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Magnetic interlayer coupling is one of the central phenomena in spintronics. It has been predicted that the sign of interlayer coupling can be manipulated by electric fields, instead of electric currents, thereby offering a promising low energy magnetization switching mechanism. Here we present the experimental demonstration of voltage-controlled interlayer coupling in a new perpendicular magnetic tunnel junction system with a GdO x tunnel barrier, where a large perpendicular magnetic anisotropy and a sizable tunnelling magnetoresistance have been achieved at room temperature. Owing to the interfacial nature of the magnetism, the ability to move oxygen vacancies within the barrier, and a large proximity-induced magnetization of GdO x , both the magnitude and the sign of the interlayer coupling in these junctions can be directly controlled by voltage. These results pave a new path towards achieving energy-efficient magnetization switching by controlling interlayer coupling. Exploring electric field controlled magnetism enables high efficiency and low energy consumption spintronic devices. Here, by manipulating oxygen vacancies and magnetic moment, the authors achieve voltage control of magnetic interlayer coupling in GdO x based magnetic tunnel junctions.

A closed-loop control framework is developed for the co-flow jet (CFJ) airfoil by combining the numerical flow field environment of a CFJ0012 airfoil with a deep reinforcement learning (DRL) module called tensorforce integrated in Python. The DRL agent, which is trained through interacting with the numerical flow field environment, is capable of acquiring a policy that instructs the mass flow rate of the CFJ to make the stalled airfoil at an angle of attack (AoA) of 18 degrees reach a specific high lift coefficient set to 2.0, thereby effectively suppressing flow separation on the upper surface of the airfoil. The subsequent test shows that the policy can be implemented to find a precise jet momentum coefficient of 0.049 to make the lift coefficient of the CFJ0012 airfoil reach 2.01 with a negligible error of 0.5%. Moreover, to evaluate the generalization ability of the policy trained at an AoA of 18 degrees, two additional tests are conducted at AoAs of 16 and 20 degrees. The results show that, although using the policy gained under another AoA cannot help the lift coefficient of the airfoil reach a set target of 2 accurately, the errors are acceptable with less than 5.5%, which means the policy trained under an AoA of 18 degrees can also be applied to other AoAs to some extent. This work is helpful for the practical application of CFJ technology, as the closed-loop control framework ensures good aerodynamic performance of the CFJ airfoil, even in complex and changeable flight conditions.

A co-flow jet (CFJ), an active flow control method combining blowing and suction control, can effectively suppress the stall of airfoils. However, the streamwise jet channel along the upper surface of a conventional CFJ airfoil reduces the thickness and camber of the baseline, degrading the aerodynamic performance when the jet is inactive. The conformal slot CFJ airfoil was proposed to address this problem, but the design method is still absent. This paper proposed a general design method based on parameters including the slot angle, transition shape and distance of the injection and suction slot. The mechanism of the best parameter was analyzed. The designed conformal slot CFJ airfoil was checked under different jet intensities, and the turbine power curve was predicted when substituting CFJ airfoils for the baseline. Compared with the conventional CFJ airfoil, the designed conformal slot CFJ airfoil has three advantages: eliminating the performance loss when the jet is off, saving jet energy when suppressing the flow separation, and improving the power generation of wind turbines at low wind speeds.

Phosphatidylinositol-3 kinases (PI3K)-Protein kinase B (Akt)-mammalian target of rapamycin (mTOR) pathway plays an important role in the synthesis and secretion of triacylglycerol. However, the mechanism of PI3K-Akt-mTOR pathway in regulating lipid metabolism of goose liver was poorly understood. The purpose of this study was to determine how PI3K-Akt-mTOR pathway regulating lipid metabolic homeostasis in goose hepatocytes. Goose primary hepatocytes were treated with different PI3K-Akt-mTOR signal inhibitors (LY294002, rapamycin and NVP-BEZ235) for 24 h. The results showed that these inhibitors evidently inhibited PI3K-Akt-mTOR downstream signaling. Meanwhile, these PI3K-Akt-mTOR inhibitors reduced intracellular lipid accumulation, decreased the mRNA expression and protein content of genes involved in the de novo fatty acid synthesis, while increased the transcriptional and protein level of key factors involved in fatty acid oxidation and very low density lipoprotein (VLDL) assembly and secretion. Conclusion: These findings suggested that the reduction of lipids accumulation induced-by inhibiting PI3K-Akt-mTOR pathway was closely linked to the decrease of lipogenesis, the increase of fatty acids oxidation, and the increase of VLDL assembly and secretion in goose hepatocytes.

