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Cancer-related burden of morbidity and mortality is rapidly rising worldwide. Medical imaging plays an important role in every phase of cancer management, including diagnosis, staging, treatment planning and evaluation. Iron oxide nanoparticles (IONPs) could serve as contrast agents or labeling agents to enhance the identification and visualization of pathological tissues as well as target cells. Multimodal or multifunctional imaging can be easily acquired by modifying IONPs with other imaging agents or functional groups, allowing the accessibility of combined imaging techniques and providing more comprehensive information for cancer care. To date, IONPs-enhanced medical imaging has gained intensive application in early diagnosis, monitoring treatment as well as guiding radio-frequency ablation, sentinel lymph node dissection, radiotherapy and hyperthermia therapy. Besides, IONPs mediated imaging is also capable of promoting the development of anti-cancer nanomedicines through identifying patients potentially sensitive to nanotherapeutics. Based on versatile imaging modes and application fields, this review highlights and summarizes recent research advances of IONPs-based medical imaging in cancer management. Besides, currently existing challenges are also discussed to provide perspectives and advices for the future development of IONPs-based imaging in cancer management.

In this study, for COVID-19, we divide people into four categories: susceptible St, closely contacted Ct, infective It, and removed Rt according to the current epidemic situation and then investigate two models: the SCIR models with immigration (Model (2) and without immigration (Model 1). For the former, Model 1, we obtain the condition for global stability of its disease-free equilibrium. For the latter, Model 2, we establish the local asymptotic stability of its endemic equilibrium by constructing Lyapunov function. Afterwards, by the bifurcation theory, we qualitatively analyze the properties of its Hopf bifurcations of the latter. Finally, numerical simulations are given to illustrate the obtained results of two models. The results imply the importance of finding closely contacted and overseas imports on epidemic control. It indicates that not only the incubation delay τ is crucial for the containment of the COVID-19 but also the scientific and rigorous containment measures are the key factors of the success of the containment.

Background Diapause is a crucial adaptive strategy employed across numerous insect species, endowing them to survive in unfavorable environments. Helicoverpa armigera , one of the most destructive pests globally, undergoes diapause in the pupa stage, which is essential for its survival during the overwintering period and ultimately determines the following year's population density. 20E is a primary hormone that regulates the process of pupae diapause. However, a comprehensive analysis of the mechanisms by which 20E regulates the initiation and termination of diapause in H. armigera remains lacking. Results In the present study, exogenous 20E was initially administered to diapausing pupae, and the results demonstrated that 20E markedly enhanced the development and eclosion rate of diapausing pupae, indicating that 20E treatment effectively terminated the diapause of H. armigera . Subsequently, RNA-Seq was employed to construct a comprehensive transcriptome map of the 20E-induced termination of diapause. The results demonstrated that there were 2836 differentially expressed genes, including 1315 genes that were upregulated and 1521 genes that were downregulated, in the 20E injection group relative to the control group. KEGG and GO enrichment analysis showed that these genes were associated with various metabolic pathways. Moreover, additional analysis revealed that the majority of the pivotal genes associated with metabolism (including glycolysis/gluconeogenesis, glycerolipid, amino sugar and nucleotide sugar metabolism), cell signaling pathways (such as insulin, Wnt, MAPK signaling pathways), the cell cycle, and stress resistance exhibited altered expression following 20E injection. These findings suggest that 20E exerts its primary influence on metabolic processes, cell signaling pathways, cell cycle, and stress resistance during the termination of diapause. Conclusions Our study presents a systematic and comprehensive analysis of the genes associated with 20E-induced diapause termination, thereby providing a foundation for elucidating the molecular mechanism of 20E regulating diapause. Furthermore, the findings lend support to the utilization of ecdysone analogs as pesticides in diapause-based pest management.

