Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
18,042
result(s) for
"Xiao, Jie"
Sort by:
How lithium dendrites form in liquid batteries
Studies of interfacial reactions and mass transport may allow safe use of lithium metal anodes Conventional rechargeable lithium (Li)–ion batteries generally use graphite as the anode, where Li ions are stored in the layered graphite. However, the use of Li metal as the anode is now being reconsidered. These next-generation battery technologies could potentially double the cell energy of conventional Li-ion batteries ( 1 ). Rechargeable Li metal batteries were commercialized more than four decades ago but were in use only briefly because of safety concerns ( 2 ). With the advancements of electrolyte ( 3 , 4 ), electrode architecture ( 5 ), and characterization techniques ( 6 ) in recent years, a better fundamental understanding of the interfacial reactions during charging and discharging that dictate cell performance has developed and inspired a reevaluation of the use of Li metal anodes in rechargeable batteries.
Journal Article
تحديث الاقتصاد الصيني
في كتابه \"تحديث الاقتصاد الصيني\" يتناول تشياو جنغ عملية الإصلاح الاقتصادي في الصين خلال ثلاثة عقود تم فيها وصف التطور السريع لاقتصاد الصين ب\"المعجزة الاقتصادية\"، ولكنه وصف غير دقيق -بتعبير المؤلف- وبمعنى أكثر دقة، يعتبر التطور السريع لاقتصاد الصين مجرد عملية انتعاش اقتصادي. إنها عملية مواكبة لاقتصادات الأسواق في المناطق المتقدمة.
Book
T Cell Dysfunction in Cancer Immunity and Immunotherapy
In cancer, T cells become dysfunctional owing to persistent antigen exposure. Dysfunctional T cells are characterized by reduced proliferative capacity, decreased effector function, and overexpression of multiple inhibitory receptors. Due to the presence of various inhibitory signals in the complex tumor microenvironment, tumor-specific T cells have distinct dysfunction states. Therapeutic reactivation of tumor-specific T cells has yielded good results in cancer patients. Here, we review the hallmarks of T cell dysfunction in cancer. Also, we discuss the relationship between T cell dysfunction and cancer immunotherapy.
Journal Article
Gut Microbiota and Acute Central Nervous System Injury: A New Target for Therapeutic Intervention
Acute central nervous system (CNS) injuries, including stroke, traumatic brain injury (TBI), and spinal cord injury (SCI), are the common causes of death or lifelong disabilities. Research into the role of the gut microbiota in modulating CNS function has been rapidly increasing in the past few decades, particularly in animal models. Growing preclinical and clinical evidence suggests that gut microbiota is involved in the modulation of multiple cellular and molecular mechanisms fundamental to the progression of acute CNS injury-induced pathophysiological processes. The altered composition of gut microbiota after acute CNS injury damages the equilibrium of the bidirectional gut-brain axis, aggravating secondary brain injury, cognitive impairments, and motor dysfunctions, which leads to poor prognosis by triggering pro-inflammatory responses in both peripheral circulation and CNS. This review summarizes the studies concerning gut microbiota and acute CNS injuries. Experimental models identify a bidirectional communication between the gut and CNS in post-injury gut dysbiosis, intestinal lymphatic tissue-mediated neuroinflammation, and bacterial-metabolite-associated neurotransmission. Additionally, fecal microbiota transplantation, probiotics, and prebiotics manipulating the gut microbiota can be used as effective therapeutic agents to alleviate secondary brain injury and facilitate functional outcomes. The role of gut microbiota in acute CNS injury would be an exciting frontier in clinical and experimental medicine.
Journal Article
Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer
Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but few clinical studies have explored its relationship with response to immune checkpoint inhibitors (ICIs). Here we report results from cohort 1 of the prospective observational STRESS-LUNG study, which investigated the association between ED and clinical efficacy of first-line treatment of ICIs in patients with advanced non-small-cell lung cancer. ED was assessed by Patient Health Questionnaire-9 and Generalized Anxiety Disorder 7-item scale. The study included 227 patients with 111 (48.9%) exhibiting ED who presented depression (Patient Health Questionnaire-9 score ≥5) and/or anxiety (Generalized Anxiety Disorder 7-item score ≥5) symptoms at baseline. On the primary endpoint analysis, patients with baseline ED exhibited a significantly shorter median progression-free survival compared with those without ED (7.9 months versus 15.5 months, hazard ratio 1.73, 95% confidence interval 1.23 to 2.43,
P
= 0.002). On the secondary endpoint analysis, ED was associated with lower objective response rate (46.8% versus 62.1%, odds ratio 0.54,
P
= 0.022), reduced 2-year overall survival rate of 46.5% versus 64.9% (hazard ratio for death 1.82, 95% confidence interval 1.12 to 2.97,
P
= 0.016) and detriments in quality of life. The exploratory analysis indicated that the ED group showed elevated blood cortisol levels, which was associated with adverse survival outcomes. This study suggests that there is an association between ED and worse clinical outcomes in patients with advanced non-small-cell lung cancer treated with ICIs, highlighting the potential significance of addressing ED in cancer management. ClinicalTrials.gov registration:
NCT05477979
.
In a prospective observational study, symptoms of anxiety and/or depression were associated with worse response to first-line treatment with immunotherapy in patients with advanced non-small-cell lung cancer.
Journal Article
Lung transplantation as therapeutic option in acute respiratory distress syndrome for coronavirus disease 2019-related pulmonary fibrosis
Critical patients with the coronavirus disease 2019 (COVID-19), even those whose nucleic acid test results had turned negative and those receiving maximal medical support, have been noted to progress to irreversible fatal respiratory failure. Lung transplantation (LT) as the sole therapy for end-stage pulmonary fibrosis related to acute respiratory distress syndrome has been considered as the ultimate rescue therapy for these patients.