Yanbian yellow cattle are one of the top five largest breeds of cattle in China. We had previously found that bta-miR-1271 is differentially expressed in the longissimus dorsi muscles of Yanbian yellow bulls and steers. However, whether bta-miR-1271 affects bovine fat formation is unclear. In this study, we used target gene prediction, dual-luciferase reporter assay, and transfection-mediated overexpression and inhibition of bta-miR-1271 in a culture of Yanbian yellow cattle preadipocytes to investigate the role of bta-miR-1271 in adipogenesis. We showed that bta-miR-1271 directly targets the 3′-untranslated region (3′-UTR) of the activating transcription factor 3 (ATF3) mRNA and downregulates its expression. Overexpression of bta-miR-1271 enforced by the miRNA mimics promoted triglyceride accumulation and significantly upregulated expression of the adipogenic peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding protein α (C/EBPα) genes at both the protein and mRNA levels, as demonstrated by RT-qPCR and Western blot analyses. Conversely, inhibition of bta-miR-1271 expression produced the opposite effect. Our results show that bta-miR-1271 regulates differentiation of Yanbian yellow cattle preadipocytes by inhibiting ATF3 expression, which highlights the importance of microRNA-mediated regulation of adipogenesis. miR-1271 and its target gene(s) may provide a new research direction for investigating biological agents affecting intramuscular fat deposition in cattle.

As to low observable platform, one of the major contributing sources of target RCS is the scattering due to onboard antennas. So the research on RCS reduction of the antenna is important. In this paper, a holly-leaf-shaped monopole antenna with low RCS is designed. A square notch is etched to improve impedance matching and expand the bandwidth in the ground. The measured -10dB bandwidth is from 2.1 to 15.4GHz (only a little higher than -10dB around 7.5 GHz). The radiation patterns retain symmetry and are relatively stable at 2.5, 8 and 11 GHz. The monostatic RCS performance in four different incident cases is studied to obtain some helpful conclusions for the RCS reduction of the UWB antenna. The RCS achieves effective reduction in comparison with that of the reference antenna. The largest reduction is 4.1, 19.8, 3.9 dBsm in three different incident cases, respectively, while the largest loss of gain is only about -1.3dB. The antenna suits the occasion of desiring UWB antenna with low RCS.

The cotton (+)-delta-cadinene synthase (CAD1), a sesquiterpene cyclase, catalyzes a branch-point step leading to biosynthesis of sesquiterpene phytoalexins, including gossypol. CAD1-A is a member of CAD1 gene family, and its promoter contains a W-box palindrome with two reversely oriented TGAC repeats, which are the proposed binding sites of WRKY transcription factors. We isolated several WRKY cDNAs from Gossypium arboreum. One of them, GaWRKY1, encodes a protein containing a single WRKY domain and a putative N-terminal Leu zipper. Similar to genes encoding enzymes of cotton sesquiterpene pathway, GaWRKY1 was down-regulated in a glandless cotton cultivar that contained much less gossypol. GaWRKY1 showed a temporal and spatial pattern of expression comparable to that of CAD1-A in various aerial organs examined, including sepal, stigma, anther, and developing seeds. In suspension cells, expression of both GaWRKY1 and CAD1-A genes and biosynthesis of sesquiterpene aldehydes were strongly induced by a fungal elicitor preparation and methyl jasmonate. GaWRKY1 interacted with the 3 x W-box derived from CAD1-A promoter in yeast (Saccharomyces cerevisiae) one-hybrid system and in vitro. Furthermore, in transgenic Arabidopsis plants, overexpression of GaWRKY1 highly activated the CAD1-A promoter, and transient assay in tobacco (Nicotiana tabacum) leaves demonstrated that W-box was required for this activation. These results suggest that GaWRKY1 participates in regulation of sesquiterpene biosynthesis in cotton, and CAD1-A is a target gene of this transcription factor.

