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Existing research has often characterized religious rituals as formalized and predetermined actions involving collective participation, emphasizing their structured and communal nature. However, our empirical findings revealed that rituals, shaped by citizens’ healing needs, can also be individualized and intentionally constructed behaviors. These individualized rituals were not rooted in religious beliefs, but are closely connected to Chinese citizens’ strong healing needs, which have developed in a highly mobile and socially competitive (“involuted”) society. These rituals are characterized by their orientation toward life concerns, self-interested motives, and perceived connections to mystical power. These qualities enable rituals to fulfill a broader range of healing functions. Rituals not only had a direct impact on anxiety relief, especially health and class anxiety, but also had a beneficial effect on adjustment of individual goal or behavior and social inclusion.

Airborne fungi are one of the most ubiquitous kinds of inhalant allergens which can result in allergic diseases. Fungi tend to grow in warm and humid environments with regional and seasonal variations. Their nomenclature and taxonomy are related to the sensitization of immunoglobulin E (IgE). Allergic cross-reactivity among different fungal species appears to be widely existing. Fungus-related foods, such as edible mushrooms, mycoprotein, and fermented foods by fungi, can often induce to fungus food allergy syndrome (FFAS) by allergic cross-reactivity with airborne fungi. FFAS may involve one or more target organs, including the oral mucosa, the skin, the gastrointestinal and respiratory tracts, and the cardiovascular system, with various allergic symptoms ranging from oral allergy syndrome (OAS) to severe anaphylaxis. This article reviews the current knowledge on the field of allergic cross-reactivity between fungal allergens and related foods, as well as the diagnosis and treatment on FFAS.

Preeclampsia (PE) is a common pregnancy disorder, and mounting evidence has revealed that circular RNA participates in PE development. However, the detailed molecular mechanism of circ_0007611 in PE progression remains unknown. RNA expressions of circ_0007611, microRNA-558 (miR-558), and IL-1 receptor accessory protein (IL1RAP) were detected by quantitative real-time polymerase chain reaction. Cell proliferation was investigated by clonogenicity, 5-Ethynyl-29-deoxyuridine, and DNA content quantitation assays. Cell apoptotic rate and angiogenesis were analyzed by cell apoptosis and tube formation assays, respectively. Protein expression was detected by western blot. The binding relationship between miR-558 and circ_0007611 or IL1RAP was identified by a dual-luciferase reporter or RNA immunoprecipitation assay. Circ_0007611 and IL1RAP expressions were significantly upregulated, while miR-558 was downregulated in the placental tissues of PE women in comparison with normal placental tissues. Functionally, circ_0007611 overexpression inhibited trophoblast cell proliferation and angiogenesis and induced cell apoptosis; however, circ_0007611 downregulation showed the opposite effects. Mechanistically, circ_0007611 acted as a miR-558 sponge, and miR-558 bound to IL1RAP. Besides, miR-558 overexpression or IL1RAP absence relieved circ_0007611-induced trophoblast cell dysfunction. Moreover, miR-558 contributed to cell proliferation and tube formation and inhibited cell apoptosis by reducing IL1RAP expression in trophoblast cells. Circ_0007611 aggravated trophoblast cell disorders by the miR-558/IL1RAP pathway in PE.

BackgroundMigraine has been recognized as one of common diseases in the world whose current treatment options are not ideal. Lasmiditan, an oral 5-hydroxytryptamine (HT)1F receptor agonist, appears more promising for the acute treatment of migraine because of considerably better effect profiles with no severe adverse events (AEs). This review aimed to systematically evaluate the efficacy and safety of lasmiditan from the results of randomized controlled trials (RCTs).MethodsPubMed, Cochrane Library, Embase were searched on lasmiditan for the acute treatment of migraine from inception of the databases to Feb 1, 2020. Pain free and pain relief, global impression (very much/much better), and no/mild disability at 2 h in efficacy; total treatment-emergent adverse events (TEAEs), dizziness, nausea, fatigue, paraesthesia and somnolence in safety were extracted from the included studies. A systematic review and meta-analysis was performed using Review Manager Software version 5.3 (RevMan 5.3).ResultsFour RCTs with a total of 4960 subjects met our inclusion criteria. The overall effect estimate showed that lasmiditan was significantly superior to placebo in terms of pain free (RR 1.71, 95% CI 1.55–1.87), pain relief (RR 1.40, 95% CI 1.33–1.47), global impression (very much/much better) (RR 1.55, 95% CI 1.44–1.67), and no/mild disability (RR 1.15, 95% CI 1.10–1.20) at 2 h. For the safety, significant number of patients experienced TEAEs with lasmiditan than with placebo (RR 2.77, 95% CI 2.53–3.03), most TEAEs were central nervous system (CNS)-related and included dizziness (RR 5.81, 95% CI 4.72–7.14), nausea (RR 2.58, 95% CI 1.87–3.57), fatigue (RR 5.38, 95% CI 3.78–7.66), paraesthesia (RR 4.48, 95% CI 3.33–6.02), and somnolence (RR 2.82, 95% CI 2.18–3.66).ConclusionsThis meta-analysis suggests that lasmiditan is effective for the acute treatment of migraine with a higher incidence of CNS-related adverse reactions compared with placebo. Long-term, open-label, multi-dose trials are required to verify the current findings.

