Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
27,644
result(s) for
"Xu, Xin"
Sort by:
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19
Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein.
Journal Article
Bioceramics in Endodontics: Updates and Future Perspectives
Bioceramics, with excellent bioactivity and biocompatibility, have been widely used in dentistry, particularly in endodontics. Mineral trioxide aggregate (MTA) is the most widely used bioceramic in endodontics. Recently, many new bioceramics have been developed, showing good potential for the treatment of endodontic diseases. This paper reviews the characteristics of bioceramics and their applications in various clinical endodontic situations, including root-end filling, root canal therapy, vital pulp therapy, apexification/regenerative endodontic treatment, perforation repair, and root defect repair. Relevant literature published from 1993 to 2023 was searched by keywords in PubMed and Web of Science. Current evidence supports the predictable outcome of MTA in the treatment of endodontic diseases. Although novel bioceramics such as Biodentine, EndoSequence, and calcium-enriched mixtures have shown promising clinical outcomes, more well-controlled clinical trials are still needed to provide high-level evidence for their application in endodontics. In addition, to better tackle the clinical challenges in endodontics, efforts are needed to improve the bioactivity of bioceramics, particularly to enhance their antimicrobial activity and mechanical properties and reduce their setting time and solubility.
Journal Article
الثقة في النظرية : نجاح لنظام التنمية (البديل) الخاص بالصين
جاء هذا الكتاب تحت عنوان «الثقة في النظرية : نجاح لنظام التنمية \"البديل\" الخاص بالصين» وهو من تأليف (مايا غيو) وترجمة عبد الرحمن النجار. يبحث الكتاب في التطور الصيني السريع خلال الستة عقود الماضية، والدور الذي لعبه الحزب الشيوعي الصيني في تحويل الصين إلى دولة اشتراكية حديثة مزدهرة وقوية وديمقراطية ومتطورة ثقافيا ويستكشف ويستكشف فيما إذا كان صعود الصين يهدد نموذج التنمية الغربي وخاصة بعد أن أضحى صعود الصين حقيقة لا جدال فيها. يعتبر هذا الكتاب من أنجح الكتب التي نشرت عن الصين اليوم. فهو يقدم حججا مقنعة حول نهوض الصين. وتستند الآراء المعبر عنها في الكتاب ليس فقط إلى 60 عاما من تاريخ جمهورية الصين الشعبية وإنجازاتها الملحوظة في العقود الثلاثة الماضية، ولكن أيضا على تاريخها الحديث منذ عام 1840، وتاريخها الذي دام 2000 عام كدولة موحدة، وحضارتها ذات ال 5000 سنة. وتعكس المقابلات التي أجرتها المؤلفة \"مايا غيو\" مراقبتها الدقيقة للصين اليوم. إذ تضمنت أشخاصا من دوائر مختلفة، تشمل مجالات خبرتهم السياسة والاقتصاد والمجتمع والوضع الوطني وتاريخ دبلوماسية الحزب الشيوعي الصيني والاستراتيجية العسكرية وإدارة ممتلكات الدولة والرعاية الصحية والأعمال التجارية الخاصة. وتختلف موضوعات المقابلات على نطاق واسع؛ فمن النظم والنظرية والتطوير والإصلاح، إلى نوعية الحياة والاستراتيجية والدبلوماسية وجميع من كان فيها يؤيدون التعلم من الحضارات الإنسانية، ولكنهم يصرون في الوقت نفسه على ضرورة اتخاذ مسار يناسب الصين بدلا من استنساخ النموذج الغربي. يأتي هذا الكتاب من ضمن سلسلة تتألف من ثلاثة كتب وهي : الثقة في المسار : نموذج جديد لقوة صاعدة، الثقة في النظرية : فلسفة الصين لنظام دولي جديد، والثقة في النظام : نجاح نظام التنمية \"البديل\" في الصين. بما يوفر للقارئ مقاربة نظرية وواقعية لمسار الصين ونظريتها ونظامها، ويشرح أسباب ثقة الدولة الصينية في خياراتها.
Book
TranSIC-Net: An End-to-End Transformer Network for OFDM Symbol Demodulation with Validation on DroneID Signals
Demodulating Orthogonal Frequency Division Multiplexing (OFDM) signals in complex wireless environments remains a fundamental challenge, especially when traditional receiver designs rely on explicit channel estimation under adverse conditions such as low signal-to-noise ratio (SNR) or carrier frequency offset (CFO). Motivated by practical challenges in decoding DroneID—a proprietary OFDM-like signaling format used by DJI drones with a nonstandard frame structure—we present TranSIC-Net, a Transformer-based end-to-end neural network that unifies channel estimation and symbol detection within a single architecture. Unlike conventional methods that treat these steps separately, TranSIC-Net implicitly learns channel dynamics from pilot patterns and exploits the attention mechanism to capture inter-subcarrier correlations. While initially developed to tackle the unique structure of DroneID, the model demonstrates strong generalizability: with minimal adaptation, it can be applied to a wide range of OFDM systems. Extensive evaluations on both synthetic OFDM waveforms and real-world unmanned aerial vehicle (UAV) signals show that TranSIC-Net consistently outperforms least-squares plus zero-forcing (LS+ZF) and leading deep learning baselines such as ProEsNet in terms of bit error rate (BER), estimation accuracy, and robustness—highlighting its effectiveness and flexibility in practical wireless communication scenarios.
