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The electrostatic effects of separators under the internal electric field are often overlooked, leading to the unreliability of traditional theoretical models. Here we introduce the dielectric constant as a descriptor and develop a high dielectric constant fiber separator primarily composed of phosphorylated cellulose. Under the internal electric field, the intense electron displacement polarization within the high dielectric constant separator enhances the charge transfer kinetics and optimizes the solvation structure, thus mitigating the formation of amorphous organic oligomers at the solid-electrolyte interphase. Furthermore, the separator induces the formation of LiF, thereby forming a robust and low-resistance solid-electrolyte interphase. The separator exhibits high ionic conductivity (0.76 mS cm −1 at 25 °C) and Li + transference number (0.68). Consequently, the Li||LiFePO 4 pouch cell with the prepared separator achieve high specific energy exceeding 350 Wh kg −1 (relative to the mass of pouch cells) under practical quantities of active materials and electrolyte. Electrostatic effects of separators under internal electric field is crucial for Li metal batteries. Here, authors develop a high dielectric constant fiber separator that shows substantial polarization under electric field to facilitate a robust and low-resistance solid-electrolyte interphase.

Background Studies examining the therapeutic potential of Mesenchymal stem cells-derived extracellular vesicles (MSC-EVs) in wound healing and skin regeneration have progressed rapidly. Prior to considering clinical translation, a systematic and comprehensive understanding of these experimental details and the overall impact of MSC-EVs on skin regeneration is necessary. Methods 83 studies were identified in Web of Science, Embase, and PubMed that satisfied a set of prespecified inclusion criteria. A random effects meta-analysis was conducted for wound closure rate, scar width, blood vessel density and collagen deposition. Conclusions Our findings demonstrate clear potential of MSC-EVs to be developed as therapy for wound healing and skin regeneration both in diabetic and non-diabetic animal models. Moreover, subgroup analyses demonstrated that apoptotic small extracellular vesicles (ApoSEVs) showed better efficacy than apoptotic bodies (ApoBDs) and small extracellular vesicles (sEVs) in wound closure outcome and collagen deposition, while sEVs displayed better than ApoEVs in revascularization. Among frequently used routes of administration, subcutaneous injection displayed a greater improvement to wound closure, collagen deposition and revascularization as compared to dressing/covering. Among easier-access source of MSCs, ADSCs demonstrated the best effect in wound closure rate and collagen deposition, as compared, BMMSCs displayed better in revascularization. Additionally, high heterogeneity observed in collection conditions, separation methods, storage methods, modifications, treatment dose, administration route, and frequency of MSC-EVs underscores the urgent need for standardization in these areas, prior to clinical translation. Protocol Registration PROSPERO CRD42024499172.

The accurate estimation of the zero-height geopotential level in a local vertical datum (LVD) is critical for linking traditional height reference systems to a global height system. In this paper, we investigate the theoretical and practical challenges involved in determining the offset between the North American vertical datum (NAVD) and the global vertical datum (GVD). Drawing on the classical theory of the vertical system in physical geodesy, we define the vertical datum offset and derive rigorous formulas for its calculation. We examine various factors that affect the determination of the offset, including the global gravitational models (GGMs), geodetic reference system, tide system, tilt error, and omission error. Using terrestrial gravity data and gravity anomalies from multiple GGMs in conjunction with Global Navigation Satellite System (GNSS) and orthometric heights, we estimate the vertical offset between the NAVD and GVD. Our results indicate that the geopotential difference approach and the geodetic boundary value problem (GBVP) approach yield consistent results. When the normal gravity geopotential of the geodetic reference system is selected as the gravity geopotential of the global height datum, the NAVD is approximately 0.04 m higher than the GVD relative to the GRS80 ellipsoid, and 0.97 cm higher than the GVD relative to the WGS84 ellipsoid. When the Gauss–Listing geopotential value is chosen as the gravity geopotential of the global height datum, the NAVD is roughly 1.45 m higher than the GVD relative to the GRS80 ellipsoid, and approximately 0.52 m higher than the GVD relative to the WGS84 ellipsoid.

