors during fiscal 2003, while occupancy rates of its approximately 5,800 hotel rooms fell 3.1 percentage points to 85%. \"Management has to come up with an operating plan that is convincing,\" brokerage firm Fideuram Wargny in Paris said. \"Euro Disney has to find a way quickly of increasing its sales in order to generate sufficient cash flow to cover its debt repayments.\"

The COVID-19 pandemic has had unprecedented effects on mental health and community functioning. Negative effects related to disruption of individuals' social connections may have been more severe for those who had tenuous social connections prior to the pandemic. Veterans who have recently experienced homelessness (RHV) or have a psychotic disorder (PSY) are considered particularly vulnerable because many had poor social connections prior to the pandemic. We conducted a 15-month longitudinal study between May 2020 -July 2021 assessing clinical (e.g., depression, anxiety) and community (e.g., social functioning, work functioning) outcomes. Eighty-one PSY, 76 RHV, and 74 Veteran controls (CTL) were interviewed over 5 assessment periods. We assessed changes in mental health and community functioning trajectories relative to pre-pandemic retrospective ratings and examined group differences in these trajectories. All groups had significantly increased symptoms of depression, anxiety, and concerns with contamination at the onset of the pandemic. However, RHV and PSY showed faster returns to their baseline levels compared to CTL, who took nearly 15 months to return to baseline. With regards to functioning, both RHV and PSY, but not CTL, had significant improvements in family and social networks over time. Work functioning worsened over time only in PSY, and independent living increased over time in both RHV and PSY but not CTL. These results reveal that vulnerable Veterans with access to VA mental health and case management services exhibited lower negative impacts of the COVID-19 pandemic on mental health and community functioning than expected.

Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. Since a systematic review of key outcomes from randomised trials of therapeutic interventions in neonatal sepsis was published recently, we will complement this with a qualitative systematic review of the key outcomes of neonatal sepsis identified by parents, other family members, parent representatives, healthcare providers, policymakers, and researchers. We will interpret the outcomes of both studies using a previously established framework. Stakeholders across three different groups i.e., (1) researchers, (2) healthcare providers, and (3) patients’ parents/family members and parent representatives will rate the importance of the outcomes in an online Real-Time Delphi Survey. Afterwards, consensus meetings will be held to agree on the final COS through online discussions with key stakeholders. This COS is expected to minimize outcome heterogeneity in measurements and publications, improve comparability and synthesis, and decrease research waste.

To the Editor: In the Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM) trial, Lenze et al. (March 23 issue) 1 found that treatment-resistant geriatric depression was roughly equally responsive to augmentation with aripiprazole and augmentation with bupropion; they favor aripiprazole augmentation because it was associated with fewer falls. The associated editorial by Lewis and Lewis 2 concurs but advises clinicians “to tailor treatment in light of potential adverse effects,” such as aripiprazole-induced akathisia and weight gain or metabolic syndrome. The authors do not mention the risk of tardive dyskinesia, which can persist even after discontinuation of treatment with aripiprazole. Aripiprazole, . . .

Abstract Background Human beings find social stimuli rewarding, which is thought to facilitate efficient social functioning. Although reward processing has been extensively studied in schizophrenia, a few studies have examined neural processes specifically involved in social reward processing. This study examined neural sensitivity to social and nonsocial rewards in schizophrenia. Methods Twenty-seven patients with schizophrenia and 25 community controls completed a One-Armed Bandit Task, an implicit reinforcement learning task, in the scanner. There were 2 conditions with an identical trial structure, one with social rewards and the other with nonsocial rewards. The data were analyzed using a region of interest (ROI) approach, focusing on the ventral striatum, ventromedial prefrontal cortex, and anterior cingulate cortex. Results Across all 3 ROIs, patients showed reduced activation for social rewards compared to controls. However, the 2 groups showed comparable levels of activation for nonsocial rewards. Within the patient group, levels of neural activation in these ROIs during the social reward condition were associated with better performance. Conclusions This study found reduced neural sensitivity in patients with schizophrenia in key reward-processing regions for social but not for nonsocial rewards. These findings suggest a relatively specific social reward-processing deficit in schizophrenia during an implicit reinforcement learning task.