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شي جين بينغ : حول الحكم والإدارة
ترجع أهمية هذا الكتاب، وما حظي به من إقبال دولي كبير خارج الصين إلى ثلاثة عوامل رئيسية هامة. الأول : أنه يتحدث عن الدولة التي أصبحت محط أنظار العالم خلال الفترة الأخيرة، فالكتاب يسلط الضوء على النظريات الهامة والقضايا الواقعية لتنمية الصين في العصر الجديد، ويفتح نافذة للمجتمع الدولي لتعزيز معرفته وفهمه للمفهوم الصيني للتنمية وطريق التنمية وسياسات الصين الداخلية والخارجية. العامل الثاني، يتمثل في شخصية مؤلف الكتاب، وهو الرئيس شي جين بينغ، الذي لفت أنظار العالم بفضل سماته الشخصية الصادقة والودية منذ المؤتمر الثامن عشر للحزب الشيوعي الصيني، إذ تركت أقواله وأفعاله انطباعا عميقا لدى المجتمع الدولي. وبصفته أعلى قائد للصين حزبا ودولة، فقد ألقى الرئيس شي كلمات كثيرة حول حوكمة الدولة وإدارة شؤونها، طرح فيها الكثير من الأفكار والنظريات والاستنتاجات الجديدة، وأجاب عن المسائل النظرية والواقعية الهامة حول تطور الحزب والدولة في الظروف التاريخية الجديدة. وعرض بصورة مركزة مفهوم حوكمة الدولة واستراتيجية تنفيذ الحكم للجماعة القيادية الجديدة للجنة المركزية للحزب الشيوعي الصيني. وبالتالي فإن قراءة هذا الكتاب تساعد على فهم أفكار الرئيس شي حول حكم البلاد وإدارة شؤونها، بجانب التعرف على سمات وخصائص شخصيته من تواضع وتسامح وثقة بالنفس وأدب جم ورغبة في خدمة الشعب. أما العامل الثالث، فيتمثل في تنوع المفاهيم التي يحتوي عليها الكتاب، فهو يضم العديد من المفاهيم المتقدمة حول حكم البلاد وإدارة شؤونها، والتي لا تقتصر فائدتها وتأثيراتها على التنمية في الصين فقط، وإنما تمتد أيضا إلى التنمية في دول العالم الأخرى. القراءة المتفحصة لعناوين الفصول الثمانية عشر التي يضمها الكتاب بين دفتيه وما تضمنه من أفكار ومفاهيم قيمة، تجعلنا نستنتج أن ثمة ركيزتين رئيسيتين يركز عليهما الرئيس شي في سبيل تحقيق ليس فقط حلم الصين للنهضة العظيمة للأمة الصينية، وإنما أيضا تحقيق الرفاه والسعادة لدول وشعوب العالم.
Book
Paeoniflorin Prevents Intestinal Barrier Disruption and Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in Caco-2 Cell Monolayers
AbstractInflammatory bowel disease (IBD) in humans is closely related to bacterial infection and the disruption of the intestinal barrier. Paeoniflorin (PF), a bioactive compound from Paeonia lactiflora Pallas plants, exerts a potential effect of anti-inflammatory reported in various researches. However, the effect of PF on intestinal barrier function and its related mechanisms has not been identified. Here, we investigate the PF potential anti-inflammatory effect on lipopolysaccharide (LPS)-stimulated human Caco-2 cell monolayers and explore its underlying key molecular mechanism. In this context, PF significantly increased TEER value, decreased intestinal epithelium FITC-dextran flux permeability, and restored the expressions of occludin, ZO-1, and claudin5 in LPS-induced Caco-2 cell. In vitro, treatment of PF significantly inhibited LPS-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and matrix metalloproteinase-9 (MMP-9). In addition, we found that PF suppressed nuclear factor kappa B (NF-κB) signaling via activating the Nrf2/HO-1 signaling pathways in ILPS-stimulated Caco-2 cells. Our findings indicate that PF has an inhibitory effect on endothelial injury. Our findings suggested that PF has an anti-inflammatory effect in ILPS-stimulated Caco-2 cells, which might be a potential therapeutic agent against IBD and intestinal inflammation.
