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"Xu, Li"
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Acute respiratory failure in COVID-19: is it “typical” ARDS?
In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) was identified in Wuhan, China. The World Health Organization (WHO) declared this outbreak a significant threat to international health. COVID-19 is highly infectious and can lead to fatal comorbidities especially acute respiratory distress syndrome (ARDS). Thus, fully understanding the characteristics of COVID-19-related ARDS is conducive to early identification and precise treatment. We aimed to describe the characteristics of COVID-19-related ARDS and to elucidate the differences from ARDS caused by other factors. COVID-19 mainly affected the respiratory system with minor damage to other organs. Injury to the alveolar epithelial cells was the main cause of COVID-19-related ARDS, and endothelial cells were less damaged with therefore less exudation. The clinical manifestations were relatively mild in some COVID-19 patients, which was inconsistent with the severity of laboratory and imaging findings. The onset time of COVID-19-related ARDS was 8–12 days, which was inconsistent with ARDS Berlin criteria, which defined a 1-week onset limit. Some of these patients might have a relatively normal lung compliance. The severity was redefined into three stages according to its specificity: mild, mild-moderate, and moderate-severe. HFNO can be safe in COVID-19-related ARDS patients, even in some moderate-severe patients. The more likely cause of death is severe respiratory failure. Thus, the timing of invasive mechanical ventilation is very important. The effects of corticosteroids in COVID-19-related ARDS patients were uncertain. We hope to help improve the prognosis of severe cases and reduce the mortality.
Journal Article
Tomb Treasures : New Discoveries from China's Han Dynasty
\"This exhibition catalogue features archaeological discoveries found in kings' and other royalty's mausoleums and tombs from the Western Han dynasty (206 BCE-9 CE) in Jiangsu province, China. These royals lived extravagantly and, after death, were buried in grand style to ensure a prosperous afterlife. Royal mausoleums were furnished with enormous quantities of treasures comprising not only luxurious goods used in real life, but also artifacts made specifically for burial. About 100 objects (made of gold, silver, jade, bronze, pottery, lacquer, and other refined materials) will be featured, and most of these will be exhibited for the first time outside of China. Masterworks include a full-length jade suit sewn with gold threads, a huge coffin shrouded in jade, and a complete set of functional bronze bell chimes for court music\"-- Provided by publisher.
Book
Positivity bounds at one-loop level: the Higgs sector
A
bstract
In this paper, we promote the convex cone method of positive bounds from tree level to loop level. This method is general and can be applied to obtain leading
s
2
positivity bounds on the forward scattering process in the standard model effective field theory. To obtain the loop level bounds, the original tree level bounds are modified by loop corrections, which involve low dimensional coefficients. New positivity bounds being valid at one loop level on the four-Higgs scattering have been provided. We study some specific ultraviolet models to check the validity of the new bounds. In addition, the renormalisation group effect on positivity is explored. We point out that as long as the new bounds are satisfied at the cutoff scale Λ, they will also be satisfied at all scales below Λ.
Journal Article
وجوه لا تلتقيها مرتين : حكايات غير عادية عن أبطال عاديين
\"وجوه لا تلتقيها مرتين\" يروي حكايات غير عادية عن أبطال عاديين، ربما تجدهم في مجتمعك بغض النظر عن طبيعة تكوين هذا المجتمع أو نطاقه الجغرافي أو خلفياته الثقافية والاقتصادية، وهو كتاب واقعي غير مثالي، تعرض فيه الصحفية الشهيرة لي يوان تشنغ الأحداث الخفية والتفاصيل المبهمة التي أفرزت التنمية الصينية الهائلة، والنقلة الاجتماعية كتجربة غير مسبوقة، ولكن من منظور إنساني، فهو لا يتطرق إلى استراتيجيات ولا سياسات ولا خطط خمسية، بل يركز على الفرد، كونه إنسانا فحسب.
Book
Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment
The tumor microenvironment is a highly complex ecosystem of diverse cell types, which shape cancer biology and impact the responsiveness to therapy. Here, we analyze the microenvironment of esophageal squamous cell carcinoma (ESCC) using single-cell transcriptome sequencing in 62,161 cells from blood, adjacent nonmalignant and matched tumor samples from 11 ESCC patients. We uncover heterogeneity in most cell types of the ESCC stroma, particularly in the fibroblast and immune cell compartments. We identify a tumor-specific subset of CST1
+
myofibroblasts with prognostic values and potential biological significance. CST1
+
myofibroblasts are also highly tumor-specific in other cancer types. Additionally, a subset of antigen-presenting fibroblasts is revealed and validated. Analyses of myeloid and T lymphoid lineages highlight the immunosuppressive nature of the ESCC microenvironment, and identify cancer-specific expression of immune checkpoint inhibitors. This work establishes a rich resource of stromal cell types of the ESCC microenvironment for further understanding of ESCC biology.
The microenvironment of oesophageal squamous cell carcinomas (ESCC) is heterogeneous and can strongly impact response to treatment. Here, the authors characterize the ESCC tumour microenvironment with single-cell RNA-seq, finding CST1 + myofibroblasts with potential biological and prognostic significance as well as immunosuppression signatures.
Journal Article
Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting
Esophageal cancer (EC) is a type of aggressive cancer without clinically relevant molecular subtypes, hindering the development of effective strategies for treatment. To define molecular subtypes of EC, we perform mass spectrometry-based proteomic and phosphoproteomics profiling of EC tumors and adjacent non-tumor tissues, revealing a catalog of proteins and phosphosites that are dysregulated in ECs. The EC cohort is stratified into two molecular subtypes—S1 and S2—based on proteomic analysis, with the S2 subtype characterized by the upregulation of spliceosomal and ribosomal proteins, and being more aggressive. Moreover, we identify a subtype signature composed of ELOA and SCAF4, and construct a subtype diagnostic and prognostic model. Potential drugs are predicted for treating patients of S2 subtype, and three candidate drugs are validated to inhibit EC. Taken together, our proteomic analysis define molecular subtypes of EC, thus providing a potential therapeutic outlook for improving disease outcomes in patients with EC.
Proteomics can aid in the identification of molecular subtypes in cancers. Here, the authors perform proteomic profiling of 124 paired oesophageal cancer and adjacent non-tumour tissues and identify two subtypes that are associated with patient survival for therapeutic targeting.
Journal Article
The Internet of Things—A survey of topics and trends
The Internet of Things is a paradigm where everyday objects can be equipped with identifying, sensing, networking and processing capabilities that will allow them to communicate with one another and with other devices and services over the Internet to accomplish some objective. Ultimately, IoT devices will be ubiquitous, context-aware and will enable ambient intelligence. This article reports on the current state of research on the Internet of Things by examining the literature, identifying current trends, describing challenges that threaten IoT diffusion, presenting open research questions and future directions and compiling a comprehensive reference list to assist researchers.
Journal Article