β-Elemene is commonly used as an anti-cancer agent in different types of cancers and its effects on glioblastoma have been studied through different pathways. However, its effect through ring finger protein 135 (RNF135, OMIM 611358) (RNF135), which is upregulated in glioblastomas, has not yet been explored. The current study is focused on the effects of β-elemene on human glioblastoma cell lines U251, U118, A172 and U87 through RNF13 5. A cell counting kit-8 assay and wound healing assay have been utilized to test the proliferation and migration of the cells. Western blot and quantitative real-time-polymerase chain reaction (qRT-PCR) were used to evaluate the level of expression of RNF135. A model of nude mice was used to explore progression of the tumor . It was observed that increasing treatment time or dose of β-elemene remarkably decreased viability of the cells. The cells that were treated with β-elemene had a much lower speed of moving toward the gap in comparison to untreated cell lines. β-Elemene-treated cells showed a much lower level of expression of RNF135 mRNA than control groups ( <0.05) and the levels of RNF135 protein were lower in the cells treated with β-elemene than in control groups ( <0.05). Moreover, tumor progression in subcutaneous xenograft nude mice was delayed with the injection of β-elemene. Altogether, our findings suggest that β-elemene inhibits proliferation, migration and tumorigenicity of human glioblastoma cells through suppressing RNF135.

Procurement is a critical supply chain management function that is susceptible to risk, due mainly to uncertain customer demand and purchase price volatility. A procurement approach in the form of a portfolio that incorporates the common procurement means is proposed. Such means include long-term contracts, spot procurements and option-based supply contracts. The objective is to explore possible synergies among the various procurement means, and so be able to produce optimal or near optimal results in profit while mitigating risk. The implementation of the portfolio approach is based on a multi-stage stochastic programming model in which replenishment decisions are made at various stages along a time horizon, with replenishment quantities being determined by simultaneously considering the stochastic demand and the price volatility of the spot market. The model attempts to minimise the risk exposure of procurement decisions measured as conditional value-at-risk. Numerical experiments to test the effectiveness of the proposed model are performed using demand data from a large air conditioner manufacturer in China and price volatility data from the Shanghai steel market. The results indicate that the proposed model can fairly reliably outperform other approaches, especially when either the demand and/or prices exhibit significant variability.

It is well known from laboratory testing that the rock failure process becomes unstable in a soft test machine due to excessive energy released from the machine. Great efforts had been devoted to increasing the loading system stiffness (LSS) of laboratory test machines to ensure that the post-peak stress–strain curve of rock can be obtained for underground rock engineering design. A comprehensive literature review on the development of stiff test machines reveals that because of the differences in the manufacturing arrangement of the test machines, LSS values of the test machines used for rock property testing are always finite and vary in a large range, and the influence of LSS on stable rock failure is less understood. A FEM-based numerical experiment is carried out to study the influence of LSS on the stress–strain curves of stable rock failure in uniaxial compression, with a focus on the post-peak deformation stage. Three test machine loadings including idealized rigid loading, platen loading, and frame–platen loading with finite LSS are considered, and the simulation results are analyzed and compared. The modeling results obtained from the simulations indicate that even if the LSS value is large enough to inhibit unstable rock failure, as long as LSS is finite, it has an influence on the post-peak stress–strain curve of rock. It is revealed that because the input energy supplied by the external energy source to drive the stable rock failure process is affected by the finite LSS of a test machine, the post-peak descending slopes of the stress–strain curves are all steeper than the post-peak descending slope obtained under an ideal loading condition of infinite LSS. An insight from this numerical experiment is that it might be more feasible to develop laboratory test machines with variable LSS that can match the local mine stiffness in the field for rock property testing.