Journal Article
The gravity dual of Rényi entropy
A remarkable yet mysterious property of black holes is that their entropy is proportional to the horizon area. This area law inspired the holographic principle, which was later realized concretely in gauge-gravity duality. In this context, entanglement entropy is given by the area of a minimal surface in a dual spacetime. However, discussions of area laws have been constrained to entanglement entropy, whereas a full understanding of a quantum state requires Rényi entropies. Here we show that all Rényi entropies satisfy a similar area law in holographic theories and are given by the areas of dual cosmic branes. This geometric prescription is a one-parameter generalization of the minimal surface prescription for entanglement entropy. Applying this we provide the first holographic calculation of mutual Rényi information between two disks of arbitrary dimension. Our results provide a framework for efficiently studying Rényi entropies and understanding entanglement structures in strongly coupled systems and quantum gravity.
The discovery that the entropy of black holes is given by their horizon area inspired the holographic principle and led to gauge-gravity duality. Here, the author shows that all Rényi entropies satisfy a similar area law in holographic theories and are given by the areas of dual cosmic branes.
Journal Article
Xi Jinping, the governance of China
\"As general secretary of the CPC Central Committee and president of the People's Republic of China, Xi Jinping has delivered many speeches on a broad range of issues. He has offered his thoughts, views and judgments, and answered a series of important theoretical and practical questions about the Party and the country in these changing times. His speeches embody the philosophy of the new central leadership. To respond to rising international interest and to enhance the rest of the world's understanding of the Chinese government's philosophy and its domestic and foreign policies, the State Council Information Office, the Party Literature Research Office of the CPC Central Committee and the China International Publishing Group have worked together to produce this book. The book is a compilation of Xi Jinping's major works from November 15, 2012 to June 13, 2014. It includes, speeches, talks, interviews, instructions, and correspondence for a total of 70 pieces. It also contains 45 pictures of Xi Jinping at work and in daily life with focus on the period since the 18th National Congress of the Communist Party of China in 2012\"--Publisherʹs note.
Book
The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging
Both Alzheimer's disease (AD) and osteoporosis (OP) are common age‐associated degenerative diseases and are strongly correlated with clinical epidemiology. However, there is a lack of clear pathological relationship between the brain and bone in the current understanding. Here, it is found that young osteocyte, the most abundant cells in bone, secretes extracellular vesicles (OCYYoung‐EVs) to ameliorate cognitive impairment and the pathogenesis of AD in APP/PS1 mice and model cells. These benefits of OCYYoung‐EVs are diminished in aged osteocyte‐derived EVs (OCYAged‐EVs). Based on the self‐constructed OCY‐EVs tracer transgenic mouse models and the in vivo fluorescent imaging system, OCY‐EVs have been observed to be transported to the brain under physiological and pathological conditions. In the hippocampal administration of Aβ40 induced young AD model mice, the intramedullary injection of Rab27a‐shRNA adenovirus inhibits OCYYoung‐EVs secretion from bone and aggravates cognitive impairment. Proteomic quantitative analysis reveals that OCYYoung‐EVs, compared to OCYAged‐EVs, enrich multiple protective factors of AD pathway. The study uncovers the role of OCY‐EV as a regulator of brain health, suggesting a novel mechanism in bone‐brain communication. It is found that the osteocyte‐derived extracellular vesicles (OCY‐EVs) isolated from young osteocytes can ameliorate cognitive impairment and pathogenies of AD, but not OCY‐EVs isolated from aged osteocytes. OCY‐EV can transfer to the brain under physiological and pathological conditions. The study uncovers the role of OCY‐EVs as a regulator of brain, suggesting a novel mechanism in bone‐brain communication.
