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"Xie, Hui"
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Reconfigurable multifunctional ferrofluid droplet robots
Magnetically actuated miniature soft robots are capable of programmable deformations for multimodal locomotion and manipulation functions, potentially enabling direct access to currently unreachable or difficult-to-access regions inside the human body for minimally invasive medical operations. However, magnetic miniature soft robots are so far mostly based on elastomers, where their limited deformability prevents them from navigating inside clustered and very constrained environments, such as squeezing through narrow crevices much smaller than the robot size. Moreover, their functionalities are currently restricted by their predesigned shapes, which is challenging to be reconfigured in situ in enclosed spaces. Here, we report a method to actuate and control ferrofluid droplets as shape-programmable magnetic miniature soft robots, which can navigate in two dimensions through narrow channels much smaller than their sizes thanks to their liquid properties. By controlling the external magnetic fields spatiotemporally, these droplet robots can also be reconfigured to exhibit multiple functionalities, including on-demand splitting and merging for delivering liquid cargos and morphing into different shapes for efficient and versatile manipulation of delicate objects. In addition, a single-droplet robot can be controlled to split into multiple subdroplets and complete cooperative tasks, such as working as a programmable fluidic-mixing device for addressable and sequential mixing of different liquids. Due to their extreme deformability, in situ reconfigurability and cooperative behavior, the proposed ferrofluid droplet robots could open up a wide range of unprecedented functionalities for lab/organ-on-a-chip, fluidics, bioengineering, and medical device applications.
Journal Article
فرص شبكة الجيل الخامس (5G) : أي فرص تحملها لنا شبكة الجيل الخامس (5G) ؟ وكيف نغتنم هذه الفرص ؟
يثير الجيل الخامس (5G) متابعة العالم بأسره ويحظى أيضا باهتمام في الصين من القمة إلى القاعدة، وكل ذلك يبرهن على أمر معين وهو ما يتحلى به الناس من تطلع عميق تجاه الجيل الخامس (5G) بعد أن عشنا الجيل الرابع من الاتصالات (4G) ونحن على ثقة بأن الجيل الخامس (5G) يمثل فرصة كبرى لتغيير العالم ؛ فما الفرص التي سيجلب لنا الجيل الخامس (5G) يا ترى ؟ ومتى ستظهر هذه الفرص ؟ وكيف تغتنمها ؟ ؛ بعد فترة طويلة من المراقبة والتحليل والإحساس ومن خلال رسم خط مستقيم من الفرص ونظرة استشرافية شاركنا خبير الاتصالات شيانغ لي قانغ فرص الجيل الخامس (5G)، وهذا لم يسمح للمزيد من الناس بمعرفة ما الذي يعنيه الجيل الخامس (5G) فحسب، بل اطلعوا بشكل أوضح على ما يكن أن ينجز الجيل الخامس (5G) واستوعبوا أكثر من ذلك ما يمكن أن يفعله كل واحد منا من خلال الجيل الخامس (5G)
BOOK
Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in major depressive disorder patients
The microbiota-gut-brain axis, especially the microbial tryptophan (Trp) biosynthesis and metabolism pathway (MiTBamp), may play a critical role in the pathogenesis of major depressive disorder (MDD). However, studies on the MiTBamp in MDD are lacking. The aim of the present study was to analyze the gut microbiota composition and the MiTBamp in MDD patients.
We performed shotgun metagenomic sequencing of stool samples from 26 MDD patients and 29 healthy controls (HCs). In addition to the microbiota community and the MiTBamp analyses, we also built a classification based on the Random Forests (RF) and Boruta algorithm to identify the gut microbiota as biomarkers for MDD.
The Bacteroidetes abundance was strongly reduced whereas that of Actinobacteria was significantly increased in the MDD patients compared with the abundance in the HCs. Most noteworthy, the MDD patients had increased levels of Bifidobacterium, which is commonly used as a probiotic. Four Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologies (KOs) (K01817, K11358, K01626, K01667) abundances in the MiTBamp were significantly lower in the MDD group. Furthermore, we found a negative correlation between the K01626 abundance and the HAMD scores in the MDD group. Finally, RF classification at the genus level can achieve an area under the receiver operating characteristic curve of 0.890.
The present findings enabled a better understanding of the changes in gut microbiota and the related Trp pathway in MDD. Alterations of the gut microbiota may have the potential as biomarkers for distinguishing MDD patients form HCs.
