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The traditional disease-oriented model of healthcare is inadequate to address the needs of the older population. Greater attention should be given to strategies that promote healthy aging. Recently proposed constructs of intrinsic capacity (IC) and physical resilience (PR) hold great potential to reshape geriatric medicine and aging research. These constructs accentuate the positive health attributes of older people in contrast to the popular frailty construct that is centered on functional deficits. IC was introduced by the World Health Organization (WHO) as a composite of all the physical and mental capacities. WHO has emphasized enhancement of IC throughout the life course so as to maintain functional ability in old age. PR, recently highlighted by the National Institute on Aging, is the ability to successfully cope with stressors. High levels of resilience can result in desirable clinical and functional outcomes after stressors. Therefore, it is important to understand the underlying physiology of PR and the risk factors contributing to diminished PR. The main goal of this article is to explore the potential relationship between IC and PR. Based on a classical theory of aging, we postulate that IC is a determinant of PR and is also a high-level integrative measure of physiologic reserve which is the fundamental factor underlying one's ability to withstand stressors. A major implication of our postulates is that even though IC is only one of the many determinants of PR, it could serve as an important intervenable target for enhancing resilience in older adults.

Aluminum (Al) is the most abundant metal in the Earth's crust and is not an essential element for plant growth. In contrast, nitrogen (N) is the most important mineral element for plant growth, but this non-metal is often present at low levels in soils, and plants are often N deficient. Aluminum toxicity is dominant in acid soils, and so plants growing in acid soils have to overcome both Al toxicity and N limitation. Because of low N-use efficiency, large amounts of N fertilizers are applied to crop fields to achieve high yields, leading to soil acidification and potential Al toxicity. Aluminum lowers plant N uptake and N-use efficiency because Al inhibits root growth. Although numerous studies have investigated the interactions between Al and N, a complete review of these studies was lacking. This review describes: (1) the link between plant Al tolerance and ammonium/nitrate (NH /NO ) preference; (2) the effects of NH /NO and pH on Al toxicity; (3) the effects of Al on soil N transformations; and (4) the effects of Al on NH /NO uptake and assimilation by plants. Acid soils are characterized chemically by a relatively high ratio of NH to NO and high concentrations of toxic Al. Aluminum-tolerant plants generally prefer NH as an N source, while Al-sensitive plants prefer NO . Compared with NO , NH increases the solubilization of toxic Al into soil solutions, but NH generally alleviates Al phytotoxicity under solution culture because the protons from NH compete with Al for adsorption sites on the root surface. Plant NO uptake and nitrate reductase activity are both inhibited by Al, while plant NH uptake is inhibited to a smaller degree than NO . Together, the results of numerous studies indicate that there is a synergistic interaction between plant Al tolerance and NH nutrition. This has important implications for the adaptation of plants to acid soils that are dominated chemically by toxic Al as well as NH . Finally, we discuss how this knowledge can be used to increase plant Al tolerance and N-use efficiency in acid soils.

Mergers of neutron stars are known to be associated with short γ-ray bursts 1 – 4 . If the neutron-star equation of state is sufficiently stiff (that is, the pressure increases sharply as the density increases), at least some such mergers will leave behind a supramassive or even a stable neutron star that spins rapidly with a strong magnetic field 5 – 8 (that is, a magnetar). Such a magnetar signature may have been observed in the form of the X-ray plateau that follows up to half of observed short γ-ray bursts 9 , 10 . However, it has been expected that some X-ray transients powered by binary neutron-star mergers may not be associated with a short γ-ray burst 11 , 12 . A fast X-ray transient (CDF-S XT1) was recently found to be associated with a faint host galaxy, the redshift of which is unknown 13 . Its X-ray and host-galaxy properties allow several possible explanations including a short γ-ray burst seen off-axis, a low-luminosity γ-ray burst at high redshift, or a tidal disruption event involving an intermediate-mass black hole and a white dwarf 13 . Here we report a second X-ray transient, CDF-S XT2, that is associated with a galaxy at redshift z  = 0.738 (ref. 14 ). The measured light curve is fully consistent with the X-ray transient being powered by a millisecond magnetar. More intriguingly, CDF-S XT2 lies in the outskirts of its star-forming host galaxy with a moderate offset from the galaxy centre, as short γ-ray bursts often do 15 , 16 . The estimated event-rate density of similar X-ray transients, when corrected to the local value, is consistent with the event-rate density of binary neutron-star mergers that is robustly inferred from the detection of the gravitational-wave event GW170817. Observations of an X-ray transient associated with a galaxy at redshift 0.738 suggest that the X-ray transient is powered by a millisecond magnetar and that it is the remnant of a merger between two neutron stars.