Journal Article
Ancient Demographics Determine the Effectiveness of Genetic Purging in Endangered Lizards
Abstract
The purging of deleterious alleles has been hypothesized to mitigate inbreeding depression, but its effectiveness in endangered species remains debatable. To understand how deleterious alleles are purged during population contractions, we analyzed genomes of the endangered Chinese crocodile lizard (Shinisaurus crocodilurus), which is the only surviving species of its family and currently isolated into small populations. Population genomic analyses revealed four genetically distinct conservation units and sharp declines in both effective population size and genetic diversity. By comparing the relative genetic load across populations and conducting genomic simulations, we discovered that seriously deleterious alleles were effectively purged during population contractions in this relict species, although inbreeding generally enhanced the genetic burden. However, despite with the initial purging, our simulations also predicted that seriously deleterious alleles will gradually accumulate under prolonged bottlenecking. Therefore, we emphasize the importance of maintaining a minimum population capacity and increasing the functional genetic diversity in conservation efforts to preserve populations of the crocodile lizard and other endangered species.
Journal Article
La gouvernance de la Chine
\"As general secretary of the CPC Central Committee and president of the People's Republic of China, Xi Jinping has delivered many speeches on a broad range of issues. He has offered his thoughts, views and judgments, and answered a series of important theoretical and practical questions about the Party and the country in these changing times. His speeches embody the philosophy of the new central leadership. To respond to rising international interest and to enhance the rest of the world's understanding of the Chinese government's philosophy and its domestic and foreign policies, the State Council Information Office, the Party Literature Research Office of the CPC Central Committee and the China International Publishing Group have worked together to produce this book. The book is a compilation of Xi Jinping's major works from November 15, 2012 to June 13, 2014. It includes, speeches, talks, interviews, instructions, and correspondence for a total of 70 pieces. It also contains 45 pictures of Xi Jinping at work and in daily life with focus on the period since the 18th National Congress of the Communist Party of China in 2012\"--Publisher's note.
Safety and feasibility analysis of rapid daratumumab infusion in Chinese patients with multiple myeloma
Background With the increasing use of daratumumab (DARA)‐containing regimens for multiple myeloma (MM) patients in China, the standard infusion time of DARA is long, with the potential for infusion‐related reactions (IRRs) and increased hospitalization and use of resources. Shortening the duration of DARA infusion helps to optimize the hospital stay and enhance the patient treatment experience. The current, commonly used 90‐min rapid DARA infusion regimen may not be applicable to Chinese MM patients, and therefore, we explored a new 110‐min rapid DARA infusion regimen aimed at reducing the treatment burden on patients to guarantee therapeutic safety. Methods MM inpatients treated with the DARA regimen were divided into two groups according to the number of times the DARA regimen was used: a standard infusion regimen for patients treated with the first two doses of DARA and a 110‐min rapid infusion regimen for patients treated with more than two doses of DARA. Anti‐allergy medications were routinely administered prior to the start of DARA infusion, patient consent, and authorization was obtained for all treatments, and statistical evaluation of the results was conducted via descriptive analyses, one‐way ANOVA and chi‐square tests. Results A total of 129 patients were included in this study: 68 in the standard infusion group, with 121 DARA infusions, and 129 in the rapid infusion group (patients who participated in the standard infusion subsequently participated in the rapid infusion), with 738 DARA infusions. The incidence of IRRs was 27.27% (36/121) in the standard infusion group and 1.35% (10/738) in the rapid infusion group, which were significantly different (p < 0.001). The incidence of IRRs after rapid infusion in other studies was <6%. The incidence of grade 1 IRRs in the rapid infusion group was 0.81% (6/738), the incidence of grade 2 IRRs was 0.54% (4/738), and there were no IRRs above grade 3; age, sex, and underlying disease had no effect on the choice of infusion method (p > 0.05). The mean infusion time after the occurrence of IRRs was also shorter in the rapid infusion group than in the standard infusion group (F = 24.781, p < 0.001). Conclusion The 110‐min rapid infusion DARA regimen is feasible and safe for use in Chinese MM patients.
Journal Article