Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
24,990
result(s) for
"Xu, Fang"
Sort by:
لقاء في القرية العالمية = An encounter in the global village : قصص مختارة من المؤتمر الدولي الرابع عشر للقصة القصيرة
هذا الكتاب يحتوي على قصص مختارة من المؤتمر الدولي الرابع عشر للقصة القصيرة وهذا اللقاء الذي نظم من قبل جمعية دراسة القصص القصيرة الإنجليزية (أس أس أس أس إي) وهي جمعية عالمية أنشئت في الولايات المتحدة عام 1992 وينعقد كل عامين ويعتبر اللقاء العالمي الوحيد الذي يركز بشكل خاص على دراسات القصة القصيرة أما القصص المشاركة في اللقاء فهي مكتوبة من قبل 29 كاتبا ينتمون إلى عشرة دول هي الصين وتايوان والهند والولايات المتحدة وكندا ونيوزلندا وفرنسا وإيرلندا والنمسا وسنغافورا وجامايكا.
BOOK
Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses
K. galanga is an aromatic medicinal herb. It is locally to India and distributed in China, Myanmar, Indonesia, Malaysia, and Thailand. K. galanga is a Traditional Chinese Herb Medicine (TCHM), which has been applied to treat cold, dry cough, toothaches, rheumatism, hypertension and so on. In addition, it has been used widely as spices since its highly aromas. The aim of this review is to compile and update the current progresses of ethnomedicinal uses, phytochemistry, pharmacology and toxicology of K. galanga . All the data on K. galanga were based on different classical literary works, multiple electronic databases including SciFinder, Web of Science, PubMed, etc. The results showed that ninety-seven compounds have been identified from rhizome of K. galanga , including terpenoids, phenolics, cyclic dipeptides, flavonoids, diarylheptanoids, fatty acids and esters. Modern pharmacology studies revealed that extracts or secondary metabolites of the herb possessed anti-inflammatory, anti-oxidant, anti-tumorous, anti-bacterial, and anti-angiogenesis effects, which were closely related to its abundant ethnomedicinal uses. In conclusion, although previous research works have provided various information of K. galanga , more in-depth studies are still necessary to systemically evaluate phytochemistry, pharmacological activities, toxicity and quality control of this herb.
Journal Article
Catalytic enantioselective reductive alkynylation of amides enables one-pot syntheses of pyrrolidine, piperidine and indolizidine alkaloids
The primary objective in synthetic organic chemistry is to develop highly efficient, selective, and versatile synthetic methodologies, which are essential for discovering new drug candidates and agrochemicals. In this study, we present a unified strategy for a one-pot, catalytic enantioselective synthesis of α-alkyl and α,α′-dialkyl pyrrolidine, piperidine, and indolizidine alkaloids using readily available amides and alkynes. This synthesis is enabled by the identification and development of an Ir/Cu/
N
-PINAP catalyzed highly enantioselective and chemoselective reductive alkynylation of α-unbranched aliphatic amides, which serves as the key reaction. This reaction is combined with Pd-catalyzed tandem reactions in a one-pot approach, enabling the collective, catalytic enantioselective total syntheses of eight alkaloids and an anticancer antipode with 90–98%
ee
. The methodology’s enantio-divergence is exemplified by the one-step access to either enantiomer of alkaloid bgugaine.
Saturated α-alkyl aza-heterocycles are found in a wide array of bioactive molecules. Here, the authors disclosed a one-pot, catalytic enantioselective synthesis of pyrrolidine, piperidine and indolizidine alkaloids from amides and alkynes.
Journal Article
In situ photodeposition of platinum clusters on a covalent organic framework for photocatalytic hydrogen production
Photocatalytic hydrogen production has been considered a promising approach to obtain green hydrogen energy. Crystalline porous materials have arisen as key photocatalysts for efficient hydrogen production. Here, we report a strategy to in situ photodeposit platinum clusters as cocatalyst on a covalent organic framework, which makes it an efficient photocatalyst for light-driven hydrogen evolution. Periodically dispersed adsorption sites of platinum species are constructed by introducing adjacent hydroxyl group and imine-N in the region of the covalent organic framework structural unit where photogenerated electrons converge, leading to the in situ reduction of the adsorbed platinum species into metal clusters by photogenerated electrons. The widespread platinum clusters on the covalent organic framework expose large active surface and greatly facilitate the electron transfer, finally contributing to a high photocatalytic hydrogen evolution rate of 42432 μmol g
−1
h
−1
at 1 wt% platinum loading. This work provides a direction for structural design on covalent organic frameworks to precisely manipulate cocatalyst morphologies and positions at the atomic level for developing efficient photocatalysts.
