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Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. Distant metastasis is thought to be one of the most important factors responsible for the failure of NSCLC therapy. MicroRNA-7-5p (miR-7-5p) has been demonstrated to be a tumor suppressor in breast cancer, hepatocarcinoma, prostate cancer and glioblastoma multiforme (GBM). However, its role in NSCLC is still not fully understood. This study evaluated the role of miR-7-5p in the progression of NSCLC and explored the underlying mechanism. Materials & methods The quantitative real-time PCR (qPCR), MTT, migration and invasion assays were used to evaluate the effects of miR-7-5p on the proliferation, migration and invasion of A549 and SPCA-1 cells. A tumor xenograft model was created to determine the effects of miR-7-5p on metastasis in vivo. The dual-luciferase reporter gene, neuro-oncological ventral antigen 2 (NOVA2) overexpression and western blotting assays were performed to explore the underlying mechanism. Results MiR-7-5p is downregulated in NSCLC tissues and lung cancer cell lines. It suppresses proliferation, migration, invasion and EMT marker expression in vitro and in vivo. Further study showed that miR-7-5p suppresses tumor metastasis of NSCLC by targeting NOVA2. Overexpression of NOVA2 attenuates the miR-7-5p-mediated inhibitory effect on lung cancer cells. Conclusion MiR-7-5p suppresses NSCLC metastasis. Targeting miR-7-5p may contribute to the success of NSCLC therapy.

High alkali-metal sulfate contents in ash from high-alkali coal are a result of the alkali metals’ strong sulfur-capturing capacity. In this work, the effects of sulfates in ash on SO 3 formation were investigated by adding alkali-metal sulfates (Na 2 SO 4 and K 2 SO 4 ) to ash and performing experiments to simulate SO 3 formation. The results show that Na 2 SO 4 and K 2 SO 4 addition significantly increased SO 3 formation and the formation rate increased with increasing temperature. The formed SO 3 concentration increased by 6.8 ppm (adding Na 2 SO 4 ) and 6.3 ppm (adding K 2 SO 4 ) at 1000 °C. These increases are the result of SO 3 release from sulfate during the formation of aluminosilicates such as NaAlSi 3 O 8 (albite), NaAlSiO 4 (nepheline), KAlSiO 4 (kalsilite), and KAlSi 3 O 8 (feldspar) with the SiO 2 and Al 2 O 3 in the ash. This was confirmed by X-ray diffraction (XRD) and thermodynamic calculation. In addition, increasing the SO 2 concentration increased the SO 3 concentration and decreased the SO 3 conversion ratio. Graphical abstract Note: This data is mandatory.

Single-frequency GPS/BeiDou navigation satellite system (BDS) real-time kinematic (RTK) and inertial navigation system (INS) integration has wide range of application prospects due to the global deployment of GPS along with the rapid development of BDS. The instantaneous single-frequency ambiguity resolution will be significantly improved by the combined GPS/BDS and INS configuration. Owing to road conditions and an inertial measurement unit (IMU) on the carrier not being rigidly mounted, biased measurements in the IMU will occasionally emerge, leading to biased INS predictions. However, bias or inaccuracy from INS-predicted position can prevent the successful resolution of the whole set of ambiguities. This paper proposes the use of a positional polynomial fitting (PPF) constraint to compensate for the epochs with abnormal INS predictions. The aid from PPF is provided at two levels, i.e., at the ambiguity resolution (AR) level and at the solution level. In order to further increase the availability of ambiguity-fixed positioning solutions, a partial ambiguity resolution (PAR) strategy is introduced when full ambiguity resolution (FAR) fails. A field vehicular experiment was performed to show the validity of the proposed PPF-aided method by comparing different schemes regarding different INS-aided satellite system configurations, different AR strategies, and whether the PPF-aided method was adopted. The results show that the most attractive scheme is to combine the PAR with the PPF-aided dual-constellation and INS integration.

Zinc-extraction kiln slag is a hazardous solid waste rich in heavy metals. It is a great challenge to utilize it economically and harmlessly. This study aims to convert this zinc-extraction kiln slag (proportion of 50–60%) into solid-waste ceramics, by simultaneously utilizing other solid waste, fly ash, and desulfurization gypsum. By using X-ray diffraction, leaching experiments, and SEM analysis, the paper studied the solid-waste ceramics ‘ability to solidify heavy metals. Under optimal conditions, C5 (zinc-extraction kiln slag, desulfurization gypsum, and fly ash with mass percentages of 60:20:20, at a sintering temperature of 1180 °C) shows an excellent performance with 43.02 MPa bending strength and 0.74% water absorption. The solidification ratios of Cr, Mn, Ni, Cu, and Zn were all exceed 97%. The main phases in the solid-waste ceramics were diopside and hematite. Diopside can efficiently solidify Zn, Mn, and Ni, while Cr and Cu can be solidified in the minor phase of spinel. During the sintering process, the ceramics produced the liquid phase, which promoted crystallization for solid solution of heavy metals and accelerated densification by elimination of pores. The ceramic system with diopside as the main phase not only shows excellent performance but also effectively solidifies heavy metals. Therefore, it is suitable for the resource utilization of metallurgical solid wastes containing heavy metals.