Superconducting and topological states are two most intriguing quantum phenomena in solid materials. The entanglement of these two states, the topological superconducting state, will give rise to even more exotic quantum phenomena. While many materials are found to be either a superconductor or a topological insulator, it is very rare that both states exist in one material. Here, we demonstrate by first-principles theory as well as scanning tunnelling spectroscopy and angle-resolved photoemission spectroscopy experiments that the recently discovered ‘two-dimensional (2D) superconductor’ of single-layer FeSe also exhibits 1D topological edge states within an energy gap of ∼40 meV at the M point below the Fermi level. It is the first 2D material that supports both superconducting and topological states, offering an exciting opportunity to study 2D topological superconductors through the proximity effect. The coexistence of topological and superconducting states in a single layer of FeSe on a SrTiO 3 substrate is reported.

Frailty is a pervasive condition among older people worldwide. Despite the association between higher protein intake and lower frailty risk has been well documented, older individuals encounter barriers to enhancing their protein consumption due to reduced appetite and impaired digestive capacity. This study aims to delve into the potential correlation between dietary protein diversity, protein patterns, and the risk of frailty among older Chinese individuals. Prospective cohort study. Community-based. 2,216 participants aged 65 and above and not frail at the baseline were recruited from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) dataset spanning from 2014 to 2018. Dietary protein diversity was evaluated utilizing a protein diversity score (PDS), calculated based on the results of a food frequency questionnaire. Dietary protein patterns were identified by employing principal component analysis (PCA). Frailty was ascertained using a 40-item frailty index (FI) where FI > 0.21 indicated frailty. Logistic analysis was employed to investigate the association between dietary variables and frailty. 541 participants were identified as frail after a 4-year follow-up. After adjusting for confounders, each 1-unit increase in PDS was linked to a 10% decrease in frailty risk. Compared to individuals with PDS ≤ 1, those with PDS scores of 2–3, 4–5, and 6 had lower risks of frailty, with OR (95% CI) of 0.78 (0.58–1.06), 0.58 (0.38–0.87), 0.42 (0.20–0.81), respectively (P trend = 0.038). Individuals who consistently maintained high PDS demonstrated a lower frailty risk in contrast to those who maintained low PDS (OR = 0.60, 95% CI, 0.41–0.87). Additionally, the “meat-fish” pattern exhibited a protective association with frailty, with OR Q4 versus Q1 (95% CI) of 0.54 (0.40–0.74), P trend < 0.001. Maintaining a variety of dietary protein sources and following a “meat-fish” protein pattern might decrease the likelihood of frailty among the older Chinese population.

Nematicity, where electrons break rotational symmetry while preserving translational symmetry, is ubiquitous in strongly correlated quantum matters, including high‐Tc cuprates and iron‐based superconductors. A central question in nematicity is whether it is driven by Fermi surface instability in momentum space or orbital order (polarization) in real space, especially as nematicity intertwines with superconductivity. FeSe/SrTiO3 (STO), where nematicity occurs without long‐range magnetic order, is an ideal platform for studying the nature and origin of the electronic nematicity. Here, direct evidence of d‐wave nematic order in two monolayer FeSe/STO using angle‐resolved photoemission spectroscopy is presented, revealing a remarkable degeneracy of dxz and dyz bands at the Brillouin zone center, but a significant band separation at the zone corner. This momentum‐dependent nematicity demonstrates that nematicity in FeSe/STO originates from the d‐wave Fermi surface instability of the Pomeranchuk‐type, offering insights into the relationship between nematicity and superconductivity. The results establish 2D FeSe thin film as a powerful platform for investigating quantum physics under complex intertwinement. Angle‐resolved photoemission spectroscopy reveals a d‐wave nematic order in two‐monolayer FeSe/SrTiO3, showing degenerate dxz/dyz bands at Γ but a pronounced splitting at M. This momentum‐dependent anisotropy identifies the nematicity as a d‐wave Fermi surface (Pomeranchuk) instability, highlighting 2D FeSe as a model platform to explore the interplay between nematicity and superconductivity.