Porous covalent organic frameworks have arisen as tunable photocatalysts for H
2
production. Here, authors report frameworks engineered with co-catalyst binding sites to improve photocatalytic H
2
evolution performances.
Journal Article
Clinical Findings in 111 Cases of Influenza A (H7N9) Virus Infection
Human infection with the novel avian-origin influenza A (H7N9) virus has aroused global concern. In this report, the clinical characteristics of 111 laboratory-confirmed cases in China are presented.
On March 30, 2013, three patients with fatal cases of rapid, progressive pneumonia were confirmed to be infected with a novel avian-origin influenza A (H7N9) virus that had not been detected in humans and animals previously.
1
,
2
The new human H7N9 viruses are the product of reassortment of viruses that are of avian origin.
Global attention was soon focused on the situation because of the increasing number of new cases and the high rate of death associated with these infections.
3
As of May 9, the World Health Organization (WHO) had reported 131 laboratory-confirmed cases, including 32 deaths.
4
However, data on . . .
Journal Article
An Isopotential Electron Titration Device Enables Real-Time Measurement of Transient Charge Transfer on Surfaces
Abdelrahman and co-workers developed a device to measure transient charge transfer during hydrogen dissociation on a Pt surface.Abdelrahman and co-workers developed a device to measure transient charge transfer during hydrogen dissociation on a Pt surface.
Journal Article
SubPhaser
• With advanced sequencing technology, dozens of complex polyploid plant genomes have been characterized. However, for many polyploid species, their diploid ancestors are unknown or extinct, making it impossible to unravel the subgenomes and genome evolution directly.
• We developed a novel subgenome-phasing algorithm, SubPhaser, specifically designed for a neoallopolyploid or a homoploid hybrid. SubPhaser first searches for the subgenome-specific sequence (k-mer), then assigns homoeologous chromosomes into subgenomes, and further provides tools to annotate and investigate specific sequences.
• SubPhaser works well on neoallopolyploids and homoploid hybrids containing subgenome-specific sequences like wheat, but fails on autopolyploids lacking subgenome-specific sequences like alfalfa, indicating that SubPhaser can phase neoallopolyploid/homoploid hybrids with high accuracy, sensitivity and performance.
• This highly accurate, highly sensitive, ancestral data free chromosome phasing algorithm, SubPhaser, offers significant application value for subgenome phasing in neoallopolyploids and homoploid hybrids, and for the subsequent exploration of genome evolution and related genetic/epigenetic mechanisms.
Journal Article
Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation
Immune checkpoint inhibitor (ICI)-induced myocarditis involves intensive immune/inflammation activation; however, its molecular basis is unclear. Here, we show that gasdermin-E (GSDME), a gasdermin family member, drives ICI-induced myocarditis. Pyroptosis mediated by GSDME, but not the canonical GSDMD, is activated in myocardial tissue of mice and cancer patients with ICI-induced myocarditis. Deficiency of GSDME in male mice alleviates ICI-induced cardiac infiltration of T cells, macrophages, and monocytes, as well as mitochondrial damage and inflammation. Restoration of GSDME expression specifically in cardiomyocytes, rather than myeloid cells, in GSDME-deficient mice reproduces ICI-induced myocarditis. Mechanistically, quantitative proteomics reveal that GSDME-dependent pyroptosis promotes cell death and mitochondrial DNA release, which in turn activates cGAS-STING signaling, triggering a robust interferon response and myocardial immune/inflammation activation. Pharmacological blockade of GSDME attenuates ICI-induced myocarditis and improves long-term survival in mice. Our findings may advance the understanding of ICI-induced myocarditis and suggest that targeting the GSDME-cGAS-STING-interferon axis may help prevent and manage ICI-associated myocarditis.
