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"Xue, Xiang-Xiang"
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Death from Covid-19 of 23 Health Care Workers in China
This report describes the deaths from Covid-19 of 23 health care workers, including physicians, surgeons, a nurse, and an electrocardiography technician. Only 2 of the health care workers were physicians in respiratory medicine who had been specifically assigned to treat patients with Covid-19. Eleven had come out of retirement to serve as clinicians.
Journal Article
Contribution of Gaia Sausage to the Galactic Stellar Halo Revealed by K Giants and Blue Horizontal Branch Stars from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope, Sloan Digital Sky Survey, and Gaia
We explore the contribution of the Gaia Sausage to the stellar halo of the Milky Way by making use of a Gaussian mixture model (GMM) and applying it to halo star samples of Large Sky Area Multi-Object Fiber Spectroscopic Telescope K giants, Sloan Extension for Galactic Understanding and Exploration K giants, and Sloan Digital Sky Survey blue horizontal branch stars. The GMM divides the stellar halo into two parts, of which one represents a more metal-rich and highly radially biased component associated with an ancient, head-on collision referred to as the Gaia Sausage, and the other one is a more metal-poor and isotropic halo. A symmetric bimodal Gaussian is used to describe the distribution of spherical velocity of the Gaia Sausage, and we find that the mean absolute radial velocity of the two lobes decreases with the Galactocentric radius. We find that the Gaia Sausage contributes about 41%–74% of the inner (Galactocentric radius r gc < 30 kpc) stellar halo. The fraction of stars of the Gaia Sausage starts to decline beyond r gc ∼ 25–30 kpc, and the outer halo is found to be significantly less influenced by the Gaia Sausage than the inner halo. After the removal of halo substructures found by integrals of motion, the contribution of the Gaia Sausage falls slightly within r gc ∼ 25 kpc but is still as high as 30%–63%. Finally, we select several possible Sausage-related substructures consisting of stars on highly eccentric orbits. The GMM/Sausage component agrees well with the selected substructure stars in their chemodynamical properties, which increases our confidence in the reliability of the GMM fits.
Journal Article
A New Tidal Stream Discovered in Gaia DR3
Thanks to the precise astrometric measurements of proper motions by the Gaia mission, a new tidal stellar stream has been discovered in the northern hemisphere. The distribution of star count shows that the stream is approximately 80° long and 1.°70 wide. Observations of 21 member stars, including 14 RR Lyrae stars, indicate that the stream has an eccentric and retrograde orbit with e = 0.58. The low metallicity, high total energy, and large angular momentum suggest that it is associated with the merging event Sequoia. This discovery suggests the possibility of finding more substructures with high eccentricity orbits, even in the inner halo.
Journal Article
Milky Way Mass Through Escape Velocity Curve from LAMOST K Giants
Escape velocity has long been used to constrain the mass of the dark matter (DM) halo in the Milky Way (MW). Here, we present a study of the escape velocity curve using a sample of high-velocity K giants with full 6D phase-space information and of relatively good quality, selected from LAMOST DR8 and cross-matched with Gaia DR3. To expand the high-velocity stars to larger distances, we used radius-dependent criteria of total velocity, i.e., vGC > 300 km s−1 for the solar neighborhood and vGC>vmin∼0.6×vesc(rGC) for the outer region. We also selected halo stars based on vϕ − [Fe/H] information to ensure that the sample is isotropic. We modeled the velocity distribution with traditional power-law models to determine the escape velocity in each radial bin. For the first time, we have directly measured a relatively continuous escape velocity curve that can extend to Galactocentric radii of ∼50 kpc, finding a decline in agreement with previous studies. The escape velocity at the solar position yielded by our measurements is 523.74−13.47+12.83kms−1 . Combined with the local circular velocity, we estimated the mass of the MW assuming a Navarro–Frenk–White DM profile, which resulted in a total mass of M200,total=0.90−0.07+0.06×1012M⊙ , with a concentration of c200=13.47−1.70+1.85 . The small uncertainty implies that including the escape velocities beyond the solar neighborhood can result in a more precise mass estimate. Our derived MW mass is consistent with some recent studies using the escape velocity as well as other tracers, which may support a lower mass of the DM halo than in the past.
Journal Article
Beyond Spectroscopy. II. Stellar Parameters for over 20 Million Stars in the Northern Sky from SAGES DR1 and Gaia DR3
We present precise photometric estimates of stellar parameters, including effective temperature, metallicity, luminosity classification, distance, and stellar age, for nearly 26 million stars using the methodology developed in the first paper of this series, based on the stellar colors from the Stellar Abundances and Galactic Evolution Survey (SAGES) Data Release 1 and Gaia Early Data Release 3. The optimal design of stellar-parameter sensitive uv filters by SAGES has enabled us to determine photometric-metallicity estimates down to −3.5, similar to our previous results with the SkyMapper Southern Survey (SMSS), yielding a large sample of over five million metal-poor ([Fe/H] ≤ −1.0) stars and nearly one million very metal-poor ([Fe/H] ≤ −2.0) stars. The typical precision is around 0.1 dex for both dwarf and giant stars with [Fe/H] > −1.0, and 0.15–0.25/0.3–0.4 dex for dwarf/giant stars with [Fe/H] < −1.0. Using the precise parallax measurements and stellar colors from Gaia, effective temperature, luminosity classification, distance, and stellar age are further derived for our sample stars. This huge data set in the Northern sky from SAGES, together with similar data in the Southern sky from SMSS, will greatly advance our understanding of the Milky Way, in particular its formation and evolution.