Bladder cancer (BLCA) is one of the most frequent genitourinary cancers, with a high rate of morbidity and mortality. The connection of m6A-related lncRNAs with PD-L1 and tumor immune microenvironment (TIME) in BLCA prognosis was extensively investigated in this study, which could suggest novel therapeutic targets for further investigation. 30 m6A-associated lncRNAs with predictive values from the TCGA data set were identified with co-expression analysis. Cluster2 was correlated with a poor prognosis, upregulated PD-L1 expression, and higher immune ratings. Cluster2 had larger amounts of resting CD4 memory-activated T cells, M2 macrophages, neutrophils, and NK cells infiltration. “CHEMOKINE SIGNALING PATHWAY” was the most significantly enriched signaling pathway according to GSEA, which may play an important role in the different immune cell infiltrates between cluster1/2. The risk model for m6A-related lncRNAs could be employed in a prognostic model to predict BLCA prognosis, regardless of other clinical features. Collectively, m6A-related lncRNAs were linked to PD-L1 and TIME, which would dynamically affect the number of tumor-infiltrating immune cells. m6A-related lncRNAs may be key mediators of PD-L1 expression and immune cells infiltration and may strongly affect the TIME of BLCA.

Next-generation neutrino telescopes with substantially improved sensitivity are required to pinpoint the sources of the diffuse astrophysical neutrino flux detected by IceCube and uncover the century-old puzzle of cosmic-ray origins. A detector near the Equator will provide a unique viewpoint of the neutrino sky, complementing IceCube and other neutrino telescopes in the Northern Hemisphere. Here we present results from an expedition to the northeastern region of the South China Sea, in the western Pacific Ocean. A favourable neutrino telescope site was found on an abyssal plain at a depth of ~3.5 km. At depths below 3 km, the sea current speed, water absorption and scattering lengths for Cherenkov light were measured to be vc < 10 cm s−1, λabs ≈ 27 m and λsca ≈ 63 m, respectively. Accounting for these measurements, we present the design and expected performance of a next-generation neutrino telescope, Tropical Deep-sea Neutrino Telescope (TRIDENT). With its advanced photon-detection technology and large dimensions, TRIDENT expects to observe the IceCube steady source candidate NGC 1068 with 5σ significance within 1 year of operation. This level of sensitivity will open a new arena for diagnosing the origin of cosmic rays and probing fundamental physics over astronomical baselines.A South China Sea expedition in 2021 identified a 3.5-km-deep site close to the Equator for a next-generation neutrino telescope: TRIDENT. A large array of advanced detectors will be arrayed on the seabed to probe fundamental physics and explore the extreme Universe.

Chimeric Antigen Receptor T cell(CAR T-cell) therapy has been a great success in relapsed/refractory acute B lymphoblastic leukemia and B-cell lymphoma. At the same time, there are also related adverse reactions, especially cytokine release syndrome(CRS) and immune effector cell associated neurotoxicity syndrome(ICANS). However, Double CRS caused by CRA T cells are very rare. Here, we report a 33-year-male with secondary central diffuse large B-cell lymphoma(CNSL) who develpoed double CRS following sequential infusion of Anti-CD22 and Anti-CD19 CAR T cells after autologous hematopoietic stem cell transplantation(ASCT). On d+5, the patient developed high fever, along with chilly sensation, shivering, headache, blood oxygen desaturation, shock, weakness, severe thirst, and heart rate decline. IL-6 and ferritin increased significantly. The patient was diagnosed with the first CRS (grade 3). On d+36, the patient again had a persistent fever(T>39C) and limbs rash. IL-6 and ferritin again increased significantly on d+38. After exclusion of infection, a diagnosis of double CRS was made. The patient's symptoms were completely relieved after receiving tocilizumab, glucocorticoids, and other supportive treatments on d+45.On d+90, contrast-enhanced MR angiogram shows that the lesion basically disappeared, indicating the patient had achieved CR. At the end of the follow-up at d+150, the patient was functioning normally without any sequelae. This is the first reported case worldwide where the patient with secondary CNSL suffered double CRS after CAR T-cell infusion. Our findings showed that it is important to increase awareness of early detection and diagnosis of double CRS and adopt appropriate treatment strategies.

Evidence suggests that built environment characteristics affect older adults’ travel activity behaviors, e.g., walking and cycling, which have well-established health benefits. However, the relationship between urban greenery and walking behaviors remains unclear, partly due to methodological limitation. Previous studies often measured urban greenery from a bird’s eye perspective, which may mismatch with the pedestrian’s perception from the street. In this study, we measured greenery view index from eye-level streetscape photos retrieved from Baidu Street View, an online mapping service provider. Walking behaviors of 180 older adults in six neighborhoods were collected from questionnaires. We also measured land use diversity, pedestrian-oriented design (street connectivity), and population density—the three Ds of the built environment. Results show that street greenery view index contributes to walking time of older adults, suggesting street greenery should be taken into design consideration to promote walking behaviors of older adults.