One-sentence summary
GSDME inflames ICI-associated myocarditis.
ICI-induced myocarditis is fatal, but its mechanism is unclear. Here, the authors identify GSDME as a key driver by promoting cGAS-STING signaling, enhancing our understanding of its pathogenesis.
Journal Article
Genome-wide identification, expression analysis of taars (trace amine-associated receptors) and response to cadaverine and putrescine in Mandarin fish (Siniperca chuatsi)
Background
The unique feeding behavior of
Siniperca chuatsi
(
S. chuatsi
), which exclusively consumes live fry and rejects dead fry, severely limits the development of its aquaculture industry. This rejection of dead fry likely stems from an aversion to necromones (death-associated odors). Although a subset of trace amine-associated receptors (TAARs) containing key conserved residues (Asp
3.32
and/or Asp
5.42
) are implicated in detecting amine-related odors, the
taar
gene members in
S. chuatsi
and their responsiveness to necromones remain unexplored.
Results
In this study, we found that the aversion of
S. chuatsi
to dead prey is associated with necromones. Furthermore, we identified 68
taar
family members in the
S. chuatsi
genome, distributed across six chromosomes, with 36 tandem duplication events generating 54 duplicated genes. Phylogenetic analysis classified
taar
s into two classes, Class I and Class III, with a total of eight subfamilies. Synteny analysis revealed low synteny between the
taar
s of
S. chuatsi
and
Dicentrarchus labrax
, with only 12 pairs of genes showing syntenic relationships. Protein sequence analysis demonstrated that
taar
s contain amine recognition sites,
N
-glycosylation, and conserved cysteine structures, with high conservation and purifying selection observed within subfamilies. Subcellular localization revealed that TAARs are localized to the cell membrane and nucleus. Transcriptome data indicated that 61
taar
s are expressed in the olfactory epithelium, while only 19 are expressed in the brain. The response of representative taars to putrescine and cadaverine was divergent when comparing olfactory and brain tissues.
Conclusions
This study systematically identified the
taar
gene family in
S. chuatsi
, analyzing their evolutionary relationships, protein structures, subcellular localization, expression profiles in olfactory and brain tissues, and the response of selected TAARs to necromones (cadaverine and putrescine). This work establishes a foundation for further investigation into TAAR-mediated death odor recognition in
S. chuatsi
.
Journal Article
Remaining useful life prediction of lithium–ion batteries via spatial attention TLSTM and dilated CNN with evolutionary optimization
The precise estimation of the Remaining Useful Life (RUL) of lithium–ion batteries is essential for averting unforeseen failures and enhancing operational efficiency and maintenance planning. This paper presents an advanced deep learning framework that couples a spatial-attention mechanism with a Transductive Long Short-Term Memory (TLSTM) model, augmented by one-dimensional dilated convolutional layers to capture long-range temporal dependencies. In contrast to traditional LSTM or GRU models, our methodology utilizes one-dimensional dilated convolutional layers to effectively capture long-range temporal relationships and implements a clustering-based Differential Evolution (DE) strategy for resilient weight initialization and optimization. This hybrid architecture boosts prediction robustness and solves the persistent issue of capacity regeneration effects, frequently neglected by previous models. Additionally, we offer a many-to-one multi-channel learning framework that incorporates several operational signals (voltage, current, temperature) instead of depending exclusively on single-channel capacity data. This invention minimizes parameter complexity while markedly enhancing generalization to unfamiliar settings. Extensive experiments performed on the publicly accessible NASA lithium–ion battery dataset reveal that the proposed model significantly outperforms existing state-of-the-art methods, achieving error reductions of over 10–14% and an exceptionally low Mean Absolute Percentage Error ranging from 0.0053 to 0.0095. These findings distinctly underscore the originality of our research: It represents the inaugural framework that amalgamates spatial attention-driven TLSTM with dilated convolution and clustering-based DE optimization in a multi-channel context, setting a new standard for precise and dependable RUL prediction in battery health monitoring and predictive maintenance applications.
Journal Article