Edge detection plays an important role in interpreting geophysical potential field data and revealing faults, contacts, and other linear tectonic structures. Various methods have been proposed to detect and enhance edges; however, they are often sensitive to noise, unable to adequately balance amplitude information across different depths, and may introduce false edges that require manual removal. To overcome these limitations, we present an improved method called the hyperbolic tangent function with Gaussian envelope constraints on the horizontal gravity gradient tilt angle (THTAHG) that is based on the tilt angle of the horizontal gravity gradient and the hyperbolic tangent (TANH) function under Gaussian envelope constraints. The applicability of the method is illustrated with three synthetic models and actual gravity data. Compared with existing edge detection techniques, our method provides clearer and more precise identification results, with enhanced stability and without introducing spurious boundaries. Finally, to address the problem of the plate boundary division and internal response of the Tibetan Plateau, this research studies the characteristics of the distribution of the tectonic structures of the Tibetan Plateau and its surroundings on the basis of the THTAHG method with Bouguer gravity anomaly data. A total of 20 fault zones are identified, which have been verified by previous studies. We verify the existence of the central uplift zone of the Qiangtang Basin. These experiments demonstrate that this work provides an effective method for studying tectonic boundaries and geodynamic evolution. Graphical Abstract

Density imaging is a method that uses the inversion of the gravity and gravity gradient spectra in the wavenumber domain to create accurate 3D reconstructions of subsurface density distributions. This approach offers computational efficiency and rapid calculations. This research used preliminary inversions to examine the spectral characteristics of gravity and gravity gradient anomalies, as well as the resulting models, were scrutinized through preliminary inversions. 3D density imaging of gravity and gravity gradient was performed in the wavenumber domain using depth weighting on both noise-added and theoretical data, producing a density model that was consistent with the theoretical one. The technique was then used in the Decorah region of the United States, where 3D density imaging was performed and an examination of the properties of gravity and gravity gradient anomalies was conducted. The results showed where high-density Decorah complexes, low-density siliceous intrusive rocks, and high-density intrusive rock masses, were the distributed within the surrounding rock. Each of these provided comprehensive insights into the intrusive pathways to the rock mass. Thus, the appropriateness and effectiveness of the density imaging method were confirmed, supporting a deeper understanding of the structural division and geological evolution in the region.

Cellulose, as one of the most abundant natural biopolymers, has been widely used in textile industry. However, owing to its drawbacks of flammability and ignitability, the large-scale commercial application of neat cellulose is limited. This study investigated some TEMPO-oxidized cellulose (TOC) which was prepared by selective TEMPO-mediated oxidation and ion exchange. The prepared TOC was characterized by Fourier transform infrared (FT-IR) spectroscopy and solid-state 13C-nuclear magnetic resonance (13C-NMR) spectroscopy. The thermal stability and combustion performance of TOC were investigated by thermogravimetry analysis (TG), microscale combustion calorimetry (MCC) and limiting oxygen index (LOI). The results demonstrated that the thermal stability of TOC was less than that of the pristine material cellulose, but the peak of heat release rate (pHHR) and the total heat release (THR) of all TOC were significantly reduced. Additionally, the LOI values of all TOC products were much higher 25%. In summary, the above results indicated that the modified cellulose with carboxyl groups and metal ions by selective oxidation and ion exchange endows efficient flame retardancy.

Background In the repair of massive tissue defects using expanded large skin flaps, the incidence of complications increases with the size of the expanded area. Currently, stem cell therapy has limitations to solve this problem. We hypothesized that conditioned medium of adipose-derived stem cells (ADSC-CM) collected following mechanical pretreatment can assist skin expansion. Methods Rat aortic endothelial cells and fibroblasts were cultured with ADSC-CM collected under 0%, 10%, 12%, and 15% stretching force. Ten-milliliter cylindrical soft tissue expanders were subcutaneously implanted into the backs of 36 Sprague-Dawley rats. The 0% and 10% stretch groups were injected with ADSC-CM collected under 0% and 10% stretching force, respectively, while the control group was not injected. After 3, 7, 14, and 30 days of expansion, expanded skin tissue was harvested for staining and qPCR analyses. Results Endothelial cells had the best lumen formation and highest migration rate, and fibroblasts secreted the most collagen upon culture with ADSC-CM collected under 10% stretching force. The skin expansion rate was significantly increased in the 10% stretch group. After 7 days of expansion, the number of blood vessels in the expanded area, expression of the angiogenesis-associated proteins vascular endothelial growth factor, basic fibroblast growth factor, and hepatocyte growth factor, and collagen deposition were significantly increased in the 10% stretch group. Conclusions The optimal mechanical force upregulates specific paracrine proteins in ADSCs to increase angiogenesis and collagen secretion, and thereby promote skin regeneration and expansion. This study provides a new auxiliary method to expand large skin flaps.