Journal Article
Bioinspired thermadapt shape-memory polymer with light-induced reversible fluorescence for rewritable 2D/3D-encoding information carriers
Fluorescent materials have attracted widespread attention for information encryption owing to their stimuli-responsive color-shifting. However, the 2D encoding of fluorescent images poses a risk of information leakage. Herein, inspired by the mimic octopus capable of camouflage by changing colors and shapes, we develop a thermadapt shape-memory fluorescent film (TSFF) for integrating 2D/3D encoding in one system. The TSFF is based on anthracene group with reversible photo-cross-linking and poly (ethylene-co-vinyl acetate) network with thermadapt shape-memory properties. The reversible photo-cross-linking of anthracene is accompanied by repeatable fluorescence-shifting and enables rewritable 2D encoding. Meanwhile, the thermadapt shape-memory properties not only enables the reconfiguration of the permanent shape for creating and erasing 3D patterns, i.e., rewritable 3D information, but also facilitates recoverable shape programming for 3D encoding. This rewritable 2D/3D encoding strategy can enhance information security because only designated inspectors can decode the information by providing sequential heating for shape recovery and UV exposure. Overall, TSFF capable of rewritable 2D/3D encoding will inspire the design of smart materials for high-security information carriers.
The stimuli responsive color-shifting properties of fluorescent materials have been used for 2D encoding for information encryption applications but possessing a risk of information leakage. Here, the authors develop shape-memory fluorescent films with reversible fluorescence-shifting and thermadapt shape-memory properties for integrating rewritable 2D/3D encoding in one system.
Journal Article
Nanocontainers-enhanced self-healing Ni coating for corrosion protection of Mg alloy
Self-healing coating based on nanocontainers (NCs) has been emerging as a great strategy to improve the anticorrosion ability of susceptible metal substrate. However, all the research referred to such smart coating to date is focus on organic coating instead of metallic coating. To fill this gap, 2-mercaptobenzothiazole (MBT) loaded porous hollow SiO
2
NCs are synthesized and incorporated successfully into an electroless Ni coating on Mg alloy in this work. The surface morphologies and the loading properties of the NCs are characterized by scanning electron microscopy, transmission electron microscopy, ultraviolet–visible spectrophotometer, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy. The favorable performance of Ni coating after incorporation of NCs is demonstrated by potentiodynamic polarization (PDP), linear polarization, and electrochemical impedance spectroscopy. Based on the results of PDP test, the corrosion current density (
i
c
) of the MBT@NCs (MNCs)-engineered Ni coating reduces slightly from 6.4 to 5.4 μA cm
−2
after immersion in a corrosive media, while the value for MNCs-free coating increases by almost a factor of ten from 6.8 to 67.4 μA cm
−2
. Our findings demonstrate the possibility of using corrosion inhibitors loaded NCs to enhance the corrosion resistance of a metallic coating and give new perspectives for functionalization of a metallic coating with nanomaterials.
Journal Article
Conciliatory Anti-Allergic Decoction Attenuates Pyroptosis in RSV-Infected Asthmatic Mice and Lipopolysaccharide (LPS)-Induced 16HBE Cells by Inhibiting TLR3/NLRP3/NF-κB/IRF3 Signaling Pathway
Respiratory syncytial virus (RSV) infection can deteriorate asthma by inducing persistent airway inflammation. Increasing evidence elucidated that pyroptosis plays a pivotal role in asthma. Conciliatory anti-allergic decoction (CAD) exhibits an anti-inflammatory effect in ovalbumin (OVA)-induced asthma; however, the effects and mechanisms of CAD in RSV-infected asthmatic mice have not yet been elucidated. The RSV-infected asthmatic mice model and lipopolysaccharide (LPS)-induced 16HBE cell pyroptosis model were established, respectively. Pulmonary function, ELISA, and histopathologic analysis were performed to assess the airway inflammation and remodeling in mice with CAD treatment. Furthermore, ultra-performance liquid chromatography-quadrupole time-of-flight/mass spectrometry (UPLC-Q-TOF/MS) was conducted to identify the chemical compounds of high-dose CAD (30 g/kg). Cell viability and apoptosis of 16HBE cells were assessed by CCK-8 and flow cytometry assays, respectively. Finally, the expression levels of apoptosis-, pyroptosis-, and TLR3/NLRP3/NF-κB/IRF3 signaling-related genes were measured with qRT-PCR or western blotting, respectively. Pulmonary function tests showed that CAD significantly ameliorated respiratory dysfunction, airway hyperresponsiveness, inflammation cell recruitment in BALF, pulmonary inflammation, collagen deposition, and cell death in lung tissues. CAD significantly decreased the content of TNF-α, IL-13, IL-4, IL-1β and IL-5 in the bronchoalveolar lavage fluid (BALF), IL-17, IL-6, and OVA-specific IgE in serum and increased serum IFN-γ in asthma mice. The results of UPLC-Q-TOF/MS showed that high-dose CAD had 88 kinds of chemical components. In vitro, CAD-contained serum significantly suppressed LPS-induced 16HBE cell apoptosis. Additionally, CAD and CAD-contained serum attenuated the up-regulated expressions of Bax, Cleaved caspase-3, NLRP3, ASC, Cleaved caspase-1, GSDMD-N, IL-18, IL-1β, TLR3, p-P65, p-IκBα, and IRF3 but increased Bcl-1 and GSDMD levels in the asthma mice and LPS-induced 16HBE cells, respectively. These results illustrated that CAD may have a potential role in improving airway inflammation and pyroptosis through inhibition of the TLR3/NLRP3/NF-κB/IRF3 signaling pathway.