Background Chimeric antigen receptor engineered T cells (CAR-T) have demonstrated extraordinary efficacy in B cell malignancy therapy and have been approved by the US Food and Drug Administration for diffuse large B cell lymphoma and acute B lymphocytic leukemia treatment. However, treatment of T cell malignancies using CAR-T cells remains limited due to the shared antigens between malignant T cells and normal T cells. CD5 is considered one of the important characteristic markers of malignant T cells and is expressed on almost all normal T cells but not on NK-92 cells. Recently, NK-92 cells have been utilized as CAR-modified immune cells. However, in preclinical models, CAR-T cells seem to be superior to CAR-NK-92 cells. Therefore, we speculate that in addition to the short lifespan of NK-92 cells in mice, the costimulatory domain used in CAR constructs might not be suitable for CAR-NK-92 cell engineering. Methods Two second-generation anti-CD5 CAR plasmids with different costimulatory domains were constructed, one using the T-cell-associated activating receptor-4-1BB (BB.z) and the other using a NK-cell-associated activating receptor-2B4 (2B4.z). Subsequently, BB.z-NK and 2B4.z-NK were generated. Specific cytotoxicity against CD5 + malignant cell lines, primary CD5 + malignant cells, and normal T cells was evaluated in vitro. Moreover, a CD5 + T cell acute lymphoblastic leukemia (T-ALL) mouse model was established and used to assess the efficacy of CD5-CAR NK immunotherapy in vivo. Results Both BB.z-NK and 2B4.z-NK exhibited specific cytotoxicity against CD5 + malignant cells in vitro and prolonged the survival of T-ALL xenograft mice. Encouragingly, 2B4.z-NK cells displayed greater anti-CD5 + malignancy capacity than that of BB.z-NK, accompanied by a greater direct lytic side effect versus BB.z-NK. Conclusions Anti-CD5 CAR-NK cells, particularly those constructed with the intracellular domain of NK-cell-associated activating receptor 2B4, may be a promising strategy for T cell malignancy treatment.

Despite economic development and social changes, folk religion in China has not died out, but has survived and has even experienced a revival. Oscillating state policies have in general had a strong impact on religion in China. Though there is no official recognition of ethnic folk-religions, the state classifies them positively as manifestations of local cultural heritage and in this context has supported—not stifled—public folk religious practices among the Tu. This study deals with folk religious’ practice among the Tu ethnic group in Northwest China. The article highlights animist ontology as a theoretical perspective for analyzing the religious practices of the Tu ethnic group in China. The authors carried out anthropological procedures of participant observation and interviewing in the Tu community distributed in Qinghai Province and now present a portrait of the folk religion in typical Tu communities located in Minhe County and Huzhu County. The article also discusses the tripartite cosmology of the Tu and the positive interactions with national authorities. Quite apart from the issue of the impact of the state, the authors document, via prolonged ethnographic immersion in two regions, that the folk religion of the Tu is also closely linked to, and continues to have an impact on, daily life, particularly with regard to the construction and maintenance of ethnic community structure. This paper is organized as follows. First, we present ethnographic information on the religious beliefs and ritual practices of the Tu. The subsequent section then discusses how public folk-religious performances receive support from the state in the context of tourism and local economic development and how they contribute to the maintenance of community structure and social order. The conclusion summarizes the process by which ethnic folk religions have not only survived, but, in part as a result of state support for ethnic cultural heritage, experienced a revival.

Background Chimeric antigen receptor-engineered T (CAR-T) cells have extraordinary effect in treating lymphoblastic leukemia. However, treatment of acute myeloid leukemia (AML) using CAR-T cells remains limited to date. Leukemogenesis always relates with the abnormalities of cytogenetics, and nearly one third of AML patients have activating mutations in Fms-like tyrosine kinase 3 (FLT3) which reminded poor prognosis. Considering the FLT3 expressed in AML patients’ blast cells, it may be a new candidate target for CAR-T therapy to treat FLT3 + AML, especially patients harboring FLT3-ITD mutation. Methods The FLT3L CAR-T using FLT3 ligand as recognizing domain was constructed. The specific cytotoxicity against FLT3 + leukemia cell lines, primary AML cells, and normal hematopoietic progenitor stem cells (HPSCs) in vitro were evaluated. In addition, FLT3 + AML mouse model was used to assess the effect of FLT3L CAR-T therapy in vivo. Results FLT3L CAR-T cells could specifically kill FLT3 + leukemia cell lines and AML patients’ bone marrow mononuclear cells in vitro (with or without FLT3 mutation) and have more potent cytotoxicity to FLT3-ITD cells. In a human FLT3 + AML xenograft mouse model, FLT3L CAR-T cells could significantly prolong the survival of mice. Furthermore, it was found that FLT3L CAR-T cells could activate the FLT3/ERK signaling pathway of FLT3 + leukemia cells with wild-type FLT3; meanwhile, it had no inhibitory effects on the colony formation of CD34 + stem cells derived from normal human umbilical cord blood. Conclusions The ligand-based FLT3L CAR-T cells could be a promising strategy for FLT3 + AML treatment, especially those carried FLT3 mutation.