Repair of large soft tissue defects by tissue expansion often faces difficulties in skin expansion. Particularly in those who have lost a significant amount of skin and subcutaneous tissue due to total mastectomy, tissue expansion may result in skin breakdown and exposure of the expander. Subcutaneous fat construction by autologous fat grafting before expansion seems to assist skin expansion. We hypothesize that it may be related to the adipose‐derived stem cells (ADSCs) in subcutaneous fat. In this study, we confirmed this phenomenon through animal experiments and provided a preliminary investigation of the possible mechanisms involved. Four groups were designed for the experiment, experimental group (EG) for autologous fat flap transfer and tissue expansion. Fat grafting control group (FGCG), where only autologous fat flap transfer was performed without tissue expansion. Tissue expansion control group (TECG) did not perform autologous fat flap transfer but only skin tissue expansion on the back. Blank control group (BCG) has not received any surgery. In each group of 20 rats, skin, and fat flaps of the dilated area were sampled at four time points (7, 14, 21, and 28 days, n = 5), and the immediate skin retraction rate of the expanded area in the EG and TECG groups was measured to evaluate the expansion effect. GFP + ADSCs were observed to demonstrate whether they were facilitated by tissue expansion and migrated from autologous fat flaps to skin. Our study supported that fat layer construction prior to skin expansion helps to promote skin growth. The promotion may be related to the migration of ADSCs from adipose to dermis by compression, and ADSCs migrating to dermis further promote skin stretching through direct differentiation or paracrine cytokines to promote cell proliferation and collagen synthesis.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by augmented type I interferon signaling. High-throughput technologies have identified plenty of SLE susceptibility single-nucleotide polymorphisms (SNPs) yet the exact roles of most of them are still unknown. Functional studies are principally focused on SNPs in the coding regions, with limited attention paid to the SNPs in non-coding regions. Long non-coding RNAs (lncRNAs) are important players in shaping the immune response and show relationship to autoimmune diseases. In order to reveal the role of SNPs located near SLE related lncRNAs, we performed a transcriptome profiling of SLE patients and identified linc00513 as a significantly over expressed lncRNA containing functional SLE susceptibility loci in the promoter region. The risk-associated G allele of rs205764 and A allele of rs547311 enhanced linc00513 promoter activity and related to increased expression of linc00513 in SLE. We also identified linc00513 to be a novel positive regulator of type I interferon pathway by promoting the phosphorylation of STAT1 and STAT2. Elevated linc00513 expression positively correlated with IFN score in SLE patients. Linc00513 expression was higher in active disease patients than those inactive ones. In conclusion, our data identify two functional promoter variants of linc00513 that contribute to increased level of linc00513 and confer susceptibility on SLE. The study provides new insights into the genetics of SLE and extends the role of lncRNAs in the pathogenesis of SLE.

This study presents a methodology for constructing a quasi-geoid model with millimeter-level accuracy over the Shangyu area in China, following the guidelines of the International Association of Geodesy Joint Working Group 2.2.2, known as “The 1 cm geoid experiment”. Our approach combines two steps to ensure exceptional accuracy. First, we employ Molodensky’s theory to model the gravity field, accounting for non-level surfaces and considering complex terrain effects. Through an exhaustive analysis of these influential factors, we implement a comprehensive suite of applicable formulae within Molodensky’s series solution, enabling a thorough assessment of their impacts on height anomalies within the gravimetric quasi-geoid model. Second, we utilize a hybrid method that involves a multi-surface function using the least-squares method and a robust estimation technique. This approach enables the interpolation of quasi-geoid heights by incorporating ellipsoidal and leveling normal heights, as well as gravimetric quasi-geoid data. Through a numerical example, we demonstrate the efficiency of our solution concept, achieving an accuracy of 0.79 cm compared to independent global navigation satellite system (GNSS)/leveling measurements. By developing this methodology, our study contributes to the advancement of geodesy research and provides a valuable methodology for creating highly precise quasi-geoid models in geodetic applications.