Capacitive deionization is an emerging desalination technology with mild operation conditions and high energy efficiency. However, its application is limited due to the low deionization capacity of traditional capacitive electrodes. Herein, we report a novel dual-ion capacitive deionization system with a lithium-ion battery cathode LiMn2O4/C and a sodium-ion battery anode NaTi2(PO4)3/C. Lithium ions could enhance the charge transfer during CDI desalination, while NaTi2(PO4)3/C provided direct intercalation sites for sodium ions. The electrochemical capacities of the battery electrodes fitted well, which was favorable for the optimization of the desalination capacity. The low potential of the redox couple Ti3+/Ti4+ (−0.8 V versus Ag/AgCl) and intercalation/deintercalation behaviors of sodium ions that suppressed hydrogen evolution could enlarge the voltage window of the CDI process to 1.8 V. The novel CDI cell achieved an ultrahigh desalination capacity of 140.03 mg·g−1 at 1.8 V with an initial salinity of 20 mM, revealing a new direction for the CDI performance enhancement.

Aulaskari et al. proved if 0 < p < 1 and ε n is sequence of independent, identically distributed Rademacher random variables on a probability space, then the condition Σ n = 0 ∞ n 1 − p a n 2 < ∞ implies that the random power series R f z = ∑ n = 0 ∞ a n ε n z n ∈ Q p almost surely. In this paper, we improve this result showing that the condition Σ n = 0 ∞ n 1 − p a n 2 < ∞ actually implies R f ∈ Q p , 0 almost surely.

The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2 synthesis to activate mucosal-associated invariant T (MAIT) cells. Key aspects of this evolutionarily conserved pathway remain uncharacterized, including where MR1 acquires ligands and what accessory proteins assist ligand binding. We answer these questions by using a fluorophore-labeled stable MR1 antigen analog, a conformation-specific MR1 mAb, proteomic analysis, and a genome-wide CRISPR/Cas9 library screen. We show that the endoplasmic reticulum (ER) contains a pool of two unliganded MR1 conformers stabilized via interactions with chaperones tapasin and tapasin-related protein. This pool is the primary source of MR1 molecules for the presentation of exogenous metabolite antigens to MAIT cells. Deletion of these chaperones reduces the ER-resident MR1 pool and hampers antigen presentation and MAIT cell activation. The MR1 antigen-presentation pathway thus co-opts ER chaperones to fulfill its unique ability to present exogenous metabolite antigens captured within the ER.

Polypyrrole (PPy) is widely available and has excellent potential for removing fluoride. Current research on PPy for fluoride removal mainly focuses on low-pollution neutral solution systems, such as drinking water and groundwater. However, there are fewer systematic studies on defluorination in acidic wastewater. In this work, a highly efficient hydrous CeO 2 polypyrrole nanocomposite (HCeO 2 @PPy) was prepared by in situ oxidative polymerization. The composites were characterized using XRD, SEM–EDS, FTIR, XPS, and point-of-zero charge (pzc) determination. The material was tested for its ability to remove fluoride from both simulated and industrial wastewater. The results showed that the adsorption capacity of HCeO 2 @PPy increased by 3 times to 43.6 mg/g when compared to PPy. The adsorbent was particularly effective in removing F − under acidic conditions. The Langmuir model was used to describe the adsorption process, and the maximum adsorption capacity was 80.93 mg/g. In competitive anion adsorption experiments, other ions had negligible effects on fluoride ion removal and the adsorbent had a strong affinity for F − . In addition, the adsorbent was able to achieve a removal efficiency of 71.7% in acidic wastewater. The main adsorption mechanism is attributed to ion exchange and electrostatic attraction. This study provides new insights for the development of efficient and stable fluoride removal materials in acidic fluoride wastewater with complex compositions.