From February 10 to March 10, 2020, three male patients were urgently assessed and listed for transplantation. After conducting a full ethical review and after obtaining assent from the family of the patients, we performed three LT procedures for COVID-19 patients with illness durations of more than one month and extremely high sequential organ failure assessment scores.
Two of the three recipients survived post-LT and started participating in a rehabilitation program. Pearls of the LT team collaboration and perioperative logistics were summarized and continually improved. The pathological results of the explanted lungs were concordant with the critical clinical manifestation, and provided insight towards better understanding of the disease. Government health affair systems, virology detection tools, and modern communication technology all play key roles towards the survival of the patients and their rehabilitation.
LT can be performed in end-stage patients with respiratory failure due to COVID-19-related pulmonary fibrosis. If confirmed positive-turned-negative virology status without organ dysfunction that could contraindicate LT, LT provided the final option for these patients to avoid certain death, with proper protection of transplant surgeons and medical staffs. By ensuring instant seamless care for both patients and medical teams, the goal of reducing the mortality rate and salvaging the lives of patients with COVID-19 can be attained.
Journal Article
Oxidative stress marker aberrations in children with autism spectrum disorder: a systematic review and meta-analysis of 87 studies (N = 9109)
There is increasing awareness that oxidative stress may be implicated in the pathophysiology of autism spectrum disorder (ASD). Here we aimed to investigate blood oxidative stress marker profile in ASD children by a meta-analysis. Two independent investigators systematically searched Web of Science, PubMed, and Cochrane Library and extracted data from 87 studies with 4928 ASD children and 4181 healthy control (HC) children. The meta-analysis showed that blood concentrations of oxidative glutathione (GSSG), malondialdehyde, homocysteine, S-adenosylhomocysteine, nitric oxide, and copper were higher in children with ASD than that of HC children. In contrast, blood reduced glutathione (GSH), total glutathione (tGSH), GSH/GSSG, tGSH/GSSG, methionine, cysteine, vitamin B9, vitamin D, vitamin B12, vitamin E, S-adenosylmethionine/S-adenosylhomocysteine, and calcium concentrations were significantly reduced in children with ASD relative to HC children. However, there were no significance differences between ASD children and HC children for the other 17 potential markers. Heterogeneities among studies were found for most markers, and meta-regressions indicated that age and publication year may influence the meta-analysis results. These results therefore clarified blood oxidative stress profile in children with ASD, strengthening clinical evidence of increased oxidative stress implicating in pathogenesis of ASD. Additionally, given the consistent and large effective size, glutathione metabolism biomarkers have the potential to inform early diagnosis of ASD.
Journal Article
Literati Ingredients in the 17th-Century Chinese Christian Paintings
In this paper, the modification methods of the Chinese Christian painting created by the missionaries in the late Ming Dynasty (1573–1644) were analyzed with the Chinese Catholic studies of the “Song nianzhu guicheng” and the “Tianzhu Jiangsheng Chuxiang Jingjie”. After carefully studying the differences between the Chinese Christian painting and the original European version, the study shows that these Chinese Christian paintings were integrated with the Chinese literati paintings’ elements and literati symbols, which include the “Yudiancun” (raindrop texture stroke), “Pimacun” (hemp-fiber texture stroke), “landscape screen” (painted screens with natural landscapes), and the mark of Chinese famous literati such as Dong Qichang. These adjustments conducted by missionaries aimed to make religious paintings more in line with literati aesthetics, which could build connections between the missionaries and the literati community for proselytization. However, the missionaries neglected that the literati community certainly would not sacrifice the existing social order and the vested interest brought by the current Confucian culture to support new ideas of “liberty” and “equality” in the Catholic doctrine, which caused a huge setback in the missionary work since the Nanjing Teaching Case in 1616. This research makes significant contributions to the understanding of cultural exchanges in the 17th century through a detailed exploration of the adjustments made by missionaries in the visual representations within Chinese Catholic literature.
Journal Article
Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis
Recent interest in the control of bone metabolism has focused on a specialized subset of CD31
hi
endomucin
hi
vessels, which are reported to couple angiogenesis with osteogenesis. However, the underlying mechanisms that link these processes together remain largely undefined. Here we show that the zinc-finger transcription factor ZEB1 is predominantly expressed in CD31
hi
endomucin
hi
endothelium in human and mouse bone. Endothelial cell-specific deletion of ZEB1 in mice impairs CD31
hi
endomucin
hi
vessel formation in the bone, resulting in reduced osteogenesis. Mechanistically, ZEB1 deletion reduces histone acetylation on
Dll
4 and
Notch1
promoters, thereby epigenetically suppressing Notch signaling, a critical pathway that controls bone angiogenesis and osteogenesis. ZEB1 expression in skeletal endothelium declines in osteoporotic mice and humans. Administration of
Zeb1
-packaged liposomes in osteoporotic mice restores impaired Notch activity in skeletal endothelium, thereby promoting angiogenesis-dependent osteogenesis and ameliorating bone loss. Pharmacological reversal of the low ZEB1/Notch signaling may exert therapeutic benefit in osteoporotic patients by promoting angiogenesis-dependent bone formation.
An endothelial cell subtype, expressing endomucin and CD31, has been reported to couple angiogenesis with osteogenesis. Here, the authors show that loss of ZEB1 in these cells epigenetically suppresses Notch signaling, leading to impaired angiogenesis and osteogenesis, and that Zeb1 delivery via liposomes ameliorates bone loss in osteoporotic mice
Journal Article