Journal Article
Dynamic evolution of the active center driven by hemilabile coordination in Cu/CeO2 single-atom catalyst
Hemilability is an important concept in homogeneous catalysis where both the reactant activation and the product formation can occur simultaneously through a reversible opening and closing of the metal-ligand coordination sphere. However, this effect has rarely been discussed in heterogeneous catalysis. Here, by employing a theoretical study on CO oxidation over substituted Cu
1
/CeO
2
single atom catalysts, we show that dynamic evolution of metal-support coordination can significantly change the electronic structure of the active center. The evolution of the active center is shown to either strengthen or weaken the metal-adsorbate bonding as the reaction proceeds from reactants, through intermediates, to products. As a result, the activity of the catalyst can be increased. We explain our observations by extending hemilability effects to single atom heterogenous catalysts and anticipate that introducing this concept can offer a new insight into the important role active site dynamics have in catalysis toward the rational design of more sophisticated single atom catalyst materials.
This work explores the concept of hemilability in single atom catalysts. The results imply that this effect can promote reactant activation and product desorption simultaneously to provide a potential approach to circumvent the Sabatier volcano.
Journal Article
Concise Review: Periodontal Tissue Regeneration Using Stem Cells: Strategies and Translational Considerations
Periodontitis is a widespread disease characterized by inflammation‐induced progressive damage to the tooth‐supporting structures until tooth loss occurs. The regeneration of lost/damaged support tissue in the periodontium, including the alveolar bone, periodontal ligament, and cementum, is an ambitious purpose of periodontal regenerative therapy and might effectively reduce periodontitis‐caused tooth loss. The use of stem cells for periodontal regeneration is a hot field in translational research and an emerging potential treatment for periodontitis. This concise review summarizes the regenerative approaches using either culture‐expanded or host‐mobilized stem cells that are currently being investigated in the laboratory and with preclinical models for periodontal tissue regeneration and highlights the most recent evidence supporting their translational potential toward a widespread use in the clinic for combating highly prevalent periodontal disease. We conclude that in addition to in vitro cell‐biomaterial design and transplantation, the engineering of biomaterial devices to encourage the innate regenerative capabilities of the periodontium warrants further investigation. In comparison to cell‐based therapies, the use of biomaterials is comparatively simple and sufficiently reliable to support high levels of endogenous tissue regeneration. Thus, endogenous regenerative technology is a more economical and effective as well as safer method for the treatment of clinical patients. Stem Cells Translational Medicine 2019;8:392–403
Periodontal regeneration can potentially be achieved via either the in vitro design of cell‐material constructs that may undergo remodeling and revascularization to integrate with the host tissue following transplantation or based on the in vivo manipulation of the cell‐material interplay at the target site to recruit endogenous stem cells to regenerate new tissues.
Journal Article
Predicting bowel necrosis in pediatric acute intussusception using roundness and other related factors
Objective
This study aimed to investigate the risk factors of intestinal necrosis in children with intussusception and intestinal necrosis was established.
Methods
The clinical data of children diagnosed with intestinal necrosis after surgical treatment in our hospital were retrospectively analyzed and assigned to the bowel necrosis group.A control group was established treated successfully with air enema, without bowel necrosis, during the same period. Ultrasonic manifestation and clinical features were recorded and analyzed. Factors associated with bowel necrosis were analyzed using univariate and multivariate unconditional logistic regression analyses.
Results
(1) The bowel necrosis group included a higher proportion of children under 12 months of age, and had more cases with blood flow signal < grade 4, peritoneal effusion, and bloody stools (
P
< 0.05) than the non-intestinal necrosis group. The values for roundness, concentric ring thickness, length of the intussuscepted segment, head-to-neck diameter ratio, bowel wall thickness, and neutrophil-to-lymphocyte ratio ( NLR) were all higher in the bowel necrosis group (
P
< 0.05). (2) The logistic regression analysis indicated that roundness (×100) [odds ratio (
OR
) = 1.397, 95% confidence interval (
CI
): 1.086–1.796] and blood flow signal (< grade 4) (
OR
= 0.099, 95%
CI
: 0.018–0.543) were independent predictors of bowel necrosis in intussusception.
Conclusions
Roundness and blood flow signal grading are independent predictors for diagnosing bowel necrosis in pediatric intussusception.
Journal Article