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"Xu, Chen"
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Online health communities influence people’s health behaviors in the context of COVID-19
The online health community has the functions of online consultation, health record management and disease information interaction as an online medical platform. In the context of the pandemic, the existence of online health communities has provided a favorable environment for information acquisition and knowledge sharing among different roles, effectively improving the health of human, and popularizing health knowledge. This paper analyzes the development and importance of domestic online health communities, and sorts out users’ participation behaviors, types of behaviors, and continuous participation behaviors, influence motives, and motivational patterns in online health communities. Taking the operation status of the online health community during the pandemic period as an example, the computer sentiment analysis method was used to obtain seven categories of participation behaviors and the proportion of various behaviors of online health community users, and the conclusion is: the emergence of the pandemic, making the online health community a platform where people are more inclined to choose to consult health issues, and user interaction behaviors have become more active on the platform.
Journal Article
SERS Tags for Biomedical Detection and Bioimaging
Surface-enhanced Raman scattering (SERS) has emerged as a valuable technique for molecular identification. Due to the characteristics of high sensitivity, excellent signal specificity, and photobleaching resistance, SERS has been widely used in the fields of environmental monitoring, food safety, and disease diagnosis. By attaching the organic molecules to the surface of plasmonic nanoparticles, the obtained SERS tags show high-performance multiplexing capability for biosensing. The past decade has witnessed the progress of SERS tags for liquid biopsy, bioimaging, and theranostics applications. This review focuses on the advances of SERS tags in biomedical fields. We first introduce the building blocks of SERS tags, followed by the summarization of recent progress in SERS tags employed for detecting biomarkers, such as DNA, miRNA, and protein in biological fluids, as well as imaging from
cell, bacteria, tissue to
tumors. Further, we illustrate the appealing applications of SERS tags for delineating tumor margins and cancer diagnosis. In the end, perspectives of SERS tags projecting into the possible obstacles are deliberately proposed in future clinical translation.
Journal Article
Prevalence and socio-demographic correlates of psychological health problems in Chinese adolescents during the outbreak of COVID-19
Psychological health problems, especially emotional disorders, are common among adolescents. The epidemiology of emotional disorders is greatly influenced by stressful events. This study sought to assess the prevalence rate and socio-demographic correlates of depressive and anxiety symptoms among Chinese adolescents affected by the outbreak of COVID-19. We conducted a cross-sectional study among Chinese students aged 12–18 years during the COVID-19 epidemic period. An online survey was used to conduct rapid assessment. A total of 8079 participants were involved in the study. An online survey was used to collect demographic data, assess students’ awareness of COVID-19, and assess depressive and anxiety symptoms with the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) questionnaire, respectively. The prevalence of depressive symptoms, anxiety symptoms, and a combination of depressive and anxiety symptoms was 43.7%, 37.4%, and 31.3%, respectively, among Chinese high school students during the COVID-19 outbreak. Multivariable logistic regression analysis revealed that female gender was the higher risk factor for depressive and anxiety symptoms. In terms of grades, senior high school was a risk factor for depressive and anxiety symptoms; the higher the grade, the greater the prevalence of depressive and anxiety symptoms. Our findings show there is a high prevalence of psychological health problems among adolescents, which are negatively associated with the level of awareness of COVID-19. These findings suggest that the government needs to pay more attention to psychological health among adolescents while combating COVID-19.
Journal Article
m6A modification: recent advances, anticancer targeted drug discovery and beyond
Abnormal N6-methyladenosine (m6A) modification is closely associated with the occurrence, development, progression and prognosis of cancer, and aberrant m6A regulators have been identified as novel anticancer drug targets. Both traditional medicine-related approaches and modern drug discovery platforms have been used in an attempt to develop m6A-targeted drugs. Here, we provide an update of the latest findings on m6A modification and the critical roles of m6A modification in cancer progression, and we summarize rational sources for the discovery of m6A-targeted anticancer agents from traditional medicines and computer-based chemosynthetic compounds. This review highlights the potential agents targeting m6A modification for cancer treatment and proposes the advantage of artificial intelligence (AI) in the discovery of m6A-targeting anticancer drugs.
Graphical abstract
Three stages of m6A-targeting anticancer drug discovery: traditional medicine-based natural products, modern chemical modification or synthesis, and artificial intelligence (AI)-assisted approaches for the future.
Journal Article
التنمية الاقتصادية في الصين : الأقاليم الغربية نموذجا
يقدم هذا الكتاب رؤية صينية شاملة معززة ببيانات رسمية بأقلام عدد من المختصين الصينين البارزين في الشأن الاقتصادي والتنموي، لخطط الحكومة الصينية الخمسية، لشحذ كافة الجهود للنعوض بأحد عشر مقاطعة ومنطقة في غرب الصين في كافة المجالات الاقتصادية والاجتماعية، ويقدم كذلك عرضا مفصلا لكافة الدراسات المتعلقة بقدرات مناطق الغرب التنافسية في تسعى مجالات تشمل: القدرة التنافسية للاقتصاد الكلي، منافسة اقتصاد الصناعات، القدرة التنافسية للمؤسسات، القدرة التنافسية للعلوم والتعليم والابتكارات، القدرة التنافسية البيئية، القدرة التنافسية للموارد، القدرة التنافسية المالية، مناقسة الانفتاح على الخارج، ومنافسة الدور الحكومي.
Book
Exosomes derived from mesenchymal stem cells repair a Parkinson’s disease model by inducing autophagy
Parkinson’s disease (PD) is a progressively debilitating neurodegenerative condition that leads to motor and cognitive dysfunction. At present, clinical treatment can only improve symptoms, but cannot effectively protect dopaminergic neurons. Several reports have demonstrated that human umbilical cord mesenchymal stem cells (hucMSCs) afford neuroprotection, while their application is limited because of their uncontrollable differentiation and other reasons. Stem cells communicate with cells through secreted exosomes (Exos), the present study aimed to explore whether Exos secreted by hucMSCs could function instead of hucMSCs. hucMSCs were successfully isolated and characterized, and shown to contribute to 6-hydroxydopamine (6-OHDA)-stimulated SH-SY5Y cell proliferation; hucMSC-derived Exos were also involved in this process. The Exos were purified and identified, and then labeled with PKH 26, it was found that the Exos could be efficiently taken up by SH-SY5Y cells after 12 h of incubation. Pretreatment with Exos promoted 6-OHDA-stimulated SH-SY5Y cells to proliferate and inhibited apoptosis by inducing autophagy. Furthermore, Exos reached the substantia nigra through the blood–brain barrier (BBB) in vivo, relieved apomorphine-induced asymmetric rotation, reduced substantia nigra dopaminergic neuron loss and apoptosis, and upregulated the level of dopamine in the striatum. These results demonstrate that hucMSCs-Exos have a treatment capability for PD and can traverse the BBB, indicating their potential for the effective treatment of PD.
Journal Article