Journal Article
The Rotating Bulge and Halo in the Milky Way: Evidence of Angular Momentum Transferred from the Decelerating Bar
Recent observations indicate that both the Milky Way bulge and inner halo exhibit angular momentum, although the origin and evolution of this prograde signature remain ambiguous. One plausible scenario involves secular evolution induced by the central bar and spiral arms. In this study, we identified a component consisting of 1,175,737 stars with net rotation through the application of a neural network (NN) method. To investigate the composition of this rotating sample and the origin of its rotation, we conducted a test particle simulation incorporating an equilibrium axisymmetric background potential together with a central decelerating bar. The test particles were generated using a distribution function model derived from observational constraints. Our results indicate that the decelerating bar transfers angular momentum to the pseudo-stars, and the rotational profile from our simulation shows strong agreement with observational data. These findings suggest that the rotating sample identified by our NN model is predominantly comprised of bulge, halo, and thick disk stars, and that the central decelerating bar is pivotal in shaping the inner Galaxy’s kinematics through angular momentum transfer.
Journal Article
Four-hundred Very Metal-poor Stars Studied with LAMOST and Subaru. III. Dynamically Tagged Groups and Chemodynamical Properties
Very metal-poor (VMP) stars record the signatures of early accreted galaxies, making them essential tools for unraveling the early stages of Galaxy formation. Understanding the origin of VMP stars requires comprehensive studies of their chemical compositions and kinematics, which are currently lacking. Hence, we conduct a chemodynamical analysis of 352 VMP stars selected from one of the largest uniform high-resolution VMP star samples, jointly obtained from LAMOST and Subaru. We apply a friends-of-friends clustering algorithm to the master catalog of this high-resolution sample, which consists of 5778 VMP stars. It results in 131 dynamically tagged groups with 89 associated with known substructures in the Milky Way, including Gaia-Sausage-Enceladus (GSE), Thamnos, Helmi streams, Sequoia, Wukong, Pontus, and the very metal-poor disk (VMPD). Our findings are: (i) the VMPD shows lower Zn abundances than the rest, which indicates that it could be a relic of small stellar systems; (ii) Sequoia shows moderately high r-process abundances; (iii) Helmi streams show deficiencies in carbon and light neutron-capture elements; (iv) the fraction of carbon-enhanced metal-poor stars with no enhancement in heavy elements (CEMP-no stars) seems low in the VMPD and the Helmi streams; and (v) a subgroup in GSE exhibits a very high fraction of r-process enhanced stars, with four out of five showing [Eu/Fe]> +1.0. The abundance patterns of other elements in VMP substructures largely match the whole VMP sample. We also study large-scale correlations between abundance ratios and kinematics without classifying stars into substructures, but it does not yield significant correlations once the overall chemical evolution is considered for most elements.
Journal Article
Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the US. Understanding the mechanisms of CRC progression is essential to improve treatment. Mitochondria is the powerhouse for healthy cells. However, in tumor cells, less energy is produced by the mitochondria and metabolic reprogramming is an early hallmark of cancer. The metabolic differences between normal and cancer cells are being interrogated to uncover new therapeutic approaches. Mitochondria targeting PTEN-induced kinase 1 (PINK1) is a key regulator of mitophagy, the selective elimination of damaged mitochondria by autophagy. Defective mitophagy is increasingly associated with various diseases including CRC. However, a significant gap exists in our understanding of how PINK1-dependent mitophagy participates in the metabolic regulation of CRC. By mining Oncomine, we found that PINK1 expression was downregulated in human CRC tissues compared to normal colons. Moreover, disruption of PINK1 increased colon tumorigenesis in two colitis-associated CRC mouse models, suggesting that PINK1 functions as a tumor suppressor in CRC. PINK1 overexpression in murine colon tumor cells promoted mitophagy, decreased glycolysis and increased mitochondrial respiration potentially via activation of p53 signaling pathways. In contrast, PINK1 deletion decreased apoptosis, increased glycolysis, and reduced mitochondrial respiration and p53 signaling. Interestingly, PINK1 overexpression in vivo increased apoptotic cell death and suppressed colon tumor xenograft growth. Metabolomic analysis revealed that acetyl-CoA was significantly reduced in tumors with PINK1 overexpression, which was partly due to activation of the HIF-1α-pyruvate dehydrogenase (PDH) kinase 1 (PDHK1)-PDHE1α axis. Strikingly, treating mice with acetate increased acetyl-CoA levels and rescued PINK1-suppressed tumor growth. Importantly, PINK1 disruption simultaneously increased xenografted tumor growth and acetyl-CoA production. In conclusion, mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming and reducing acetyl-CoA production.
Journal Article