In order to study the emission characteristics of the products during the blending of antibiotic residues in coal-fired power plants, blending tests were performed on a 140 t/h circulating fluidized bed boiler. It was found that during combustion, 64 to 87.6% of Cr, As, and Pb are concentrated in the fly ash, and 11.4 to 35% are concentrated in the bottom ash. Only a small amount of these elements are captured by the desulfurization system or enter the environment. During the material distribution of the desulfurization system, trace elements are mostly concentrated in gypsum. In the desulfurization system, the proportion of Cr, As, Pb, Be, Mn, Co, Ni, Se, and Mo in the gypsum range from 82.8 to 99.9%, and the content has reached the level of ppm. When the blending ratio is controlled within 7%, the blending of antibiotic residues has little effect on the elemental composition of coal. The contents of Cr, Ni, Cu, Zn, and Ba in the products increased by 9.5 to 22.3%. This may mean when the blending ratio is increased, it will be harmful to the environment.

Abstract Boerhaave syndrome is a rare but potentially life-threatening condition. Although various optimized treatment methods have contributed to an improvement in the cure rate. However, cases with chronic esophageal pleural fistula and empyema resulting from delayed diagnosis or inadequate treatment occasionally occur. Chronic esophageal pleural fistula and empyema lead to long-term consumption and significant decline in quality of life for patients. We present a case of chronic esophageal-pleural fistula complicated by empyema formation following Boerhaave syndrome, which remained unresolved over a two-year period. A favorable clinical outcome was achieved after the performance of modified thoracoplasty.

We described two cases with idiopathic bronchoesophageal fistula presented recurrent postprandial coughing. Abnormal tracts connecting the oesophagus and bronchus were identified by videofluoroscopy. Thoracoscopic surgery was successfully performed, which involved the resection of the fistula and the interposition of a pedicle of viable parietal pleura between oesophageal and bronchial closures. Neither patient experienced symptoms of any subsequent complications.

Long non-coding RNAs (lncRNAs) are important regulatory factors in tumor development and progression. The lncRNA CASC9.5 is located on chromosome 8 and has a total length of 1316 bp. CASC9.5 plays a tumor-promoting role in the development and progression of brain tumor and colon cancer; however, limited research has been conducted on the role of this lncRNA in lung adenocarcinoma. The present study analyzed 44 lung adenocarcinoma specimens and 2 lung cancer cell lines. It was found that CASC9.5 expression levels were significantly higher in lung cancer tissues and cells compared with normal lung tissues. In addition, the expression level of CASC9.5 was closely related to the TNM ( tumor , node and metastasis) stage of lung adenocarcinomas, tumor size, tumor metastasis and tumor metabolism. Moreover, results of the in vivo and in vitro experiments all demonstrated that CASC9.5 promoted lung adenocarcinoma cell proliferation and metabolism by regulating the expression levels of cyclin D1, E-cadherin, N-cadherin and β-catenin. In summary, the present study demonstrated that high levels of CASC9.5 expression promote the proliferation, metastasis and metabolism of lung adenocarcinoma cells and might serve as a prognostic indicator. The present study provides novel findings regarding the diagnosis and treatment of lung adenocarcinoma.

There are many accidents of slope failure due to rainfall at home and abroad, which have caused heavy casualties and property losses. Stability analysis and evaluation of slope have become a research hotspot. Aiming at the slope stability under different rainfall, this paper takes Yuebao Open-pit Mine slope as an example, has constructed a dynamic variable weight (VW) model of influencing factors on slope stability, and has analyzed the dynamic change and correlation of the slope indexes weights under different monthly maximum rainfall. On this basis, the dynamic evaluation model of slope stability has been established based on uncertainty measurement (UM), and the risk importance (RI) q which is proposed has quantitatively evaluated the risk degree of slope. The results show that under different monthly maximum rainfall the weight of each index is no longer a fixed value but a nonlinear and dynamic change law, and there is a strong correlation among the monthly maximum rainfall, internal friction angle, and cohesion. In addition, the q increases gradually with the increase of the monthly maximum rainfall, and the stability evaluation results are highly consistent with the HP1 slope, which have verified the reliability of the dynamic evaluation model. So, it can provide technical support for the safety production and management of open-pit slope and can also provide reference for related research.

The effects of slag, fly ash (formed in boiler above 1500 °C), and experimental ash (formed in muffle furnace at 815 °C) on the formation of sulfur trioxide (SO 3 ) were studied in a fixed bed rector. The results showed that the slag had the best catalytic effect on SO 3 formation, the effect of fly ash was second, and the effect of experimental ash was the worst. The reason may be that the forms of iron in different samples were different. Iron in the experimental ash all existed in the form of Fe 2 O 3 . Iron in the fly ash mainly existed in the form of composite iron oxides, such as Fe 0.3 Mg 0.7 SiO 3 , Ca 3 Fe 2 (SiO 4 ) 3 , and MgFe 2 O 4 . Iron in the slag also mainly existed in the form of composite iron oxides, such as CaFe 2 O 4 , MgFe 2 O 4 , and CaMgO 0.88 Fe 0.12 SiO 4 . The different forms of iron had different effects on SO 3 formation. Composite iron oxides could produce more oxygen vacancies owing to lattice defects. This likely promoted the migration and regeneration of lattice oxygen and thus better promoted the formation of SO 3 than Fe 2 O 3 . Moreover, MgFe 2 O 4 and Ca 3 Fe 2 (SiO 4 ) 3 could better promote SO 3 formation than CaMgO 0.88 Fe 0.12 SiO 4 and Fe 0.3 Mg 0.7 SiO 3 . In addition, increasing the SO 2 concentration and O 2 concentration increased the SO 3 concentration but increasing the SO 2 concentration decreased the SO 3 formation ratio.