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In this paper, we propose a secure multi-party summation based on single photons. With the help of a semi-honest third party, n participants can simultaneously obtain the summation result without revealing their secret inputs. Our protocol uses single photon states as the information carriers. In addition, each participant with secret input only performs simple single-particle operators rather than particle preparation and any complex quantum measurements. These features make our protocol more feasible to implement. We demonstrate the correctness and security of the proposed protocol, which is resistant to participant attack and outside attack. In the end, we compare in detail the performance of the quantum summation protocol in this paper with other schemes in terms of different indicators. By comparison, our protocol is efficient and easy to implement.

Nao-an Dropping Pill (NADP) is a Chinese patent medicine which commonly used in clinic for ischemic stroke (IS). However, the material basis and mechanism of its prevention or treatment of IS are unclear, then we carried out this study. 52 incoming blood components were resolved by UHPLC-MS/MS from rat serum, including 45 prototype components. The potential active prototype components hydroxysafflor yellow A, ginsenoside F1, quercetin, ferulic acid and caffeic acid screened by network pharmacology showed strongly binding ability with PIK3CA, AKT1, NOS3, NFE2L2 and HMOX1 by molecular docking. In vitro oxygen–glucose deprivation/reperfusion (OGD/R) experimental results showed that NADP protected HA1800 cells from OGD/R-induced apoptosis by affecting the release of LDH, production of NO, and content of SOD and MDA. Meanwhile, NADP could improve behavioral of middle cerebral artery occlusion/reperfusion (MCAO/R) rats, reduce ischemic area of cerebral cortex, decrease brain water and glutamate (Glu) content, and improve oxidative stress response. Immunohistochemical results showed that NADP significantly regulated the expression of PI3K, Akt, p-Akt, eNOS, p-eNOS, Nrf2 and HO-1 in cerebral ischemic tissues. The results suggested that NADP protects brain tissues and ameliorates oxidative stress damage to brain tissues from IS by regulating PI3K/Akt/eNOS and Nrf2/HO-1 signaling pathways.

Designer chromosomes are artificially synthesized chromosomes. Nowadays, these chromosomes have numerous applications ranging from medical research to the development of biofuels. However, some chromosome fragments can interfere with the chemical synthesis of designer chromosomes and eventually limit the widespread use of this technology. To address this issue, this study aimed to develop an interpretable machine learning framework to predict and quantify the synthesis difficulties of designer chromosomes in advance. Through the use of this framework, six key sequence features leading to synthesis difficulties were identified, and an eXtreme Gradient Boosting model was established to integrate these features. The predictive model achieved high-quality performance with an AUC of 0.895 in cross-validation and an AUC of 0.885 on an independent test set. Based on these results, the synthesis difficulty index (S-index) was proposed as a means of scoring and interpreting synthesis difficulties of chromosomes from prokaryotes to eukaryotes. The findings of this study emphasize the significant variability in synthesis difficulties between chromosomes and demonstrate the potential of the proposed model to predict and mitigate these difficulties through the optimization of the synthesis process and genome rewriting.

A three-dimensional model of CMSX-6 superalloy coupons was built in the paper, temperature field was calculated with software ProCAST. The temperature values of coupons were indicated from the measurement at the rate of 3 mm min-1 withdrawal velocity during directional solidification process, and the temperature gradient of different location of the coupons were calculated. It turned out that: the simulated results and the measured results are in good agreement; due to the different medial and lateral affected by radiation, isotherms showed sloped distributions in the process of the withdrawal; the temperature gradient of the measured positions in the coupons which are 10 mm, 50 mm, 100 mm, 150 mm far from the copper chill, are 8.0 Kmm-1, 3.0 Kmm-1, 2.5 Kmm-1, 1.8 Kmm-1 respectively.

Outer-cryostat is one of the important equipments of the International Thermonuclear Experimental Reactor (ITER). It is the outer part of ITER Tokomak that can offer the vacuum to avoid the great quantity of thermal force influencing the magnet system. In order to improve the efficiency of designing and modifying the system of the outer-cryostat, this paper will research on the exploitation of a sort of software which is based on the CATIA that can conquer the field of parametric design of the outer-cryostat, facing to the complex construction of outer-cryostat with numerous parts.

AlN thin films are of continuing interest for excitation of acoustic waves in surface and bulk acoustic wave devices. We report herein on preparation and characterization of c -axis inclined AlN films by a new method of rotating the substrate holder plate to different angles in an off-center system. The microstructure of the c -axis inclined AlN films was investigated using x-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The analyses showed that polycrystalline AlN films with c -axis inclination of up to 12° could be obtained using the off-center system. Solidly mounted resonators based on the deposited c -axis inclined and vertical AlN films were successfully realized. The frequency responses showed dual-mode resonance characteristics located at 1.12 GHz and 1.87 GHz, corresponding to shear and longitudinal resonant modes, respectively.

OBJECTIVE To explore the extent of lymphadenectomy deemed reasonable by analyzing the infl uence of the regular pattern and ratio of lymph node metastasis on the prognosis of the patients with middle third thoracic esophageal squamous cell carcinoma. METHODS Clinical data from 129 patients with middle third thoracic esophageal squamous cell carcinoma who underwent curative esophagectomy with modern two-fi eld lymphadenectomy were retrospectively analyzed. RESULTS The rate of lymphatic metastasis in EC patients was 56.6% in all groups, and the ratio of lymph node metastasis (RLNM, i.e. positive nodes/total dissected nodes) was 11.3%, with a lymphatic metastasis rate of 43.4% in the superior mediastinum. The most commonly involved regions included the sites around the esophagus, the right recurrent laryngeal nerve and the left-sided blood vessels of stomach, as well as the cardia and the inferior tracheal protuberance. The main factors influencing lymphatic metastasis were the depth of tumor infiltration, differentiation of tumor cells and the size of the tumor. The 5-year survival rate for patients in the groups without lymphatic metastasis, with a RLNM ≤ 20%, and a metastasis ratio > 20% was 50.4%, 31.0% and 6.8%, respectively. The differences were statistically significant among the groups (P = 0.000). CONCLUSION The RLNM is one of the key factors affecting the prognosis of EC patients. For conventional therapy for patients with middle third thoracic esophageal carcinoma, modern 2-field lymphadenectomy, including node dissection in the bilateral superior mediastinum, should be performed.