Ethnopharmacological relevance: Pien-Tze-Huang (PZH)—a traditional Chinese medicine (TCM) compound—has been employed to treat various liver inflammation and tumors for over 10 decades. Interestingly, most of the pharmacological effects had been validated and explored toward liver ailment along with pro-inflammatory conditions and cancer at the cellular and molecular level to date. Aim of the study: The present study aimed to investigate the therapeutic effect of PZH on autophagy and TGF-β1 signaling pathways in rats with liver fibrosis and hepatic stellate cell line (HSC). Materials and methods: Male SD rats with carbon tetrachloride (CCl4)-induced liver fibrosis were used as the animal model. Next, PZH treatment was given for 8 weeks. Afterward, the therapeutic effects of PZH were analyzed through a hepatic tissue structure by hematoxylin-eosin (H&E), Van Gieson (VG) staining, and transmission electron microscopy (TEM), activity of ALT and AST by enzyme-associated immunosorbent assay as well. Subsequently, mRNA and protein expression were examined by quantitative polymerase chain reaction (qPCR), Western blotting, and immunohistochemistry (IHC). Then, the cell vitality of PZH-treated HSC and the expression of key molecules prevailing to autophagy were studied in vitro. Meanwhile, SM16 (a novel small molecular inhibitor which inhibits TGFβ-induced Smad2 phosphorylation) was employed to confirm PZH’s effects on the proliferation and autophagy of HSC. Results: PZH pharmacologically exerted anti-hepatic fibrosis effects as demonstrated by protecting hepatocytes and improving hepatic function. The results revealed the reduced production of extracellular collagen by adjusting the balance of matrix metalloproteinase (MMP) 2, MMP9, and tissue inhibitor of matrix metalloproteinase 1 (TIMP1) in PZH-treated CCl4-induced liver fibrosis. Interestingly, PZH inhibited the activation of HSC by down-regulating TGF-β1 and phosphorylating Smad2. Furthermore, PZH down-regulated yeast Atg6 (Beclin-1) and microtubule-associated protein light chain 3 (LC3) toward suppressing HSC autophagy, and PZH exhibited similar effects to that of SM16. Conclusion: To conclude, PZH alleviated CCl4-induced liver fibrosis to reduce the production of extracellular collagen and inhibiting the activation of HSC. In addition, their pharmacological mechanisms related to autophagy and TGF-β1/Smad2 signaling pathways were revealed for the first time.

Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, has an approximately 25% in-hospital mortality rate. Identifying early biomarkers of pediatric sepsis is crucial for improving outcomes. This study explored the differential expression of peptides in patients with sepsis compared to healthy controls and those with common infections using plasma peptidomic analysis. Blood samples were collected from 10 pediatric patients with sepsis admitted to Hunan Children’s Hospital in 2021, along with 20 age- and sex-matched healthy controls and five children with common infections. Differential peptide precursor proteins underwent gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses and protein–protein interaction analysis using the STRING database. Intotal, 3149 endogenous peptides corresponding to 480 precursor proteins were identified. Compared to the healthy group, the sepsis group exhibited 1113 differentially expressed peptides, with 880 upregulated and 233 downregulated. Compared with the common infection group, the sepsis group showed 181 upregulated and 86 downregulated peptides. These differences were primarily in the humoral immune response and complement and coagulation cascades. This study identified specific alterations in peptide expression in the plasma of patients with sepsis, most notably in peptides related to SAA1, complement C3, hemoglobin, and haptoglobin. These peptides are involved in the acute inflammatory response, complement system, and free hemoglobin pathways, indicating their crucial roles in sepsis pathology. These findings provide new insights into the mechanisms of sepsis and suggest potential applications for these peptides in sepsis diagnosis and treatment, to enhance early diagnosis and therapeutic outcomes.

Background Stereotactic body radiotherapy (SBRT) is a novel radio-therapeutic technique that has recently emerged as standard-of-care treatment for medically inoperable, early-stage non-small cell lung cancer (NSCLC). In this study, we compared the cost-effectiveness of SBRT with that of conventional fractionated radiotherapy (CFRT) in patients with medically inoperable, early-stage NSCLC from the perspective of the Chinese health system. Methods A Markov model was developed to describe health states of patients after treatment with SBRT and CFRT. The recurrence risks, treatment toxicities, and utilities inputs were obtained from the literature. The costs were based on listed prices and real-world evidence. A simulation was conducted to determine the post-treatment lifetime years. For each treatment, the total costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs) per QALY were calculated. Deterministic and probabilistic sensitivity analyses were performed to assess the uncertainty of the model parameters. Results In the base case analysis, SBRT was associated with a mean cost of USD16,933 and 2.05 QALYs, whereas CFRT was associated with a mean cost of USD17,726 and 1.61 QALYs. SBRT is a more cost-effective strategy compared with CFRT for medically inoperable, early-stage NSCLC, with USD 1802 is saved for every incremental QALY. This result was validated by DSA and PSA, in which SBRT remained the most cost-effective option. Conclusions The findings suggested that, compared to CFRT, SBRT may be considered a more cost-effective strategy for medically inoperable, early-stage NSCLC.