Acute myeloid leukemia (AML) is a biologically and clinically heterogeneous disease with a dismal prognosis and limited treatment options. Chimeric antigen receptor (CAR) T cells have achieved unprecedented clinical responses in patients with B cell malignancies but a dismal consequences in AML. In our previous study, we found that interleukin-10 receptor (IL-10R) was overexpressed in most AML cells, and played an important role in promoting the stemness of leukemia cells. In this study, we developed a novel ligand-based CAR-T cell targeting IL-10R, which displayed striking cytotoxicity both in vitro and in vivo against AML cells. Except for monocytes, it had no significant adverse effects on the normal hematopoietic system, including CD34+ hematopoietic stem and progenitor cells (HSPCs). In addition, even though the incorporation of IL-10 in the CAR cassette led to phenotypes change, it had few adverse effects on the survival and biological activity of IL-10 CAR-T cells and did not cause excessive proliferation of leukemia cells. Therefore, we propose IL-10R is a novel promising therapeutic candidate for AML, and IL-10R targeted CAR-T therapy provides a new treatment strategy to improve the prognosis of AML.

Glioblastoma (GBM) is an aggressive and highly heterogeneous brain tumor that continues to pose a significant clinical challenge. Current therapeutic strategies, including surgical resection, radiotherapy, and chemotherapy, are hindered by the tumor’s invasive behavior, resistance to treatment, and the difficulty of selectively targeting tumor cells. Emerging modalities, such as immunotherapy and photodynamic therapy, hold considerable promise; however, their efficacy in treating GBM is limited by critical barriers, including poor penetration of the blood-brain barrier (BBB), tumor heterogeneity, and insufficient accumulation of therapeutic agents at the tumor site. In this study, innovative biomimetic copper selenide nanoparticles (CS@CM) are developed for targeted photothermal therapy of GBM. These nanoparticles are functionalized with glioma cell membranes (CM), and this biomimetic design leverages the homing capability of the membranes to achieve efficient BBB penetration and enhanced targeting of GBM tissues. CS@CM act as potent photothermal agents upon light activation, which can amplify reactive oxygen species-induced oxidative stress to damage glioma cells. Such combination therapy effectively triggers immunogenic cell death to achieve splendid antitumor efficacy, offering a promising therapeutic strategy for GBM. Collectively, this approach addresses the limitations of conventional treatments, paving the way for improved clinical outcomes in managing this formidable malignancy. Graphical Abstract

Background The purpose of this study is to evaluate the reliability and validity of the multiple happiness questionnaire (MHQ) in new-generation migrant workers (NGMW), to compare the difference of well-being and Health-Related Quality of Life (HRQOL) in NGMW with first-generation migrant workers (FGMW) and urban workers (UW), and to explore the relationship between well-being and HRQOL and analyze influential factors to well-being in NGMW in Zhejiang province, China. Methods By stratified sampling, 542 NGMW, 226 FGMW and 200 UW had completed the questionnaires in 2018. Cronbach’s alpha coefficient (a) for internal consistency of the multiple happiness questionnaire (MHQ) was used. Factor analysis was applied for construct validity. Scores of well-being and HRQOL were compared between NGMW and control groups. Spearman’s correlation was performed to clarify the relationship between well-being and HRQOL in NGMW. Multiple linear regression analytical methods were used to adjust confounding effects and to identify the variables that were associated with well-being. Results MHQ had good internal consistency (Cronbach’s alpha overall was 0.960, subscales ranged from 0.754 to 0.957) and structural validity based on factor analysis. Except for life satisfaction and altruism commitment, there was a positive correlation between well-being and HRQOL in NGMW. There were significant differences in psychological well-being (PWB), health concern, subjective vitality, physical component summary (PCS) and mental component summary (MCS) between NGMW and FGMW. Compared to UW, NGMW’s general well-being (GWB), subjective well-being (SWB), life satisfaction, positive relation and altruism commitment scores were lower and their negative affect was higher. The GWB score was related to MCS, PCS, self-reported social status, marital status, age and monthly income. Conclusion The results suggest that the MHQ is a reliable and valid measure for well-being in NGMW. There is a significant difference in well-being and HRQOL between NGMW and control groups. Well-being is higher in NGMW than in FGMW, but is lower than in UW. Well-being is related with HRQOL and may be affected by MCS, PCS, self-reported social status, marital status, age and monthly income in NGMW.