Journal Article
A Self‐Assembly Pro‐Coagulant Powder Capable of Rapid Gelling Transformation and Wet Adhesion for the Efficient Control of Non‐Compressible Hemorrhage
Rapid and effective control of non‐compressible massive hemorrhage poses a great challenge in first‐aid and clinical settings. Herein, a biopolymer‐based powder is developed for the control of non‐compressible hemorrhage. The powder is designed to facilitate rapid hemostasis by its excellent hydrophilicity, great specific surface area, and adaptability to the shape of wound, enabling it to rapidly absorb fluid from the wound. Specifically, the powder can undergo sequential cross‐linking based on “click” chemistry and Schiff base reaction upon contact with the blood, leading to rapid self‐gelling. It also exhibits robust tissue adhesion through covalent/non‐covalent interactions with the tissues (adhesive strength: 89.57 ± 6.62 KPa, which is 3.75 times that of fibrin glue). Collectively, this material leverages the fortes of powder and hydrogel. Experiments with animal models for severe bleeding have shown that it can reduce the blood loss by 48.9%. Studies on the hemostatic mechanism also revealed that, apart from its physical sealing effect, the powder can enhance blood cell adhesion, capture fibrinogen, and synergistically induce the formation of fibrin networks. Taken together, this hemostatic powder has the advantages for convenient preparation, sprayable use, and reliable hemostatic effect, conferring it with a great potential for the control of non‐compressible hemorrhage. To control the non‐compressible hemorrhage, an efficient self‐assembly biocompatible powder is prepared. Owing to the ingenious materials’ design, it can rapidly gelling transform, realize wet adhesion and exert pro‐coagulant bioactivity, fully leveraging the fortes of powder‐ and hydrogel‐type. Moreover, the outstanding hemostatic performance is synthetically verified in rat, rabbit, and canine hemorrhage models, signifying it a promising hemostatic material.
Journal Article
Minimally invasive transforaminal lumbar interbody fusion versus oblique lateral interbody fusion for lumbar degenerative disease: a meta-analysis
Background
Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and oblique lateral interbody fusion (OLIF) are widely used in the treatment of lumbar degenerative diseases. In the present study, a meta-analysis was conducted to compare the clinical and radiographic efficacy of these two procedures.
Methods
A systematic literature review was performed, and the quality of retrieved studies was evaluated with the Newcastle-Ottawa Scale (NOS). Clinical outcomes, including operation time, intraoperative blood loss, improvement in Visual Analogue Scale (VAS), improvement in Oswestry Disability Index (ODI), Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) effectiveness rate and complications, in addition to radiographic outcomes, including restoration of disc height, disc angle, overall lumbar lordosis, fusion rate and subsidence, were extracted and input into a fixed or random effect model to compare the efficacy of MIS-TLIF and OLIF.
Results
Seven qualified studies were included. Clinically, OLIF resulted in less intraoperative blood loss and shorter operation time than MIS-TLIF. Improvement of VAS for leg pain was more obvious in the OLIF group (
P
< 0.0001), whereas improvement of VAS for back pain (
P
= 0.08) and ODI (
P
= 0.98) as well as JOABPEQ effectiveness rate (
P
= 0.18) were similar in the two groups. Radiographically, OLIF was more effective in restoring disc height (
P
= 0.01) and equivalent in improving the disc angle (
P
= 0.18) and lumbar lordosis (
P
= 0.48) compared with MIS-TLIF. The fusion rate (
P
= 0.11) was similar in both groups, while the subsidence was more severe in the MIS-TLIF group (
P
< 0.00001).
Conclusions
The above evidence suggests that OLIF is associated with a shorter operation time (with supplementary fixation in the prone position) and less intraoperative blood loss than MIS-TLIF and can lead to better leg pain alleviation, disc height restoration and subsidence resistance. No differences regarding back pain relief, functional recovery, complications, disc angle restoration, lumbar lordosis restoration and fusion rate were found. However, due to the limited number of studies, our results should be confirmed with high-level studies to fully compare the therapeutic efficacy of MIS-TLIF and OLIF.
Trial registration
PROSPERO ID:
CRD42020201903
.
Journal Article